MPO (myeloperoxidase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: MPO (myeloperoxidase) Sus scrofa
Analyze
Symbol: MPO
Name: myeloperoxidase
RGD ID: 14167425
Description: ENCODES a protein that exhibits peroxidase activity (ortholog); INVOLVED IN defense response to fungus (ortholog); defense response to Gram-positive bacterium (ortholog); hydrogen peroxide catabolic process (ortholog); PARTICIPATES IN etoposide pharmacodynamics pathway; etoposide pharmacokinetics pathway; interleukin-23 signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); alcoholic liver cirrhosis (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1234,556,408 - 34,567,904 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11234,557,031 - 34,570,091 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21236,245,391 - 36,256,372 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (ISO)
Alzheimer's disease 1  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
bacterial pneumonia  (ISO)
brain disease  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Burns  (ISO)
cardiovascular system disease  (ISO)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (ISO)
Contrast-Induced Nephropathy  (ISO)
cystic fibrosis  (ISO)
cystitis  (ISO)
Drug Eruptions  (ISO)
end stage renal disease  (ISO)
Enteritis  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
extrahepatic cholestasis  (ISO)
glomerulonephritis  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hypoxia  (ISO)
Inflammation  (ISO)
intellectual disability  (ISO)
interstitial lung disease  (ISO)
Joubert syndrome 1  (ISO)
keratosis  (ISO)
Kidney Calculi  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
liver cirrhosis  (ISO)
lung cancer  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lupus nephritis  (ISO)
major depressive disorder  (ISO)
Myeloperoxidase Deficiency  (ISO)
Myocardial Ischemia  (ISO)
Occupational Diseases  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
pleurisy  (ISO)
pre-malignant neoplasm  (ISO)
Prostatic Neoplasms  (ISO)
renovascular hypertension  (ISO)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
status asthmaticus  (ISO)
Systemic Candidiasis  (ISO)
traumatic brain injury  (ISO)
trichuriasis  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
urticaria  (ISO)
vasculitis  (ISO)
Viral Bronchiolitis  (ISO)
Wounds and Injuries  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:23691142   PMID:30032202  


Genomics

Comparative Map Data
MPO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1234,556,408 - 34,567,904 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11234,557,031 - 34,570,091 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21236,245,391 - 36,256,372 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MPO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381758,269,855 - 58,280,935 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1758,269,855 - 58,280,935 (-)EnsemblGRCh38hg38GRCh38
GRCh371756,347,216 - 56,358,296 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361753,702,216 - 53,713,295 (-)NCBINCBI36Build 36hg18NCBI36
Build 341753,702,215 - 53,713,295NCBI
Celera1752,808,995 - 52,820,066 (-)NCBICelera
Cytogenetic Map17q22NCBI
HuRef1751,708,013 - 51,718,966 (-)NCBIHuRef
CHM1_11756,412,238 - 56,423,315 (-)NCBICHM1_1
T2T-CHM13v2.01759,137,736 - 59,148,814 (-)NCBIT2T-CHM13v2.0
Mpo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391187,684,610 - 87,695,238 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1187,684,407 - 87,695,239 (+)EnsemblGRCm39 Ensembl
GRCm381187,793,784 - 87,804,412 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1187,793,581 - 87,804,413 (+)EnsemblGRCm38mm10GRCm38
MGSCv371187,607,286 - 87,617,914 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361187,609,776 - 87,620,592 (+)NCBIMGSCv36mm8
Celera1197,389,547 - 97,400,150 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1152.22NCBI
Mpo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81073,092,124 - 73,102,057 (+)NCBIGRCr8
mRatBN7.21072,594,883 - 72,608,862 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1072,594,661 - 72,604,819 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1077,205,622 - 77,215,277 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01076,710,570 - 76,720,225 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01072,175,076 - 72,184,731 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01075,087,892 - 75,098,260 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1075,087,892 - 75,098,260 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01075,004,128 - 75,014,496 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41076,085,872 - 76,097,012 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1071,507,771 - 71,517,382 (+)NCBICelera
Cytogenetic Map10q26NCBI
Mpo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554514,743,744 - 4,753,358 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554514,743,744 - 4,753,358 (+)NCBIChiLan1.0ChiLan1.0
MPO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21974,441,104 - 74,453,615 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11779,252,255 - 79,263,874 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01752,333,882 - 52,357,838 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11757,189,654 - 57,212,111 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1757,201,073 - 57,212,111 (-)Ensemblpanpan1.1panPan2
MPO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1932,927,483 - 32,938,007 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl932,927,483 - 32,937,820 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha932,164,643 - 32,175,070 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0933,734,267 - 33,744,696 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl933,734,273 - 33,744,637 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1932,520,407 - 32,530,846 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0932,803,860 - 32,814,324 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0932,897,366 - 32,907,792 (-)NCBIUU_Cfam_GSD_1.0
Mpo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560232,254,998 - 32,265,476 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364904,809,631 - 4,819,070 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364904,809,773 - 4,819,070 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MPO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11635,120,194 - 35,130,851 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1635,120,581 - 35,130,671 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660775,935,107 - 5,946,375 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mpo
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624871121,026 - 131,323 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624871121,026 - 131,433 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MPO
419 total Variants

