KCNJ8 (potassium inwardly rectifying channel subfamily J member 8) - Rat Genome Database

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Gene: KCNJ8 (potassium inwardly rectifying channel subfamily J member 8) Sus scrofa
Analyze
Symbol: KCNJ8
Name: potassium inwardly rectifying channel subfamily J member 8
RGD ID: 14093296
Description: ENCODES a protein that exhibits ATP binding (ortholog); ATP-activated inward rectifier potassium channel activity (ortholog); ATPase-coupled monoatomic cation transmembrane transporter activity (ortholog); INVOLVED IN action potential (ortholog); adaptive immune response (ortholog); apoptotic process (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Brugada syndrome (ortholog); Brugada syndrome 1 (ortholog); cardiac arrest (ortholog); FOUND IN glutamatergic synapse (ortholog); inward rectifying potassium channel (ortholog); presynapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ATP-sensitive inward rectifier potassium channel 8; Kir6.1; potassium inwardly-rectifying channel, subfamily J, member 8; potassium voltage-gated channel subfamily J member 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl551,696,188 - 51,703,813 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1551,695,927 - 51,704,402 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2554,978,919 - 54,987,396 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential  (IEA,ISO)
adaptive immune response  (IEA,ISO)
apoptotic process  (IEA,ISO)
atrioventricular node cell differentiation  (IEA,ISO)
blood vessel development  (IEA,ISO)
calcium ion transmembrane transport  (IEA,ISO)
CAMKK-AMPK signaling cascade  (IEA,ISO)
cardiac pacemaker cell differentiation  (IEA,ISO)
cell population proliferation  (IEA,ISO)
circulatory system development  (IEA,ISO)
coronary vasculature development  (IEA,ISO)
defense response to virus  (IEA,ISO)
determination of adult lifespan  (IEA,ISO)
establishment of cell polarity  (IEA,ISO)
fat cell differentiation  (IEA,ISO)
fatty acid transport  (IEA,ISO)
fibroblast proliferation  (IEA,ISO)
gene expression  (IEA,ISO)
glutamate secretion, neurotransmission  (IEA,ISO)
heart development  (IEA,ISO)
heart morphogenesis  (IEA,ISO)
inflammatory response  (IEA,ISO)
inorganic cation transmembrane transport  (ISO)
kidney development  (ISO)
membrane repolarization during ventricular cardiac muscle cell action potential  (IEA)
microglial cell activation  (IEA,ISO)
monoatomic ion transmembrane transport  (IEA)
nervous system process  (IEA,ISO)
neuromuscular process  (IEA,ISO)
NLRP3 inflammasome complex assembly  (IEA,ISO)
p38MAPK cascade  (IEA,ISO)
potassium ion import across plasma membrane  (IBA,IEA,ISO)
potassium ion transmembrane transport  (IEA,ISO)
potassium ion transport  (IEA,ISO)
protein secretion  (IEA,ISO)
reactive gliosis  (IEA,ISO)
regulation of blood pressure  (IEA,ISO)
regulation of cation channel activity  (ISO)
regulation of heart rate  (IEA,ISO)
regulation of monoatomic ion transmembrane transport  (IBA)
regulation of presynaptic membrane potential  (IEA)
response to ATP  (IEA,ISO)
response to cytokine  (IEA,ISO)
response to endoplasmic reticulum stress  (IEA,ISO)
response to exogenous dsRNA  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to insulin  (IEA,ISO)
response to ischemia  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to resveratrol  (IEA,ISO)
response to stress  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)
synaptic assembly at neuromuscular junction  (IEA,ISO)
transmission of nerve impulse  (IEA,ISO)
vasculature development  (IEA,ISO)
vasodilation  (IEA,ISO)
ventricular cardiac muscle tissue development  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:14681463   PMID:16820413   PMID:17145712   PMID:18945825   PMID:18996111   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KCNJ8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl551,696,188 - 51,703,813 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1551,695,927 - 51,704,402 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2554,978,919 - 54,987,396 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNJ8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381221,764,955 - 21,774,706 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1221,764,955 - 21,775,600 (-)EnsemblGRCh38hg38GRCh38
GRCh371221,917,889 - 21,927,640 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,809,156 - 21,819,014 (-)NCBINCBI36Build 36hg18NCBI36
Build 341221,809,155 - 21,819,014NCBI
Celera1227,072,901 - 27,082,758 (-)NCBICelera
Cytogenetic Map12p12.1NCBI
HuRef1221,691,442 - 21,701,306 (-)NCBIHuRef
CHM1_11221,883,171 - 21,893,034 (-)NCBICHM1_1
T2T-CHM13v2.01221,643,637 - 21,653,388 (-)NCBIT2T-CHM13v2.0
Kcnj8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396142,510,563 - 142,517,340 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6142,510,563 - 142,517,340 (-)EnsemblGRCm39 Ensembl
GRCm386142,564,837 - 142,571,614 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6142,564,837 - 142,571,614 (-)EnsemblGRCm38mm10GRCm38
MGSCv376142,513,459 - 142,519,876 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366142,522,161 - 142,528,581 (-)NCBIMGSCv36mm8
Celera6145,626,686 - 145,633,104 (-)NCBICelera
Cytogenetic Map6G2NCBI
cM Map674.31NCBI
Kcnj8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84177,240,692 - 177,246,548 (-)NCBIGRCr8
mRatBN7.24175,508,908 - 175,515,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4175,508,912 - 175,515,603 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4181,804,515 - 181,810,357 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04177,588,783 - 177,594,629 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04176,209,354 - 176,215,202 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04176,783,287 - 176,789,143 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,782,498 - 176,789,304 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04240,996,986 - 241,003,081 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44180,144,084 - 180,149,935 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14180,388,422 - 180,395,042 (-)NCBI
Celera4164,042,167 - 164,048,023 (-)NCBICelera
Cytogenetic Map4q44NCBI
Kcnj8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541317,364,213 - 17,371,255 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541317,364,447 - 17,371,255 (-)NCBIChiLan1.0ChiLan1.0
KCNJ8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21075,026,276 - 75,036,939 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11275,022,673 - 75,033,355 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01264,522,172 - 64,532,848 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11267,126,584 - 67,137,128 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1267,127,263 - 67,137,128 (+)Ensemblpanpan1.1panPan2
KCNJ8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12725,368,565 - 25,375,754 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2725,368,810 - 25,375,009 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2720,985,001 - 20,992,186 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02725,588,424 - 25,595,600 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2725,588,452 - 25,595,598 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12725,386,897 - 25,394,078 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02725,410,445 - 25,417,631 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02721,155,847 - 21,163,033 (-)NCBIUU_Cfam_GSD_1.0
Kcnj8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494587,202,938 - 87,209,604 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365485,125,555 - 5,133,078 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365485,125,583 - 5,132,490 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNJ8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11121,624,963 - 21,634,940 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1121,624,970 - 21,634,042 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606913,508,221 - 13,518,244 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnj8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475216,939,384 - 16,946,723 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475216,939,289 - 16,945,692 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KCNJ8
162 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 5 14 12 23 3 6 1

