TGFB2 (transforming growth factor beta 2) - Rat Genome Database

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Gene: TGFB2 (transforming growth factor beta 2) Sus scrofa
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Symbol: TGFB2
Name: transforming growth factor beta 2
RGD ID: 14226657
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN neutrophil chemotaxis; positive regulation of immune response; activation of protein kinase activity (ortholog); PARTICIPATES IN glypican signaling pathway; Hedgehog signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Aberrant Crypt Foci (ortholog); aortic aneurysm (ortholog); aortic disease (ortholog); FOUND IN axon (ortholog); basement membrane (ortholog); cell surface (ortholog); INTERACTS WITH resveratrol
Type: protein-coding
RefSeq Status: MODEL
Also known as: Transforming growth factor beta-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl108,305,424 - 8,405,771 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1108,306,136 - 8,435,307 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21010,353,794 - 10,476,143 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap10p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
resveratrol  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (IEA,ISS)
aging  (ISO)
ascending aorta morphogenesis  (ISO)
atrial septum morphogenesis  (ISO)
atrial septum primum morphogenesis  (ISO)
atrioventricular valve morphogenesis  (ISO)
axon guidance  (ISO)
blood vessel development  (ISO)
blood vessel remodeling  (ISO)
BMP signaling pathway  (IBA)
cardiac epithelial to mesenchymal transition  (IEA,ISS)
cardiac muscle cell proliferation  (IEA,ISS)
cardiac right ventricle morphogenesis  (ISO)
cardioblast differentiation  (IEA,ISS)
cartilage condensation  (ISO)
cell death  (ISS)
cell migration  (ISS)
cell morphogenesis  (IEA,ISS)
cell-cell junction organization  (IEA,ISS)
collagen fibril organization  (IEA,ISS)
cranial skeletal system development  (ISO)
digestive tract development  (ISO)
dopamine biosynthetic process  (ISS)
embryonic digestive tract development  (IEA,ISS)
embryonic limb morphogenesis  (ISO)
embryonic neurocranium morphogenesis  (ISO)
endocardial cushion fusion  (ISO)
endocardial cushion morphogenesis  (ISO)
epithelial to mesenchymal transition  (ISS)
extracellular matrix organization  (ISO)
extrinsic apoptotic signaling pathway  (IEA,ISS)
eye development  (IEA,ISS)
face morphogenesis  (ISO)
female pregnancy  (ISO)
frontal suture morphogenesis  (ISO)
glial cell migration  (IEA,ISS)
hair follicle development  (IEA,ISO,ISS)
hair follicle morphogenesis  (ISS)
heart development  (ISO,ISS)
heart morphogenesis  (ISS)
heart valve morphogenesis  (ISO)
hemopoiesis  (ISS)
hindbrain development  (ISO)
inner ear development  (ISO)
kidney development  (ISO)
male gonad development  (ISO)
membranous septum morphogenesis  (ISO)
mesoderm formation  (TAS)
negative regulation of alkaline phosphatase activity  (IEA,ISS)
negative regulation of angiogenesis  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of cartilage development  (ISO)
negative regulation of cell growth  (IEA,ISS)
negative regulation of cell population proliferation  (ISO,ISS)
negative regulation of epithelial cell proliferation  (IEA,ISS)
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of immune response  (ISO)
negative regulation of macrophage cytokine production  (IEA,ISS)
negative regulation of Ras protein signal transduction  (ISO)
negative regulation of release of sequestered calcium ion into cytosol  (ISO)
neural retina development  (ISO)
neural tube closure  (ISO)
neuron development  (ISS)
neuron fate commitment  (ISO)
neutrophil chemotaxis  (IDA)
outflow tract septum morphogenesis  (ISO)
pancreas development  (ISO)
pathway-restricted SMAD protein phosphorylation  (IEA,ISS)
pericyte cell differentiation  (ISO)
pharyngeal arch artery morphogenesis  (ISO)
positive regulation of activation-induced cell death of T cells  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cardioblast differentiation  (IEA,ISS)
positive regulation of cell adhesion mediated by integrin  (IEA,ISS)
positive regulation of cell cycle  (ISS)
positive regulation of cell division  (IEA)
positive regulation of cell growth  (IEA,ISS)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IEA,ISO,ISS)
positive regulation of epithelial cell migration  (IEA,ISS)
positive regulation of epithelial to mesenchymal transition  (IEA,ISS)
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