Expression

RNA-SEQ Expression

ectoderm
hemolymphoid system
nervous system
respiratory system
2 1 2 1

Sequence


Ensembl Acc Id: ENSSSCT00000019199   ⟹   ENSSSCP00000018691
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1234,556,408 - 34,567,826 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000035412   ⟹   ENSSSCP00000030636
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1234,557,031 - 34,567,904 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000096878   ⟹   ENSSSCP00000076835
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1234,557,031 - 34,567,180 (-)Ensembl
RefSeq Acc Id: XM_003131655   ⟹   XP_003131703
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11234,557,031 - 34,570,091 (-)NCBI
Sequence:
RefSeq Acc Id: XP_003131703   ⟸   XM_003131655
- UniProtKB: A0A8D1DLZ0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000018691   ⟸   ENSSSCT00000019199
Ensembl Acc Id: ENSSSCP00000030636   ⟸   ENSSSCT00000035412
Ensembl Acc Id: ENSSSCP00000076835   ⟸   ENSSSCT00000096878


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000017637 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025025190 UniProtKB/TrEMBL
  ENSSSCG00040016308 UniProtKB/TrEMBL
  ENSSSCG00045014498 UniProtKB/TrEMBL
  ENSSSCG00055018927 UniProtKB/TrEMBL
  ENSSSCG00065028391 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000019199.5 UniProtKB/TrEMBL
  ENSSSCT00000035412 ENTREZGENE
  ENSSSCT00000035412.3 UniProtKB/TrEMBL
  ENSSSCT00000096878.1 UniProtKB/TrEMBL
  ENSSSCT00025034335.1 UniProtKB/TrEMBL
  ENSSSCT00040021986.1 UniProtKB/TrEMBL
  ENSSSCT00045024834.1 UniProtKB/TrEMBL
  ENSSSCT00055037838.1 UniProtKB/TrEMBL
  ENSSSCT00065038332.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.640.10 UniProtKB/TrEMBL
InterPro Haem_peroxidase_animal UniProtKB/TrEMBL
  Haem_peroxidase_sf UniProtKB/TrEMBL
  Haem_peroxidase_sf_animal UniProtKB/TrEMBL
  Peroxidase/ROS_Generation UniProtKB/TrEMBL
KEGG Report ssc:100517120 UniProtKB/TrEMBL
NCBI Gene MPO ENTREZGENE
PANTHER OXIDASE/PEROXIDASE UniProtKB/TrEMBL
  PTHR11475:SF108 UniProtKB/TrEMBL
Pfam An_peroxidase UniProtKB/TrEMBL
PRINTS ANPEROXIDASE UniProtKB/TrEMBL
PROSITE PEROXIDASE_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF48113 UniProtKB/TrEMBL
UniProt A0A8D0RKB4_PIG UniProtKB/TrEMBL
  A0A8D1DLZ0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FBY9_PIG UniProtKB/TrEMBL
  F1RRP1_PIG UniProtKB/TrEMBL
  K7GRV6_PIG UniProtKB/TrEMBL
  Q9TT25_PIG UniProtKB/TrEMBL
VGNC ID VGNC:90328 ENTREZGENE