RELA (RELA proto-oncogene, NF-kB subunit) - Rat Genome Database

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Gene: RELA (RELA proto-oncogene, NF-kB subunit) Sus scrofa
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Symbol: RELA
Name: RELA proto-oncogene, NF-kB subunit
RGD ID: 14272472
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription factor binding (ortholog); enzyme binding (ortholog); INVOLVED IN acetaldehyde metabolic process (ortholog); aging (ortholog); animal organ morphogenesis (ortholog); PARTICIPATES IN ceramide signaling pathway; interleukin-1 signaling pathway; interleukin-12 signaling pathway; ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); alcoholic liver cirrhosis (ortholog); amphetamine abuse (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 1,3-thiazolidine-2,4-dione; 3,3',4,4'-tetrachlorobiphenyl; cadmium dichloride
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: NF-kappaB transcription factor p65 subunit; transcription factor p65; v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl26,593,969 - 6,603,471 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.126,594,869 - 6,602,684 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.225,699,452 - 5,707,267 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute necrotizing pancreatitis  (ISO)
alcoholic liver cirrhosis  (ISO)
amphetamine abuse  (ISO)
anaplastic large cell lymphoma  (ISO)
arteriosclerosis  (ISO)
Barrett's esophagus  (ISO)
Brain Injuries  (ISO)
Brain Injuries, Traumatic  (ISO)
brain ischemia  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
Cardiomegaly  (ISO)
Cerebral Hemorrhage  (ISO)
cervix uteri carcinoma in situ  (ISO)
Childhood Schizophrenia  (ISO)
cholestasis  (ISO)
cholesteatoma of middle ear  (ISO)
colitis  (ISO)
Colonic Neoplasms  (ISO)
cryptorchidism  (ISO)
cystitis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
Drug Eruptions  (ISO)
Drug-Induced Dyskinesia  (ISO)
ductal carcinoma in situ  (ISO)
encephalitis  (ISO)
end stage renal disease  (ISO)
epilepsy  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Neoplasms  (ISO)
extrahepatic cholestasis  (ISO)
familial temporal lobe epilepsy 8  (ISO)
fatty liver disease  (ISO)
Heat Stroke  (ISO)
Hemorrhagic Shock  (ISO)
Hepatic Insufficiency  (ISO)
Hepatomegaly  (ISO)
high grade glioma  (ISO)
hypertension  (ISO)
Insulin Resistance  (ISO)
intellectual disability  (ISO)
laryngeal squamous cell carcinoma  (ISO)
Left Ventricular Hypertrophy  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
lymphoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
mastoiditis  (ISO)
MUCOCUTANEOUS ULCERATION, CHRONIC  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplastic Cell Transformation  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
otitis media  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
Parkinsonism  (ISO)
Pneumococcal Meningitis  (ISO)
primary biliary cholangitis  (ISO)
prostate adenocarcinoma  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
renovascular hypertension  (ISO)
Reperfusion Injury  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
Subarachnoid Hemorrhage  (ISO)
Transplant Rejection  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
uveitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acetaldehyde metabolic process  (ISO)
aging  (ISO)
animal organ morphogenesis  (IEA,ISO)
cellular response to angiotensin  (IEA)
cellular response to hepatocyte growth factor stimulus  (IEA,ISO)
cellular response to hydrogen peroxide  (IEA)
cellular response to interleukin-1  (ISO)
cellular response to interleukin-6  (IEA)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to lipoteichoic acid  (IEA)
cellular response to nicotine  (IEA)
cellular response to peptidoglycan  (IEA)
cellular response to tumor necrosis factor  (ISO)
cellular response to vascular endothelial growth factor stimulus  (IEA)
chromatin organization  (IEA)
cytokine-mediated signaling pathway  (ISO)
defense response  (ISO)
hair follicle development  (IEA,ISO)
I-kappaB kinase/NF-kappaB signaling  (IBA)
inflammatory response  (IBA,IEA)
innate immune response  (IBA)
interleukin-1-mediated signaling pathway  (IEA)
liver development  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of NIK/NF-kappaB signaling  (IEA)
