CAT (catalase) - Rat Genome Database

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Gene: CAT (catalase) Sus scrofa
Analyze
Symbol: CAT
Name: catalase
RGD ID: 14103484
Description: ENCODES a protein that exhibits antioxidant activity (ortholog); catalase activity (ortholog); identical protein binding (ortholog); INVOLVED IN aerobic respiration (ortholog); aging (ortholog); cellular response to growth factor stimulus (ortholog); PARTICIPATES IN disulfiram pharmacodynamics pathway; tryptophan metabolic pathway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); acatalasia (ortholog); acne (ortholog); FOUND IN cytosol (ortholog); endoplasmic reticulum (ortholog); extracellular space (ortholog); INTERACTS WITH bisphenol A; cadmium atom; cadmium dichloride
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl226,487,653 - 26,581,452 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1226,493,664 - 26,533,881 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2228,860,864 - 28,900,834 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2p16-p15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Abnormalities, Drug-Induced  (ISO)
acatalasia  (ISO)
acne  (ISO)
Acute Lung Injury  (ISO)
alcoholic liver cirrhosis  (ISO)
allergic rhinitis  (ISO)
angle-closure glaucoma  (ISO)
aortic disease  (ISO)
asphyxia neonatorum  (ISO)
asthma  (ISO)
autistic disorder  (ISO)
background diabetic retinopathy  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
brain ischemia  (ISO)
breast adenocarcinoma  (ISO)
Breast Neoplasms  (ISO)
Bronchopulmonary Dysplasia  (ISO)
calcium oxalate nephrolithiasis  (ISO)
cardiomyopathy  (ISO)
cataract  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chromosome Breakage  (ISO)
Chronic Hepatitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
chronic venous insufficiency  (ISO)
colitis  (ISO)
colorectal carcinoma  (ISO)
congestive heart failure  (ISO)
COVID-19  (ISO)
cutaneous leishmaniasis  (ISO)
cystitis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
diffuse large B-cell lymphoma  (ISO)
dilated cardiomyopathy  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Drug-Induced Dyskinesia  (ISO)
Edema  (ISO)
end stage renal disease  (ISO)
essential hypertension  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial Mediterranean fever  (ISO)
fatty liver disease  (ISO)
Femur Head Necrosis  (ISO)
fetal alcohol spectrum disorder  (ISO)
fibromyalgia  (ISO)
focal segmental glomerulosclerosis  (ISO)
gastric adenocarcinoma  (ISO)
gastric ulcer  (ISO)
Graves Ophthalmopathy  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
Hearing Loss, Cisplatin-Induced  (ISO)
Hearing Loss, Noise-Induced  (ISO)
hepatitis  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Human Influenza  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
Hyperemia  (ISO)
Hyperhidrosis  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
Hypotension  (ISO)
hypothyroidism  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
keratosis  (ISO)
Kidney Calculi  (ISO)
Left Ventricular Hypertrophy  (ISO)
lichen planus  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
major depressive disorder  (ISO)
Marfan syndrome  (ISO)
melanoma  (ISO)
mental depression  (ISO)
Mesothelioma  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
nephrosis  (ISO)
neurodegenerative disease  (ISO)
newborn respiratory distress syndrome  (ISO)
non-alcoholic fatty liver disease  (ISO)
optic neuritis  (ISO)
otitis media  (ISO)
pancreatic cancer  (ISO)
pemphigus  (ISO)
Perennial Allergic Rhinitis  (ISO)
phenylketonuria  (ISO)
phobic disorder  (ISO)
pleurisy  (ISO)
pneumoconiosis  (ISO)
Postmenopausal Osteoporosis  (ISO)
pre-malignant neoplasm  (ISO)
Prehypertension  (ISO)
Premature Birth  (ISO)
Presbycusis  (ISO)
proliferative diabetic retinopathy  (ISO)
Protein Deficiency  (ISO)
pseudoxanthoma elasticum  (ISO)
psoriasis  (ISO)
pterygium  (ISO)
pulmonary edema  (ISO)
pulmonary embolism  (ISO)
pulmonary fibrosis  (ISO)
Raynaud disease  (ISO)
Renoprival Hypertension  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (ISO)
retinal disease  (ISO)
retinitis pigmentosa  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
scabies  (ISO)
sciatic neuropathy  (ISO)
seborrheic dermatitis  (ISO)
senile cataract  (ISO)
sensorineural hearing loss  (ISO)
Sepsis  (ISO)
Skin Neoplasms  (ISO)
status epilepticus  (ISO)
stomatitis  (ISO)
systemic lupus erythematosus  (ISO)
thyroid gland papillary carcinoma  (ISO)
toxic encephalopathy  (ISO)
Turner syndrome  (ISO)
tympanosclerosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Ureteral Calculi  (ISO)
ureteral obstruction  (ISO)
Viral Bronchiolitis  (ISO)
visual epilepsy  (ISO)
vitiligo  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:7592879   PMID:9475954   PMID:14681463   PMID:17145712   PMID:17407547   PMID:19786062  