Sequence


Ensembl Acc Id: ENSSSCT00000046832   ⟹   ENSSSCP00000052629
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl551,696,188 - 51,703,813 (+)Ensembl
RefSeq Acc Id: XM_003126434   ⟹   XP_003126482
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1551,695,927 - 51,704,402 (+)NCBI
Sequence:
RefSeq Acc Id: XP_003126482   ⟸   XM_003126434
- UniProtKB: A0A4X1VEF0 (UniProtKB/TrEMBL),   F1SR09 (UniProtKB/TrEMBL),   A0A287B831 (UniProtKB/TrEMBL),   A0A8D0M8P8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000052629   ⟸   ENSSSCT00000046832
Protein Domains
Inward rectifier potassium channel C-terminal   Potassium channel inwardly rectifying transmembrane


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000000573 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015019910 UniProtKB/TrEMBL
  ENSSSCG00025059041 UniProtKB/TrEMBL
  ENSSSCG00030066105 UniProtKB/TrEMBL
  ENSSSCG00035016144 UniProtKB/TrEMBL
  ENSSSCG00040065393 UniProtKB/TrEMBL
  ENSSSCG00045033496 UniProtKB/TrEMBL
  ENSSSCG00050069192 UniProtKB/TrEMBL
  ENSSSCG00055001257 UniProtKB/TrEMBL
  ENSSSCG00060073701 UniProtKB/TrEMBL
  ENSSSCG00065013891 UniProtKB/TrEMBL
  ENSSSCG00070023801 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000046832 ENTREZGENE
  ENSSSCT00000046832.3 UniProtKB/TrEMBL
  ENSSSCT00015026450.1 UniProtKB/TrEMBL
  ENSSSCT00025080872.1 UniProtKB/TrEMBL
  ENSSSCT00030092389.1 UniProtKB/TrEMBL
  ENSSSCT00035020609.1 UniProtKB/TrEMBL
  ENSSSCT00040089361.1 UniProtKB/TrEMBL
  ENSSSCT00045057357.1 UniProtKB/TrEMBL
  ENSSSCT00050094416.1 UniProtKB/TrEMBL
  ENSSSCT00055002273.1 UniProtKB/TrEMBL
  ENSSSCT00060100786.1 UniProtKB/TrEMBL
  ENSSSCT00065018497.1 UniProtKB/TrEMBL
  ENSSSCT00070047492.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  2.60.40.1400 UniProtKB/TrEMBL
InterPro Ig_E-set UniProtKB/TrEMBL
  IRK_C UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir6.1 UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir_cyto UniProtKB/TrEMBL
  Kir_TM UniProtKB/TrEMBL
NCBI Gene KCNJ8 ENTREZGENE
PANTHER PTHR11767 UniProtKB/TrEMBL
  PTHR11767:SF11 UniProtKB/TrEMBL
Pfam IRK UniProtKB/TrEMBL
  IRK_C UniProtKB/TrEMBL
PIRSF GIRK_kir UniProtKB/TrEMBL
PRINTS KIR61CHANNEL UniProtKB/TrEMBL
  KIRCHANNEL UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A287B831 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VEF0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0M8P8 ENTREZGENE
  F1SR09 ENTREZGENE
UniProt Secondary F1SR09 UniProtKB/TrEMBL
VGNC ID VGNC:89361 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-23 KCNJ8  potassium inwardly rectifying channel subfamily J member 8  KCNJ8  potassium voltage-gated channel subfamily J member 8  Symbol and/or name change 5135510 APPROVED