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Gene: JUND (JunD proto-oncogene, AP-1 transcription factor subunit) Sus scrofa

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Symbol:

JUND

Name:

JunD proto-oncogene, AP-1 transcription factor subunit

RGD ID:

13924005

Description:

ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); cellular response to fatty acid (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); cardiomyopathy (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); protein-containing complex (ortholog); INTERACTS WITH deoxynivalenol

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

jun D proto-oncogene; transcription factor jun-D

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	2	59,530,991 - 59,532,846 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis type 1 (ISO)

cardiomyopathy (ISO)

Chemical and Drug Induced Liver Injury (ISO)

Cocaine-Related Disorders (ISO)

crescentic glomerulonephritis (ISO)

glomerulonephritis (ISO)

hepatocellular carcinoma (ISO)

liver cirrhosis (ISO)

Lung Neoplasms (ISO)

Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1 (ISO)

obesity (ISO)

renal carcinoma (ISO)

status epilepticus (ISO)

tongue squamous cell carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

deoxynivalenol (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to calcium ion (ISO)

cellular response to fatty acid (ISO)

cellular response to hypoxia (ISO)

circadian rhythm (ISO)

gene expression (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

osteoblast development (ISO)

positive regulation of macrophage activation (ISO)

positive regulation of osteoblast differentiation (ISO)

positive regulation of peroxisome proliferator activated receptor signaling pathway (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of DNA-binding transcription factor activity (ISO)

regulation of DNA-templated transcription (IEA,ISO)

response to forskolin (ISO)

response to light stimulus (ISO)

response to lipopolysaccharide (ISO)

response to mechanical stimulus (ISO)

response to peptide hormone (ISO)

transcription by RNA polymerase II (ISO)

Cellular Component

nucleoplasm (ISO)

nucleus (IEA,ISO)

protein-containing complex (ISO)

protein-DNA complex (ISO)

RNA polymerase II transcription regulator complex (ISO)

transcription factor AP-1 complex (ISO)

transcription repressor complex (ISO)

Molecular Function

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (ISO)

DNA-binding transcription factor activity (IEA,ISO)

double-stranded DNA binding (ISO)

enzyme binding (ISO)

nuclear receptor binding (ISO)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (ISO)

sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

transcription cis-regulatory region binding (ISO)

transcription coactivator activity (ISO)

transcription coregulator binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

platelet-derived growth factor signaling pathway (ISO)

References

Additional References at PubMed

PMID:14681463	PMID:17145712	PMID:30032202

Genomics

Comparative Map Data

JUND
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	2	59,530,991 - 59,532,846 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

JUND
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	18,279,694 - 18,281,622 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	18,279,694 - 18,281,622 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	18,390,504 - 18,392,432 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	18,251,570 - 18,253,432 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	18,251,569 - 18,253,468	NCBI
Celera	19	18,292,287 - 18,294,173 (-)	NCBI		Celera
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	17,954,230 - 17,965,959 (-)	NCBI		HuRef
CHM1_1	19	18,390,809 - 18,392,678 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	18,413,794 - 18,415,722 (-)	NCBI		T2T-CHM13v2.0

Jund
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	71,150,389 - 71,153,265 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	71,151,599 - 71,153,265 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	70,697,739 - 70,700,616 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	70,698,949 - 70,700,616 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	73,221,638 - 73,224,515 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	73,627,938 - 73,629,605 (+)	NCBI		MGSCv36	mm8
Celera	8	73,254,240 - 73,257,113 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	34.15	NCBI

Jund
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	18,768,093 - 18,769,771 (-)	NCBI		GRCr8
mRatBN7.2	16	18,734,121 - 18,735,799 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	18,734,122 - 18,735,799 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	18,775,785 - 18,777,473 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	19,908,865 - 19,910,549 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	18,828,735 - 18,830,423 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	20,485,028 - 20,486,707 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	20,485,029 - 20,486,707 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	20,342,096 - 20,343,775 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	19,239,694 - 19,241,529 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	19,239,692 - 19,241,527 (-)	NCBI
Celera	16	18,926,295 - 18,927,907 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

Jund
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955524	3,176,849 - 3,177,936 (+)	NCBI	ChiLan1.0	ChiLan1.0

JUND
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	23,137,209 - 23,139,083 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	22,145,537 - 22,147,409 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	17,755,331 - 17,757,164 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	18,728,466 - 18,729,502 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