negative regulation of pri-miRNA transcription by RNA polymerase II  (IEA)
negative regulation of protein catabolic process  (IEA,ISO)
negative regulation of protein sumoylation  (IEA)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
neuropeptide signaling pathway  (IEA)
NIK/NF-kappaB signaling  (IBA)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (IEA,ISO)
positive regulation of amyloid-beta formation  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of chondrocyte differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IEA)
positive regulation of interleukin-12 production  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA)
positive regulation of leukocyte adhesion to vascular endothelial cell  (IEA)
positive regulation of miRNA metabolic process  (IEA)
positive regulation of NF-kappaB transcription factor activity  (IEA,ISO)
positive regulation of NIK/NF-kappaB signaling  (IEA)
positive regulation of pri-miRNA transcription by RNA polymerase II  (IEA)
positive regulation of Schwann cell differentiation  (ISO)
positive regulation of T cell receptor signaling pathway  (IEA)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus  (IEA)
positive regulation of transcription, DNA-templated  (ISO)
postsynapse to nucleus signaling pathway  (IEA)
regulation of DNA-templated transcription in response to stress  (IEA)
regulation of inflammatory response  (IEA,ISO)
regulation of NIK/NF-kappaB signaling  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription, DNA-templated  (ISO)
response to amino acid  (ISO)
response to bacterium  (ISO)
response to cAMP  (ISO)
response to cobalamin  (ISO)
response to cytokine  (IBA,ISO)
response to hydrogen peroxide  (ISO)
response to inorganic substance  (ISO)
response to insulin  (ISO)
response to interleukin-1  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to morphine  (ISO)
response to muramyl dipeptide  (IEA,ISO)
response to muscle stretch  (IEA,ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to progesterone  (ISO)
response to UV-B  (IEA)
response to xenobiotic stimulus  (ISO)
transcription, DNA-templated  (IEA)
tumor necrosis factor-mediated signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:20426870   PMID:20701940   PMID:21269694   PMID:21450812   PMID:23186553   PMID:24443222   PMID:25027053   PMID:25093672   PMID:26898342   PMID:27555521   PMID:28448848   PMID:28683436  
PMID:28751780   PMID:30322331   PMID:31671754   PMID:32247758   PMID:32605753  


Genomics

Comparative Map Data
RELA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl26,593,969 - 6,603,471 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.126,594,869 - 6,602,684 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.225,699,452 - 5,707,267 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RELA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1165,653,597 - 65,663,090 (-)EnsemblGRCh38hg38GRCh38
GRCh381165,653,601 - 65,662,946 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371165,421,072 - 65,430,387 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,178,393 - 65,186,951 (-)NCBINCBI36hg18NCBI36
Build 341165,178,392 - 65,186,951NCBI
Celera1162,747,772 - 62,757,128 (-)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1161,748,056 - 61,757,436 (-)NCBIHuRef
CHM1_11165,305,002 - 65,314,374 (-)NCBICHM1_1
Rela
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,687,569 - 5,698,162 (+)NCBIGRCm39mm39
GRCm39 Ensembl195,687,511 - 5,698,158 (+)Ensembl
GRCm38195,637,442 - 5,648,134 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,637,483 - 5,648,130 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,637,490 - 5,648,130 (+)NCBIGRCm37mm9NCBIm37
MGSCv36195,637,490 - 5,648,130 (+)NCBImm8
Celera195,507,082 - 5,517,707 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.34NCBI
Rela
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21202,925,001 - 202,935,484 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1202,924,945 - 202,935,484 (+)Ensembl
Rnor_6.01220,992,770 - 221,003,249 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1220,992,770 - 221,003,249 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,928,092 - 227,938,571 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41208,262,669 - 208,273,148 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11208,416,121 - 208,426,601 (+)NCBI
