PRKCD (protein kinase C delta) - Rat Genome Database
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Gene: PRKCD (protein kinase C delta) Sus scrofa
Analyze
Symbol: PRKCD
Name: protein kinase C delta
RGD ID: 13989802
Description: ENCODES a protein that exhibits calcium-independent protein kinase C activity (ortholog); enzyme binding (ortholog); kinase binding (ortholog); INVOLVED IN aging (ortholog); cellular response to glucose starvation (ortholog); cellular response to insulin stimulus (ortholog); PARTICIPATES IN ceramide signaling pathway; eicosanoid signaling pathway; endothelin signaling pathway; ASSOCIATED WITH autoimmune lymphoproliferative syndrome type 3 (ortholog); brain ischemia (ortholog); Burns (ortholog); FOUND IN membrane (ortholog); mitochondrion (ortholog); postsynaptic cytosol (ortholog); INTERACTS WITH phorbol 13-acetate 12-myristate; sodium arsenite
Type: protein-coding
RefSeq Status: MODEL
Also known as: PKCdelta; protein kinase C delta type
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1335,290,264 - 35,323,356 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11335,290,835 - 35,323,245 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21338,361,707 - 38,390,508 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (IEA)
aging  (ISO)
apoptotic process  (IEA)
B cell proliferation  (IEA)
cell chemotaxis  (IEA)
cellular response to angiotensin  (IEA)
cellular response to glucose starvation  (ISO)
cellular response to hydrogen peroxide  (IEA)
cellular response to hydroperoxide  (IEA)
cellular response to insulin stimulus  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to UV  (IEA)
cellular senescence  (IEA)
collagen metabolic process  (ISO)
D-aspartate import across plasma membrane  (ISO)
defense response to bacterium  (IEA)
histone phosphorylation  (IEA)
immunoglobulin mediated immune response  (IEA)
intracellular signal transduction  (IBA,IEA)
negative regulation of actin filament polymerization  (IEA)
negative regulation of filopodium assembly  (IEA)
negative regulation of glial cell apoptotic process  (IEA)
negative regulation of insulin receptor signaling pathway  (IEA)
negative regulation of MAP kinase activity  (IEA)
negative regulation of peptidyl-tyrosine phosphorylation  (IEA)
negative regulation of platelet aggregation  (IEA)
neutrophil activation  (IEA)
peptidyl-serine phosphorylation  (IBA,IEA)
peptidyl-threonine phosphorylation  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (IEA)
positive regulation of ceramide biosynthetic process  (IEA)
positive regulation of endodeoxyribonuclease activity  (IEA)
positive regulation of glucose import  (ISO)
positive regulation of glucosylceramide catabolic process  (IEA)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of phospholipid scramblase activity  (IEA)
positive regulation of protein dephosphorylation  (IEA)
positive regulation of protein import into nucleus  (IEA)
positive regulation of response to DNA damage stimulus  (IEA)
positive regulation of sphingomyelin catabolic process  (IEA)
positive regulation of superoxide anion generation  (IEA)
protein autophosphorylation  (ISO)
protein phosphorylation  (IEA)
regulation of actin cytoskeleton organization  (ISO)
regulation of ceramide biosynthetic process  (ISO)
regulation of phosphorylation  (ISO)
response to amino acid  (ISO)
response to drug  (ISO)
response to ethanol  (ISO)
response to glucose  (ISO)
response to heat  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to mechanical stimulus  (ISO)
response to organic cyclic compound  (ISO)
response to organonitrogen compound  (ISO)
response to oxidative stress  (ISO)
termination of signal transduction  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:16243844   PMID:17507429   PMID:25155198  


Genomics

Comparative Map Data
PRKCD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1335,290,264 - 35,323,356 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11335,290,835 - 35,323,245 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21338,361,707 - 38,390,508 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKCD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl353,156,009 - 53,192,717 (+)EnsemblGRCh38hg38GRCh38
GRCh38353,161,209 - 53,192,717 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37353,195,223 - 53,226,733 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36353,170,263 - 53,201,773 (+)NCBINCBI36hg18NCBI36
Build 34353,170,262 - 53,201,771NCBI
Celera353,162,239 - 53,193,756 (+)NCBI
Cytogenetic Map3p21.1NCBI
HuRef353,210,511 - 53,276,026 (+)NCBIHuRef
CHM1_1353,146,796 - 53,178,291 (+)NCBICHM1_1
Prkcd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,317,310 - 30,348,637 (-)NCBIGRCm39mm39
GRCm381430,595,353 - 30,626,414 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1430,595,354 - 30,626,210 (-)EnsemblGRCm38mm10GRCm38
MGSCv371431,408,555 - 31,423,498 (-)NCBIGRCm37mm9NCBIm37
MGSCv361429,424,378 - 29,447,560 (-)NCBImm8
Celera1426,853,019 - 26,867,962 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1418.82NCBI
Prkcd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0166,655,131 - 6,675,746 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl166,655,120 - 6,675,746 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0166,588,990 - 6,608,725 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4165,954,218 - 5,975,743 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1165,954,214 - 5,975,741 (-)NCBI
Celera169,398,816 - 9,419,806 (+)NCBICelera
Cytogenetic Map16p16NCBI
Prkcd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554303,124,738 - 3,153,274 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554303,125,066 - 3,151,857 (+)NCBIChiLan1.0ChiLan1.0
PRKCD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1354,330,328 - 54,357,910 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl354,330,328 - 54,357,910 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0353,104,137 - 53,135,588 (+)NCBIMhudiblu_PPA_v0panPan3
PRKCD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2036,723,809 - 36,752,191 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12036,723,491 - 36,751,982 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Prkcd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364733,892,625 - 3,923,467 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKCD
