IL12RB2 (interleukin 12 receptor subunit beta 2) - Rat Genome Database

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Gene: IL12RB2 (interleukin 12 receptor subunit beta 2) Sus scrofa
Analyze
Symbol: IL12RB2
Name: interleukin 12 receptor subunit beta 2
RGD ID: 13976076
Description: ENCODES a protein that exhibits coreceptor activity (inferred); cytokine receptor activity (inferred); protein kinase binding (inferred); INVOLVED IN peptidyl-tyrosine phosphorylation (ortholog); response to cytokine (ortholog); response to lipopolysaccharide (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-27 signaling pathway; ASSOCIATED WITH Brain Injuries (ortholog); congenital disorder of glycosylation It (ortholog); intellectual disability (ortholog); FOUND IN external side of plasma membrane (inferred); membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IL-12 receptor subunit beta-2; IL-12R subunit beta-2; IL-12R-beta-2; IL-12RB2; interleukin-12 receptor beta 2; interleukin-12 receptor subunit beta-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6145,212,981 - 145,281,791 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16145,210,251 - 145,292,399 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26134,096,042 - 134,163,740 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:12383645   PMID:12543551   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
IL12RB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6145,212,981 - 145,281,791 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16145,210,251 - 145,292,399 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26134,096,042 - 134,163,740 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL12RB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38167,307,364 - 67,398,724 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl167,307,364 - 67,398,724 (+)EnsemblGRCh38hg38GRCh38
GRCh37167,773,047 - 67,864,407 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36167,545,635 - 67,635,171 (+)NCBINCBI36Build 36hg18NCBI36
Build 34167,485,067 - 67,574,604NCBI
Celera166,062,815 - 66,152,324 (+)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef165,882,963 - 65,972,440 (+)NCBIHuRef
CHM1_1167,888,407 - 67,977,959 (+)NCBICHM1_1
T2T-CHM13v2.0167,181,083 - 67,276,270 (+)NCBIT2T-CHM13v2.0
Il12rb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39667,263,914 - 67,353,277 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl667,268,302 - 67,353,172 (-)EnsemblGRCm39 Ensembl
GRCm38667,285,986 - 67,376,293 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl667,291,318 - 67,376,188 (-)EnsemblGRCm38mm10GRCm38
MGSCv37667,242,012 - 67,326,131 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36667,221,596 - 67,305,715 (-)NCBIMGSCv36mm8
Celera669,414,576 - 69,494,819 (-)NCBICelera
Cytogenetic Map6C1NCBI
cM Map630.81NCBI
Il12rb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8497,756,089 - 97,844,937 (-)NCBIGRCr8
mRatBN7.2496,426,396 - 96,515,251 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl496,426,842 - 96,515,289 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4101,682,750 - 101,748,342 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0497,457,722 - 97,523,310 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0495,881,608 - 95,947,275 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0498,049,195 - 98,141,562 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl498,052,842 - 98,141,482 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04162,835,618 - 162,927,057 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4496,929,755 - 96,995,733 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1497,174,599 - 97,182,220 (-)NCBI
Celera491,119,174 - 91,184,692 (-)NCBICelera
Cytogenetic Map4q31NCBI
Il12rb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542323,774,557 - 23,806,744 (-)NCBIChiLan1.0ChiLan1.0
IL12RB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21159,467,321 - 159,559,572 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11158,615,544 - 158,719,401 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0166,549,650 - 66,640,623 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1168,543,509 - 68,612,168 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl168,543,509 - 68,612,168 (-)Ensemblpanpan1.1panPan2
IL12RB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1543,197,034 - 43,269,571 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl543,197,034 - 43,257,594 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha543,385,096 - 43,448,024 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0543,381,977 - 43,454,682 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl543,381,997 - 43,442,686 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1543,348,361 - 43,411,066 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0543,295,000 - 43,357,916 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0543,534,014 - 43,597,143 (-)NCBIUU_Cfam_GSD_1.0