positive regulation of extracellular matrix disassembly  (ISO)
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of GTP binding  (ISO)
positive regulation of heart contraction  (IEA,ISS)
positive regulation of immune response  (IDA)
positive regulation of integrin biosynthetic process  (IEA,ISS)
positive regulation of neuron apoptotic process  (IEA,ISS)
positive regulation of Notch signaling pathway  (IEA)
positive regulation of ossification  (IEA,ISS)
positive regulation of pathway-restricted SMAD protein phosphorylation  (IBA)
positive regulation of phosphatidylinositol 3-kinase signaling  (IEA,ISS)
positive regulation of pri-miRNA transcription by RNA polymerase II  (IEA)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein secretion  (IEA,ISS)
positive regulation of stress-activated MAPK cascade  (IEA,ISS)
positive regulation of timing of catagen  (IEA,ISS)
protein phosphorylation  (ISS)
pulmonary valve morphogenesis  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of apoptotic process  (ISO)
regulation of apoptotic process involved in outflow tract morphogenesis  (ISO)
regulation of cell cycle  (IEA,ISS)
regulation of cell population proliferation  (IBA)
regulation of complement-dependent cytotoxicity  (ISO)
regulation of extracellular matrix organization  (ISO)
regulation of timing of catagen  (ISS)
regulation of transforming growth factor beta2 production  (IEA,ISS)
response to cold  (ISO)
response to cytokine  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to hypoxia  (IEA,ISS)
response to laminar fluid shear stress  (ISO)
response to organonitrogen compound  (ISO)
response to progesterone  (IEA,ISS)
response to radiation  (ISO)
response to retinoic acid  (ISO)
response to vitamin D  (ISO)
response to wounding  (IEA,ISS)
response to xenobiotic stimulus  (IEA,ISO,ISS)
salivary gland morphogenesis  (IEA,ISS)
secondary palate development  (ISO)
signal transduction  (IEA)
skeletal muscle tissue development  (ISO)
skeletal system development  (ISO)
SMAD protein signal transduction  (IBA,IEA,ISS)
somatic stem cell division  (ISS)
substantia propria of cornea development  (ISO)
thyroid gland development  (ISO)
transforming growth factor beta receptor signaling pathway  (IBA,IEA,ISS)
uterus development  (ISO)
ventricular septum morphogenesis  (ISO)
ventricular trabecula myocardium morphogenesis  (ISO)
wound healing  (ISO,ISS)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:1280203   PMID:2879635   PMID:8133057   PMID:8661698   PMID:8785609   PMID:14681463   PMID:17694440   PMID:20378284   PMID:25147235  


Genomics

Comparative Map Data
TGFB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl108,305,424 - 8,405,771 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1108,306,136 - 8,435,307 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21010,353,794 - 10,476,143 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap10p16NCBI
TGFB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1218,345,336 - 218,444,619 (+)EnsemblGRCh38hg38GRCh38
GRCh381218,345,336 - 218,444,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371218,518,678 - 218,617,961 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361216,586,491 - 216,681,596 (+)NCBINCBI36hg18NCBI36
Build 341214,908,262 - 215,003,365NCBI
Celera1191,735,848 - 191,834,418 (+)NCBI
Cytogenetic Map1q41NCBI
HuRef1189,186,842 - 189,286,057 (+)NCBIHuRef
CHM1_11219,791,024 - 219,890,484 (+)NCBICHM1_1
Tgfb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391186,354,984 - 186,441,504 (-)NCBIGRCm39mm39
GRCm39 Ensembl1186,354,989 - 186,438,186 (-)Ensembl
GRCm381186,622,787 - 186,709,697 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,622,792 - 186,705,989 (-)EnsemblGRCm38mm10GRCm38
MGSCv371188,447,065 - 188,529,871 (-)NCBIGRCm37mm9NCBIm37
MGSCv361188,324,430 - 188,406,777 (-)NCBImm8
Celera1193,563,609 - 193,649,724 (-)NCBICelera
Cytogenetic Map1H5NCBI
cM Map189.95NCBI
Tgfb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21398,160,075 - 98,261,771 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1398,160,087 - 98,261,405 (-)Ensembl
Rnor_6.013105,039,639 - 105,142,010 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13105,039,853 - 105,141,030 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013109,679,866 - 109,792,609 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413102,718,703 - 102,818,768 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.113102,907,748 - 103,007,811 (-)NCBI
Celera1397,669,691 - 97,769,426 (-)NCBICelera