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12214,561,401 - 14,592,877 (+)NCBI
ChlSab1.1 Ensembl2214,565,282 - 14,592,873 (+)Ensembl
Prkcd
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248224,035,819 - 4,062,907 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 2 5 2 3
Low 2 2 3 2 23 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000026074   ⟹   ENSSSCP00000026618
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1335,300,270 - 35,320,924 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000038457   ⟹   ENSSSCP00000052774
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1335,290,843 - 35,323,356 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000041118   ⟹   ENSSSCP00000054041
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1335,290,264 - 35,323,356 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000050050   ⟹   ENSSSCP00000052783
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1335,290,892 - 35,320,952 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000052690   ⟹   ENSSSCP00000037835
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1335,291,163 - 35,319,818 (+)Ensembl
RefSeq Acc Id: XM_013981774   ⟹   XP_013837228
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11335,291,132 - 35,323,245 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068957   ⟹   XP_020924616
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11335,300,179 - 35,323,245 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068958   ⟹   XP_020924617
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11335,290,836 - 35,323,245 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068959   ⟹   XP_020924618
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11335,290,836 - 35,323,245 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068960   ⟹   XP_020924619
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11335,291,128 - 35,323,245 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068961   ⟹   XP_020924620
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11335,290,835 - 35,323,245 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068962   ⟹   XP_020924621
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11335,291,132 - 35,323,245 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068963   ⟹   XP_020924622
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11335,290,836 - 35,323,245 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068964   ⟹   XP_020924623
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11335,291,128 - 35,323,245 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021068966   ⟹   XP_020924625
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11335,291,143 - 35,323,245 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020924620   ⟸   XM_021068961
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020924617   ⟸   XM_021068958
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020924618   ⟸   XM_021068959
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020924622   ⟸   XM_021068963
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020924619   ⟸   XM_021068960
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020924623   ⟸   XM_021068964
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013837228   ⟸   XM_013981774
- Peptide Label: isoform X2
- UniProtKB: A0A287BBY6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020924621   ⟸   XM_021068962
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020924625   ⟸   XM_021068966
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020924616   ⟸   XM_021068957
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000052783   ⟸   ENSSSCT00000050050
RefSeq Acc Id: ENSSSCP00000054041   ⟸   ENSSSCT00000041118
RefSeq Acc Id: ENSSSCP00000026618   ⟸   ENSSSCT00000026074
RefSeq Acc Id: ENSSSCP00000037835   ⟸   ENSSSCT00000052690
RefSeq Acc Id: ENSSSCP00000052774   ⟸   ENSSSCT00000038457
Protein Domains
AGC-kinase C-terminal   Phorbol-ester/DAG-type   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000023503 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070025316 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000026618 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000037835 UniProtKB/TrEMBL
  ENSSSCP00000052774 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000052783 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000054041 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070042815 UniProtKB/TrEMBL
  ENSSSCP00070042816 UniProtKB/TrEMBL
  ENSSSCP00070042817 UniProtKB/TrEMBL
  ENSSSCP00070042818 UniProtKB/TrEMBL
  ENSSSCP00070042819 UniProtKB/TrEMBL
  ENSSSCP00070042820 UniProtKB/TrEMBL
  ENSSSCP00070042821 UniProtKB/TrEMBL
  ENSSSCP00070042822 UniProtKB/TrEMBL
  ENSSSCP00070042823 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000026074 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000038457 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000041118 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000050050 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000052690 UniProtKB/TrEMBL
  ENSSSCT00070050653 UniProtKB/TrEMBL
  ENSSSCT00070050655 UniProtKB/TrEMBL
  ENSSSCT00070050656 UniProtKB/TrEMBL
  ENSSSCT00070050657 UniProtKB/TrEMBL
  ENSSSCT00070050658 UniProtKB/TrEMBL
  ENSSSCT00070050659 UniProtKB/TrEMBL
  ENSSSCT00070050661 UniProtKB/TrEMBL
  ENSSSCT00070050662 UniProtKB/TrEMBL
  ENSSSCT00070050664 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
  PKC_delta UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
  Prot_kin_PKC_delta UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report ssc:100622955 UniProtKB/TrEMBL
NCBI Gene PRKCD ENTREZGENE
Pfam C1_1 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
PIRSF PKC_delta UniProtKB/TrEMBL
  Protein_kin_C_delta UniProtKB/TrEMBL
PRINTS DAGPEDOMAIN UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniGene Ssc.34139 ENTREZGENE
UniProt A0A287A287_PIG UniProtKB/TrEMBL
  A0A287B8W9_PIG UniProtKB/TrEMBL
  A0A287B9L9_PIG UniProtKB/TrEMBL
  A0A287BBY6 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VHD2_PIG UniProtKB/TrEMBL
  A0A4X1VLX7_PIG UniProtKB/TrEMBL
  A0A4X1VMX9_PIG UniProtKB/TrEMBL
  A0A4X1VMY4_PIG UniProtKB/TrEMBL
  A0A4X1VP62_PIG UniProtKB/TrEMBL
  I3LR85_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91806 ENTREZGENE