Akap12 (A kinase anchor protein 12) - Rat Genome Database

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Gene: Akap12 (A kinase anchor protein 12) Mus musculus
Analyze
Symbol: Akap12
Name: A kinase anchor protein 12
RGD ID: 737244
MGI Page MGI
Description: Predicted to enable adenylate cyclase binding activity. Involved in modulation of chemical synaptic transmission. Is active in Schaffer collateral - CA1 synapse. Is expressed in central nervous system; gut; neural ectoderm; renal interstitium; and retina. Human ortholog(s) of this gene implicated in chronic kidney disease; colorectal carcinoma; and juvenile myelomonocytic leukemia. Orthologous to human AKAP12 (A-kinase anchoring protein 12).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A kinase (PRKA) anchor protein (gravin) 12; A-kinase anchor protein 12; AI317366; AKAP-12; gercelin; germ cell lineage protein gercelin; Sr; src-suppressed C kinase substrate; Srcs5; SSe; SSeCKS; testis specific gene A12; Tsga; Tsga12; v-src suppressed transcript 5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39104,216,329 - 4,309,471 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl104,216,380 - 4,309,470 (+)EnsemblGRCm39 Ensembl
GRCm38104,266,329 - 4,359,471 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl104,266,380 - 4,359,470 (+)EnsemblGRCm38mm10GRCm38
MGSCv37105,987,070 - 6,080,212 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36105,987,070 - 6,080,163 (-)NCBIMGSCv36mm8
Celera104,190,840 - 4,288,877 (+)NCBICelera
Cytogenetic Map10A1NCBI
cM Map102.06NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-butoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acids  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-lapachone  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chloroprene  (EXP)
chromium(6+)  (ISO)
chrysene  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cumene  (EXP)
cyclosporin A  (EXP,ISO)
DDE  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
dioxygen  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
etoposide  (ISO)
folic acid  (EXP,ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
glycidyl methacrylate  (ISO)
hydrogen cyanide  (EXP)
hydrogen peroxide  (EXP,ISO)
indometacin  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
menadione  (ISO)
mercaptopurine  (ISO)
metacetamol  (EXP)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mitomycin C  (ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
PD 0325901  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
PhIP  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
potassium cyanide  (EXP)
progesterone  (ISO)
purine-6-thiol  (ISO)
quercetin  (ISO)
resorcinol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
senecionine  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thiram  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tungsten  (EXP)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A-kinase anchoring proteins: from protein complexes to physiology and disease. Carnegie GK, etal., IUBMB Life. 2009 Apr;61(4):394-406.
2. Vagal efferent fiber stimulation ameliorates pulmonary microvascular endothelial cell injury by downregulating inflammatory responses. Chen C, etal., Inflammation. 2013 Dec;36(6):1567-75. doi: 10.1007/s10753-013-9701-4.
3. Silencing of Cited2 and Akap12 genes in radiation-induced rat osteosarcomas. Daino K, etal., Biochem Biophys Res Commun. 2009 Dec 18;390(3):654-8. Epub 2009 Oct 13.
4. The scaffold protein muscle A-kinase anchoring protein beta orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure. Kritzer MD, etal., Circ Heart Fail. 2014 Jul;7(4):663-72. doi: 10.1161/CIRCHEARTFAILURE.114.001266. Epub 2014 May 8.
5. Involvement of Src-suppressed C kinase substrate in experimental autoimmune encephalomyelitis: a link between release of astrocyte proinflammatory factor and oligodendrocyte apoptosis. Li X, etal., J Neurosci Res. 2010 Jul;88(9):1858-71. doi: 10.1002/jnr.22355.
6. Re-expression of AKAP12 inhibits progression and metastasis potential of colorectal carcinoma in vivo and in vitro. Liu W, etal., PLoS One. 2011;6(8):e24015. doi: 10.1371/journal.pone.0024015. Epub 2011 Aug 30.
7. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Localized effects of cAMP mediated by distinct routes of protein kinase A. Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.
14. Epigenetic silencing of AKAP12 in juvenile myelomonocytic leukemia. Wilhelm T, etal., Epigenetics. 2016;11(2):110-9. doi: 10.1080/15592294.2016.1145327. Epub 2016 Feb 18.
15. A critical role of SRC-suppressed C kinase substrate in rat astrocytes after chronic constriction injury. Xia Y, etal., Neuromolecular Med. 2010 Sep;12(3):205-16. doi: 10.1007/s12017-009-8093-y. Epub 2009 Nov 25.
16. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. Yoshida T, etal., Int J Mol Med. 2009 Oct;24(4):539-47.
17. Increased SSeCKS expression in rat hepatic stellate cells upon activation in vitro and in vivo. You T, etal., Inflammation. 2013 Dec;36(6):1415-23. doi: 10.1007/s10753-013-9681-4.
18. Temporal profile of Src, SSeCKS, and angiogenic factors after focal cerebral ischemia: correlations with angiogenesis and cerebral edema. Zan L, etal., Neurochem Int. 2011 Jul;58(8):872-9. doi: 10.1016/j.neuint.2011.02.014. Epub 2011 Feb 18.
Additional References at PubMed
PMID:7832805   PMID:8889548   PMID:8916035   PMID:9403069   PMID:10349636   PMID:10805381   PMID:11042159   PMID:11076861   PMID:11165490   PMID:11217851   PMID:11429284   PMID:11544199  
PMID:11799143   PMID:11814414   PMID:11820772   PMID:12083796   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:15468953   PMID:15496411   PMID:15590635   PMID:16141072  
PMID:16141073   PMID:16602821   PMID:17626016   PMID:17967808   PMID:18287559   PMID:18554416   PMID:18593908   PMID:18799693   PMID:20360068   PMID:20939879   PMID:21099353   PMID:21128249  
PMID:21803034   PMID:21873635   PMID:21903576   PMID:22249313   PMID:23238728   PMID:24058627   PMID:24492704   PMID:24760034   PMID:24997765   PMID:25229625   PMID:25356636   PMID:26365490  
PMID:26406118   PMID:26930384   PMID:28378742   PMID:28428008   PMID:28535371   PMID:28671696   PMID:29314444   PMID:29501491   PMID:29700280   PMID:30457570   PMID:30595499   PMID:31351040  
PMID:31441691   PMID:31685872   PMID:31809872   PMID:32325033   PMID:32715478   PMID:33046507   PMID:33260683   PMID:33492625   PMID:33842485   PMID:34155146   PMID:35576690   PMID:36114006  
PMID:36193675   PMID:36464273   PMID:37875657   PMID:38506047  


Genomics

Comparative Map Data
Akap12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39104,216,329 - 4,309,471 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl104,216,380 - 4,309,470 (+)EnsemblGRCm39 Ensembl
GRCm38104,266,329 - 4,359,471 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl104,266,380 - 4,359,470 (+)EnsemblGRCm38mm10GRCm38
MGSCv37105,987,070 - 6,080,212 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36105,987,070 - 6,080,163 (-)NCBIMGSCv36mm8
Celera104,190,840 - 4,288,877 (+)NCBICelera
Cytogenetic Map10A1NCBI
cM Map102.06NCBI
AKAP12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386151,239,967 - 151,358,559 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6151,239,967 - 151,358,559 (+)EnsemblGRCh38hg38GRCh38
GRCh376151,561,102 - 151,679,694 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366151,603,202 - 151,719,602 (+)NCBINCBI36Build 36hg18NCBI36
Build 346151,738,936 - 151,770,022NCBI
Celera6152,295,018 - 152,413,580 (+)NCBICelera
Cytogenetic Map6q25.1NCBI
HuRef6149,123,664 - 149,241,939 (+)NCBIHuRef
CHM1_16151,825,190 - 151,943,865 (+)NCBICHM1_1
T2T-CHM13v2.06152,440,587 - 152,559,135 (+)NCBIT2T-CHM13v2.0
Akap12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8143,135,515 - 43,225,245 (+)NCBIGRCr8
mRatBN7.2140,730,123 - 40,819,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl140,730,123 - 40,819,886 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx141,257,330 - 41,347,044 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0147,244,521 - 47,334,234 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0141,332,883 - 41,422,632 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0140,816,130 - 40,906,582 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl140,816,107 - 40,906,581 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0142,162,163 - 42,252,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4134,979,039 - 35,068,763 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1134,982,110 - 35,070,840 (+)NCBI
Celera136,421,269 - 36,510,639 (+)NCBICelera
Cytogenetic Map1q11NCBI
Akap12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543910,238,664 - 10,263,081 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543910,241,298 - 10,262,416 (-)NCBIChiLan1.0ChiLan1.0
AKAP12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25171,264,561 - 171,383,191 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16169,155,859 - 169,273,390 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06149,058,350 - 149,176,710 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16153,839,496 - 153,873,925 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6153,757,081 - 153,873,925 (+)Ensemblpanpan1.1panPan2