Genomics

Comparative Map Data
CAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl226,487,653 - 26,581,452 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1226,493,664 - 26,533,881 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2228,860,864 - 28,900,834 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2p16-p15NCBI
CAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1134,438,934 - 34,472,060 (+)EnsemblGRCh38hg38GRCh38
GRCh381134,438,934 - 34,472,060 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371134,460,481 - 34,493,607 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361134,417,054 - 34,450,183 (+)NCBINCBI36hg18NCBI36
Build 341134,417,053 - 34,450,179NCBI
Celera1134,607,658 - 34,640,793 (+)NCBI
Cytogenetic Map11p13NCBI
HuRef1134,157,829 - 34,190,968 (+)NCBIHuRef
CHM1_11134,459,461 - 34,492,601 (+)NCBICHM1_1
Cat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392103,284,249 - 103,315,498 (-)NCBIGRCm39mm39
GRCm39 Ensembl2103,284,194 - 103,315,505 (-)Ensembl
GRCm382103,453,904 - 103,485,153 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2103,453,849 - 103,485,160 (-)EnsemblGRCm38mm10GRCm38
MGSCv372103,294,061 - 103,325,310 (-)NCBIGRCm37mm9NCBIm37
MGSCv362103,254,842 - 103,285,959 (-)NCBImm8
Celera2104,700,510 - 104,731,525 (-)NCBICelera
Cytogenetic Map2E2NCBI
cM Map254.43NCBI
Cat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2389,842,393 - 89,874,577 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl389,842,399 - 89,874,478 (-)Ensembl
Rnor_6.0393,379,872 - 93,412,058 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl393,379,874 - 93,412,058 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03100,021,857 - 100,054,043 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4388,654,077 - 88,686,212 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1388,550,504 - 88,582,640 (+)NCBI
Celera388,911,241 - 88,943,392 (-)NCBICelera
RH 3.4 Map3718.62RGD
Cytogenetic Map3q32NCBI
Cat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542211,781,835 - 11,827,464 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542211,783,973 - 11,826,970 (-)NCBIChiLan1.0ChiLan1.0
CAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11134,289,603 - 34,323,160 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1134,289,603 - 34,323,160 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01134,413,253 - 34,446,831 (+)NCBIMhudiblu_PPA_v0panPan3
CAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11833,383,005 - 33,422,447 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1833,383,005 - 33,422,447 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1832,988,826 - 33,028,342 (-)NCBI
ROS_Cfam_1.01833,993,703 - 34,033,703 (-)NCBI
UMICH_Zoey_3.11833,553,399 - 33,593,082 (-)NCBI
UNSW_CanFamBas_1.01833,145,251 - 33,185,159 (-)NCBI
UU_Cfam_GSD_1.01833,780,645 - 33,820,629 (-)NCBI
Cat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494730,476,191 - 30,512,340 (-)NCBI
SpeTri2.0NW_0049365333,601,270 - 3,637,128 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1130,792,533 - 30,828,920 (-)NCBI
ChlSab1.1 Ensembl130,792,399 - 30,829,592 (-)Ensembl
Vero_WHO_p1.0NW_023666038127,903,025 - 127,939,181 (-)NCBI
Cat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476712,680,940 - 12,715,468 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000014528   ⟹   ENSSSCP00000014135
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl226,487,653 - 26,581,452 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000049964   ⟹   ENSSSCP00000038066
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl226,493,667 - 26,533,863 (-)Ensembl
RefSeq Acc Id: NM_214301   ⟹   NP_999466
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1226,493,665 - 26,533,881 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021081498   ⟹   XP_020937157
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1226,493,664 - 26,533,415 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999466 (Get FASTA)   NCBI Sequence Viewer  
  XP_020937157 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA25301 (Get FASTA)   NCBI Sequence Viewer  
  O62839 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020937157   ⟸   XM_021081498
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_999466   ⟸   NM_214301
- UniProtKB: O62839 (UniProtKB/Swiss-Prot),   A0A286ZSG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000038066   ⟸   ENSSSCT00000049964
RefSeq Acc Id: ENSSSCP00000014135   ⟸   ENSSSCT00000014528
Protein Domains
Catalase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013302 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070003335 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000014135 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000038066 UniProtKB/TrEMBL
  ENSSSCP00070005124 UniProtKB/TrEMBL
  ENSSSCP00070005144 UniProtKB/TrEMBL
  ENSSSCP00070005156 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014528 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000049964 UniProtKB/TrEMBL
  ENSSSCT00070006294 UniProtKB/TrEMBL
  ENSSSCT00070006315 UniProtKB/TrEMBL
  ENSSSCT00070006328 UniProtKB/TrEMBL
Gene3D-CATH 2.40.180.10 UniProtKB/TrEMBL
InterPro Catalase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Catalase_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Catalase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Catalase_clade1/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Catalase_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Catalase_core_sf UniProtKB/TrEMBL
  Catalase_haem_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Catalase_immune_responsive UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Catalase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397568 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene CAT ENTREZGENE
PANTHER PTHR11465 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Catalase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Catalase-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF Catalase_clade1-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CATALASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CATALASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CATALASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CATALASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Catalase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56634 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A286ZSG3 ENTREZGENE
  A0A287A2C3_PIG UniProtKB/TrEMBL
  A0A4X1SSG2_PIG UniProtKB/TrEMBL
  A0A4X1SSN8_PIG UniProtKB/TrEMBL
  A0A4X1SSR6_PIG UniProtKB/TrEMBL
  CATA_PIG UniProtKB/Swiss-Prot
  F1SGS9_PIG UniProtKB/TrEMBL
  O62839 ENTREZGENE
UniProt Secondary Q9TR38 UniProtKB/Swiss-Prot
  Q9TR39 UniProtKB/Swiss-Prot
VGNC ID VGNC:86208 ENTREZGENE