SOCS1 (suppressor of cytokine signaling 1) - Rat Genome Database

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Gene: SOCS1 (suppressor of cytokine signaling 1) Sus scrofa
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Symbol: SOCS1
Name: suppressor of cytokine signaling 1
RGD ID: 14097343
Description: ENCODES a protein that exhibits insulin-like growth factor receptor binding (inferred); kinase inhibitor activity (inferred); protein kinase binding (inferred); INVOLVED IN animal organ regeneration (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to cytokine stimulus (ortholog); PARTICIPATES IN insulin signaling pathway; interleukin-12 signaling pathway; interleukin-2 signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); alcoholic hepatitis (ortholog); allergic contact dermatitis (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH cadmium nitrate
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl331,881,225 - 31,884,969 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1331,879,143 - 31,883,041 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2332,670,021 - 32,674,785 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
cellular response to amino acid stimulus  (IEA,ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to thyrotropin-releasing hormone  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
cytokine-mediated signaling pathway  (IEA,ISO)
fat cell differentiation  (IEA,ISO)
intracellular signal transduction  (IEA)
macrophage differentiation  (IEA)
negative regulation of catalytic activity  (IEA)
negative regulation of CD8-positive, alpha-beta T cell differentiation  (IEA)
negative regulation of hepatic stellate cell proliferation  (ISO)
negative regulation of insulin receptor signaling pathway  (IEA,ISO)
negative regulation of receptor signaling pathway via JAK-STAT  (IEA,ISO)
negative regulation of signal transduction  (IEA)
negative regulation of tyrosine phosphorylation of STAT protein  (IEA,ISO)
phosphatidylinositol phosphate biosynthetic process  (IBA)
positive regulation of CD4-positive, alpha-beta T cell differentiation  (IEA)
positive regulation of fibroblast apoptotic process  (ISO)
positive regulation of regulatory T cell differentiation  (IEA)
protein ubiquitination  (IEA)
receptor signaling pathway via JAK-STAT  (IEA,ISO)
regulation of activation of Janus kinase activity  (IEA,ISO)
regulation of cytokine production  (IEA,ISO)
regulation of growth  (IEA)
regulation of interferon-gamma-mediated signaling pathway  (IEA)
regulation of phosphatidylinositol 3-kinase activity  (IEA)
regulation of protein phosphorylation  (IEA,ISO)
regulation of receptor signaling pathway via JAK-STAT  (IEA,ISO)
regulation of tyrosine phosphorylation of STAT protein  (IEA,ISO)
response to cytokine  (ISO)
response to erythropoietin  (ISO)
response to estradiol  (ISO)
response to lipopolysaccharide  (ISO)
response to peptide hormone  (ISO)
response to progesterone  (ISO)
response to xenobiotic stimulus  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:20045027   PMID:31826939   PMID:35304133  


