ADA (adenosine deaminase) - Rat Genome Database

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Gene: ADA (adenosine deaminase) Sus scrofa
Analyze
Symbol: ADA
Name: adenosine deaminase
RGD ID: 14266863
Description: ENCODES a protein that exhibits adenosine deaminase activity (ortholog); purine nucleoside binding (ortholog); INVOLVED IN adenosine catabolic process (ortholog); adenosine metabolic process (ortholog); aging (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH adenosine deaminase deficiency (ortholog); asthma (ortholog); autistic disorder (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); dendrite cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: adenosine deaminase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1747,044,495 - 47,072,245 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11747,044,492 - 47,072,232 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21752,502,115 - 52,544,469 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenosine catabolic process  (IBA,IEA,ISO)
adenosine metabolic process  (ISO)
aging  (ISO)
allantoin metabolic process  (IEA)
AMP catabolic process  (IEA)
AMP salvage  (ISO)
dAMP catabolic process  (IEA)
dATP catabolic process  (IEA,ISO)
deoxyadenosine catabolic process  (IEA,ISO)
embryonic digestive tract development  (IEA,ISO)
germinal center B cell differentiation  (IEA,ISO)
GMP salvage  (ISO)
histamine secretion  (ISO)
hypoxanthine biosynthetic process  (IEA,ISO)
hypoxanthine salvage  (IBA)
in utero embryonic development  (ISO)
inosine biosynthetic process  (IBA,IEA,ISO)
liver development  (IEA,ISO)
lung alveolus development  (IEA,ISO)
lung development  (ISO)
negative regulation of adenosine receptor signaling pathway  (IBA,IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of circadian sleep/wake cycle, non-REM sleep  (ISO)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of leukocyte migration  (IEA,ISO)
negative regulation of mature B cell apoptotic process  (IEA,ISO)
negative regulation of mucus secretion  (IEA,ISO)
negative regulation of penile erection  (IEA,ISO)
negative regulation of thymocyte apoptotic process  (IEA,ISO)
Peyer's patch development  (IEA,ISO)
placenta development  (IEA,ISO)
positive regulation of alpha-beta T cell differentiation  (IEA,ISO)
positive regulation of B cell proliferation  (IEA,ISO)
positive regulation of calcium-mediated signaling  (IEA,ISO)
positive regulation of germinal center formation  (IEA,ISO)
positive regulation of heart rate  (IEA,ISO)
positive regulation of smooth muscle contraction  (IEA,ISO)
positive regulation of T cell activation  (ISO)
positive regulation of T cell differentiation  (ISO)
positive regulation of T cell differentiation in thymus  (IEA,ISO)
positive regulation of T cell receptor signaling pathway  (IEA,ISO)
purine nucleotide salvage  (IEA)
purine ribonucleoside monophosphate biosynthetic process  (IEA)
regulation of cell-cell adhesion mediated by integrin  (IEA)
regulation of circadian sleep/wake cycle, sleep  (ISO)
regulation of T cell differentiation  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (IEA,ISO)
response to morphine  (ISO)
response to vitamin E  (ISO)
response to xenobiotic stimulus  (ISO)
T cell activation  (IBA,IEA)
trophectodermal cell differentiation  (IEA,ISO)
xanthine biosynthetic process  (IEA,ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
ADA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1747,044,495 - 47,072,245 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11747,044,492 - 47,072,232 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21752,502,115 - 52,544,469 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2044,619,522 - 44,652,233 (-)EnsemblGRCh38hg38GRCh38
GRCh382044,619,522 - 44,651,699 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372043,248,163 - 43,280,340 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362042,681,577 - 42,713,790 (-)NCBINCBI36hg18NCBI36
Build 342042,681,577 - 42,713,790NCBI
Celera2039,956,805 - 39,989,017 (-)NCBI
Cytogenetic Map20q13.12NCBI
HuRef2039,989,704 - 40,021,872 (-)NCBIHuRef
CHM1_12043,151,279 - 43,183,492 (-)NCBICHM1_1
Ada
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392163,568,491 - 163,592,161 (-)NCBIGRCm39mm39
GRCm39 Ensembl2163,568,504 - 163,592,159 (-)Ensembl
GRCm382163,726,571 - 163,750,239 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2163,726,584 - 163,750,239 (-)EnsemblGRCm38mm10GRCm38
MGSCv372163,552,320 - 163,575,913 (-)NCBIGRCm37mm9NCBIm37
