SOX4 (SRY-box transcription factor 4) - Rat Genome Database

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Gene: SOX4 (SRY-box transcription factor 4) Sus scrofa
Analyze
Symbol: SOX4
Name: SRY-box transcription factor 4
RGD ID: 14233305
Description: ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); endocrine pancreas development (ortholog); glial cell proliferation (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Asphyxia (ortholog); breast carcinoma (ortholog); FOUND IN cytoplasm (ortholog); mitochondrion (ortholog); nucleus (ortholog); INTERACTS WITH resveratrol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: SRY-box 4; transcription factor SOX-4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl716,891,319 - 16,892,752 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1716,886,834 - 16,895,488 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2717,852,748 - 17,857,158 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
resveratrol  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure morphogenesis  (IEA)
ascending aorta morphogenesis  (IEA)
atrial septum primum morphogenesis  (IEA)
cardiac right ventricle morphogenesis  (IEA)
cell differentiation  (IEA)
cellular response to glucose stimulus  (IEA,ISS)
endocrine pancreas development  (IEA,ISO)
gene expression  (IEA)
glial cell development  (IEA)
glial cell proliferation  (IEA,ISS)
glucose homeostasis  (IEA,ISS)
heart development  (IEA,ISS)
hematopoietic stem cell homeostasis  (IEA,ISO)
kidney morphogenesis  (IEA)
mesenchyme development  (IEA,ISS)
mitral valve morphogenesis  (IEA)
negative regulation of cell population proliferation  (IEA,ISS)
negative regulation of myoblast differentiation  (IEA)
negative regulation of protein ubiquitination  (IEA,ISS)
negative regulation of transcription by RNA polymerase II  (IEA)
nervous system development  (IEA,ISS)
neuroepithelial cell differentiation  (IEA,ISS)
noradrenergic neuron differentiation  (IEA,ISS)
positive regulation of apoptotic process  (IEA,ISS)
positive regulation of canonical Wnt signaling pathway  (IEA,ISS)
positive regulation of cell population proliferation  (IEA,ISS)
positive regulation of DNA-templated transcription  (IEA,ISS)
positive regulation of gamma-delta T cell differentiation  (IEA)
positive regulation of insulin secretion  (IEA,ISS)
positive regulation of myoblast differentiation  (IEA)
positive regulation of N-terminal peptidyl-lysine acetylation  (IEA,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,ISS)
positive regulation of translation  (IEA,ISS)
pro-B cell differentiation  (IEA,ISS)
protein stabilization  (IEA,ISS)
regulation of DNA damage response, signal transduction by p53 class mediator  (IEA)
regulation of DNA-templated transcription  (IEA,ISS)
regulation of protein stability  (IEA,ISS)
regulation of transcription by RNA polymerase II  (IEA)
response to hypoxia  (ISO)
somatic stem cell population maintenance  (IEA,ISO)
spinal cord development  (IEA,ISS)
sympathetic nervous system development  (IEA,ISS)
T cell differentiation  (IEA,ISS)
ventricular septum morphogenesis  (IEA)

