SREBF1 (sterol regulatory element binding transcription factor 1) - Rat Genome Database

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Gene: SREBF1 (sterol regulatory element binding transcription factor 1) Sus scrofa
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Symbol: SREBF1
Name: sterol regulatory element binding transcription factor 1
RGD ID: 14144399
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN aging (ortholog); cellular response to fatty acid (ortholog); cellular response to insulin stimulus (ortholog); PARTICIPATES IN mTOR signaling pathway; sterol regulatory element-binding protein signaling pathway; ASSOCIATED WITH alcoholic hepatitis (ortholog); autistic disorder (ortholog); Diabetic Nephropathies (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); intracellular membrane-bounded organelle (ortholog); INTERACTS WITH aldehydo-D-glucose; D-glucose; ezetimibe
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ADD1; adipocyte determination and differentiation-dependent factor 1; SCREBP1; SREBF1c; SREBP-1; SREBP-1C; SREBP1; sterol regulatory binding transcription factor 1; sterol regulatory element-binding protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,733,907 - 60,751,265 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,733,967 - 60,750,951 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
cellular response to fatty acid  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to starvation  (IEA)
cholesterol metabolic process  (IEA,ISO)
circadian rhythm  (IEA,ISO)
fat cell differentiation  (IEA,ISO)
insulin receptor signaling pathway  (IEA,ISO)
intracellular receptor signaling pathway  (IEA)
lipid biosynthetic process  (IEA,ISS)
lipid localization  (ISO)
lung development  (ISO)
mRNA transcription by RNA polymerase II  (IEA,ISO)
negative regulation of insulin secretion  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of cholesterol biosynthetic process  (IEA,ISO,ISS)
positive regulation of histone deacetylation  (IEA,ISO)
positive regulation of innate immune response  (ISO)
positive regulation of lipid biosynthetic process  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (IEA)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of triglyceride biosynthetic process  (IEA,ISO,ISS)
regulation of autophagy of mitochondrion  (IEA)
regulation of fatty acid metabolic process  (IEA,ISO)
regulation of heart rate by chemical signal  (IEA,ISO)
regulation of insulin secretion  (ISO)
regulation of lipid storage  (ISO)
regulation of protein stability  (IEA)
regulation of protein targeting to mitochondrion  (IEA)
regulation of transcription by RNA polymerase II  (IBA,ISS)
regulation of transcription, DNA-templated  (ISO,ISS)
response to cAMP  (ISO)
response to ethanol  (ISO)
response to fatty acid  (ISO)
response to food  (ISO)
response to glucagon  (ISO)
response to glucose  (IEA,ISO)
response to lipid  (ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (ISO)
response to progesterone  (ISO)
response to retinoic acid  (ISO)
response to xenobiotic stimulus  (ISO)
SREBP signaling pathway  (IEA,ISS)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:10481259   PMID:16520310   PMID:17878274   PMID:23657179   PMID:28367099  


Genomics

Comparative Map Data
SREBF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,733,907 - 60,751,265 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,733,967 - 60,750,951 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SREBF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1717,810,399 - 17,837,002 (-)EnsemblGRCh38hg38GRCh38
GRCh381717,811,334 - 17,837,017 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371717,714,648 - 17,740,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361717,656,111 - 17,681,050 (-)NCBINCBI36hg18NCBI36
Build 341717,656,110 - 17,681,050NCBI
Celera1718,654,135 - 18,680,982 (-)NCBI
Cytogenetic Map17p11.2NCBI
HuRef1717,466,908 - 17,494,061 (-)NCBIHuRef
CHM1_11717,723,458 - 17,749,109 (-)NCBICHM1_1
Srebf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,089,910 - 60,113,407 (-)NCBIGRCm39mm39
GRCm39 Ensembl1160,089,915 - 60,113,407 (-)Ensembl
GRCm381160,199,084 - 60,224,186 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,199,089 - 60,222,581 (-)EnsemblGRCm38mm10GRCm38
MGSCv371160,012,591 - 60,034,106 (-)NCBIGRCm37mm9NCBIm37
MGSCv361160,015,284 - 60,036,799 (-)NCBImm8
Celera1166,655,030 - 66,676,425 (+)NCBICelera
Cytogenetic Map11B2NCBI
Srebf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21045,007,637 - 45,029,650 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1045,007,637 - 45,029,650 (-)Ensembl
Rnor_6.01046,570,996 - 46,593,021 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,570,996 - 46,593,009 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01046,326,015 - 46,348,035 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,461,684 - 46,483,646 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1044,264,866 - 44,286,830 (-)NCBICelera
Cytogenetic Map10q22NCBI
Srebf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955577171,425 - 186,046 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955577171,425 - 183,669 (+)NCBIChiLan1.0ChiLan1.0
SREBF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11738,405,794 - 38,432,045 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1738,405,794 - 38,432,045 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01733,458,196 - 33,484,643 (+)NCBIMhudiblu_PPA_v0panPan3
SREBF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1541,663,809 - 41,686,764 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl541,663,773 - 41,686,776 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha541,802,335 - 41,825,236 (+)NCBI
ROS_Cfam_1.0541,769,693 - 41,792,654 (+)NCBI
UMICH_Zoey_3.1541,737,352 - 41,760,245 (+)NCBI
UNSW_CanFamBas_1.0541,684,736 - 41,707,631 (+)NCBI
UU_Cfam_GSD_1.0541,876,687 - 41,899,587 (+)NCBI
Srebf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560261,447,521 - 61,458,579 (+)NCBI
SpeTri2.0NW_0049367411,408,669 - 1,419,717 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SREBF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11616,847,603 - 16,874,239 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1616,845,491 - 16,859,554 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660594,037,449 - 4,063,735 (+)NCBIVero_WHO_p1.0
Srebf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248493,602,103 - 3,623,922 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 5 3 1 5 2 20 2 2 3
Below cutoff 5 1 2 3 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_214157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021066226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB686492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AEMK02000083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF102873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH015790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY272051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY307771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY338729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY496867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ417902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ464433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ519396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ519397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ904278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01043446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC480520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000055934   ⟹   ENSSSCP00000034784
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1260,733,907 - 60,751,265 (+)Ensembl
RefSeq Acc Id: NM_214157   ⟹   NP_999322
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11260,733,967 - 60,750,520 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021066226   ⟹   XP_020921885
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11260,741,312 - 60,750,951 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_999322   ⟸   NM_214157
- UniProtKB: O97676 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_020921885   ⟸   XM_021066226
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000034784   ⟸   ENSSSCT00000055934
Protein Domains
bHLH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000033626 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070003633 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000034784 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070005599 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000055934 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070006864 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397308 UniProtKB/Swiss-Prot
NCBI Gene SREBF1 ENTREZGENE
Pfam HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1SS36_PIG UniProtKB/TrEMBL
  O97676 ENTREZGENE, UniProtKB/Swiss-Prot
  W8VSW6_PIG UniProtKB/TrEMBL
UniProt Secondary A0A286ZTJ9 UniProtKB/TrEMBL
  Q1W0S6 UniProtKB/Swiss-Prot
  Q6RIB9 UniProtKB/Swiss-Prot
  Q7YS02 UniProtKB/Swiss-Prot
VGNC ID VGNC:99083 ENTREZGENE