AKAP12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1141,614,893 - 41,712,350 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl141,614,714 - 41,709,798 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha142,456,089 - 42,553,626 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0141,799,868 - 41,897,347 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl141,799,970 - 41,895,674 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1141,673,111 - 41,770,835 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0141,517,208 - 41,614,636 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0142,023,588 - 42,121,300 (+)NCBIUU_Cfam_GSD_1.0
Akap12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946136,985,500 - 137,006,417 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364894,237,439 - 4,261,141 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364894,237,466 - 4,258,408 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKAP12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl114,908,115 - 15,016,997 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1114,904,109 - 15,017,016 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2117,314,971 - 17,428,055 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AKAP12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11378,691,588 - 78,812,333 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1378,691,816 - 78,812,834 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604051,020,791 - 51,143,055 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akap12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247856,897,561 - 6,988,287 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247856,900,252 - 6,987,712 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Akap12
3770 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:348
Count of miRNA genes:257
Interacting mature miRNAs:298
Transcripts:ENSMUST00000045730
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11532718Sluc44f_msusceptibility to lung cancer 44f (mouse)10126289265Mouse
1357813Ath20_matherosclerosis 20 (mouse)Not determined10328318537283334Mouse
11532717Sluc44g_msusceptibility to lung cancer 44g (mouse)10126289265Mouse
1300881Sluc29_msusceptibility to lung cancer 29 (mouse)Not determined10126289265Mouse
12879494Facq1_mfear acquisition QTL 1 (mouse)10131279130Mouse
1300759Geot_mgeotaxia (mouse)Not determined10126289265Mouse
1300790Pgia6_mproteoglycan induced arthritis 6 (mouse)Not determined10381017137810295Mouse
15039341Nmrs28_mNAFLD-associated magnetic resonance shift 28 (mouse)1035100134351001Mouse
11533917Mts2_mmammary tumor susceptibility 2 (mouse)10126289265Mouse
11532725Sluc44b_msusceptibility to lung cancer 44b (mouse)10126289265Mouse
11532724Sluc44c_msusceptibility to lung cancer 44c (mouse)10126289265Mouse
11532723Sluc44d_msusceptibility to lung cancer 44d (mouse)10126289265Mouse
11532722Sluc44e_msusceptibility to lung cancer 44e (mouse)10126289265Mouse
11532721Sluc44_msusceptibility to lung cancer 44 (mouse)10126289265Mouse
11532720Sluc44a_msusceptibility to lung cancer 44a (mouse)10126289265Mouse

Markers in Region
D8Mit351  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38104,344,823 - 4,344,913UniSTSGRCm38
MGSCv37106,001,628 - 6,001,718UniSTSGRCm37
Celera104,274,192 - 4,274,282UniSTS
Cytogenetic Map10A1UniSTS
cM Map848.0UniSTS
cM Map10 UniSTS
Whitehead Genetic848.1UniSTS
AI317366  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38104,357,533 - 4,357,823UniSTSGRCm38
MGSCv37105,988,718 - 5,989,008UniSTSGRCm37
Celera104,286,938 - 4,287,228UniSTS
Cytogenetic Map10A1UniSTS
Whitehead/MRC_RH10129.66UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB020886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB025278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB051563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB070852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB070853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC117205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC133902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF326228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF326230 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI836130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC043939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC071185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD540754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000045730   ⟹   ENSMUSP00000035829
