MT1A (metallothionein 1A) - Rat Genome Database

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Gene: MT1A (metallothionein 1A) Sus scrofa
Analyze
Symbol: MT1A
Name: metallothionein 1A
RGD ID: 13913110
Description: ENCODES a protein that exhibits zinc ion binding (ortholog); INVOLVED IN cellular response to zinc ion (ortholog); negative regulation of growth (ortholog); response to cadmium ion (ortholog); ASSOCIATED WITH Acute-Phase Reaction (ortholog); Arsenic Poisoning (ortholog); Bardet-Biedl syndrome (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH cadmium atom; zinc sulfate
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: metallothionein-1A; metallothionein-IA; MT-IA; MT1
RGD Orthologs
Human
Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl618,672,001 - 18,673,672 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1618,672,016 - 18,673,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2626,383,569 - 26,411,799 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISS)
nucleus  (IBA,IEA,ISS)

Molecular Function

References
Additional References at PubMed
PMID:2474864   PMID:9573337   PMID:14681463   PMID:14988443   PMID:15812196   PMID:17145712   PMID:22301074   PMID:22760644   PMID:27049121   PMID:30032202  


Genomics

Comparative Map Data
MT1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl618,672,001 - 18,673,672 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1618,672,016 - 18,673,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2626,383,569 - 26,411,799 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MT1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381656,638,666 - 56,640,087 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1656,638,666 - 56,640,087 (+)EnsemblGRCh38hg38GRCh38
GRCh371656,672,578 - 56,673,999 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,230,079 - 55,231,500 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,230,081 - 55,231,498NCBI
Celera1641,170,031 - 41,171,454 (+)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1642,542,032 - 42,543,455 (+)NCBIHuRef
CHM1_11658,079,506 - 58,080,929 (+)NCBICHM1_1
T2T-CHM13v2.01662,433,646 - 62,435,069 (+)NCBIT2T-CHM13v2.0
Mt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,831,959 - 10,832,975 (-)NCBIGRCr8
mRatBN7.21910,826,032 - 10,827,048 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1774,786,654 - 74,787,135 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1910,826,032 - 10,827,049 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,794,185 - 10,795,201 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,561,039 - 11,562,055 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,848,030 - 10,849,046 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,301,991 - 11,303,007 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1778,793,336 - 78,793,724 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,277,133 - 11,278,149 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,261,631 - 11,262,647 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11911,266,456 - 11,267,404 (-)NCBI
Celera1910,711,989 - 10,713,005 (-)NCBICelera
RH 3.4 Map19128.1RGD
Cytogenetic Map19p12NCBI

Variants

.
Variants in MT1A
76 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2
Low 7 1 14 2 1
Below cutoff 1 2 2 5 1 6 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000029094   ⟹   ENSSSCP00000025883
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl618,660,642 - 18,673,671 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000031974   ⟹   ENSSSCP00000025546
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl618,660,847 - 18,673,766 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000036829   ⟹   ENSSSCP00000051123
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl618,672,001 - 18,673,672 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000066331   ⟹   ENSSSCP00000041696
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl618,660,849 - 18,662,000 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000077842   ⟹   ENSSSCP00000067816
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl618,671,925 - 18,672,823 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000079322   ⟹   ENSSSCP00000063061
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl618,672,001 - 18,672,806 (+)Ensembl
RefSeq Acc Id: NM_001001266   ⟹   NP_001001266
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1618,672,016 - 18,673,673 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001001266 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA02939 (Get FASTA)   NCBI Sequence Viewer  
  BAA19176 (Get FASTA)   NCBI Sequence Viewer  
  BAA19177 (Get FASTA)   NCBI Sequence Viewer  
  BAA19178 (Get FASTA)   NCBI Sequence Viewer  
  BAA19180 (Get FASTA)   NCBI Sequence Viewer  
  BAA19182 (Get FASTA)   NCBI Sequence Viewer  
  BAA19184 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000051123
  ENSSSCP00000051123.1
  ENSSSCP00000063061.2
  ENSSSCP00015005260.1
  ENSSSCP00015005285.1
  ENSSSCP00015005322.1
  ENSSSCP00015005359.1
  ENSSSCP00025046362.1
  ENSSSCP00025046376.1
  ENSSSCP00025046383.1
  ENSSSCP00025046399.1
  ENSSSCP00025046489.1
  ENSSSCP00030036838.1
  ENSSSCP00030037014.1
  ENSSSCP00035031944.1
  ENSSSCP00035031949.1
  ENSSSCP00035031952.1
  ENSSSCP00040015003.1
  ENSSSCP00040015055.1
  ENSSSCP00040015111.1
  ENSSSCP00040015123.1
  ENSSSCP00045039932.1
  ENSSSCP00045039964.1
  ENSSSCP00050025934.1
  ENSSSCP00050025936.1
  ENSSSCP00055024187.1
  ENSSSCP00055041334.1
  ENSSSCP00060043822.1
  ENSSSCP00060043861.1
  ENSSSCP00060043894.1
  ENSSSCP00060043937.1
  ENSSSCP00060043971.1
  ENSSSCP00060044019.1
  ENSSSCP00060044042.1
  ENSSSCP00065022818.1
  ENSSSCP00065046258.1
  ENSSSCP00070000597.1
GenBank Protein P49068 (Get FASTA)   NCBI Sequence Viewer  
  P79376 (Get FASTA)   NCBI Sequence Viewer  
  P79378 (Get FASTA)   NCBI Sequence Viewer  
  P79380 (Get FASTA)   NCBI Sequence Viewer  
  P79431 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001001266   ⟸   NM_001001266
- UniProtKB: P79378 (UniProtKB/Swiss-Prot),   P79375 (UniProtKB/Swiss-Prot),   P49068 (UniProtKB/Swiss-Prot),   A0A8D1AJD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000025883   ⟸   ENSSSCT00000029094
RefSeq Acc Id: ENSSSCP00000025546   ⟸   ENSSSCT00000031974
RefSeq Acc Id: ENSSSCP00000063061   ⟸   ENSSSCT00000079322
RefSeq Acc Id: ENSSSCP00000041696   ⟸   ENSSSCT00000066331
RefSeq Acc Id: ENSSSCP00000051123   ⟸   ENSSSCT00000036829
RefSeq Acc Id: ENSSSCP00000067816   ⟸   ENSSSCT00000077842