JUND
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	44,737,021 - 44,738,932 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	44,736,832 - 44,763,020 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	44,651,244 - 44,653,089 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	45,222,928 - 45,224,778 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	45,222,673 - 45,224,061 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	44,460,059 - 44,461,903 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	44,870,705 - 44,872,544 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	45,145,944 - 45,147,789 (+)	NCBI		UU_Cfam_GSD_1.0

JUND
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	16,754,553 - 16,756,458 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	16,755,247 - 16,756,290 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	2,598,780 - 2,600,647 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Jund
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624908	1,573,174 - 1,574,113 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624908	1,572,628 - 1,574,205 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in JUND
4 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021083521	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK349565	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK350815	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GACC01000372	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_021083521 ⟹ XP_020939180

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	2	59,530,991 - 59,532,846 (+)	NCBI

Sequence:

show sequence

GGGGCGCGCGCGTTGCGCGACTCGGGAGCCGCCGCCAGCAGAGGGCTGGGCGCAGCGGCCGCGG
CCTGGGCGGGCGCAGGGCCGAGCGGACGGGGGGGCGAGGGCCCCCCGGGCGGCCGCGGCCACTC
CCCCCCCCGGGTCGGCGCGGCGGGGGAGGCGGAGGATGGAAACACCCTTCTACGGCGATGAGGC
GCTGAGCGGCCTGGGCGGCGGCAGTGGCAGTGGCGGCGGTGGCAGCTTCGCGTCCCCGGGTCGC
CTGTTCCCCGGGGCGCCCCCGACGGCAGCCGCCGGCAGCATGATGAAGAAGGACGCGTTGACGC
TGAGCTTGAGCGAGCAGGTGGCAGCGGCGCTCAAGCCCGCGGCCGCACCGCCCCCGGCCCCTCT
GCGCACCGACGGCGCCCAGGGTGCGGCGCCCCCCGACAGCCTGCTCCCTTCGCCCGACCTGGGG
CTGCTCAAGCTCGCTTCGCCCGAGCTCGAACGTCTCATCATCCAGTCCAACGGGCTGGTCACCA
CCACGCCGACGAGCACGCAGTTTCTCTACCCCAAGGTGGCGGCAAGCGAGGAGCAGGAGTTCGC
CGAGGGCTTCGTCAAGGCCCTGGAGGACTTGCACAAGCAAAACCAGCTGGGCGCGGGCGCGGCC
TCCGCTGCCGCCGCCGCCGGAGGACCCTCAGGCACGGCTGCAGGCGCCGCACCTCCCAGCGAGC
TGGCCCCAGCGGCGGCCACGCCCGAGGCGCCCGTCTACGCGAACCTGAGCAGCTACGCGGGAGG
GACTGGGGGTTCGGGGGGAGCTGCGACGGTCGCCTTCGCCGCTGAACCCGTGCCCTTTCCGCCG
CCGCCGCCGCCAGGCGCGCTGGGGCCGCCACGCCTGGCCGCACTCAAGGATGAGCCGCAGACGG
TGCCCGACGTGCCGAGCTTCGGCGAGAGCCCGCCGCTGTCGCCCATCGACATGGACACTCAGGA
GCGCATTAAGGCGGAGCGCAAGCGGCTGCGCAACCGCATCGCTGCCTCCAAGTGCCGCAAGCGC
AAGCTGGAGCGTATCTCGCGCCTCGAGGAGAAAGTGAAGACGCTCAAGAGCCAGAACACGGAGC
TGGCGTCCACGGCGAGCCTGCTGCGCGAGCAGGTGGCGCAACTCAAGCAGAAGGTCCTCAGCCA
CGTCAACAGCGGCTGCCAGCTGCTGCCCCAGCACCAGGTGCCGGCGTACTGAGCCCGCGCGCGG
GGCGCATGCGCGGCCCCCTTCCAGAGAGGCGGGTTTGCGGGGGGGGGGCGTGGGCTCCCGGGAC
TTGGAGAGGGCGCGGCCCCGGGGACCCCCCCCCCCGAGGGTGCCAGGACTCGGAGAGGGCGCCT
CAGACTCGACAAGCTGGACCCCCTGCTCCTGGGGGGGCGAGCGCATGACCCCCCCTCCTTTTCC
CCTGCCCTCGCGCTGCCTCTGTCCTCGGCGCGCGGCCACCCGGTGTTGCACAAACCCGCGCGTC
CTGGCTGCCTCTTTGTACACATCGCCGCCGAAGGGGGCGCAGCCTCAAGCCCTGCGTTTCCTTT
TCTTTTACTTTTTTTTTTTTTTTTTTGGACTTTGGAAGAGAGAAGAACAGAGTGTTCGATTCTG
CCCTATTTATGTTTCTACTCGGGAACAAACGTTGGTTGTGTGTGTGTGTGTTTTCTTGTGTTGG
TTTTTTAAAGAAATGGGAAGAAGAAAAAAAAAAAACCCTTTTCTTGCTCTCGCTCCCCCCTCCT
ATCCCTCCGACAACCCCTCCTCTCGCCCTTTTTATTTTTTTGTTTTGTTTTGCTACCAGTCCAC
ATTCCTGTTTGTAATCCTTGGTTCGCCCGGTGTTCTGTTTTCAGTAAAGTCTCGTTACGCCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_020939180	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00025022650.1
	ENSSSCP00030037092.1
	ENSSSCP00035006030.1
	ENSSSCP00040031951.1
	ENSSSCP00045027650.1
	ENSSSCP00050044588.1
	ENSSSCP00055036928.1
	ENSSSCP00060019880.1
	ENSSSCP00065009533.1
	ENSSSCP00070024908.1
GenBank Protein	JAA74212	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_020939180 ⟸ XM_021083521