Cytogenetic Map13q26NCBI
Tgfb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955406172,814 - 249,248 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955406174,949 - 249,248 (-)NCBIChiLan1.0ChiLan1.0
TGFB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11198,758,718 - 198,856,853 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1198,758,751 - 198,859,041 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01193,907,398 - 194,005,800 (+)NCBIMhudiblu_PPA_v0panPan3
TGFB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13813,430,832 - 13,511,655 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3813,429,148 - 13,510,242 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3813,472,728 - 13,552,654 (+)NCBI
ROS_Cfam_1.03813,464,207 - 13,544,357 (+)NCBI
UMICH_Zoey_3.13813,473,487 - 13,553,481 (+)NCBI
UNSW_CanFamBas_1.03813,819,811 - 13,899,809 (+)NCBI
UU_Cfam_GSD_1.03814,128,921 - 14,209,014 (+)NCBI
Tgfb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934458,300,141 - 58,383,975 (-)NCBI
SpeTri2.0NW_004936628310,720 - 394,002 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12511,163,651 - 11,259,868 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2511,163,100 - 11,258,470 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605511,574,533 - 11,672,282 (-)NCBIVero_WHO_p1.0
Tgfb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248352,363,059 - 2,436,536 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 10 4 3 5 2 23 2 2 1
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000011833   ⟹   ENSSSCP00000011530
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl108,305,424 - 8,405,771 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000056615   ⟹   ENSSSCP00000035439
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl108,306,390 - 8,390,617 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000065533   ⟹   ENSSSCP00000059250
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl108,305,538 - 8,390,345 (+)Ensembl
RefSeq Acc Id: XM_021064293   ⟹   XP_020919952
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1108,306,181 - 8,392,257 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021064294   ⟹   XP_020919953
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1108,306,190 - 8,435,300 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021064295   ⟹   XP_020919954
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1108,306,136 - 8,392,257 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021064296   ⟹   XP_020919955
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1108,336,493 - 8,435,307 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021064297   ⟹   XP_020919956
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1108,327,779 - 8,435,306 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021064298   ⟹   XP_020919957
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1108,306,190 - 8,392,257 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020919954   ⟸   XM_021064295
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020919952   ⟸   XM_021064293
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020919953   ⟸   XM_021064294
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020919957   ⟸   XM_021064298
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_020919956   ⟸   XM_021064297
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_020919955   ⟸   XM_021064296
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSSSCP00000059250   ⟸   ENSSSCT00000065533
RefSeq Acc Id: ENSSSCP00000011530   ⟸   ENSSSCT00000011833
RefSeq Acc Id: ENSSSCP00000035439   ⟸   ENSSSCT00000056615
Protein Domains
TGF_BETA_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010816 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000011530 UniProtKB/TrEMBL
  ENSSSCP00000035439 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000059250 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011833 UniProtKB/TrEMBL
  ENSSSCT00000056615 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000065533 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene TGFB2 ENTREZGENE
PANTHER PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF TGF-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TGFBETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFBETA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A286ZV08_PIG UniProtKB/TrEMBL
  A0A287BS41_PIG UniProtKB/TrEMBL
  F1S9L0_PIG UniProtKB/TrEMBL
  P09858 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:95541 ENTREZGENE