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl104,216,380 - 4,309,470 (+)Ensembl
GRCm38.p6 Ensembl104,266,380 - 4,359,470 (+)Ensembl
Ensembl Acc Id: ENSMUST00000215696   ⟹   ENSMUSP00000150261
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl104,297,768 - 4,309,470 (+)Ensembl
GRCm38.p6 Ensembl104,347,768 - 4,359,470 (+)Ensembl
Ensembl Acc Id: ENSMUST00000216139   ⟹   ENSMUSP00000159240
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl104,296,808 - 4,309,470 (+)Ensembl
GRCm38.p6 Ensembl104,346,808 - 4,359,470 (+)Ensembl
Ensembl Acc Id: ENSMUST00000239220   ⟹   ENSMUSP00000159223
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl104,291,195 - 4,303,652 (+)Ensembl
GRCm38.p6 Ensembl104,341,195 - 4,353,652 (+)Ensembl
Ensembl Acc Id: ENSMUST00000239373   ⟹   ENSMUSP00000159267
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl104,284,545 - 4,309,470 (+)Ensembl
GRCm38.p6 Ensembl104,334,545 - 4,359,470 (+)Ensembl
RefSeq Acc Id: NM_031185   ⟹   NP_112462
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39104,216,329 - 4,309,471 (+)NCBI
GRCm38104,266,329 - 4,359,471 (+)ENTREZGENE
MGSCv37105,987,070 - 6,080,212 (-)RGD
Celera104,190,840 - 4,288,877 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_112462   ⟸   NM_031185
- UniProtKB: Q8BPK4 (UniProtKB/Swiss-Prot),   Q810D4 (UniProtKB/Swiss-Prot),   Q80SS4 (UniProtKB/Swiss-Prot),   Q99MP1 (UniProtKB/Swiss-Prot),   Q9WTQ5 (UniProtKB/Swiss-Prot),   B2RRE0 (UniProtKB/TrEMBL),   A0A668KLD3 (UniProtKB/TrEMBL),   A0A668KLV9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000035829   ⟸   ENSMUST00000045730
Ensembl Acc Id: ENSMUSP00000159223   ⟸   ENSMUST00000239220
Ensembl Acc Id: ENSMUSP00000159267   ⟸   ENSMUST00000239373
Ensembl Acc Id: ENSMUSP00000159240   ⟸   ENSMUST00000216139
Ensembl Acc Id: ENSMUSP00000150261   ⟸   ENSMUST00000215696
Protein Domains
A kinase-anchoring proteins AKAP-5 and AKAP-12

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WTQ5-F1-model_v2 AlphaFold Q9WTQ5 1-1684 view protein structure

Promoters
RGD ID:8671402
Promoter ID:EPDNEW_M13732
Type:initiation region
Name:Akap12_1
Description:Mus musculus A kinase anchor protein 12 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38104,266,363 - 4,266,423EPDNEW
RGD ID:6846678
Promoter ID:MM_ACW:3828
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour
Transcripts:AKAP12.DSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36105,989,581 - 5,990,081 (-)MPROMDB
RGD ID:6846680
Promoter ID:MM_ACW:3829
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:AKAP12.HSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36106,011,791 - 6,012,291 (-)MPROMDB
RGD ID:6818966
Promoter ID:MM_KWN:3457
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell,   MEF_B6
Transcripts:ENSMUST00000092717,   UC007EHI.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36106,079,821 - 6,080,321 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1932576 AgrOrtholog
Ensembl Genes ENSMUSG00000038587 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000045730 ENTREZGENE
  ENSMUST00000045730.7 UniProtKB/Swiss-Prot
  ENSMUST00000215696.2 UniProtKB/Swiss-Prot
  ENSMUST00000216139.3 UniProtKB/TrEMBL
  ENSMUST00000239220.2 UniProtKB/TrEMBL
  ENSMUST00000239373.2 UniProtKB/TrEMBL
InterPro AKAP12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase-A_anch_WSK-motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RII_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:83397 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1932576 ENTREZGENE
NCBI Gene 83397 ENTREZGENE
PANTHER A-KINASE ANCHOR PROTEIN 12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23209 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RII_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WSK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Akap12 PhenoGen
PROSITE AKAP_CAM_BD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A668KLD3 ENTREZGENE, UniProtKB/TrEMBL
  A0A668KLV9 ENTREZGENE, UniProtKB/TrEMBL
  A0A668KM55_MOUSE UniProtKB/TrEMBL
  AKA12_MOUSE UniProtKB/Swiss-Prot
  B2RRE0 ENTREZGENE, UniProtKB/TrEMBL
  Q6IR43_MOUSE UniProtKB/TrEMBL
  Q80SS4 ENTREZGENE
  Q810D4 ENTREZGENE
  Q8BPK4 ENTREZGENE
  Q99MP1 ENTREZGENE
  Q9WTQ5 ENTREZGENE
UniProt Secondary Q80SS4 UniProtKB/Swiss-Prot
  Q810D4 UniProtKB/Swiss-Prot
  Q8BPK4 UniProtKB/Swiss-Prot
  Q99MP1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Akap12  A kinase anchor protein 12  Akap12  A kinase (PRKA) anchor protein (gravin) 12  Symbol and/or name change 5135510 APPROVED