MGSCv362163,418,025 - 163,441,618 (-)NCBImm8
Celera2169,670,309 - 169,693,933 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map284.44NCBI
Ada
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23152,398,745 - 152,422,854 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl3152,398,747 - 152,447,088 (-)Ensembl
Rnor_6.03160,115,840 - 160,139,947 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,115,842 - 160,139,947 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03166,306,001 - 166,330,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43154,636,530 - 154,660,637 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13154,542,567 - 154,566,673 (-)NCBI
Celera3151,051,040 - 151,075,153 (-)NCBICelera
Cytogenetic Map3q42NCBI
Ada
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544512,696,096 - 12,717,488 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544512,696,096 - 12,717,488 (+)NCBIChiLan1.0ChiLan1.0
ADA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12042,044,613 - 42,076,868 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2042,044,613 - 42,076,868 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02040,950,238 - 40,982,481 (-)NCBIMhudiblu_PPA_v0panPan3
ADA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12432,083,786 - 32,119,810 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2432,083,931 - 32,111,160 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2431,725,150 - 31,756,275 (-)NCBI
ROS_Cfam_1.02432,790,716 - 32,821,895 (-)NCBI
UMICH_Zoey_3.12432,052,411 - 32,083,510 (-)NCBI
UNSW_CanFamBas_1.02432,167,117 - 32,198,181 (-)NCBI
UU_Cfam_GSD_1.02432,708,375 - 32,739,510 (-)NCBI
Ada
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640181,082,150 - 181,103,907 (-)NCBI
SpeTri2.0NW_0049365302,217,713 - 2,224,070 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1219,167,209 - 19,200,233 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605067,836,179 - 67,868,616 (+)NCBIVero_WHO_p1.0
Ada
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247909,809,550 - 9,829,199 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 1 4 1 2 3
Low 7 3 1 1 2 20 2 1
Below cutoff 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000030066   ⟹   ENSSSCP00000022085
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1747,045,121 - 47,064,473 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000081342   ⟹   ENSSSCP00000068511
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1747,044,495 - 47,072,245 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000086571   ⟹   ENSSSCP00000070139
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1747,045,121 - 47,061,955 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000089003   ⟹   ENSSSCP00000070890
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1747,044,495 - 47,072,245 (-)Ensembl
RefSeq Acc Id: XM_021077978   ⟹   XP_020933637
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11747,044,492 - 47,072,232 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020933637 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein JAG69746 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020933637   ⟸   XM_021077978
- Sequence:
RefSeq Acc Id: ENSSSCP00000022085   ⟸   ENSSSCT00000030066
RefSeq Acc Id: ENSSSCP00000070890   ⟸   ENSSSCT00000089003
RefSeq Acc Id: ENSSSCP00000070139   ⟸   ENSSSCT00000086571
RefSeq Acc Id: ENSSSCP00000068511   ⟸   ENSSSCT00000081342
Protein Domains
A_deaminase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000021255 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000022085 UniProtKB/TrEMBL
  ENSSSCP00000068511 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000070139 UniProtKB/TrEMBL
  ENSSSCP00000070890 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000030066 UniProtKB/TrEMBL
  ENSSSCT00000081342 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000086571 UniProtKB/TrEMBL
  ENSSSCT00000089003 UniProtKB/TrEMBL
InterPro A/AMP_deam_AS UniProtKB/TrEMBL
  A/AMP_deaminase_dom UniProtKB/TrEMBL
  A_deaminase UniProtKB/TrEMBL
  Ado/ade_deaminase UniProtKB/TrEMBL
  Metal_Hydrolase UniProtKB/TrEMBL
NCBI Gene ADA ENTREZGENE
Pfam A_deaminase UniProtKB/TrEMBL
PROSITE A_DEAMINASE UniProtKB/TrEMBL
Superfamily-SCOP SSF51556 UniProtKB/TrEMBL
TIGRFAMs aden_deam UniProtKB/TrEMBL
UniProt A0A5G2QU98_PIG UniProtKB/TrEMBL
  A0A5G2R146_PIG UniProtKB/TrEMBL
  A0A5G2RG61_PIG UniProtKB/TrEMBL
  I3LDF4_PIG UniProtKB/TrEMBL
VGNC ID VGNC:95889 ENTREZGENE