BMP7 (bone morphogenetic protein 7) - Rat Genome Database

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Gene: BMP7 (bone morphogenetic protein 7) Sus scrofa
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Symbol: BMP7
Name: bone morphogenetic protein 7
RGD ID: 14019134
Description: ENCODES a protein that exhibits heparin binding (ortholog); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); animal organ morphogenesis (ortholog); axon guidance (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH acute kidney tubular necrosis (ortholog); Acute Otitis Media (ortholog); Bone Fractures (ortholog); FOUND IN collagen-containing extracellular matrix (ortholog); extracellular space (ortholog); vesicle (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: osteogenic protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1757,584,091 - 57,676,944 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11757,567,770 - 57,676,516 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21764,737,755 - 64,840,710 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
allantois development  (IEA)
anatomical structure formation involved in morphogenesis  (ISO)
animal organ morphogenesis  (ISO)
axon guidance  (IEA,ISO)
BMP signaling pathway  (IEA,ISO)
branching involved in salivary gland morphogenesis  (IEA,ISO)
branching morphogenesis of an epithelial tube  (IEA,ISO)
camera-type eye morphogenesis  (ISO)
cardiac muscle tissue development  (IEA)
cardiac septum morphogenesis  (IEA)
cell development  (ISO)
cellular response to BMP stimulus  (ISO)
chorio-allantoic fusion  (IEA)
embryonic camera-type eye morphogenesis  (IEA,ISO)
embryonic limb morphogenesis  (IEA,ISO)
embryonic pattern specification  (IEA,ISO)
embryonic skeletal joint morphogenesis  (IEA,ISO)
endocardial cushion formation  (IEA)
epithelial cell differentiation  (IEA,ISO)
eye development  (ISO)
heart trabecula morphogenesis  (IEA)
hindbrain development  (IEA)
kidney development  (ISO)
mesenchymal cell differentiation  (IEA)
mesenchyme development  (ISO)
mesoderm formation  (IEA,ISO)
mesonephros development  (ISO)
metanephric mesenchymal cell proliferation involved in metanephros development  (IEA)
metanephric mesenchyme morphogenesis  (IEA)
metanephros development  (ISO)
monocyte aggregation  (IEA)
negative regulation of cell cycle  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of glomerular mesangial cell proliferation  (IEA)
negative regulation of MAP kinase activity  (IEA)
negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis  (IEA,ISO)
negative regulation of mitotic nuclear division  (IEA)
negative regulation of neurogenesis  (IEA,ISO)
negative regulation of neuron differentiation  (IEA,ISO)
negative regulation of Notch signaling pathway  (IEA,ISO)
negative regulation of phosphorylation  (ISO)
negative regulation of prostatic bud formation  (IEA,ISO)
negative regulation of transcription, DNA-templated  (IEA)
nephrogenic mesenchyme morphogenesis  (IEA)
neural fold elevation formation  (IEA)
neuron projection morphogenesis  (ISO)
odontogenesis of dentin-containing tooth  (IEA,ISO)
pattern specification process  (ISO)
pericardium morphogenesis  (IEA)
pharyngeal system development  (IEA)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of bone mineralization  (IEA)
positive regulation of brown fat cell differentiation  (IEA)
positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis  (IEA)
positive regulation of cell death  (ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of dendrite development  (IEA)
positive regulation of epithelial to mesenchymal transition  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of heterotypic cell-cell adhesion  (IEA)
positive regulation of hyaluranon cable assembly  (IEA)
positive regulation of neuron differentiation  (IEA,ISO)
positive regulation of osteoblast differentiation  (IEA)
positive regulation of pathway-restricted SMAD protein phosphorylation  (IEA)
positive regulation of peptidyl-threonine phosphorylation  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription, DNA-templated  (ISO)
protein localization to nucleus  (IEA)
regulation of branching involved in prostate gland morphogenesis  (IEA,ISO)
regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
regulation of phosphorylation  (ISO)
response to estradiol  (ISO)
response to peptide hormone  (ISO)
response to vitamin D  (ISO)
salivary gland morphogenesis  (ISO)
signal transduction  (IEA)
SMAD protein signal transduction  (IEA)
steroid hormone mediated signaling pathway  (IEA)
tube morphogenesis  (ISO)
ureteric bud development  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:24035155   PMID:25036177   PMID:32937257  


