RGD Reference Report - Temporal profile of Src, SSeCKS, and angiogenic factors after focal cerebral ischemia: correlations with angiogenesis and cerebral edema. - Rat Genome Database

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Temporal profile of Src, SSeCKS, and angiogenic factors after focal cerebral ischemia: correlations with angiogenesis and cerebral edema.

Authors: Zan, Likun  Wu, He  Jiang, Jie  Zhao, Shiguang  Song, Yuejia  Teng, Guoxin  Li, Heng  Jia, Ying  Zhou, Min  Zhang, Xin  Qi, Jiping  Wang, Jian 
Citation: Zan L, etal., Neurochem Int. 2011 Jul;58(8):872-9. doi: 10.1016/j.neuint.2011.02.014. Epub 2011 Feb 18.
RGD ID: 14348963
Pubmed: PMID:21334414   (View Abstract at PubMed)
PMCID: PMC3100427   (View Article at PubMed Central)
DOI: DOI:10.1016/j.neuint.2011.02.014   (Journal Full-text)

A better understanding of the underlying mechanisms of angiogenesis and vascular permeability is necessary for the development of therapeutic strategies for ischemic injury. The purpose of this study was to examine the spatial and temporal expression of Src and Src-suppressed C kinase substrate (SSeCKS) in brain after middle cerebral artery occlusion (MCAO) and elucidate the relationships among Src, SSeCKS, and the key angiogenic factors present after stroke. Rats were subjected to either MCAO or sham operation. Reverse transcriptase-polymerase chain reaction and Western blotting results revealed that Src gradually increased starting as early as 2 h after MCAO and remained high for 1 day. In contrast, SSeCKS decreased after MCAO. Src expression correlated positively with that of vascular endothelial growth factor and angiopoietin-2, and negatively with that of SSeCKS, angiopoietin-1, and zonula occludens-1. However, SSeCKS had the reverse correlations. Changes in the expression of these factors correlated with the progress of angiogenesis and cerebral edema. Dynamic temporal changes in Src and SSeCKS expression may modulate angiogenesis and cerebral edema formation after focal cerebral ischemia.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
brain ischemia  ISOAkap12 (Rattus norvegicus)14348963; 14348963 RGD 
brain ischemia  IEP 14348963 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Akap12  (A-kinase anchoring protein 12)

Genes (Mus musculus)
Akap12  (A kinase anchor protein 12)

Genes (Homo sapiens)
AKAP12  (A-kinase anchoring protein 12)

Objects referenced in this article
Gene AKAP6 A-kinase anchoring protein 6 Homo sapiens
Gene Akap6 A kinase anchor protein 6 Mus musculus
Gene Akap6 A-kinase anchoring protein 6 Rattus norvegicus

Additional Information