RPS6KB1 (ribosomal protein S6 kinase B1) - Rat Genome Database
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Gene: RPS6KB1 (ribosomal protein S6 kinase B1) Sus scrofa
Analyze
Symbol: RPS6KB1
Name: ribosomal protein S6 kinase B1
RGD ID: 14065987
Description: ENCODES a protein that exhibits identical protein binding (ortholog); PDZ domain binding (ortholog); peptide binding (ortholog); INVOLVED IN aging (ortholog); cell migration (ortholog); cellular response to growth factor stimulus (ortholog); PARTICIPATES IN insulin signaling pathway; insulin-like growth factor signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH Atrophy (ortholog); autosomal dominant polycystic kidney disease (ortholog); Burns (ortholog); FOUND IN cell surface (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH anthra[1,9-cd]pyrazol-6(2H)-one; deoxynivalenol; etoxazole
Type: protein-coding
RefSeq Status: MODEL
Also known as: p70S6K; ribosomal protein S6 kinase beta-1; ribosomal protein S6 kinase polypeptide 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,111,653 - 36,160,376 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,111,584 - 36,159,287 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21237,386,770 - 37,434,407 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
behavioral fear response  (IEA)
cell migration  (ISO)
cellular response to dexamethasone stimulus  (IEA)
cellular response to growth factor stimulus  (ISO)
cellular response to hormone stimulus  (ISO)
cellular response to insulin stimulus  (IBA,IEA)
cellular response to interferon-gamma  (IEA)
cellular response to organic cyclic compound  (ISO)
G1/S transition of mitotic cell cycle  (ISO)
germ cell development  (IEA)
long-chain fatty acid import into cell  (IEA)
long-term memory  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IEA)
negative regulation of insulin receptor signaling pathway  (ISO)
peptidyl-serine phosphorylation  (IBA,IEA)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of skeletal muscle tissue growth  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of translation  (ISO)
positive regulation of translational initiation  (ISO)
protein kinase B signaling  (IEA)
protein phosphorylation  (IEA)
regulation of glucose import  (ISO)
response to amino acid  (ISO)
response to drug  (ISO)
response to electrical stimulus involved in regulation of muscle adaptation  (ISO)
response to ethanol  (ISO)
response to glucagon  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to heat  (ISO)
response to insulin  (ISO)
response to leucine  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to nutrient  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to organonitrogen compound  (ISO)
response to peptide hormone  (ISO)
response to testosterone  (ISO)
response to toxic substance  (ISO)
response to tumor necrosis factor  (ISO)
response to wounding  (ISO)
signal transduction  (IEA)
skeletal muscle atrophy  (ISO)
skeletal muscle contraction  (ISO)
TOR signaling  (IBA)