Genomics

Comparative Map Data
BMP7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1757,584,091 - 57,676,944 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11757,567,770 - 57,676,516 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21764,737,755 - 64,840,710 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BMP7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2057,168,753 - 57,266,641 (-)EnsemblGRCh38hg38GRCh38
GRCh382057,168,753 - 57,266,641 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372055,743,809 - 55,841,697 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362055,178,962 - 55,274,708 (-)NCBINCBI36hg18NCBI36
Build 342055,178,961 - 55,274,708NCBI
Celera2052,484,025 - 52,581,945 (-)NCBI
Cytogenetic Map20q13.31NCBI
HuRef2052,525,580 - 52,623,004 (-)NCBIHuRef
CHM1_12055,645,001 - 55,742,816 (-)NCBICHM1_1
Bmp7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392172,709,805 - 172,782,114 (-)NCBIGRCm39mm39
GRCm39 Ensembl2172,709,805 - 172,782,114 (-)Ensembl
GRCm382172,868,012 - 172,940,321 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2172,868,012 - 172,940,321 (-)EnsemblGRCm38mm10GRCm38
MGSCv372172,695,187 - 172,765,794 (-)NCBIGRCm37mm9NCBIm37
MGSCv362172,512,625 - 172,583,232 (-)NCBImm8
Celera2178,834,089 - 178,904,564 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map295.54NCBI
Bmp7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23161,639,915 - 161,716,938 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl3161,516,462 - 161,716,788 (-)Ensembl
Rnor_6.03170,879,972 - 170,955,820 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3170,879,973 - 170,955,399 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03176,945,362 - 177,020,745 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43163,723,429 - 163,799,567 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13163,630,250 - 163,704,848 (-)NCBI
Celera3160,834,683 - 160,910,334 (-)NCBICelera
Cytogenetic Map3q42NCBI
Bmp7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554452,153,170 - 2,235,795 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554452,154,057 - 2,235,594 (+)NCBIChiLan1.0ChiLan1.0
BMP7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12054,788,974 - 54,885,015 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2054,788,974 - 54,885,021 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02053,509,484 - 53,606,889 (-)NCBIMhudiblu_PPA_v0panPan3
BMP7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12442,203,183 - 42,294,105 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2442,204,823 - 42,294,653 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2441,452,207 - 41,541,996 (-)NCBI
ROS_Cfam_1.02443,068,237 - 43,159,868 (-)NCBI
UMICH_Zoey_3.12442,155,146 - 42,244,886 (-)NCBI
UNSW_CanFamBas_1.02442,294,769 - 42,384,624 (-)NCBI
UU_Cfam_GSD_1.02442,952,879 - 43,042,732 (-)NCBI
Bmp7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640183,162,668 - 183,234,253 (+)NCBI
SpeTri2.0NW_00493653071,965 - 143,940 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMP7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.126,856,396 - 6,954,948 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl26,856,453 - 6,954,944 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605054,918,476 - 55,017,287 (+)NCBIVero_WHO_p1.0
Bmp7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474123,658,214 - 23,743,227 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 6 1 1 21 3 1
Below cutoff 3 2 2 2 1 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000008212   ⟹   ENSSSCP00000007993
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1757,584,956 - 57,676,944 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000033617   ⟹   ENSSSCP00000029077
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1757,584,956 - 57,675,986 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000086690   ⟹   ENSSSCP00000065362
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1757,584,091 - 57,676,944 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000087654   ⟹   ENSSSCP00000065725
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1757,584,363 - 57,676,944 (-)Ensembl
RefSeq Acc Id: NM_001105290   ⟹   NP_001098760
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11757,586,822 - 57,675,961 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005673044   ⟹   XP_005673101
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11757,584,958 - 57,676,514 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005673045   ⟹   XP_005673102
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11757,583,839 - 57,676,516 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021077319   ⟹   XP_020932978
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11757,569,575 - 57,676,516 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021077320   ⟹   XP_020932979
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11757,567,770 - 57,676,516 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020932979   ⟸   XM_021077320
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020932978   ⟸   XM_021077319
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005673102   ⟸   XM_005673045
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005673101   ⟸   XM_005673044
- Peptide Label: isoform X1
- UniProtKB: A5GFN2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001098760   ⟸   NM_001105290
- Peptide Label: precursor
- UniProtKB: A5GFN1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000065362   ⟸   ENSSSCT00000086690
RefSeq Acc Id: ENSSSCP00000065725   ⟸   ENSSSCT00000087654
RefSeq Acc Id: ENSSSCP00000007993   ⟸   ENSSSCT00000008212
RefSeq Acc Id: ENSSSCP00000029077   ⟸   ENSSSCT00000033617
Protein Domains
TGF_BETA_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000007501 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070018696 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000007993 UniProtKB/TrEMBL
  ENSSSCP00000029077 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000065362 UniProtKB/TrEMBL
  ENSSSCP00000065725 UniProtKB/TrEMBL
  ENSSSCP00070030812 UniProtKB/TrEMBL
  ENSSSCP00070030821 UniProtKB/TrEMBL
  ENSSSCP00070030822 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000008212 UniProtKB/TrEMBL
  ENSSSCT00000033617 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000086690 UniProtKB/TrEMBL
  ENSSSCT00000087654 UniProtKB/TrEMBL
  ENSSSCT00070036850 UniProtKB/TrEMBL
  ENSSSCT00070036859 UniProtKB/TrEMBL
  ENSSSCT00070036861 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  TGF-b_C UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/TrEMBL
  TGFb_CS UniProtKB/TrEMBL
KEGG Report ssc:492315 UniProtKB/TrEMBL
NCBI Gene BMP7 ENTREZGENE
PANTHER PTHR11848 UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/TrEMBL
SMART TGFB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A4X1UNE3_PIG UniProtKB/TrEMBL
  A0A4X1UQJ0_PIG UniProtKB/TrEMBL
  A0A4X1URG0_PIG UniProtKB/TrEMBL
  A0A5G2QNT9_PIG UniProtKB/TrEMBL
  A0A5G2R475_PIG UniProtKB/TrEMBL
  A5GFN1 ENTREZGENE, UniProtKB/TrEMBL
  A5GFN2 ENTREZGENE, UniProtKB/TrEMBL
  A8S3P5_PIG UniProtKB/TrEMBL
  F6Q2I6_PIG UniProtKB/TrEMBL
  Q5U916_PIG UniProtKB/TrEMBL
VGNC ID VGNC:95491 ENTREZGENE