RGD Reference Report - Increased SSeCKS expression in rat hepatic stellate cells upon activation in vitro and in vivo. - Rat Genome Database

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Increased SSeCKS expression in rat hepatic stellate cells upon activation in vitro and in vivo.

Authors: You, Tiangeng  Fan, Yuanzhi  Li, Qi  Gao, Yong  Yang, Yongkang  Zhao, Zhongxin  Wang, Congjun 
Citation: You T, etal., Inflammation. 2013 Dec;36(6):1415-23. doi: 10.1007/s10753-013-9681-4.
RGD ID: 14348971
Pubmed: PMID:23925424   (View Abstract at PubMed)
DOI: DOI:10.1007/s10753-013-9681-4   (Journal Full-text)

Recent reports suggest that src suppressed c kinase substrates (SSeCKS) are early inflammatory response protein. However, there is only scarce knowledge on the functional role of SSeCKS in liver under conditions of acute inflammation. In the present study, we investigated SSeCKS expression in liver after administration of carbon tetrachloride (CCl4) in rats and in isolated primary hepatic stellate cells (HSCs) upon activation on a plastic dish. We found that SSeCKS mRNA was hardly detectable in healthy liver tissue and further increased in carbon tetrachloride-mediated acute liver failure. SSeCKS protein expression was mainly found in hepatic stellate cells. In vitro, SSeCKS expression in activated rat HSCs was dramatically increased. The upregulation of SSeCKS protein expression in rat HSCs during activation in vitro and in vivo suggested the possibility of SSeCKS, an important part of function of the activated HSCs, perhaps through modulation of liver regeneration or formation of liver fibrosis after various injuries.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AKAP12Humanliver cirrhosis  ISOAkap12 (Rattus norvegicus)mRNA and protein:increased expression:liverRGD 
Akap12Ratliver cirrhosis  IEP mRNA and protein:increased expression:liverRGD 
Akap12Mouseliver cirrhosis  ISOAkap12 (Rattus norvegicus)mRNA and protein:increased expression:liverRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Akap12Rathepatic stellate cell activation  IEP  RGD 
Akap12Ratpositive regulation of hepatic stellate cell migration  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Akap12  (A-kinase anchoring protein 12)

Genes (Mus musculus)
Akap12  (A kinase anchor protein 12)

Genes (Homo sapiens)
AKAP12  (A-kinase anchoring protein 12)


Additional Information