EPHB2 (EPH receptor B2) - Rat Genome Database

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Gene: EPHB2 (EPH receptor B2) Sus scrofa
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Symbol: EPHB2
Name: EPH receptor B2
RGD ID: 14270519
Description: ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); signaling receptor activity (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); axon guidance (ortholog); camera-type eye morphogenesis (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; syndecan signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Anorectal Malformations (ortholog); Candidemia (ortholog); FOUND IN cell surface (ortholog); dendritic spine (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: ephrin type-B receptor 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl680,649,143 - 80,843,567 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1680,649,098 - 80,849,979 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,689,973 - 74,878,715 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IBA)
animal organ morphogenesis  (ISO)
axon guidance  (IBA,ISO)
axonal fasciculation  (IEA)
B cell activation  (IEA)
camera-type eye morphogenesis  (IEA,ISO)
cell morphogenesis  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to lipopolysaccharide  (ISO)
central nervous system projection neuron axonogenesis  (IBA,ISO)
commissural neuron axon guidance  (IEA)
corpus callosum development  (IEA)
dendritic spine development  (ISO)
dendritic spine morphogenesis  (IEA,ISO)
ephrin receptor signaling pathway  (IEA,ISO)
hindbrain tangential cell migration  (ISO)
inner ear morphogenesis  (IEA)
learning  (IEA,ISO)
learning or memory  (ISO)
negative regulation of axonogenesis  (IEA,ISO)
negative regulation of cell adhesion  (IEA)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of ERK1 and ERK2 cascade  (IEA)
negative regulation of NMDA glutamate receptor activity  (IEA)
negative regulation of protein kinase activity  (IEA,ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of Ras protein signal transduction  (IEA)
neuron projection retraction  (IEA)
optic nerve morphogenesis  (IEA,ISO)
peptidyl-tyrosine phosphorylation  (IEA,ISO)
phosphorylation  (ISO)
positive regulation of B cell proliferation  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of dendritic spine morphogenesis  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of immunoglobulin production  (IEA)
positive regulation of kinase activity  (IBA)
positive regulation of long-term neuronal synaptic plasticity  (IEA,ISO)
positive regulation of long-term synaptic potentiation  (IEA)
positive regulation of NMDA glutamate receptor activity  (IEA)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of synapse assembly  (IEA,ISO)
positive regulation of synaptic plasticity  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
postsynaptic membrane assembly  (ISO)
protein phosphorylation  (ISO)
regulation of axonogenesis  (ISO)
regulation of behavioral fear response  (ISO)
regulation of blood coagulation  (IEA)
regulation of body fluid levels  (ISO)
regulation of filopodium assembly  (ISO)
regulation of neuronal synaptic plasticity  (ISO)
regulation of receptor signaling pathway via JAK-STAT  (ISO)
regulation of synapse assembly  (ISO)
regulation of T-helper 17 type immune response  (ISO)
retinal ganglion cell axon guidance  (IEA,ISO)
roof of mouth development  (IEA)
tight junction assembly  (ISO)
trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission  (IEA)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA,ISO)
urogenital system development  (IEA)
vesicle-mediated intercellular transport  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
EPHB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl680,649,143 - 80,843,567 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1680,649,098 - 80,849,979 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,689,973 - 74,878,715 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPHB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl122,710,839 - 22,921,500 (+)EnsemblGRCh38hg38GRCh38
GRCh38122,710,770 - 22,921,500 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37123,037,331 - 23,247,993 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,909,918 - 23,114,410 (+)NCBINCBI36hg18NCBI36
Celera121,361,651 - 21,563,983 (+)NCBI
Cytogenetic Map1p36.12NCBI
HuRef121,351,920 - 21,485,793 (+)NCBIHuRef
CHM1_1123,149,831 - 23,354,155 (+)NCBICHM1_1
Ephb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394136,374,850 - 136,563,637 (-)NCBIGRCm39mm39
GRCm39 Ensembl4136,374,850 - 136,563,299 (-)Ensembl
GRCm384136,647,536 - 136,836,326 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4136,647,539 - 136,835,988 (-)EnsemblGRCm38mm10GRCm38
MGSCv374136,209,523 - 136,391,850 (-)NCBIGRCm37mm9NCBIm37
MGSCv364135,925,684 - 136,108,011 (-)NCBImm8
Celera4134,853,290 - 135,040,552 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.0NCBI
Ephb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25148,889,574 - 149,077,027 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl5148,897,246 - 149,077,059 (-)Ensembl
Rnor_6.05155,024,478 - 155,143,539 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,022,493 - 155,204,456 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05156,786,985 - 156,811,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05158,789,192 - 158,907,248 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45155,423,035 - 155,605,384 (-)NCBIRGSC3.4rn4RGSC3.4
Celera5147,297,353 - 147,415,432 (-)NCBICelera
Cytogenetic Map5q36NCBI
