SMAD7 (SMAD family member 7) - Rat Genome Database

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Gene: SMAD7 (SMAD family member 7) Sus scrofa
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Symbol: SMAD7
Name: SMAD family member 7
RGD ID: 14252583
Description: ENCODES a protein that exhibits ubiquitin protein ligase binding (ortholog); INVOLVED IN cellular response to leukemia inhibitory factor (ortholog); intracellular signal transduction (ortholog); negative regulation of BMP signaling pathway (ortholog); PARTICIPATES IN altered transforming growth factor-beta Smad dependent signaling pathway; Bone morphogenetic proteins signaling pathway; colorectal cancer pathway; ASSOCIATED WITH atrial fibrillation (ortholog); colorectal cancer (ortholog); Colorectal Neoplasms (ortholog); FOUND IN adherens junction (ortholog); INTERACTS WITH cadmium dichloride
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: mothers against decapentaplegic homolog 7; mothers against decapentaplegic-like protein 7; mothers against DPP 7
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl198,514,267 - 98,542,382 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1198,512,800 - 98,543,924 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21108,087,677 - 108,118,319 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adherens junction assembly  (IEA)
anatomical structure morphogenesis  (IBA)
artery morphogenesis  (IEA)
cell differentiation  (IBA)
cellular response to leukemia inhibitory factor  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (IEA)
intracellular signal transduction  (ISO)
negative regulation of BMP signaling pathway  (IEA,ISO)
negative regulation of chondrocyte proliferation  (IEA)
negative regulation of DNA-binding transcription factor activity  (IEA)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of ossification  (IEA)
negative regulation of pathway-restricted SMAD protein phosphorylation  (IEA)
negative regulation of peptidyl-serine phosphorylation  (IEA)
negative regulation of peptidyl-threonine phosphorylation  (IEA)
negative regulation of protein ubiquitination  (IEA)
negative regulation of T cell cytokine production  (IEA)
negative regulation of T-helper 17 cell differentiation  (IEA)
negative regulation of T-helper 17 type immune response  (IEA)
negative regulation of transcription by competitive promoter binding  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA)
negative regulation of ubiquitin-protein transferase activity  (IEA)
pathway-restricted SMAD protein phosphorylation  (IEA)
positive regulation of cell-cell adhesion  (IEA)
positive regulation of chondrocyte hypertrophy  (IEA)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA)
positive regulation of protein ubiquitination  (IEA)
protein stabilization  (IEA)
protein-containing complex localization  (IEA)
regulation of activin receptor signaling pathway  (IEA)
regulation of cardiac muscle contraction  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of epithelial to mesenchymal transition  (IEA)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transforming growth factor beta receptor signaling pathway  (ISO)
response to laminar fluid shear stress  (IEA)
SMAD protein signal transduction  (IBA)
transforming growth factor beta receptor signaling pathway  (IBA,IEA,ISO)
ureteric bud development  (IEA)
ventricular cardiac muscle tissue morphogenesis  (IEA)
ventricular septum morphogenesis  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:17407547   PMID:25448599   PMID:26902861   PMID:33217624  


Genomics

Comparative Map Data
SMAD7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl198,514,267 - 98,542,382 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1198,512,800 - 98,543,924 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21108,087,677 - 108,118,319 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SMAD7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381848,919,853 - 48,950,965 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1848,919,853 - 48,950,965 (-)EnsemblGRCh38hg38GRCh38
GRCh371846,446,223 - 46,477,335 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361844,700,221 - 44,731,079 (-)NCBINCBI36Build 36hg18NCBI36