- UniProtKB:

A0A4X1UAA4 (UniProtKB/TrEMBL), M3V837 (UniProtKB/TrEMBL)

- Sequence:

show sequence

METPFYGDEALSGLGGGSGSGGGGSFASPGRLFPGAPPTAAAGSMMKKDALTLSLSEQVAAALK
PAAAPPPAPLRTDGAQGAAPPDSLLPSPDLGLLKLASPELERLIIQSNGLVTTTPTSTQFLYPK
VAASEEQEFAEGFVKALEDLHKQNQLGAGAASAAAAAGGPSGTAAGAAPPSELAPAAATPEAPV
YANLSSYAGGTGGSGGAATVAFAAEPVPFPPPPPPGALGPPRLAALKDEPQTVPDVPSFGESPP
LSPIDMDTQERIKAERKRLRNRIAASKCRKRKLERISRLEEKVKTLKSQNTELASTASLLREQV
AQLKQKVLSHVNSGCQLLPQHQVPAY

hide sequence

Protein Domains

bZIP

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00025039173	UniProtKB/TrEMBL
	ENSSSCG00030057992	UniProtKB/TrEMBL
	ENSSSCG00035013791	UniProtKB/TrEMBL
	ENSSSCG00040054972	UniProtKB/TrEMBL
	ENSSSCG00045023258	UniProtKB/TrEMBL
	ENSSSCG00050074790	UniProtKB/TrEMBL
	ENSSSCG00055023532	UniProtKB/TrEMBL
	ENSSSCG00060034232	UniProtKB/TrEMBL
	ENSSSCG00065017618	UniProtKB/TrEMBL
	ENSSSCG00070015200	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00025053184.1	UniProtKB/TrEMBL
	ENSSSCT00030080885.1	UniProtKB/TrEMBL
	ENSSSCT00035017419.1	UniProtKB/TrEMBL
	ENSSSCT00040074454.1	UniProtKB/TrEMBL
	ENSSSCT00045039718.1	UniProtKB/TrEMBL
	ENSSSCT00050102380.1	UniProtKB/TrEMBL
	ENSSSCT00055046306.1	UniProtKB/TrEMBL
	ENSSSCT00060046417.1	UniProtKB/TrEMBL
	ENSSSCT00065023408.1	UniProtKB/TrEMBL
	ENSSSCT00070029866.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.170	UniProtKB/TrEMBL
InterPro	AP-1_TF_bZIP	UniProtKB/TrEMBL
	bZIP	UniProtKB/TrEMBL
	bZIP_sf	UniProtKB/TrEMBL
	JNK	UniProtKB/TrEMBL
	Leuzip_Jun	UniProtKB/TrEMBL
	TF_DNA-bd_sf	UniProtKB/TrEMBL
NCBI Gene	JUND	ENTREZGENE
PANTHER	JUN TRANSCRIPTION FACTOR-RELATED	UniProtKB/TrEMBL
	PTHR11462:SF7	UniProtKB/TrEMBL
Pfam	bZIP_1	UniProtKB/TrEMBL
	Jun	UniProtKB/TrEMBL
PRINTS	LEUZIPPRJUN	UniProtKB/TrEMBL
PROSITE	BZIP	UniProtKB/TrEMBL
	BZIP_BASIC	UniProtKB/TrEMBL
SMART	BRLZ	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47454	UniProtKB/TrEMBL
	SSF57959	UniProtKB/TrEMBL
UniProt	A0A4X1UAA4	ENTREZGENE, UniProtKB/TrEMBL
	M3V837	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)