COTL1 (coactosin like F-actin binding protein 1)

Gene: COTL1 (coactosin like F-actin binding protein 1) Sus scrofa

Analyze

Symbol:

COTL1

Name:

coactosin like F-actin binding protein 1

RGD ID:

14056612

Description:

ENCODES a protein that exhibits actin binding (inferred); actin filament binding (inferred); enzyme binding (inferred); INVOLVED IN defense response to fungus (inferred); regulation of actin filament polymerization (inferred); ASSOCIATED WITH Breast Neoplasms (ortholog); Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); FOUND IN actin filament (inferred); cortical actin cytoskeleton (inferred); cytosol (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

coactosin-like protein

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	4,099,414 - 4,147,469 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	4,099,341 - 4,146,281 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

persistent fetal circulation syndrome (ISO)

schizophrenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

defense response to fungus (IEA)

regulation of actin filament polymerization (IEA)

Cellular Component

actin filament (IEA)

cortical actin cytoskeleton (IEA)

cytosol (IEA)

site of polarized growth (IEA)

Molecular Function

actin binding (IEA)

actin filament binding (IEA)

enzyme binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

COTL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	4,099,414 - 4,147,469 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	4,099,341 - 4,146,281 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

COTL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	84,565,596 - 84,618,078 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	84,565,596 - 84,618,078 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	84,599,202 - 84,651,684 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	83,156,703 - 83,209,170 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	83,156,706 - 83,209,170	NCBI
Celera	16	68,901,034 - 68,953,456 (-)	NCBI		Celera
Cytogenetic Map	16	q24.1	NCBI
HuRef	16	70,352,055 - 70,404,781 (-)	NCBI		HuRef
CHM1_1	16	86,010,791 - 86,063,243 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	90,631,897 - 90,684,371 (-)	NCBI		T2T-CHM13v2.0

Cotl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	120,535,953 - 120,567,318 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	120,535,961 - 120,567,283 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	119,809,214 - 119,840,579 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	119,809,222 - 119,840,544 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	122,333,114 - 122,364,479 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	122,695,202 - 122,726,517 (-)	NCBI		MGSCv36	mm8
Celera	8	124,025,809 - 124,057,174 (-)	NCBI		Celera
Cytogenetic Map	8	E1	NCBI
cM Map	8	68.42	NCBI

Cotl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	64,780,309 - 64,814,629 (-)	NCBI		GRCr8
mRatBN7.2	19	47,871,689 - 47,906,010 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	47,871,694 - 47,911,689 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	54,666,008 - 54,700,332 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	55,346,754 - 55,381,075 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	57,559,721 - 57,594,016 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	52,465,074 - 52,499,433 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	52,465,087 - 52,499,433 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	63,209,153 - 63,243,569 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	50,096,620 - 50,130,253 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	50,101,505 - 50,135,146 (-)	NCBI
Celera	19	47,128,853 - 47,162,796 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

Cotl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955541	153,542 - 183,965 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955541	153,542 - 183,965 (-)	NCBI	ChiLan1.0	ChiLan1.0

COTL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	94,312,954 - 94,366,402 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	100,230,272 - 100,283,576 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	65,231,112 - 65,284,079 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	84,572,810 - 84,625,177 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	84,572,816 - 84,625,177 (-)	Ensembl	panpan1.1		panPan2

COTL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	67,872,065 - 67,909,536 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	67,872,314 - 67,908,637 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	67,886,320 - 67,924,028 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	68,105,128 - 68,142,858 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	68,104,864 - 68,142,853 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	68,118,095 - 68,155,666 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	67,954,340 - 67,992,032 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	68,369,594 - 68,407,331 (+)	NCBI		UU_Cfam_GSD_1.0

Cotl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	27,670,703 - 27,705,283 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936641	3,423,144 - 3,455,432 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936641	3,422,734 - 3,458,830 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

COTL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	69,966,655 - 70,019,338 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	69,967,900 - 70,019,307 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	5,730,731 - 5,784,025 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cotl1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	1,485,321 - 1,510,276 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624746	1,485,301 - 1,510,193 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in COTL1
1857 total Variants

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003361733	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000039	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK235815	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK239520	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK393860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK394007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK395957	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK397131	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK397743	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK400695	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01051099	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000054554 ⟹ ENSSSCP00000080183

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	6	4,099,414 - 4,147,469 (+)	Ensembl

RefSeq Acc Id:

XM_003361733 ⟹ XP_003361781

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	6	4,099,341 - 4,146,281 (+)	NCBI

Sequence:

show sequence

CCCAGGAGGCCAATGGCCGGAGGGGGCGGGGCGGCGCGGCCTGCATCTGGCCCGCGTTCCCTGC
GCACTCCGTGCCACCGCCGCGCTCGGAGCTCGGAGCTCGGAGCTCGCAGCTCGCTTCGCCCTGC
GCCTCTGTCGCCGCCGCCGCTGCCACCGCCACCCGCACACCCTTGGCGCGTCCACGCACCGCTC
CGCTCCTTGCAGCCGGCACAGAGTGCGCTTATCGCTCGTTCAGGGCAGCGTGTCCCCGTTGCAG
CCCCTCGGCGATGGCCACCAAGATCGACAAAGAGGCTTGCCGGACGGCGTATAACCTGGTGCGC
GACGACAGCTCGGCCGTCATCTGGGTGACTTTTAAATACGACGGCTCCACCATCGTCCCCGGCG
AGCAGGGAGCGGAATATCAGGACTTCATCCAACAATGCACAGATGACGTCCGATTGTTTGCCTT
CGTGCGCTTCACCACCGGGGATGCCATGAGCAAGAGGTCCAAGTTTGCCCTCATCACCTGGATT
GGCGAGAACGTCAGCGGGCTGCAGCGCGCCAAGACGGGCACCGACAAGACCCTGGTGAAGGAAG
TGGTGCAGAATTTCGCCAAAGAGTTTGTGATCAGTGATCGGAAGGAGCTGGAGGAAGATTTTAT
CAAGAGCGAGCTCAAGAAGGCCGGGGGTGCCAATTATGATGCCCAGACGGAGTAACCCCCGCAC
CCCGCGCCTTGCCAAAGTCATCTGCCTGCTCCCCGGGGGAGGGGACCGCGGCCTCAGCTACCAG
CCCATCAGCCCACCAGGGAGAGGAGACGCGATGAGAGGCAACGCCCGCCACCCCGTCCGCAACC
CAGCTCCCCTCCCCGCTTCCCCTTGTGCACCTGCTGTGTCCCGTCCCATGAAGCTCATGGAACA
TCTTTCTTTGCTTTTTTTTCTTTTCTCCCCCTGACCCCTTTCTTGTTCTAAACAAAAATCATTT
GGATGCCAAGGTCACGCACATCACCAGATCGGAGGTGCCTCCCGCGGTGACCCTCTCCTGGCAT
TTCTTAACGCACAGGCAGCCTGCCCGGCCTGACCCATCAACCTCGCGTCGCTTCTGGTGCCTGG
GCCAGTGTCGCTCTCTTGTTTTCTTTTTTTTGGCGCCCGCCTGCTTCCCACGGAGGAGGCAGCC
ACGTGGGGAGCCCGTCCTCATCGTGCCCTTGTCGCGCCCCGCTGGCCAGGCTCACATCTCCAGG
AGTCCCTCCGGAGGCCCCCCCACCCCCCACCTCCATTCCAAGTTGCCTAAGCTCCATGTCCATC
AGAGACGGTGCTCGGTGGAGAGATGGGCAGCCCTGACTCAGACCGAAGGAGGAGAGAGGAAAAT
CTGCCACCCGTCAGAAGCGGCCCGTTCCCCAGCCTTGGGATGGCGCTCTCGGGATGGCGGGGGG
TGGGGGCAGAGGTCTGAGTCCAGATTCGACGGGAGGTGCTCAGGGCTCACATCCTCGGGCTCCC
CAAGTGACGAGGACATTAGGGGTGCAGAATGGGCATTTAGGTCAAAGCGGTCCTCTGCACGACA
GCACAGACAGCAGGGGACAGAGGCTCCCTGCTCCGTCACGGTCACCACAGCTGTGTGTGCAGCC
CCCCCCCACTGGGGGGGGAACCAGAAAGTCTATGGTTTTAATCCTCGGTGGCACCTCACACAAA
AAGGATGTTTTTTTTTTTTCAAAGAAAGATGAGGTTGGCTTGGTTCTTCATGCCCATGTTAGGT
AGGGCTCTTTTTCTCTTTTCCTTGCTCGTTTCGTCGGGGGACGTCTGTGCTGTGCTGGGGTGGT
GAAGGCATCTGCACTCAAAACGGTTTACAGAAATAAATTTTTGTTTTGTTTTGTTTTTCAAAAA
A

hide sequence

Protein Sequences


Protein RefSeqs	XP_003361781	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000080183
	ENSSSCP00000080183.1
	ENSSSCP00065001361.1
	ENSSSCP00070010192.1

RefSeq Acc Id:	XP_003361781 ⟸ XM_003361733
- UniProtKB:	A0A4X1T354 (UniProtKB/TrEMBL), A0A287AJU1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MATKIDKEACRTAYNLVRDDSSAVIWVTFKYDGSTIVPGEQGAEYQDFIQQCTDDVRLFAFVRF TTGDAMSKRSKFALITWIGENVSGLQRAKTGTDKTLVKEVVQNFAKEFVISDRKELEEDFIKSE LKKAGGANYDAQTE hide sequence

RefSeq Acc Id:

ENSSSCP00000080183 ⟸ ENSSSCT00000054554

Protein Domains

ADF-H

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000037645	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00065002820	UniProtKB/TrEMBL
	ENSSSCG00070006489	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000054554	ENTREZGENE
	ENSSSCT00000054554.3	UniProtKB/TrEMBL
	ENSSSCT00065003646.1	UniProtKB/TrEMBL
	ENSSSCT00070012392.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.20.10	UniProtKB/TrEMBL
InterPro	ADF-H	UniProtKB/TrEMBL
	ADF-H/Gelsolin-like_dom_sf	UniProtKB/TrEMBL
NCBI Gene	COTL1	ENTREZGENE
PANTHER	CORTACTIN AND DREBRIN	UniProtKB/TrEMBL
	PTHR10829:SF29	UniProtKB/TrEMBL
Pfam	Cofilin_ADF	UniProtKB/TrEMBL
PROSITE	ADF_H	UniProtKB/TrEMBL
SMART	ADF	UniProtKB/TrEMBL
Superfamily-SCOP	Actin depolymerizing proteins	UniProtKB/TrEMBL
UniProt	A0A287AJU1	ENTREZGENE, UniProtKB/TrEMBL
	A0A4X1T354	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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