RGD Reference Report - Association of IGF1R polymorphisms with the development of HBV-related hepatocellular carcinoma. - Rat Genome Database

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Association of IGF1R polymorphisms with the development of HBV-related hepatocellular carcinoma.

Authors: Xie, H-Y  Xing, C-Y  Wei, B-J  Xu, X  Wu, J  Chen, L-M  Cao, G-Q  Chen, H  Chen, K-J  Yin, S-Y  Wu, L-M  Zhou, L  Zheng, S-S 
Citation: Xie HY, etal., Tissue Antigens. 2014 Sep;84(3):264-70. doi: 10.1111/tan.12360. Epub 2014 Apr 23.
RGD ID: 14985227
Pubmed: (View Article at PubMed) PMID:24758241
DOI: Full-text: DOI:10.1111/tan.12360

Although the involvement of insulin-like signaling in cancer has been well documented in various types of cancers, the association between the genetic variants in the insulin-like signaling and the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remains unclear. In this study, a total of 498 individuals including 173 HBV related cirrhosis patients, 171 HBV-related HCC patients, and 154 healthy controls were enrolled. Sixteen single nucleotide polymorphisms (SNPs) in IGF1, IGF2, IGF1R and IGF2R have been genotyped by employing SNaPshot assays. We found A/A genotype at rs3743251 of IGF1R was negatively associated with HBV related HCC [odds ratio (OR) = 0.38, 95% confidence interval (CI) = 0.20-0.72, P = 0.037]; A/G genotype decreased the risk of portal vein thrombosis (OR = 0.38, 95%CI = 0.18-0.82, P = 0.01). These results indicate that rs3743251 polymorphism in IGF1R is associated with the susceptibility of HBV-related HCC.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Igf1r  (insulin-like growth factor 1 receptor)

Genes (Mus musculus)
Igf1r  (insulin-like growth factor I receptor)

Genes (Homo sapiens)
IGF1R  (insulin like growth factor 1 receptor)


Additional Information