Il12rb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505880,164,929 - 80,254,074 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365914,238,720 - 4,310,847 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL12RB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12065,711,298 - 65,805,963 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2065,714,618 - 65,791,681 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603351,799,834 - 51,897,169 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il12rb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474227,832,883 - 27,865,139 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474227,830,691 - 27,865,176 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IL12RB2
2923 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 16 3 2 5 14 12 16 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000004204   ⟹   ENSSSCP00000004110
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6145,212,981 - 145,281,791 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000071458   ⟹   ENSSSCP00000062499
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6145,214,681 - 145,281,792 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000076373   ⟹   ENSSSCP00000060541
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6145,212,973 - 145,281,792 (-)Ensembl
RefSeq Acc Id: NM_214097   ⟹   NP_999262
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16145,213,971 - 145,279,893 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013988878   ⟹   XP_013844332
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16145,210,251 - 145,285,222 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093521   ⟹   XP_020949180
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16145,210,251 - 145,285,222 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093522   ⟹   XP_020949181
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16145,210,251 - 145,292,399 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093523   ⟹   XP_020949182
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16145,210,251 - 145,292,399 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020949182   ⟸   XM_021093523
- Peptide Label: isoform X1
- UniProtKB: F1S826 (UniProtKB/TrEMBL),   A0A8D0UJX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020949181   ⟸   XM_021093522
- Peptide Label: isoform X1
- UniProtKB: F1S826 (UniProtKB/TrEMBL),   A0A8D0UJX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020949180   ⟸   XM_021093521
- Peptide Label: isoform X1
- UniProtKB: F1S826 (UniProtKB/TrEMBL),   A0A8D0UJX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013844332   ⟸   XM_013988878
- Peptide Label: isoform X1
- UniProtKB: F1S826 (UniProtKB/TrEMBL),   A0A8D0UJX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_999262   ⟸   NM_214097
- Peptide Label: precursor
- UniProtKB: Q8WN24 (UniProtKB/Swiss-Prot),   Q8MJS1 (UniProtKB/Swiss-Prot),   A0A8D0UJX9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000060541   ⟸   ENSSSCT00000076373
Ensembl Acc Id: ENSSSCP00000062499   ⟸   ENSSSCT00000071458
Ensembl Acc Id: ENSSSCP00000004110   ⟸   ENSSSCT00000004204
Protein Domains
Fibronectin type-III


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003799 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025016825 UniProtKB/TrEMBL
  ENSSSCG00070021202 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000004204 ENTREZGENE
  ENSSSCT00000004204.6 UniProtKB/TrEMBL
  ENSSSCT00025022688.1 UniProtKB/TrEMBL
  ENSSSCT00070042638.1 UniProtKB/TrEMBL
  ENSSSCT00070042805.1 UniProtKB/TrEMBL
  ENSSSCT00070042810.1 UniProtKB/TrEMBL
  ENSSSCT00070042815.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hematopoietin_rcpt_Gp130_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IgC2-like_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Type-I_Cytokine_Rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397178 UniProtKB/Swiss-Prot
NCBI Gene IL12RB2 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lep_receptor_Ig UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMATOPO_REC_L_F2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1V2K0_PIG UniProtKB/TrEMBL
  A0A4X1V327_PIG UniProtKB/TrEMBL
  A0A4X1V4E7_PIG UniProtKB/TrEMBL
  A0A4X1V5C9_PIG UniProtKB/TrEMBL
  A0A8D0UJX9 ENTREZGENE, UniProtKB/TrEMBL
  F1S826 ENTREZGENE, UniProtKB/TrEMBL
  I12R2_PIG UniProtKB/Swiss-Prot
  Q15B92_PIG UniProtKB/TrEMBL
  Q8MJS1 ENTREZGENE
  Q8WN24 ENTREZGENE
UniProt Secondary Q8WN24 UniProtKB/Swiss-Prot
VGNC ID VGNC:98476 ENTREZGENE