APOA1 (apolipoprotein A1) - Rat Genome Database
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Gene: APOA1 (apolipoprotein A1) Sus scrofa
Analyze
Symbol: APOA1
Name: apolipoprotein A1
RGD ID: 14203008
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); apolipoprotein receptor binding (ortholog); cholesterol transfer activity (ortholog); INVOLVED IN adrenal gland development (ortholog); animal organ regeneration (ortholog); blood vessel endothelial cell migration (ortholog); PARTICIPATES IN altered lipoprotein metabolic pathway; forkhead class A signaling pathway; lipoprotein metabolic pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Acute Tubulointerstitial Nephritis (ortholog); adenocarcinoma (ortholog); FOUND IN extracellular space; cell surface (ortholog); cytoplasmic vesicle (ortholog); INTERACTS WITH (24S)-24-hydroxycholesterol; bezafibrate; cholesterol
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: apo-AI; apoA-I; apolipoprotein A-I
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl944,216,393 - 44,218,978 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1944,216,481 - 44,218,360 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2949,288,730 - 49,290,611 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9p12-p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
Acute Tubulointerstitial Nephritis  (ISO)
adenocarcinoma  (ISO)
Alzheimer's disease  (ISO)
Apolipoprotein A-I, Deficiency of  (ISO)
arteriosclerosis  (ISO)
atherosclerosis  (ISO)
Behcet's disease  (ISO)
Budd-Chiari syndrome  (ISO)
cardiomyopathy  (ISO)
cerebral amyloid angiopathy  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholangiocarcinoma  (ISO)
Chronic Hepatitis B  (ISO)
chronic kidney disease  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Death  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
Drug Eruptions  (ISO)
Dwarfism  (ISO)
Edema  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Familial Amyloid Polyneuropathies  (ISO)
Familial Amyloidosis  (ISO)
Familial HDL Deficiency  (ISO)
familial isolated deficiency of vitamin E  (ISO)
familial visceral amyloidosis  (ISO)
fatty liver disease  (ISO)
hepatitis C  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hypercholesterolemia  (ISO)
Hyperlipoproteinemia Type II  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
Hypertriglyceridemia  (ISO)
Hypoalphalipoproteinemias  (ISO)
hypolipoproteinemia  (ISO)
Hypoproteinemia  (ISO)
Hypoxia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
Inflammation  (ISO)
Kidney Reperfusion Injury  (ISO)
lipid metabolism disorder  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
major depressive disorder  (ISO)
membranous glomerulonephritis  (ISO)
Metabolic Syndrome  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
nephrotic syndrome  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (ISO)
obesity  (ISO)
ocular hypertension  (ISO)
pancreatic cancer  (ISO)
Parkinson's disease  (ISO)
Pediatric Obesity  (ISO)
polycystic kidney disease  (ISO)
pulmonary fibrosis  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
systemic lupus erythematosus  (ISO)
Tangier disease  (ISO)
transitional cell carcinoma  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IEA,ISO)
animal organ regeneration  (ISO)
axon regeneration  (ISO)
blood vessel endothelial cell migration  (IEA,ISO)
cholesterol biosynthetic process  (IBA,IEA,ISO)
cholesterol efflux  (IBA,IEA,ISO)
cholesterol homeostasis  (IBA,IEA)
cholesterol import  (IEA)
cholesterol metabolic process  (IEA,ISO)
cholesterol transport  (ISO)
endothelial cell proliferation  (IEA,ISO)
ERK1 and ERK2 cascade  (ISO)
G protein-coupled receptor signaling pathway  (IEA)
glucocorticoid metabolic process  (IEA,ISO)
high-density lipoprotein particle assembly  (IBA,IEA)
high-density lipoprotein particle remodeling  (IEA)
integrin-mediated signaling pathway  (IEA)
intermembrane lipid transfer  (IEA)
lipid storage  (IEA,ISO)
lipid transport  (IEA)
lipoprotein biosynthetic process  (IEA,ISO)
lipoprotein metabolic process  (IBA,IEA)
negative chemotaxis  (IEA)
negative regulation of cell adhesion molecule production  (IEA)
negative regulation of cytokine production involved in immune response  (IEA)
negative regulation of heterotypic cell-cell adhesion  (IEA)
negative regulation of hydrolase activity  (IEA,ISO)
negative regulation of inflammatory response  (IEA)
negative regulation of interleukin-1 beta production  (IEA)
negative regulation of lipase activity  (ISO)
negative regulation of response to cytokine stimulus  (ISO)
negative regulation of tumor necrosis factor-mediated signaling pathway  (IEA)
negative regulation of very-low-density lipoprotein particle remodeling  (IEA)
peptidyl-methionine modification  (IEA,ISS)
peripheral nervous system axon regeneration  (ISO)
phosphatidylcholine biosynthetic process  (IEA)
phosphatidylcholine metabolic process  (IBA)
phospholipid efflux  (IBA,IEA)
phospholipid homeostasis  (IEA)
phospholipid metabolic process  (ISO)
phospholipid transport  (ISO)
positive regulation of cholesterol efflux  (IEA,ISS)
positive regulation of cholesterol esterification  (IBA,IEA)
positive regulation of fatty acid biosynthetic process  (IBA)
positive regulation of hydrolase activity  (IEA)
positive regulation of lipid biosynthetic process  (IBA)
positive regulation of lipoprotein lipase activity  (IBA)
positive regulation of phagocytosis  (IEA,ISS)
positive regulation of phospholipid efflux  (IEA,ISS)
positive regulation of Rho protein signal transduction  (IEA)
positive regulation of stress fiber assembly  (IEA)
positive regulation of substrate adhesion-dependent cell spreading  (IEA)
positive regulation of triglyceride catabolic process  (IBA)
protein localization  (ISO)
protein oxidation  (IEA,ISS)
protein stabilization  (IEA,ISS)
regulation of Cdc42 protein signal transduction  (IEA)
regulation of intestinal cholesterol absorption  (IBA,IEA,ISO)
regulation of protein phosphorylation  (IEA,ISO)
response to drug  (ISO)
response to estrogen  (ISO)
response to nutrient  (ISO)
reverse cholesterol transport  (IBA,IEA)
transforming growth factor beta receptor signaling pathway  (ISO)
triglyceride homeostasis  (IBA,IEA)
very-low-density lipoprotein particle remodeling  (IBA)
vitamin transport  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:178359   PMID:2105375   PMID:7916724   PMID:8111132   PMID:8294940   PMID:8428656   PMID:8468059   PMID:8661700   PMID:12202492   PMID:14681463   PMID:15845530   PMID:15878672  
PMID:16530456   PMID:22261194   PMID:25377528  


