FGF2 (fibroblast growth factor 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: FGF2 (fibroblast growth factor 2) Sus scrofa
Analyze
Symbol: FGF2
Name: fibroblast growth factor 2
RGD ID: 14218120
Description: ENCODES a protein that exhibits chemoattractant activity (ortholog); chemokine binding (ortholog); cytokine activity (ortholog); INVOLVED IN angiogenesis (ortholog); angiogenesis involved in coronary vascular morphogenesis (ortholog); behavioral response to ethanol (ortholog); PARTICIPATES IN cerium oxide nanoparticle response pathway; fibroblast growth factor signaling pathway; glypican signaling pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Animal Mammary Neoplasms (ortholog); Arteriovenous Fistula (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH bis(2-chloroethyl) sulfide; chondroitin sulfate; dermatan sulfate
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8101,278,885 - 101,343,916 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18101,278,877 - 101,344,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28108,489,442 - 108,508,875 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
alcohol use disorder  (ISO)
Animal Mammary Neoplasms  (ISO)
Arteriovenous Fistula  (ISO)
biliary tract disease  (ISO)
bladder disease  (ISO)
bone disease  (ISO)
Bone Fractures  (ISO)
brain infarction  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Cardiomegaly  (ISO)
cataract  (ISO)
cholangiocarcinoma  (ISO)
cholesteatoma of middle ear  (ISO)
Choroidal Neovascularization  (ISO)
chronic ulcer of skin  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
cocaine abuse  (ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
decubitus ulcer  (ISO)
Delayed Hypersensitivity  (ISO)
demyelinating disease  (ISO)
depressive disorder  (ISO)
dermatitis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
Disease Progression  (ISO)
endometrial cancer  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
esophageal cancer  (ISO)
essential thrombocythemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Eye Injuries  (ISO)
Femoral Fractures  (ISO)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (ISO)
gestational diabetes  (ISO)
Gliosis  (ISO)
high grade glioma  (ISO)
Hypercholesterolemia  (ISO)
Hyperoxic Lung Injury  (ISO)
hypertension  (ISO)
Hypoglossal Nerve Injuries  (ISO)
impotence  (ISO)
Inflammation  (ISO)
Invasive Pulmonary Aspergillosis  (ISO)
Kaposiform Hemangioendothelioma  (ISO)
kidney disease  (ISO)
leiomyoma  (ISO)
liver cirrhosis  (ISO)
long QT syndrome  (ISO)
macular retinal edema  (ISO)
Mesothelioma  (ISO)
middle cerebral artery infarction  (ISO)
multiple endocrine neoplasia type 1  (ISO)
Myocardial Ischemia  (ISO)
Nasal Polyps  (ISO)
Necrosis  (ISO)
Neointima  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
nephrosclerosis  (ISO)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
neurodevelopmental disorder with hearing loss, seizures, and brain abnormalities  (ISO)
Neurodevelopmental Disorders  (ISO)
Optic Nerve Injuries  (ISO)
oral submucous fibrosis  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinsonism  (ISO)
Penetrating Eye Injuries  (ISO)
periapical periodontitis  (ISO)
polyarteritis nodosa  (ISO)
Pregnancy in Diabetics  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
prostate adenocarcinoma  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Infections  (ISO)
pterygium  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (ISO)
retinal vein occlusion  (ISO)
Spinal Cord Compression  (ISO)
Spinal Cord Injuries  (ISO)
Surgical Wound  (ISO)
transitional cell carcinoma  (ISO)
Tympanic Membrane Perforation  (ISO)
type 2 diabetes mellitus  (ISO)
Ulcer  (ISO)
urinary bladder cancer  (ISO)
Wound Infection  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
angiogenesis involved in coronary vascular morphogenesis  (ISO)
animal organ development  (IEA)
behavioral response to ethanol  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
canonical Wnt signaling pathway  (ISO)
cell differentiation  (IEA)
cell migration involved in sprouting angiogenesis  (ISO)
cell population proliferation  (ISO)
cellular response to mechanical stimulus  (ISO)
cerebellar granule cell precursor proliferation  (ISO)
chondroblast differentiation  (ISO)
corticotropin hormone secreting cell differentiation  (ISO)
embryo development ending in birth or egg hatching  (ISO)
endothelial cell migration  (ISO)
endothelial cell proliferation  (ISO)
epithelial cell proliferation  (ISO)
ERK1 and ERK2 cascade  (ISO)
fibroblast growth factor receptor signaling pathway  (IBA,ISO)
glial cell differentiation  (ISO)
growth factor dependent regulation of skeletal muscle satellite cell proliferation  (ISO)
hyaluronan catabolic process  (ISO)
inner ear auditory receptor cell differentiation  (ISO)
lung development  (ISO)
lymphatic endothelial cell migration  (ISO)
mammary gland epithelial cell differentiation  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of fibroblast migration  (ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
negative regulation of stem cell proliferation  (ISO)
negative regulation of wound healing  (ISO)
neuroblast proliferation  (ISO)
neuroepithelial cell differentiation  (ISO)
neurogenesis  (IBA)
organ induction  (ISO)
osteoblast differentiation  (ISO)
paracrine signaling  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell division  (IEA)
positive regulation of cell fate specification  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of cell population proliferation  (IBA,ISO)
positive regulation of cerebellar granule cell precursor proliferation  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of endothelial cell chemotaxis  (ISO)
positive regulation of endothelial cell chemotaxis to fibroblast growth factor  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of epithelial tube formation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of inner ear auditory receptor cell differentiation  (ISO)
positive regulation of lens fiber cell differentiation  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (IBA,ISO)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of neuroepithelial cell differentiation  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of stem cell differentiation  (ISO)
positive regulation of stem cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
regulation of cell cycle  (ISO)
regulation of cell migration  (IBA)
regulation of endothelial cell chemotaxis to fibroblast growth factor  (ISO)
regulation of retinal cell programmed cell death  (ISO)
release of sequestered calcium ion into cytosol  (ISO)
response to axon injury  (ISO)
response to ethanol  (ISO)
response to wortmannin  (ISO)
signal transduction  (IEA)
stem cell development  (ISO)
stem cell differentiation  (ISO)
stem cell proliferation  (ISO)
substantia nigra development  (ISO)
system development  (IEA)
thyroid-stimulating hormone-secreting cell differentiation  (ISO)
transcription by RNA polymerase II  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:15120423   PMID:17145712   PMID:17475322   PMID:18218921   PMID:18278782   PMID:19380425   PMID:21478100   PMID:21691119   PMID:21786158   PMID:22227366   PMID:22301074  
PMID:28186136   PMID:30032202  