Cellular Component
cytoplasm  (IEA,ISO,ISS)
mitochondrion  (IEA,ISS)
nucleoplasm  (IEA)
nucleus  (IEA,ISS)
transcription regulator complex  (IEA)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SOX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl716,891,319 - 16,892,752 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1716,886,834 - 16,895,488 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2717,852,748 - 17,857,158 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38621,593,751 - 21,598,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl621,593,751 - 21,598,619 (+)EnsemblGRCh38hg38GRCh38
GRCh37621,593,982 - 21,598,850 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36621,701,951 - 21,706,829 (+)NCBINCBI36Build 36hg18NCBI36
Build 34621,701,950 - 21,706,826NCBI
Celera622,827,304 - 22,832,182 (+)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef621,537,779 - 21,542,257 (+)NCBIHuRef
CHM1_1621,596,072 - 21,600,948 (+)NCBICHM1_1
T2T-CHM13v2.0621,466,412 - 21,471,279 (+)NCBIT2T-CHM13v2.0
Sox4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391329,132,902 - 29,137,682 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1329,132,902 - 29,137,696 (-)EnsemblGRCm39 Ensembl
GRCm381328,948,919 - 28,953,699 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1328,948,919 - 28,953,713 (-)EnsemblGRCm38mm10GRCm38
MGSCv371329,042,585 - 29,045,551 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361328,958,181 - 28,961,147 (-)NCBIMGSCv36mm8
Celera1329,175,127 - 29,178,093 (-)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map1312.87NCBI
Sox4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81735,876,298 - 35,881,004 (+)NCBIGRCr8
mRatBN7.21735,667,809 - 35,672,515 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1735,667,537 - 35,673,665 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1735,492,341 - 35,497,036 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01737,096,302 - 37,100,997 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01735,490,340 - 35,495,039 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01737,615,022 - 37,619,728 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01739,476,956 - 39,481,662 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41742,172,863 - 42,177,590 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11742,175,727 - 42,178,618 (+)NCBI
Celera1735,186,015 - 35,190,495 (+)NCBICelera
Cytogenetic Map17p12NCBI
Sox4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554835,076,664 - 5,077,059 (-)NCBIChiLan1.0ChiLan1.0
SOX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2536,226,734 - 36,239,186 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1632,233,423 - 32,238,717 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0621,422,846 - 21,427,779 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1621,765,921 - 21,771,728 (+)NCBIpanpan1.1PanPan1.1panPan2
SOX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13520,098,783 - 20,101,357 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3520,099,773 - 20,101,154 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3520,057,136 - 20,059,714 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03520,209,623 - 20,212,209 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3520,210,531 - 20,211,991 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13520,010,721 - 20,014,021 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03520,075,381 - 20,077,956 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03521,494,787 - 21,497,360 (+)NCBIUU_Cfam_GSD_1.0
Sox4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247565,128,848 - 5,156,174 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SOX4
162 total Variants

Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000100264   ⟹   ENSSSCP00000078207
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl716,891,319 - 16,892,752 (+)Ensembl
RefSeq Acc Id: XM_013977467   ⟹   XP_013832921
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1716,886,834 - 16,895,488 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013832921 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000078207
  ENSSSCP00000078207.1
  ENSSSCP00030007695.1
  ENSSSCP00040000856.1
  ENSSSCP00050016103.1
  ENSSSCP00055037204.1
  ENSSSCP00060030656.1
Reference Protein Sequences
RefSeq Acc Id: XP_013832921   ⟸   XM_013977467
- UniProtKB: F1RUF9 (UniProtKB/TrEMBL),   A0A8D1M1V6 (UniProtKB/TrEMBL),   A0A8D1VWQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000078207   ⟸   ENSSSCT00000100264
Protein Domains
HMG box


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000056309 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00030012493 UniProtKB/TrEMBL
  ENSSSCG00040002450 UniProtKB/TrEMBL
  ENSSSCG00050028951 UniProtKB/TrEMBL
  ENSSSCG00055023725 UniProtKB/TrEMBL
  ENSSSCG00060052219 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000100264 ENTREZGENE
  ENSSSCT00000100264.1 UniProtKB/TrEMBL
  ENSSSCT00030017167.1 UniProtKB/TrEMBL
  ENSSSCT00040002958.1 UniProtKB/TrEMBL
  ENSSSCT00050038903.1 UniProtKB/TrEMBL
  ENSSSCT00055046656.1 UniProtKB/TrEMBL
  ENSSSCT00060071060.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/TrEMBL
InterPro HMG_box_dom UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/TrEMBL
  SOX-11/4 UniProtKB/TrEMBL
KEGG Report ssc:100512542 UniProtKB/TrEMBL
NCBI Gene SOX4 ENTREZGENE
PANTHER SOX TRANSCRIPTION FACTOR UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR SOX-4 UniProtKB/TrEMBL
Pfam HMG_box UniProtKB/TrEMBL
PIRSF SOX-12/11/4a UniProtKB/TrEMBL
PROSITE HMG_BOX_2 UniProtKB/TrEMBL
SMART HMG UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/TrEMBL
UniProt A0A8D1M1V6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1VWQ0 ENTREZGENE, UniProtKB/TrEMBL
  F1RUF9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-06-18 SOX4  SRY-box transcription factor 4  SOX4  SRY-box 4  Symbol and/or name change 5135510 APPROVED