SPARC (secreted protein acidic and cysteine rich) - Rat Genome Database

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Gene: SPARC (secreted protein acidic and cysteine rich) Sus scrofa
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Symbol: SPARC
Name: secreted protein acidic and cysteine rich
RGD ID: 14262168
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); INVOLVED IN bone development (ortholog); cellular response to growth factor stimulus (ortholog); heart development (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); adrenocortical carcinoma (ortholog); Brain Injuries (ortholog); FOUND IN cytoplasm (ortholog); extracellular matrix (ortholog); extracellular space (ortholog); INTERACTS WITH resveratrol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: basement-membrane protein 40; BM-40; ON; osteonectin; secreted protein acidic and rich in cysteine; secreted protein, acidic, cysteine-rich (osteonectin)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1671,357,703 - 71,381,160 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11671,368,164 - 71,380,972 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21677,576,864 - 77,584,734 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
resveratrol  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:18162102  


Genomics

Comparative Map Data
SPARC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1671,357,703 - 71,381,160 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11671,368,164 - 71,380,972 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21677,576,864 - 77,584,734 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPARC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385151,661,096 - 151,686,915 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5151,661,096 - 151,686,975 (-)EnsemblGRCh38hg38GRCh38
GRCh375151,040,657 - 151,066,476 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365151,021,201 - 151,046,710 (-)NCBINCBI36hg18NCBI36
Build 345151,021,203 - 151,046,710NCBI
Celera5147,122,406 - 147,147,929 (-)NCBI
Cytogenetic Map5q33.1NCBI
HuRef5146,186,043 - 146,212,010 (-)NCBIHuRef
CHM1_15150,473,070 - 150,499,042 (-)NCBICHM1_1
Sparc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391155,284,985 - 55,310,906 (-)NCBIGRCm39mm39
GRCm39 Ensembl1155,285,326 - 55,314,009 (-)Ensembl
GRCm381155,394,159 - 55,420,080 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1155,394,500 - 55,423,183 (-)EnsemblGRCm38mm10GRCm38
MGSCv371155,208,003 - 55,233,582 (-)NCBIGRCm37mm9NCBIm37
MGSCv361155,237,924 - 55,263,289 (-)NCBImm8
Celera1159,982,920 - 59,995,424 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1133.04NCBI
Sparc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21039,516,394 - 39,538,252 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1039,516,406 - 39,538,396 (-)Ensembl
Rnor_6.01040,742,390 - 40,764,232 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,742,400 - 40,764,185 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01040,573,510 - 40,595,261 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41040,809,730 - 40,831,481 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11040,823,352 - 40,845,104 (-)NCBI
Celera1038,848,158 - 38,869,906 (-)NCBICelera
RH 3.4 Map10414.6RGD
Cytogenetic Map10q22NCBI
Sparc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554086,099,003 - 6,122,459 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554086,100,123 - 6,122,460 (-)NCBIChiLan1.0ChiLan1.0
SPARC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15153,091,160 - 153,115,745 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5153,090,181 - 153,115,750 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05147,087,903 - 147,112,466 (-)NCBIMhudiblu_PPA_v0panPan3
SPARC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1457,659,541 - 57,682,147 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl457,659,650 - 57,681,711 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha457,479,010 - 57,501,597 (+)NCBI
ROS_Cfam_1.0458,102,077 - 58,124,747 (+)NCBI
ROS_Cfam_1.0 Ensembl458,101,302 - 58,124,748 (+)Ensembl
UMICH_Zoey_3.1457,918,069 - 57,940,655 (+)NCBI
UNSW_CanFamBas_1.0458,016,600 - 58,039,187 (+)NCBI
UU_Cfam_GSD_1.0458,519,992 - 58,542,658 (+)NCBI
Sparc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213112,576,762 - 112,597,465 (+)NCBI
SpeTri2.0NW_00493651511,026,156 - 11,046,812 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPARC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12354,224,003 - 54,248,869 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2354,222,838 - 54,238,006 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603423,456,066 - 23,481,034 (+)NCBIVero_WHO_p1.0
