RGD Reference Report - The protective role of Hepatopoietin Cn on liver injury induced by carbon tetrachloride in rats*. - Rat Genome Database

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The protective role of Hepatopoietin Cn on liver injury induced by carbon tetrachloride in rats*.

Authors: Cui, CP  Wei, P  Liu, Y  Zhang, DJ  Wang, LS  Wu, CT 
Citation: Cui CP, etal., Hepatol Res. 2009 Feb;39(2):200-6. doi: 10.1111/j.1872-034X.2008.00447.x. Epub 2008 Nov 26.
RGD ID: 10401133
Pubmed: PMID:19054144   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1872-034X.2008.00447.x   (Journal Full-text)

BACKGROUND: Hepatopoietin Cn (HPPCn) is a member of the leucine-rich acidic nuclear protein family (LANP), and studies of partially hepatectomized (PH) mice show that levels of HPPCn mRNA increase following liver injury. Furthermore, the recombinant human protein (rhHPPCn) was shown to stimulate hepatic DNA synthesis and activate signaling pathways involved in hepatocyte proliferation in vitro and in vivo. AIM: The aim of the study was to evaluate the protective effect of rhHPPCn on liver injury and fibrosis induced by carbon tetrachloride (CCl4) injection. METHODS: Wistar rats weighing 200 g were given a single and repeated intraperitoneal injections of CCl4. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity in rat serum were measured using biochemical assay. Hepatic hydroxyproline (Hyp) level was determined in the hydrolysates of liver samples. Immunostaining and Masson's trichrome staining were conducted to evaluate hepatocyte proliferation and fibrosis. RESULTS: The results showed that exogenous rhHPPCn could alleviate hepatocyte necrosis and protect the liver from the development of fibrotic lesions by proliferation stimulation. Additionally, HPPCn could reduce ALT/AST levels in rat serum following single and repeated CCl4 injection. CONCLUSION: It was suggested that HPPCn could protect hepatocytes from injury induced by CCl4 as a proliferation stimulator.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Liver Cirrhosis treatmentIDA 10401133 RGD 
Experimental Liver Cirrhosis treatmentISOANP32A (Homo sapiens)10401133; 10401133 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Anp32a  (acidic nuclear phosphoprotein 32 family member A)

Genes (Mus musculus)
Anp32a  (acidic nuclear phosphoprotein 32 family member A)

Genes (Homo sapiens)
ANP32A  (acidic nuclear phosphoprotein 32 family member A)


Additional Information