Build 341844,700,221 - 44,731,079NCBI
Celera1843,299,268 - 43,330,141 (-)NCBICelera
Cytogenetic Map18q21.1NCBI
HuRef1843,299,249 - 43,329,936 (-)NCBIHuRef
CHM1_11846,441,162 - 46,472,026 (-)NCBICHM1_1
T2T-CHM13v2.01849,115,112 - 49,146,228 (-)NCBIT2T-CHM13v2.0
Smad7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391875,500,436 - 75,529,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1875,500,600 - 75,529,006 (+)EnsemblGRCm39 Ensembl
GRCm381875,367,365 - 75,395,935 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1875,367,529 - 75,395,935 (+)EnsemblGRCm38mm10GRCm38
MGSCv371875,527,019 - 75,555,588 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361875,492,894 - 75,521,292 (+)NCBIMGSCv36mm8
Celera1876,602,062 - 76,630,688 (+)NCBICelera
Cytogenetic Map18E3NCBI
Smad7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21868,988,429 - 69,016,774 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1868,988,429 - 69,016,765 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1871,094,956 - 71,123,284 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01871,764,762 - 71,793,114 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01869,620,987 - 69,649,318 (+)NCBIRnor_WKY
Rnor_6.01871,395,830 - 71,424,164 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1871,395,830 - 71,424,157 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01870,530,559 - 70,558,932 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41872,294,803 - 72,323,354 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11872,368,075 - 72,396,625 (+)NCBI
Celera1867,155,575 - 67,183,461 (+)NCBICelera
Cytogenetic Map18q12.2NCBI
Smad7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540234,028,063 - 34,058,291 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540234,028,184 - 34,058,949 (-)NCBIChiLan1.0ChiLan1.0
SMAD7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11852,147,312 - 52,178,129 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01842,306,324 - 42,337,214 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11845,659,375 - 45,689,505 (-)NCBIpanpan1.1PanPan1.1panPan2
SMAD7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1779,706,485 - 79,734,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl779,706,705 - 79,734,749 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha779,113,271 - 79,142,567 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0779,776,182 - 79,805,641 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl779,776,387 - 79,805,516 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1779,490,141 - 79,519,361 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0779,520,644 - 79,548,552 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0779,805,995 - 79,834,706 (+)NCBIUU_Cfam_GSD_1.0
Smad7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494438,655,545 - 38,682,943 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649713,894,580 - 13,922,065 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493649713,894,586 - 13,921,978 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMAD7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11831,993,543 - 32,024,088 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1831,993,681 - 32,024,850 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660506,227,954 - 6,258,760 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smad7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477812,415,282 - 12,444,835 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477812,415,364 - 12,444,882 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 4 3 5 2 23 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000004979   ⟹   ENSSSCP00000004862
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl198,514,267 - 98,542,382 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000044286   ⟹   ENSSSCP00000046968
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl198,510,229 - 98,542,382 (-)Ensembl
RefSeq Acc Id: NM_001244175   ⟹   NP_001231104
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1198,512,800 - 98,542,315 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005659454   ⟹   XP_005659511
