CA3 (carbonic anhydrase 3) - Rat Genome Database

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Gene: CA3 (carbonic anhydrase 3) Sus scrofa
Analyze
Symbol: CA3
Name: carbonic anhydrase 3
RGD ID: 13921868
Description: ENCODES a protein that exhibits phosphatase activity (ortholog); INVOLVED IN response to bacterium (ortholog); response to ethanol (ortholog); response to oxidative stress (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Experimental Liver Cirrhosis (ortholog); Experimental Liver Neoplasms (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CA-III; carbonate dehydratase III; carbonic anhydrase III, muscle specific
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl451,219,736 - 51,237,846 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1451,227,485 - 51,237,861 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2456,190,405 - 56,200,779 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO)

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:15756421   PMID:17065793   PMID:17145712   PMID:18298937   PMID:23398130  


Genomics

Comparative Map Data
CA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl451,219,736 - 51,237,846 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1451,227,485 - 51,237,861 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2456,190,405 - 56,200,779 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl885,373,436 - 85,449,040 (+)EnsemblGRCh38hg38GRCh38
GRCh38885,438,859 - 85,449,040 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37886,351,088 - 86,361,269 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36886,537,710 - 86,548,526 (+)NCBINCBI36hg18NCBI36
Build 34886,537,709 - 86,548,526NCBI
Celera882,356,136 - 82,366,348 (+)NCBI
Cytogenetic Map8q21.2NCBI
HuRef881,845,249 - 81,855,461 (+)NCBIHuRef
CHM1_1886,402,742 - 86,412,955 (+)NCBICHM1_1
Car3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39314,928,598 - 14,937,441 (+)NCBIGRCm39mm39
GRCm39 Ensembl314,928,572 - 14,937,583 (+)Ensembl
GRCm38314,863,538 - 14,872,381 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl314,863,512 - 14,872,523 (+)EnsemblGRCm38mm10GRCm38
MGSCv37314,863,538 - 14,872,381 (+)NCBIGRCm37mm9NCBIm37
MGSCv36314,840,282 - 14,849,125 (+)NCBImm8
Celera314,876,182 - 14,885,071 (+)NCBICelera
Cytogenetic Map3A1NCBI
cM Map33.22NCBI
Ca3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2286,770,418 - 86,780,011 (-)NCBI
Rnor_6.0 Ensembl288,126,667 - 88,135,410 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0288,126,519 - 88,136,063 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02107,900,433 - 107,909,977 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4288,106,727 - 88,114,686 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1288,050,843 - 88,059,683 (-)NCBI
Celera282,369,065 - 82,377,024 (-)NCBICelera
Cytogenetic Map2q23NCBI
Ca3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554173,362,492 - 3,372,932 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554173,362,091 - 3,372,270 (+)NCBIChiLan1.0ChiLan1.0
CA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1883,574,931 - 83,585,737 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0881,965,041 - 81,976,133 (+)NCBIMhudiblu_PPA_v0panPan3
CA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12931,935,192 - 31,945,585 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2931,935,172 - 31,980,579 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.02932,083,862 - 32,094,321 (+)NCBI
UMICH_Zoey_3.12932,135,278 - 32,145,713 (+)NCBI
UNSW_CanFamBas_1.02932,156,474 - 32,166,928 (+)NCBI
UU_Cfam_GSD_1.02932,543,269 - 32,553,756 (+)NCBI
Ca3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530347,444,945 - 47,454,991 (-)NCBI
SpeTri2.0NW_004936544337,437 - 347,760 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1880,805,296 - 80,816,127 (+)NCBI
ChlSab1.1 Ensembl880,805,134 - 80,816,190 (+)Ensembl
Ca3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247446,202,151 - 6,211,662 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2
Low 2 2 2 2
Below cutoff 6 1 6 2 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001008688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK233187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK233384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK346298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY680677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY680678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY680680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY680681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY680682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY680683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY789514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY789645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU468007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU571274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ157048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ157049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ675018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01124525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000006734   ⟹   ENSSSCP00000006551
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl451,227,479 - 51,237,846 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000041006   ⟹   ENSSSCP00000053920
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl451,219,736 - 51,237,844 (-)Ensembl
RefSeq Acc Id: NM_001008688   ⟹   NP_001008688
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1451,227,485 - 51,237,861 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001008688   ⟸   NM_001008688
- UniProtKB: Q5S1S4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000053920   ⟸   ENSSSCT00000041006
RefSeq Acc Id: ENSSSCP00000006551   ⟸   ENSSSCT00000006734
Protein Domains
Alpha-carbonic anhydrase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006141 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005032882 UniProtKB/Swiss-Prot
  ENSSSCG00070016319 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000006551 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000053920 UniProtKB/TrEMBL
  ENSSSCP00005032438 UniProtKB/Swiss-Prot
  ENSSSCP00070026771 UniProtKB/Swiss-Prot
  ENSSSCP00070026775 UniProtKB/TrEMBL
  ENSSSCP00070026784 UniProtKB/Swiss-Prot
  ENSSSCP00070026801 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000006734 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000041006 UniProtKB/TrEMBL
  ENSSSCT00005052521 UniProtKB/Swiss-Prot
  ENSSSCT00070032097 UniProtKB/Swiss-Prot
  ENSSSCT00070032101 UniProtKB/TrEMBL
  ENSSSCT00070032110 UniProtKB/Swiss-Prot
  ENSSSCT00070032127 UniProtKB/TrEMBL
Gene3D-CATH 3.10.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_CA3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:494016 UniProtKB/Swiss-Prot
NCBI Gene CA3 ENTREZGENE
PANTHER PTHR18952 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18952:SF127 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALPHA_CA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALPHA_CA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51069 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1UCS1_PIG UniProtKB/TrEMBL
  A0A4X1UEH4_PIG UniProtKB/TrEMBL
  A0A5S6G0V8_PIG UniProtKB/TrEMBL
  A0A5S6I8A2_PIG UniProtKB/TrEMBL
  CAH3_PIG UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q0Z809 UniProtKB/Swiss-Prot
VGNC ID VGNC:86099 ENTREZGENE