IGFBP3 (insulin like growth factor binding protein 3) - Rat Genome Database

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Gene: IGFBP3 (insulin like growth factor binding protein 3) Sus scrofa
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Symbol: IGFBP3
Name: insulin like growth factor binding protein 3
RGD ID: 13873689
Description: ENCODES a protein that exhibits insulin-like growth factor binding (ortholog); insulin-like growth factor II binding (ortholog); protein tyrosine phosphatase activator activity (ortholog); INVOLVED IN aging (ortholog); cellular response to estradiol stimulus (ortholog); cellular response to Thyroglobulin triiodothyronine (ortholog); PARTICIPATES IN insulin-like growth factor signaling pathway; ASSOCIATED WITH acoustic neuroma (ortholog); Acute-Phase Reaction (ortholog); Alzheimer's disease (ortholog); FOUND IN extracellular space (ortholog); heterochromatin (ortholog); insulin-like growth factor binary complex (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: IBP-3; IGF-binding protein 3; IGFBP-3; insulin-like growth factor-binding protein 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11850,002,921 - 50,009,425 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21854,851,168 - 54,855,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap18q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
Acute-Phase Reaction  (ISO)
Alzheimer's disease  (ISO)
ankylosing spondylitis  (ISO)
arteriosclerosis  (ISO)
autistic disorder  (ISO)
Barrett's esophagus  (ISO)
beta thalassemia  (ISO)
breast cancer  (ISO)
Burns  (ISO)
cervix uteri carcinoma in situ  (ISO)
Colorectal Neoplasms  (ISO)
Congenital Adrenal Hyperplasia due to 21 Hydroxylase Deficiency  (ISO)
congenital diaphragmatic hernia  (ISO)
congenital disorder of glycosylation Ia  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
cystic fibrosis  (ISO)
Down syndrome  (ISO)
Dwarfism  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
Endotoxemia  (ISO)
epidermolysis bullosa dystrophica  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fetal Growth Retardation  (ISO)
Fetal Macrosomia  (ISO)
Head Injuries, Closed  (ISO)
high grade glioma  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
ichthyosis  (ISO)
impotence  (ISO)
inflammatory bowel disease  (ISO)
Insulin Resistance  (ISO)
Malocclusion  (ISO)
McCune Albright syndrome  (ISO)
Metabolic Bone Diseases  (ISO)
myeloid leukemia  (ISO)
Myocardial Ischemia  (ISO)
obesity  (ISO)
ornithine carbamoyltransferase deficiency  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
Ovarian Neoplasms  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
primary progressive multiple sclerosis  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
renal cell carcinoma  (ISO)
retinopathy of prematurity  (ISO)
rheumatoid arthritis  (ISO)
Spinal Fractures  (ISO)
Spontaneous Abortions  (ISO)
Stomach Neoplasms  (ISO)
systemic scleroderma  (ISO)
tonsillitis  (ISO)
transitional cell carcinoma  (ISO)
Turner syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:1688850   PMID:1722398   PMID:8833235   PMID:9172318   PMID:12553871   PMID:14715717   PMID:15718291   PMID:17888567   PMID:18487150   PMID:19189208   PMID:21353438   PMID:21570979  
PMID:21652730  


Genomics

Comparative Map Data
IGFBP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11850,002,921 - 50,009,425 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21854,851,168 - 54,855,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap18q24NCBI
IGFBP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl745,912,245 - 45,921,874 (-)EnsemblGRCh38hg38GRCh38
GRCh38745,912,245 - 45,921,272 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37745,951,844 - 45,960,871 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36745,918,369 - 45,927,396 (-)NCBINCBI36hg18NCBI36
Build 34745,725,189 - 45,734,057NCBI
Celera746,050,761 - 46,059,785 (-)NCBI
Cytogenetic Map7p12.3NCBI
HuRef745,836,799 - 45,845,824 (-)NCBIHuRef
CHM1_1745,956,047 - 45,965,072 (-)NCBICHM1_1
CRA_TCAGchr7v2745,991,173 - 46,000,198 (-)NCBI
Igfbp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39117,156,086 - 7,165,498 (-)NCBIGRCm39mm39
GRCm39 Ensembl117,156,086 - 7,163,923 (-)Ensembl
GRCm38117,206,086 - 7,215,498 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl117,206,086 - 7,213,923 (-)EnsemblGRCm38mm10GRCm38
MGSCv37117,106,089 - 7,113,926 (-)NCBIGRCm37mm9NCBIm37
MGSCv36117,108,384 - 7,113,834 (-)NCBImm8
Celera117,681,286 - 7,689,161 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map114.75NCBI
Igfbp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21482,056,347 - 82,064,083 (-)NCBI
Rnor_6.0 Ensembl1487,457,647 - 87,465,374 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01487,457,647 - 87,465,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01481,091,987 - 81,099,675 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41487,959,153 - 87,967,085 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11487,978,297 - 87,986,223 (-)NCBI
Celera1481,130,767 - 81,138,473 (-)NCBICelera
RH 3.4 Map14598.5RGD
Cytogenetic Map14q21NCBI
Igfbp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554566,795,604 - 6,800,845 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554566,795,560 - 6,802,147 (+)NCBIChiLan1.0ChiLan1.0
IGFBP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1746,681,856 - 46,690,240 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0746,564,234 - 46,573,145 (-)NCBIMhudiblu_PPA_v0panPan3
IGFBP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1161,021,855 - 1,027,604 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl161,021,972 - 1,026,392 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha161,797,939 - 1,804,689 (+)NCBI
ROS_Cfam_1.0161,008,571 - 1,015,327 (+)NCBI
UMICH_Zoey_3.116999,220 - 1,005,969 (+)NCBI
UNSW_CanFamBas_1.016934,846 - 941,592 (+)NCBI
UU_Cfam_GSD_1.016233,123 - 239,875 (-)NCBI
Igfbp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118101,299,235 - 101,306,540 (-)NCBI
SpeTri2.0NW_00493647820,511,490 - 20,518,251 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGFBP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12112,905,309 - 12,914,199 (+)NCBI
ChlSab1.1 Ensembl2112,905,280 - 12,914,205 (+)Ensembl
Vero_WHO_p1.0NW_0236660629,622,694 - 9,631,602 (-)NCBI
Igfbp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247406,878,818 - 6,886,512 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_001005156   ⟹   NP_001005156
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11850,002,921 - 50,009,425 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001005156   ⟸   NM_001005156
- Peptide Label: precursor
- UniProtKB: P16611 (UniProtKB/Swiss-Prot)
- Sequence:

Additional Information

Database Acc Id Source(s)
Gene3D-CATH 4.10.800.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_1-6_chordata UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Insulin_GF-bd_Cys-rich_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thyroglobulin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thyroglobulin_1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:448812 UniProtKB/Swiss-Prot
NCBI Gene IGFBP3 ENTREZGENE
PANTHER PTHR11551:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IGFBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thyroglobulin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS IGFBPFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBPFAMILY3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IGFBP_N_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROGLOBULIN_1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THYROGLOBULIN_1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00121 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00211 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57610 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G9BWQ4_PIG UniProtKB/TrEMBL
  IBP3_PIG UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q6S6K2 UniProtKB/Swiss-Prot
  Q9TTI0 UniProtKB/Swiss-Prot