Genomics

Comparative Map Data
SOCS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl331,881,225 - 31,884,969 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1331,879,143 - 31,883,041 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2332,670,021 - 32,674,785 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOCS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381611,254,417 - 11,256,204 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1611,254,417 - 11,256,204 (-)EnsemblGRCh38hg38GRCh38
GRCh371611,348,274 - 11,350,039 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361611,255,775 - 11,257,540 (-)NCBINCBI36hg18NCBI36
Build 341611,255,774 - 11,257,540NCBI
Celera1611,517,679 - 11,519,444 (-)NCBI
Cytogenetic Map16p13.13NCBI
HuRef1611,266,017 - 11,267,782 (-)NCBIHuRef
CHM1_11611,348,201 - 11,349,966 (-)NCBICHM1_1
Socs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391610,601,672 - 10,603,400 (-)NCBIGRCm39mm39
GRCm39 Ensembl1610,600,104 - 10,603,400 (-)Ensembl
GRCm381610,783,808 - 10,785,536 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1610,782,240 - 10,785,536 (-)EnsemblGRCm38mm10GRCm38
MGSCv371610,783,901 - 10,785,629 (-)NCBIGRCm37mm9NCBIm37
MGSCv361610,697,386 - 10,699,114 (-)NCBImm8
Celera1611,411,246 - 11,412,974 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map165.81NCBI
Socs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2104,882,651 - 4,884,342 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl104,882,560 - 4,884,383 (+)Ensembl
Rnor_6.0104,956,795 - 4,958,472 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl104,957,326 - 4,958,461 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0103,782,936 - 3,783,574 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4104,819,971 - 4,820,609 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1104,819,970 - 4,820,609 (+)NCBI
Celera103,904,246 - 3,905,811 (+)NCBICelera
Cytogenetic Map10q11NCBI
Socs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554427,321,337 - 7,323,109 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554427,321,337 - 7,323,109 (+)NCBIChiLan1.0ChiLan1.0
SOCS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v01610,196,432 - 10,198,205 (-)NCBIMhudiblu_PPA_v0panPan3
SOCS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1631,511,003 - 31,511,995 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl631,509,268 - 31,511,557 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha632,893,176 - 32,894,903 (+)NCBI
ROS_Cfam_1.0631,692,882 - 31,694,609 (+)NCBI
UMICH_Zoey_3.1631,506,103 - 31,507,841 (+)NCBI
UNSW_CanFamBas_1.0631,380,389 - 31,382,114 (+)NCBI
UU_Cfam_GSD_1.0631,804,768 - 31,806,494 (+)NCBI
Socs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344111,469,049 - 111,470,661 (-)NCBI
SpeTri2.0NW_0049365309,312,965 - 9,315,593 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOCS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1510,731,866 - 10,733,745 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl510,732,350 - 10,732,991 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606819,430,111 - 19,432,041 (+)NCBIVero_WHO_p1.0
Socs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248248,444,877 - 8,446,628 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system hemolymphoid system nervous system reproductive system respiratory system
High
Medium
Low 9 2 4 1 1 3
Below cutoff 1 1 1 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000029636   ⟹   ENSSSCP00000024749
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl331,881,225 - 31,884,969 (+)Ensembl
RefSeq Acc Id: NM_001204768   ⟹   NP_001191697
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1331,881,891 - 31,882,722 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005662125   ⟹   XP_005662182
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1331,881,178 - 31,883,041 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005662126   ⟹   XP_005662183
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1331,879,143 - 31,883,041 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001191697 (Get FASTA)   NCBI Sequence Viewer  
  XP_005662182 (Get FASTA)   NCBI Sequence Viewer  
  XP_005662183 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACV65523 (Get FASTA)   NCBI Sequence Viewer  
  ADU03229 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005662183   ⟸   XM_005662126
- Peptide Label: isoform X1
- UniProtKB: E7CR04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005662182   ⟸   XM_005662125
- Peptide Label: isoform X1
- UniProtKB: E7CR04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001191697   ⟸   NM_001204768
- UniProtKB: E7CR04 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000024749   ⟸   ENSSSCT00000029636
Protein Domains
SH2   SOCS box


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000027855 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00015053793 UniProtKB/TrEMBL
  ENSSSCG00025045953 UniProtKB/TrEMBL
  ENSSSCG00030032229 UniProtKB/TrEMBL
  ENSSSCG00035049919 UniProtKB/TrEMBL
  ENSSSCG00040013020 UniProtKB/TrEMBL
  ENSSSCG00045024061 UniProtKB/TrEMBL
  ENSSSCG00050076754 UniProtKB/TrEMBL
  ENSSSCG00055012973 UniProtKB/TrEMBL
  ENSSSCG00060075067 UniProtKB/TrEMBL
  ENSSSCG00065075477 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000024749 UniProtKB/TrEMBL
  ENSSSCP00015028692 UniProtKB/TrEMBL
  ENSSSCP00025026503 UniProtKB/TrEMBL
  ENSSSCP00030020044 UniProtKB/TrEMBL
  ENSSSCP00035026970 UniProtKB/TrEMBL
  ENSSSCP00040007025 UniProtKB/TrEMBL
  ENSSSCP00045028497 UniProtKB/TrEMBL
  ENSSSCP00050046414 UniProtKB/TrEMBL
  ENSSSCP00055020263 UniProtKB/TrEMBL
  ENSSSCP00060044795 UniProtKB/TrEMBL
  ENSSSCP00065046120 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000029636 UniProtKB/TrEMBL
  ENSSSCT00015071619 UniProtKB/TrEMBL
  ENSSSCT00025062368 UniProtKB/TrEMBL
  ENSSSCT00030044562 UniProtKB/TrEMBL
  ENSSSCT00035066510 UniProtKB/TrEMBL
  ENSSSCT00040017267 UniProtKB/TrEMBL
  ENSSSCT00045041040 UniProtKB/TrEMBL
  ENSSSCT00050105498 UniProtKB/TrEMBL
  ENSSSCT00055025514 UniProtKB/TrEMBL
  ENSSSCT00060102740 UniProtKB/TrEMBL
  ENSSSCT00065104151 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
InterPro SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SOCS1 UniProtKB/TrEMBL
  SOCS1_SH2 UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
  SOCS_box-like_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:100307052 UniProtKB/TrEMBL
NCBI Gene SOCS1 ENTREZGENE
PANTHER PTHR10155:SF4 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
Superfamily-SCOP SSF158235 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A8D1C5N0_PIG UniProtKB/TrEMBL
  C9DRN2_PIG UniProtKB/TrEMBL
  E7CR04 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:93330 ENTREZGENE