Genomics

Comparative Map Data
FGF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8101,278,885 - 101,343,916 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18101,278,877 - 101,344,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28108,489,442 - 108,508,875 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384122,826,682 - 122,898,236 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4122,826,682 - 122,898,236 (+)EnsemblGRCh38hg38GRCh38
GRCh374123,747,837 - 123,819,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364123,967,313 - 124,038,840 (+)NCBINCBI36Build 36hg18NCBI36
Build 344124,105,467 - 124,176,995NCBI
Celera4121,130,707 - 121,202,234 (+)NCBICelera
Cytogenetic Map4q28.1NCBI
HuRef4119,474,437 - 119,545,817 (+)NCBIHuRef
CHM1_14123,724,372 - 123,795,895 (+)NCBICHM1_1
T2T-CHM13v2.04126,130,781 - 126,202,343 (+)NCBIT2T-CHM13v2.0
Fgf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39337,402,616 - 37,464,255 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl337,402,495 - 37,464,257 (+)EnsemblGRCm39 Ensembl
GRCm38337,348,477 - 37,410,106 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl337,348,346 - 37,410,108 (+)EnsemblGRCm38mm10GRCm38
MGSCv37337,247,575 - 37,303,752 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36337,540,399 - 37,596,346 (+)NCBIMGSCv36mm8
Celera337,228,587 - 37,279,676 (+)NCBICelera
Cytogenetic Map3BNCBI
cM Map318.41NCBI
Fgf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82122,164,454 - 122,218,796 (+)NCBIGRCr8
mRatBN7.22120,236,328 - 120,290,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2120,236,328 - 120,291,221 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2126,799,241 - 126,853,523 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02124,911,739 - 124,966,029 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02119,540,703 - 119,594,985 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02124,081,072 - 124,134,133 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2124,081,072 - 124,134,681 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02143,689,407 - 143,742,070 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42123,893,314 - 123,947,136 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12123,838,275 - 123,897,453 (+)NCBI
Celera2115,183,003 - 115,237,310 (+)NCBICelera
RH 3.4 Map2677.29RGD
Cytogenetic Map2q25NCBI
Fgf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542817,840,628 - 17,894,773 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542817,840,554 - 17,894,779 (-)NCBIChiLan1.0ChiLan1.0
FGF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23120,604,078 - 120,675,314 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14120,869,886 - 120,941,139 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04115,005,136 - 115,076,369 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14126,149,750 - 126,220,774 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4126,149,813 - 126,214,942 (+)Ensemblpanpan1.1panPan2
FGF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11917,403,288 - 17,463,143 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1916,994,661 - 17,463,151 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1917,610,808 - 17,690,535 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01917,510,798 - 17,588,734 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11917,466,635 - 17,533,082 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01917,745,360 - 17,822,472 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01918,217,074 - 18,293,705 (-)NCBIUU_Cfam_GSD_1.0
FGF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1770,089,394 - 70,157,423 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603749,060,630 - 49,133,030 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247773,268,953 - 3,321,145 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247773,268,674 - 3,321,424 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FGF2
1592 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000040673   ⟹   ENSSSCP00000055271
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl8101,278,885 - 101,343,916 (-)Ensembl
RefSeq Acc Id: XM_021100546   ⟹   XP_020956205
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.18101,278,877 - 101,344,084 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001392443 (Get FASTA)   NCBI Sequence Viewer  
  XP_020956205 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE11791 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000055271.1
RefSeq Acc Id: XP_020956205   ⟸   XM_021100546
- Sequence:
Ensembl Acc Id: ENSSSCP00000055271   ⟸   ENSSSCT00000040673


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000036213 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000040673.3 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/TrEMBL
InterPro Fibroblast_GF_fam UniProtKB/TrEMBL
  IL1/FGF UniProtKB/TrEMBL
NCBI Gene FGF2 ENTREZGENE
PANTHER PTHR11486 UniProtKB/TrEMBL
  PTHR11486:SF83 UniProtKB/TrEMBL
Pfam FGF UniProtKB/TrEMBL
PRINTS HBGFFGF UniProtKB/TrEMBL
  IL1HBGF UniProtKB/TrEMBL
PROSITE HBGF_FGF UniProtKB/TrEMBL
SMART FGF UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/TrEMBL
UniProt A0A287BGK8_PIG UniProtKB/TrEMBL
  Q7YRN5_PIG UniProtKB/TrEMBL
VGNC ID VGNC:98928 ENTREZGENE