Sparc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473337,348,993 - 37,369,804 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 1
Low
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000018598   ⟹   ENSSSCP00000018097
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1671,359,321 - 71,381,155 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000070928   ⟹   ENSSSCP00000064858
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1671,359,607 - 71,381,159 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000088328   ⟹   ENSSSCP00000072749
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1671,357,703 - 71,381,160 (+)Ensembl
RefSeq Acc Id: NM_001031794   ⟹   NP_001026964
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11671,368,164 - 71,380,972 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001026964 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAX83050 (Get FASTA)   NCBI Sequence Viewer  
  CAM32245 (Get FASTA)   NCBI Sequence Viewer  
  P20112 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001026964   ⟸   NM_001031794
- Peptide Label: precursor
- UniProtKB: P20112 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000072749   ⟸   ENSSSCT00000088328
RefSeq Acc Id: ENSSSCP00000064858   ⟸   ENSSSCT00000070928
RefSeq Acc Id: ENSSSCP00000018097   ⟸   ENSSSCT00000018598
Protein Domains
EF-hand   Follistatin-like   Kazal-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000017082 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00005017688 UniProtKB/Swiss-Prot
  ENSSSCG00015024195 UniProtKB/Swiss-Prot
  ENSSSCG00025037875 UniProtKB/Swiss-Prot
  ENSSSCG00030007808 UniProtKB/Swiss-Prot
  ENSSSCG00035049628 UniProtKB/Swiss-Prot
  ENSSSCG00040075656 UniProtKB/Swiss-Prot
  ENSSSCG00045003926 UniProtKB/Swiss-Prot
  ENSSSCG00050056796 UniProtKB/Swiss-Prot
  ENSSSCG00060061892 UniProtKB/Swiss-Prot
  ENSSSCG00065034205 UniProtKB/Swiss-Prot
  ENSSSCG00070011676 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000018097 UniProtKB/TrEMBL
  ENSSSCP00000064858 UniProtKB/TrEMBL
  ENSSSCP00000072749 UniProtKB/TrEMBL
  ENSSSCP00005017157 UniProtKB/Swiss-Prot
  ENSSSCP00005017187 UniProtKB/Swiss-Prot
  ENSSSCP00005017209 UniProtKB/Swiss-Prot
  ENSSSCP00015012870 UniProtKB/Swiss-Prot
  ENSSSCP00025022032 UniProtKB/Swiss-Prot
  ENSSSCP00030004544 UniProtKB/Swiss-Prot
  ENSSSCP00035026843 UniProtKB/Swiss-Prot
  ENSSSCP00040047984 UniProtKB/Swiss-Prot
  ENSSSCP00045004433 UniProtKB/Swiss-Prot
  ENSSSCP00050033326 UniProtKB/Swiss-Prot
  ENSSSCP00060036582 UniProtKB/Swiss-Prot
  ENSSSCP00065019995 UniProtKB/Swiss-Prot
  ENSSSCP00070018831 UniProtKB/TrEMBL
  ENSSSCP00070018841 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000018598 UniProtKB/TrEMBL
  ENSSSCT00000070928 UniProtKB/TrEMBL
  ENSSSCT00000088328 UniProtKB/TrEMBL
  ENSSSCT00005028103 UniProtKB/Swiss-Prot
  ENSSSCT00005028143 UniProtKB/Swiss-Prot
  ENSSSCT00005028179 UniProtKB/Swiss-Prot
  ENSSSCT00015032407 UniProtKB/Swiss-Prot
  ENSSSCT00025051623 UniProtKB/Swiss-Prot
  ENSSSCT00030010505 UniProtKB/Swiss-Prot
  ENSSSCT00035066175 UniProtKB/Swiss-Prot
  ENSSSCT00040105033 UniProtKB/Swiss-Prot
  ENSSSCT00045006510 UniProtKB/Swiss-Prot
  ENSSSCT00050077449 UniProtKB/Swiss-Prot
  ENSSSCT00060084460 UniProtKB/Swiss-Prot
  ENSSSCT00065046549 UniProtKB/Swiss-Prot
  ENSSSCT00070022771 UniProtKB/TrEMBL
  ENSSSCT00070022781 UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fol_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Follistatin/Osteonectin_EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Osteonectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPARC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPARC/Testican_Ca-bd-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:595124 UniProtKB/Swiss-Prot
NCBI Gene SPARC ENTREZGENE
PANTHER PTHR13866:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FOLN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPARC_Ca_bdg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OSTEONECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OSTEONECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FOLN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAZAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1TP83_PIG UniProtKB/TrEMBL
  A0A4X1TU66_PIG UniProtKB/TrEMBL
  A0A5G2QK28_PIG UniProtKB/TrEMBL
  A0A5G2R6P1_PIG UniProtKB/TrEMBL
  A4H2I5_PIG UniProtKB/TrEMBL
  A4H2R5_PIG UniProtKB/TrEMBL
  F1RQB3_PIG UniProtKB/TrEMBL
  P20112 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q4Z8Q2 UniProtKB/Swiss-Prot
VGNC ID VGNC:98332 ENTREZGENE