Genomics

Comparative Map Data
APOA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl944,216,393 - 44,218,978 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1944,216,481 - 44,218,360 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2949,288,730 - 49,290,611 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9p12-p11NCBI
APOA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11116,835,751 - 116,837,950 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl11116,835,751 - 116,837,622 (-)EnsemblGRCh38hg38GRCh38
GRCh3811116,835,751 - 116,837,950 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711116,706,467 - 116,708,666 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,211,679 - 116,213,548 (-)NCBINCBI36hg18NCBI36
Celera11113,864,272 - 113,866,141 (-)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11112,638,728 - 112,640,597 (-)NCBIHuRef
CHM1_111116,591,219 - 116,593,418 (-)NCBICHM1_1
Apoa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39946,139,928 - 46,141,767 (+)NCBIGRCm39mm39
GRCm39 Ensembl946,139,878 - 46,141,764 (+)Ensembl
GRCm38946,228,630 - 46,230,469 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl946,228,580 - 46,230,466 (+)EnsemblGRCm38mm10GRCm38
MGSCv37946,036,713 - 46,038,549 (+)NCBIGRCm37mm9NCBIm37
MGSCv36945,979,705 - 45,981,461 (+)NCBImm8
Celera943,517,584 - 43,519,420 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.36NCBI
Apoa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2846,527,251 - 46,529,035 (+)NCBI
Rnor_6.0 Ensembl850,525,091 - 50,526,875 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0850,525,091 - 50,526,875 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0849,151,163 - 49,152,947 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera846,109,311 - 46,111,065 (+)NCBICelera
RH 3.4 Map8472.0RGD
Cytogenetic Map8q22NCBI
Apoa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541218,170,331 - 18,172,298 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541218,170,331 - 18,172,298 (-)NCBIChiLan1.0ChiLan1.0
APOA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111115,606,136 - 115,608,335 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11115,606,136 - 115,608,122 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011111,673,539 - 111,675,428 (-)NCBIMhudiblu_PPA_v0panPan3
APOA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl516,740,130 - 16,741,943 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1516,740,071 - 16,742,081 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Apoa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365422,111,055 - 2,112,626 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOA1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11108,201,967 - 108,203,902 (-)NCBI
ChlSab1.1 Ensembl1108,201,439 - 108,203,609 (-)Ensembl
Apoa1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478412,249,283 - 12,251,215 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 5 2 19 2
Low 5 4 3 3 2 4 2 1 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_214398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK233525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK234086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK393967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK395364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK395818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK400968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU582845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01120921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L00626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X17057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X59414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X69477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X69478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X69479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z14124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000034599   ⟹   ENSSSCP00000028928
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl944,216,394 - 44,218,978 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000053994   ⟹   ENSSSCP00000033805
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl944,216,393 - 44,218,172 (-)Ensembl
RefSeq Acc Id: NM_214398   ⟹   NP_999563
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1944,216,481 - 44,218,360 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999563 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA30992 (Get FASTA)   NCBI Sequence Viewer  
  CAA42050 (Get FASTA)   NCBI Sequence Viewer  
  CAA49234 (Get FASTA)   NCBI Sequence Viewer  
  P18648 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_999563   ⟸   NM_214398
- Peptide Label: preproprotein
- UniProtKB: P18648 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000028928   ⟸   ENSSSCT00000034599
RefSeq Acc Id: ENSSSCP00000033805   ⟸   ENSSSCT00000053994


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000030921 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000028928 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000033805 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000034599 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000053994 UniProtKB/TrEMBL
InterPro ApoA_E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397691 UniProtKB/Swiss-Prot
NCBI Gene APOA1 ENTREZGENE
Pfam Apolipoprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A286ZQC7_PIG UniProtKB/TrEMBL
  APOA1_PIG UniProtKB/Swiss-Prot
  K7GM40_PIG UniProtKB/TrEMBL
  P18648 ENTREZGENE
VGNC ID VGNC:85415 ENTREZGENE