RGD Reference Report - Association of gene polymorphisms with chronic kidney disease in Japanese individuals. - Rat Genome Database

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Association of gene polymorphisms with chronic kidney disease in Japanese individuals.

Authors: Yoshida, Tetsuro  Kato, Kimihiko  Yokoi, Kiyoshi  Oguri, Mitsutoshi  Watanabe, Sachiro  Metoki, Norifumi  Yoshida, Hidemi  Satoh, Kei  Aoyagi, Yukitoshi  Nozawa, Yoshinori  Yamada, Yoshiji 
Citation: Yoshida T, etal., Int J Mol Med. 2009 Oct;24(4):539-47.
RGD ID: 14349027
Pubmed: PMID:19724895   (View Abstract at PubMed)

Chronic kidney disease (CKD) is recognized as a risk factor not only for end-stage renal disease but also for cardiovascular disease. Early detection and treatment of CKD is a likely key factor for prevention of its complications. Although genetic linkage analyses and association studies have implicated several loci and candidate genes in predisposition to CKD, the genes that underlie genetic susceptibility to this condition have remained largely unknown. The purpose of the present study was to identify genetic variants that confer susceptibility to CKD in Japanese individuals. The study population comprised 4,829 Japanese individuals (2,697 men, 2,132 women), including 757 subjects with CKD [464 men, 293 women; estimated glomerular filtration rate (eGFR) <50 ml min 1.73 m(-2)] and 4,072 controls (2,233 men, 1,839 women; eGFR >or=60 ml min 1.73 m(-2)). The genotypes for 40 polymorphisms of 39 candidate genes were determined. The chi-square test, multivariable logistic regression analysis with adjustment for covariates, as well as a stepwise forward selection procedure revealed that six polymorphisms of F10, PITRM1, PCSK2, JPH3, MYO7B, and AKAP12 were related (P<0.05) to the prevalence of CKD. Among these polymorphisms, the Cright curved arrow T polymorphism of F10 (rs5962) was most significantly associated with this condition. Determination of genotypes for the Cright curved arrow T polymorphism of F10 may prove informative for assessment of genetic risk for CKD in Japanese individuals.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AKAP12Humanchronic kidney disease susceptibilityIAGP DNA:polymorphism: :rs756009(human)RGD 
Akap12Ratchronic kidney disease susceptibilityISOAKAP12 (Homo sapiens)DNA:polymorphism: :rs756009(human)RGD 
Akap12Mousechronic kidney disease susceptibilityISOAKAP12 (Homo sapiens)DNA:polymorphism: :rs756009(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Akap12  (A-kinase anchoring protein 12)

Genes (Mus musculus)
Akap12  (A kinase anchor protein 12)

Genes (Homo sapiens)
AKAP12  (A-kinase anchoring protein 12)

Additional Information