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1198,512,800 - 98,543,922 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013992844   ⟹   XP_013848298
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1198,512,800 - 98,543,924 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013992845   ⟹   XP_013848299
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1198,512,800 - 98,541,678 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013992846   ⟹   XP_013848300
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1198,512,800 - 98,541,061 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_013848298   ⟸   XM_013992844
- Peptide Label: isoform X2
- UniProtKB: A0A287ASU5 (UniProtKB/TrEMBL),   A0A4X1UKJ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005659511   ⟸   XM_005659454
- Peptide Label: isoform X1
- UniProtKB: F1CK19 (UniProtKB/TrEMBL),   A0A8D1CF02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001231104   ⟸   NM_001244175
- UniProtKB: A0A4X1UM82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013848299   ⟸   XM_013992845
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013848300   ⟸   XM_013992846
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSSSCP00000046968   ⟸   ENSSSCT00000044286
RefSeq Acc Id: ENSSSCP00000004862   ⟸   ENSSSCT00000004979
Protein Domains
MH1   MH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000004507 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015030426 UniProtKB/TrEMBL
  ENSSSCG00025004341 UniProtKB/TrEMBL
  ENSSSCG00030062011 UniProtKB/TrEMBL
  ENSSSCG00035001002 UniProtKB/TrEMBL
  ENSSSCG00040042622 UniProtKB/TrEMBL
  ENSSSCG00045016161 UniProtKB/TrEMBL
  ENSSSCG00050004045 UniProtKB/TrEMBL
  ENSSSCG00055007588 UniProtKB/TrEMBL
  ENSSSCG00060068684 UniProtKB/TrEMBL
  ENSSSCG00065016328 UniProtKB/TrEMBL
  ENSSSCG00070018041 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000004862 ENTREZGENE
  ENSSSCP00000004862.2 UniProtKB/TrEMBL
  ENSSSCP00015015986.1 UniProtKB/TrEMBL
  ENSSSCP00025002308.1 UniProtKB/TrEMBL
  ENSSSCP00025002313.1 UniProtKB/TrEMBL
  ENSSSCP00030039999.1 UniProtKB/TrEMBL
  ENSSSCP00035000346.1 UniProtKB/TrEMBL
  ENSSSCP00040023737.1 UniProtKB/TrEMBL
  ENSSSCP00045018989.1 UniProtKB/TrEMBL
  ENSSSCP00050002299.1 UniProtKB/TrEMBL
  ENSSSCP00050002308.1 UniProtKB/TrEMBL
  ENSSSCP00055011641.1 UniProtKB/TrEMBL
  ENSSSCP00055011672.1 UniProtKB/TrEMBL
  ENSSSCP00060040568.1 UniProtKB/TrEMBL
  ENSSSCP00060040578.1 UniProtKB/TrEMBL
  ENSSSCP00065008784.1 UniProtKB/TrEMBL
  ENSSSCP00070029753.1 UniProtKB/TrEMBL
  ENSSSCP00070029760.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000004979 ENTREZGENE
  ENSSSCT00000004979.5 UniProtKB/TrEMBL
  ENSSSCT00015040448.1 UniProtKB/TrEMBL
  ENSSSCT00025005798.1 UniProtKB/TrEMBL
  ENSSSCT00025005807.1 UniProtKB/TrEMBL
  ENSSSCT00030086719.1 UniProtKB/TrEMBL
  ENSSSCT00035001203.1 UniProtKB/TrEMBL
  ENSSSCT00040057080.1 UniProtKB/TrEMBL
  ENSSSCT00045027481.1 UniProtKB/TrEMBL
  ENSSSCT00050005505.1 UniProtKB/TrEMBL
  ENSSSCT00050005517.1 UniProtKB/TrEMBL
  ENSSSCT00055014797.1 UniProtKB/TrEMBL
  ENSSSCT00055014836.1 UniProtKB/TrEMBL
  ENSSSCT00060093777.1 UniProtKB/TrEMBL
  ENSSSCT00060093793.1 UniProtKB/TrEMBL
  ENSSSCT00065021672.1 UniProtKB/TrEMBL
  ENSSSCT00070035599.1 UniProtKB/TrEMBL
  ENSSSCT00070035606.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.10 UniProtKB/TrEMBL
  3.90.520.10 UniProtKB/TrEMBL
InterPro Dwarfin UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/TrEMBL
KEGG Report ssc:100521305 UniProtKB/TrEMBL
NCBI Gene SMAD7 ENTREZGENE
PANTHER MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 7 UniProtKB/TrEMBL
  PTHR13703 UniProtKB/TrEMBL
Pfam MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
PROSITE MH1 UniProtKB/TrEMBL
  MH2 UniProtKB/TrEMBL
SMART DWA UniProtKB/TrEMBL
  DWB UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/TrEMBL
  SSF56366 UniProtKB/TrEMBL
UniProt A0A287ASU5 ENTREZGENE
  A0A4X1UKJ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UM82 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1CF02 ENTREZGENE, UniProtKB/TrEMBL
  C7C1K7_PIG UniProtKB/TrEMBL
  F1CK19 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:93221 ENTREZGENE