Celera1200,460,753 - 200,471,232 (+)NCBICelera
Cytogenetic Map1q43NCBI
Rela
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542219,603,345 - 19,611,516 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542219,602,930 - 19,612,263 (+)NCBIChiLan1.0ChiLan1.0
RELA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11164,347,859 - 64,357,461 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1164,347,859 - 64,356,868 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01161,012,839 - 61,022,225 (-)NCBIMhudiblu_PPA_v0panPan3
RELA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11851,550,003 - 51,558,861 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1851,550,040 - 51,558,875 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1850,158,512 - 50,167,377 (+)NCBI
ROS_Cfam_1.01852,587,297 - 52,596,161 (+)NCBI
UMICH_Zoey_3.11851,687,144 - 51,696,009 (+)NCBI
UNSW_CanFamBas_1.01851,261,264 - 51,270,127 (+)NCBI
UU_Cfam_GSD_1.01852,051,615 - 52,060,481 (+)NCBI
Rela
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049477,359,432 - 7,368,234 (+)NCBI
SpeTri2.0NW_0049365993,800,142 - 3,810,583 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RELA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118,576,059 - 8,585,561 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl18,576,542 - 8,586,516 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038105,871,180 - 105,881,402 (+)NCBIVero_WHO_p1.0
Rela
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476720,732,813 - 20,742,016 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 10 4 3 4 2 23 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000014191   ⟹   ENSSSCP00000013805
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl26,594,279 - 6,603,471 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000029216   ⟹   ENSSSCP00000028005
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl26,593,969 - 6,603,470 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000044525   ⟹   ENSSSCP00000031433
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl26,593,969 - 6,602,684 (+)Ensembl
RefSeq Acc Id: NM_001114281   ⟹   NP_001107753
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.126,594,869 - 6,602,684 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001107753   ⟸   NM_001114281
- UniProtKB: B0LXP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000031433   ⟸   ENSSSCT00000044525
RefSeq Acc Id: ENSSSCP00000028005   ⟸   ENSSSCT00000029216
RefSeq Acc Id: ENSSSCP00000013805   ⟸   ENSSSCT00000014191
Protein Domains
RHD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000012981 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070017805 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000013805 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000028005 UniProtKB/TrEMBL
  ENSSSCP00000031433 UniProtKB/TrEMBL
  ENSSSCP00070029385 UniProtKB/TrEMBL
  ENSSSCP00070029398 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014191 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000029216 UniProtKB/TrEMBL
  ENSSSCT00000044525 UniProtKB/TrEMBL
  ENSSSCT00070035184 UniProtKB/TrEMBL
  ENSSSCT00070035201 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  IPT_dom UniProtKB/TrEMBL
  IPT_NFkappaB UniProtKB/TrEMBL
  NFkB/Dor UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL
  RelA UniProtKB/TrEMBL
  RHD_CS UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind_dom UniProtKB/TrEMBL
  RHD_DNA_bind_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:100135665 UniProtKB/TrEMBL
NCBI Gene RELA ENTREZGENE
PANTHER PTHR24169 UniProtKB/TrEMBL
  PTHR24169:SF1 UniProtKB/TrEMBL
Pfam RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind UniProtKB/TrEMBL
PRINTS NFKBTNSCPFCT UniProtKB/TrEMBL
PROSITE REL_1 UniProtKB/TrEMBL
  REL_2 UniProtKB/TrEMBL
SMART IPT UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/TrEMBL
  SSF81296 UniProtKB/TrEMBL
UniProt A0A286ZJ10_PIG UniProtKB/TrEMBL
  A0A4X1UL81_PIG UniProtKB/TrEMBL
  A0A4X1ULV4_PIG UniProtKB/TrEMBL
  B0LXP3 ENTREZGENE, UniProtKB/TrEMBL
  F2Q9C1_PIG UniProtKB/TrEMBL
  F2QA75_PIG UniProtKB/TrEMBL
  F6PVF4_PIG UniProtKB/TrEMBL
UniProt Secondary A0A480J288 UniProtKB/TrEMBL
  I3LV53 UniProtKB/TrEMBL
VGNC ID VGNC:92203 ENTREZGENE