RGD Reference Report - Vagal efferent fiber stimulation ameliorates pulmonary microvascular endothelial cell injury by downregulating inflammatory responses. - Rat Genome Database

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Vagal efferent fiber stimulation ameliorates pulmonary microvascular endothelial cell injury by downregulating inflammatory responses.

Authors: Chen, Chao  Zhang, Ying  Du, Zhaohui  Zhang, Min  Niu, Li  Wang, Yanlin  Li, Jianguo 
Citation: Chen C, etal., Inflammation. 2013 Dec;36(6):1567-75. doi: 10.1007/s10753-013-9701-4.
RGD ID: 14348970
Pubmed: PMID:23912647   (View Abstract at PubMed)
DOI: DOI:10.1007/s10753-013-9701-4   (Journal Full-text)

Electrical stimulation of the vagus nerve may have positive effects on many inflammatory diseases. This study determined the beneficial effects of vagus nerve stimulation and the mechanisms by which it attenuates lipopolysaccharide (LPS)-induced acute lung injury (ALI). Rats were intraperitoneally injected with 10 mg/kg LPS to induce ALI. The results showed that vagus nerve stimulation could improve lung injury, as evidenced by remarkable reductions in lung edema (wet-to-dry weight ratio), neutrophil infiltration (myeloperoxidase activity), and pulmonary permeability [total number of cells and protein concentrations in bronchoalveolar lavage fluid (BALF)]. In addition, vagus nerve stimulation not only decreased the expressions of Src-suppressed C kinase substrate and E-selectin proteins in lung tissue but also effectively attenuated the concentrations of the proinflammatory cytokines tumor necrosis factor-α, interleukin-1β, and interleukin-6 in BALF. These suggest that vagus nerve stimulation is a suitable treatment for LPS-induced ALI and indicate that it helps ameliorate pulmonary microvascular endothelial cell injury by downregulating inflammatory responses.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AKAP12HumanAcute Lung Injury  ISOAkap12 (Rattus norvegicus)mRNA and protein:increased expression:lungRGD 
Akap12RatAcute Lung Injury  IEP mRNA and protein:increased expression:lungRGD 
Akap12MouseAcute Lung Injury  ISOAkap12 (Rattus norvegicus)mRNA and protein:increased expression:lungRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Akap12Ratresponse to electrical stimulus  IEP  RGD 
Akap12Ratresponse to lipopolysaccharide  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Akap12  (A-kinase anchoring protein 12)

Genes (Mus musculus)
Akap12  (A kinase anchor protein 12)

Genes (Homo sapiens)
AKAP12  (A-kinase anchoring protein 12)


Additional Information