Cellular Component

References
Additional References at PubMed
PMID:18156399   PMID:19038864  


Genomics

Comparative Map Data
RPS6KB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,111,653 - 36,160,376 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,111,584 - 36,159,287 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21237,386,770 - 37,434,407 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RPS6KB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1759,893,046 - 59,950,574 (+)EnsemblGRCh38hg38GRCh38
GRCh381759,893,121 - 59,950,574 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371757,970,407 - 58,027,787 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361755,325,225 - 55,382,569 (+)NCBINCBI36hg18NCBI36
Build 341755,325,224 - 55,382,566NCBI
Celera1754,433,949 - 54,491,301 (+)NCBI
Cytogenetic Map17q23.1NCBI
HuRef1753,342,941 - 53,400,248 (+)NCBIHuRef
CHM1_11758,034,428 - 58,091,804 (+)NCBICHM1_1
Rps6kb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391186,389,695 - 86,435,711 (-)NCBIGRCm39mm39
GRCm381186,498,869 - 86,544,885 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,498,871 - 86,544,805 (-)EnsemblGRCm38mm10GRCm38
MGSCv371186,312,511 - 86,358,309 (-)NCBIGRCm37mm9NCBIm37
MGSCv361186,330,178 - 86,360,969 (-)NCBImm8
Celera1196,115,093 - 96,160,675 (-)NCBICelera
Cytogenetic Map11CNCBI
Rps6kb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01073,824,200 - 73,865,503 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1073,824,202 - 73,865,364 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01076,234,192 - 76,278,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41076,657,024 - 76,698,088 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11076,671,395 - 76,712,458 (-)NCBI
Celera1070,248,523 - 70,289,589 (-)NCBICelera
Cytogenetic Map10q26NCBI
Rps6kb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554513,181,085 - 3,225,610 (-)NCBIChiLan1.0ChiLan1.0
RPS6KB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11758,798,930 - 58,856,480 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1758,799,069 - 58,853,653 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01753,958,807 - 54,014,752 (+)NCBIMhudiblu_PPA_v0panPan3
RPS6KB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl934,387,091 - 34,425,292 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1934,387,084 - 34,590,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Rps6kb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364903,441,046 - 3,492,917 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPS6KB1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1633,497,392 - 33,556,453 (-)Ensembl
ChlSab1.11633,498,098 - 33,556,553 (-)NCBI
Rps6kb1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248711,667,292 - 1,705,550 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 2 3 5 2 16 2 3 3
Low 2 2 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000019234   ⟹   ENSSSCP00000018724
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1236,111,668 - 36,159,284 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000067171   ⟹   ENSSSCP00000068555
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1236,111,653 - 36,112,694 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000072865   ⟹   ENSSSCP00000072269
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1236,111,663 - 36,157,375 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000075587   ⟹   ENSSSCP00000066965
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1236,111,664 - 36,160,376 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000085524   ⟹   ENSSSCP00000067410
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1236,111,664 - 36,160,376 (+)Ensembl
RefSeq Acc Id: XM_003131671   ⟹   XP_003131719
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11236,111,584 - 36,159,287 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021067293   ⟹   XP_020922952
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11236,112,375 - 36,159,287 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021067294   ⟹   XP_020922953
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11236,121,506 - 36,159,287 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003131719 (Get FASTA)   NCBI Sequence Viewer  
  XP_020922952 (Get FASTA)   NCBI Sequence Viewer  
  XP_020922953 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABD35301 (Get FASTA)   NCBI Sequence Viewer  
  JAG69207 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003131719   ⟸   XM_003131671
- Peptide Label: isoform X1
- UniProtKB: F1S224 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020922952   ⟸   XM_021067293
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020922953   ⟸   XM_021067294
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSSSCP00000018724   ⟸   ENSSSCT00000019234
RefSeq Acc Id: ENSSSCP00000066965   ⟸   ENSSSCT00000075587
RefSeq Acc Id: ENSSSCP00000067410   ⟸   ENSSSCT00000085524
RefSeq Acc Id: ENSSSCP00000072269   ⟸   ENSSSCT00000072865
RefSeq Acc Id: ENSSSCP00000068555   ⟸   ENSSSCT00000067171
Protein Domains
AGC-kinase C-terminal   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000017670 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070003639 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000018724 UniProtKB/TrEMBL
  ENSSSCP00000066965 UniProtKB/TrEMBL
  ENSSSCP00000067410 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000068555 UniProtKB/TrEMBL
  ENSSSCP00000072269 UniProtKB/TrEMBL
  ENSSSCP00070005561 UniProtKB/TrEMBL
  ENSSSCP00070005585 UniProtKB/TrEMBL
  ENSSSCP00070005589 UniProtKB/TrEMBL
  ENSSSCP00070005592 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000019234 UniProtKB/TrEMBL
  ENSSSCT00000067171 UniProtKB/TrEMBL
  ENSSSCT00000072865 UniProtKB/TrEMBL
  ENSSSCT00000075587 UniProtKB/TrEMBL
  ENSSSCT00000085524 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070006819 UniProtKB/TrEMBL
  ENSSSCT00070006850 UniProtKB/TrEMBL
  ENSSSCT00070006854 UniProtKB/TrEMBL
  ENSSSCT00070006857 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ribosomal_S6_kinase UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report ssc:100127158 UniProtKB/TrEMBL
NCBI Gene RPS6KB1 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
PIRSF Ribsml_S6_kin_1 UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniGene Ssc.22127 ENTREZGENE
UniProt A0A481C7T7_PIG UniProtKB/TrEMBL
  A0A4X1SS87_PIG UniProtKB/TrEMBL
  A0A4X1ST56_PIG UniProtKB/TrEMBL
  A0A4X1STL0_PIG UniProtKB/TrEMBL
  A0A4X1STM5_PIG UniProtKB/TrEMBL
  A0A5G2QPZ2_PIG UniProtKB/TrEMBL
  A0A5G2QWN1_PIG UniProtKB/TrEMBL
  A0A5G2R4X6_PIG UniProtKB/TrEMBL
  A9NIU2_PIG UniProtKB/TrEMBL
  F1S224 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:99037 ENTREZGENE