Ephb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,844,713 - 2,980,445 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554522,844,713 - 2,986,790 (+)NCBIChiLan1.0ChiLan1.0
EPHB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1122,914,584 - 23,054,752 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl122,912,570 - 23,047,118 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0121,895,961 - 22,107,649 (+)NCBIMhudiblu_PPA_v0panPan3
EPHB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1276,427,112 - 76,551,494 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl276,428,203 - 76,612,786 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha272,932,009 - 73,056,438 (-)NCBI
ROS_Cfam_1.0276,986,320 - 77,110,768 (-)NCBI
UMICH_Zoey_3.1273,807,403 - 73,931,772 (-)NCBI
UNSW_CanFamBas_1.0274,815,673 - 74,940,002 (-)NCBI
UU_Cfam_GSD_1.0275,819,294 - 75,943,710 (-)NCBI
Ephb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505842,251,873 - 42,378,453 (+)NCBI
SpeTri2.0NW_0049364748,109,800 - 8,203,106 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120109,747,883 - 109,954,936 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl20109,746,925 - 109,890,777 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660336,358,996 - 6,570,523 (+)NCBIVero_WHO_p1.0
Ephb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247647,421,818 - 7,599,800 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 10 2 3 4 2 21 3
Below cutoff 2 1 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000003918   ⟹   ENSSSCP00000003828
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl680,650,740 - 80,843,567 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000028438   ⟹   ENSSSCP00000020068
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl680,649,143 - 80,843,567 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000068010   ⟹   ENSSSCP00000060767
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl680,711,681 - 80,843,567 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000085751   ⟹   ENSSSCP00000059882
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl680,712,004 - 80,843,567 (+)Ensembl
RefSeq Acc Id: XM_005656047   ⟹   XP_005656104
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1680,649,098 - 80,849,979 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021095499   ⟹   XP_020951158
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1680,650,610 - 80,849,979 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021095500   ⟹   XP_020951159
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1680,650,710 - 80,849,979 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021095501   ⟹   XP_020951160
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1680,650,610 - 80,849,979 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021095502   ⟹   XP_020951161
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1680,650,610 - 80,849,979 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005656104   ⟸   XM_005656047
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020951158   ⟸   XM_021095499
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020951160   ⟸   XM_021095501
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_020951161   ⟸   XM_021095502
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_020951159   ⟸   XM_021095500
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSSSCP00000060767   ⟸   ENSSSCT00000068010
RefSeq Acc Id: ENSSSCP00000003828   ⟸   ENSSSCT00000003918
RefSeq Acc Id: ENSSSCP00000059882   ⟸   ENSSSCT00000085751
RefSeq Acc Id: ENSSSCP00000020068   ⟸   ENSSSCT00000028438
Protein Domains
Eph LBD   Fibronectin type-III   Protein kinase   SAM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003527 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070028033 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000003828 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000020068 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000059882 UniProtKB/TrEMBL
  ENSSSCP00000060767 UniProtKB/TrEMBL
  ENSSSCP00070047881 UniProtKB/TrEMBL
  ENSSSCP00070047888 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003918 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000028438 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000068010 UniProtKB/TrEMBL
  ENSSSCT00000085751 UniProtKB/TrEMBL
  ENSSSCT00070056352 UniProtKB/TrEMBL
  ENSSSCT00070056360 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
InterPro Eph_TM UniProtKB/TrEMBL
  EphB2_rcpt_lig-bd UniProtKB/TrEMBL
  Ephrin_rcpt_lig-bd_dom UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr-kin_ephrin_A/B_rcpt-like UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_ephrin_rcpt UniProtKB/TrEMBL
  Tyr_kinase_rcpt_V_CS UniProtKB/TrEMBL
NCBI Gene EPHB2 ENTREZGENE
Pfam EphA2_TM UniProtKB/TrEMBL
  Ephrin_lbd UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/TrEMBL
  fn3 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  SAM_1 UniProtKB/TrEMBL
PIRSF TyrPK_ephrin_receptor UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE EPH_LBD UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_1 UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_2 UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/TrEMBL
SMART EPH_lbd UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF47769 UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
  SSF49785 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A4X1VVX1_PIG UniProtKB/TrEMBL
  A0A4X1W2X8_PIG UniProtKB/TrEMBL
  A0A5G2Q924_PIG UniProtKB/TrEMBL
  A0A5G2Q9B1_PIG UniProtKB/TrEMBL
  F1STZ2_PIG UniProtKB/TrEMBL
  I3L7R2_PIG UniProtKB/TrEMBL
VGNC ID VGNC:87737 ENTREZGENE