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000023684 Ensembl
  ENSSSCG00000061081 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00015010287 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00025075608 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00025075721 UniProtKB/TrEMBL
  ENSSSCG00030057620 UniProtKB/TrEMBL
  ENSSSCG00030057834 UniProtKB/TrEMBL
  ENSSSCG00035058234 UniProtKB/TrEMBL
  ENSSSCG00040027068 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00045033408 UniProtKB/TrEMBL
  ENSSSCG00050044306 UniProtKB/TrEMBL
  ENSSSCG00055015424 UniProtKB/TrEMBL
  ENSSSCG00055026167 UniProtKB/TrEMBL
  ENSSSCG00060073787 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00065038408 UniProtKB/TrEMBL
  ENSSSCG00065075624 UniProtKB/TrEMBL
  ENSSSCG00070000370 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000036829 ENTREZGENE
  ENSSSCT00000036829.3 UniProtKB/Swiss-Prot
  ENSSSCT00000079322.2 UniProtKB/TrEMBL
  ENSSSCT00015013562.1 UniProtKB/Swiss-Prot
  ENSSSCT00015013616.1 UniProtKB/Swiss-Prot
  ENSSSCT00015013720.1 UniProtKB/Swiss-Prot
  ENSSSCT00015013810.1 UniProtKB/TrEMBL
  ENSSSCT00025104329.1 UniProtKB/Swiss-Prot
  ENSSSCT00025104353.1 UniProtKB/Swiss-Prot
  ENSSSCT00025104368.1 UniProtKB/TrEMBL
  ENSSSCT00025104396.1 UniProtKB/TrEMBL
  ENSSSCT00025104540.1 UniProtKB/TrEMBL
  ENSSSCT00030080393.1 UniProtKB/TrEMBL
  ENSSSCT00030080704.1 UniProtKB/TrEMBL
  ENSSSCT00035077954.1 UniProtKB/TrEMBL
  ENSSSCT00035077965.1 UniProtKB/TrEMBL
  ENSSSCT00035077976.1 UniProtKB/TrEMBL
  ENSSSCT00040036175.1 UniProtKB/Swiss-Prot
  ENSSSCT00040036304.1 UniProtKB/TrEMBL
  ENSSSCT00040036426.1 UniProtKB/TrEMBL
  ENSSSCT00040036450.1 UniProtKB/TrEMBL
  ENSSSCT00045057140.1 UniProtKB/TrEMBL
  ENSSSCT00045057179.1 UniProtKB/TrEMBL
  ENSSSCT00050060316.1 UniProtKB/TrEMBL
  ENSSSCT00050060319.1 UniProtKB/TrEMBL
  ENSSSCT00055030373.1 UniProtKB/TrEMBL
  ENSSSCT00055051727.1 UniProtKB/TrEMBL
  ENSSSCT00060100865.1 UniProtKB/Swiss-Prot
  ENSSSCT00060100957.1 UniProtKB/TrEMBL
  ENSSSCT00060101036.1 UniProtKB/Swiss-Prot
  ENSSSCT00060101141.1 UniProtKB/Swiss-Prot
  ENSSSCT00060101223.1 UniProtKB/TrEMBL
  ENSSSCT00060101350.1 UniProtKB/TrEMBL
  ENSSSCT00060101389.1 UniProtKB/TrEMBL
  ENSSSCT00065052495.1 UniProtKB/TrEMBL
  ENSSSCT00065104384.1 UniProtKB/TrEMBL
  ENSSSCT00070000683.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Metalthion_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_dom_sf_vert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_vert UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metalthion_vert_metal_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397417 UniProtKB/Swiss-Prot
NCBI Gene MT1A ENTREZGENE
PANTHER METALLOTHIONEIN 1H-LIKE PROTEIN 1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  METALLOTHIONEIN-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23299 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Metallothio UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MTVERTEBRATE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE METALLOTHIONEIN_VRT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57868 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1SEJ3_PIG UniProtKB/TrEMBL
  A0A5G2QFQ8_PIG UniProtKB/TrEMBL
  A0A8D1AJD9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1IYW8_PIG UniProtKB/TrEMBL
  A0A8D1RR49_PIG UniProtKB/TrEMBL
  A0A8D1WXC0_PIG UniProtKB/TrEMBL
  MT1A_PIG UniProtKB/Swiss-Prot
  MT1C_PIG UniProtKB/Swiss-Prot
  MT1E_PIG UniProtKB/Swiss-Prot
  MT1F_PIG UniProtKB/Swiss-Prot
  MT2B_PIG UniProtKB/Swiss-Prot
  P49068 ENTREZGENE
  P79375 ENTREZGENE
  P79376 ENTREZGENE
  P79378 ENTREZGENE
  P79380 ENTREZGENE
  P79431 ENTREZGENE
UniProt Secondary P79375 UniProtKB/Swiss-Prot