NPC1 (NPC intracellular cholesterol transporter 1) - Rat Genome Database
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Gene: NPC1 (NPC intracellular cholesterol transporter 1) Sus scrofa
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Symbol: NPC1
Name: NPC intracellular cholesterol transporter 1
RGD ID: 14280877
Description: ENCODES a protein that exhibits cholesterol binding (ortholog); INVOLVED IN adult walking behavior (ortholog); bile acid metabolic process (ortholog); cellular response to low-density lipoprotein particle stimulus (ortholog); ASSOCIATED WITH Ataxia (ortholog); atherosclerosis (ortholog); brucellosis (ortholog); FOUND IN endoplasmic reticulum (ortholog); endosome (ortholog); extracellular region (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Niemann-Pick C disease protein; niemann-Pick C1 protein; Niemann-Pick type C1 protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6108,402,877 - 108,450,990 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16108,403,126 - 108,450,486 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26101,001,696 - 101,049,542 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:11796528  


Genomics

Comparative Map Data
NPC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6108,402,877 - 108,450,990 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16108,403,126 - 108,450,486 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26101,001,696 - 101,049,542 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1823,506,184 - 23,586,506 (-)EnsemblGRCh38hg38GRCh38
GRCh381823,506,184 - 23,586,506 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371821,111,406 - 21,166,470 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh371821,086,148 - 21,166,581 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361819,365,461 - 19,420,468 (-)NCBINCBI36hg18NCBI36
Build 341819,365,461 - 19,420,426NCBI
Celera1817,927,454 - 17,982,730 (-)NCBI
Cytogenetic Map18q11.2NCBI
HuRef1817,966,414 - 18,021,712 (-)NCBIHuRef
CHM1_11821,038,743 - 21,093,877 (-)NCBICHM1_1
Npc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391812,322,751 - 12,369,851 (-)NCBIGRCm39mm39
GRCm381812,189,694 - 12,236,506 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1812,189,692 - 12,236,400 (-)EnsemblGRCm38mm10GRCm38
MGSCv371812,348,203 - 12,394,895 (-)NCBIGRCm37mm9NCBIm37
MGSCv361812,333,398 - 12,379,894 (-)NCBImm8
Celera1812,423,091 - 12,469,783 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map186.15NCBI
Npc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2183,379,482 - 3,425,100 (-)NCBI
Rnor_6.0 Ensembl183,616,878 - 3,662,683 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0183,616,878 - 3,662,656 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0183,626,015 - 3,671,677 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,725,415 - 3,777,707 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1183,725,710 - 3,726,684 (-)NCBI
Celera183,239,322 - 3,285,547 (-)NCBICelera
Cytogenetic Map18p13NCBI
Npc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540211,699,434 - 11,742,899 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540211,699,434 - 11,742,899 (-)NCBIChiLan1.0ChiLan1.0
NPC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11820,409,040 - 20,463,623 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1820,409,040 - 20,463,623 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01816,783,096 - 16,838,301 (-)NCBIMhudiblu_PPA_v0panPan3
NPC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl764,760,121 - 64,802,902 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1764,764,941 - 64,802,507 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Npc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365502,983,172 - 3,032,222 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPC1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11856,956,557 - 57,007,951 (+)NCBI
ChlSab1.1 Ensembl1856,956,174 - 57,007,474 (+)Ensembl
Npc1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247708,592,473 - 8,642,063 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 1 18 1 2
Low 8 4 3 4 2 5 2 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000004106   ⟹   ENSSSCP00000004014
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6108,402,877 - 108,439,194 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000069095   ⟹   ENSSSCP00000074577
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6108,402,877 - 108,450,990 (-)Ensembl
RefSeq Acc Id: NM_214322   ⟹   NP_999487
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16108,403,126 - 108,450,486 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999487 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD47090 (Get FASTA)   NCBI Sequence Viewer  
  AAL37473 (Get FASTA)   NCBI Sequence Viewer  
  P56941 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_999487   ⟸   NM_214322
- Peptide Label: precursor
- UniProtKB: P56941 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000074577   ⟸   ENSSSCT00000069095
RefSeq Acc Id: ENSSSCP00000004014   ⟸   ENSSSCT00000004106
Protein Domains
SSD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003707 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070025517 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000004014 UniProtKB/TrEMBL
  ENSSSCP00000074577 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070043135 UniProtKB/TrEMBL
  ENSSSCP00070043136 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000004106 UniProtKB/TrEMBL
  ENSSSCT00000069095 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070051013 UniProtKB/TrEMBL
  ENSSSCT00070051014 UniProtKB/TrEMBL
InterPro NPC1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPC1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ptc/Disp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397591 UniProtKB/Swiss-Prot
NCBI Gene NPC1 ENTREZGENE
Pfam NPC1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Patched UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sterol-sensing UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SSD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs 2A060601 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1VMS8_PIG UniProtKB/TrEMBL
  A0A4X1VPY9_PIG UniProtKB/TrEMBL
  A0A5G2RDJ5_PIG UniProtKB/TrEMBL
  F1SBB5_PIG UniProtKB/TrEMBL
  NPC1_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:98521 ENTREZGENE