FN1 (fibronectin 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: FN1 (fibronectin 1) Sus scrofa
Analyze
Symbol: FN1
Name: fibronectin 1
RGD ID: 13923809
Description: ENCODES a protein that exhibits mercury ion binding (ortholog); protease binding (ortholog); INVOLVED IN calcium-independent cell-matrix adhesion (ortholog); cell adhesion (ortholog); cell-matrix adhesion (ortholog); PARTICIPATES IN syndecan signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Otitis Media (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN basement membrane (ortholog); extracellular matrix (ortholog); extracellular space (ortholog); INTERACTS WITH 4-methylumbelliferone; anthra[1,9-cd]pyrazol-6(2H)-one; arecoline
Type: protein-coding
RefSeq Status: MODEL
Previously known as: fibronectin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15117,658,099 - 117,731,014 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115117,658,158 - 117,737,145 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215130,357,895 - 130,430,785 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Otitis Media  (ISO)
Animal Mammary Neoplasms  (ISO)
aortic valve insufficiency  (ISO)
brain disease  (ISO)
Breast Neoplasms  (ISO)
calcium oxalate nephrolithiasis  (ISO)
carcinoma  (ISO)
Cardiac Fibrosis  (ISO)
Chronic Intermittent Hypoxia  (ISO)
chronic kidney disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
end stage renal disease  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
focal segmental glomerulosclerosis  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
glomerulonephritis  (ISO)
Glomerulopathy with Giant Fibrillar Deposits  (ISO)
hypertension  (ISO)
IgA glomerulonephritis  (ISO)
iron deficiency anemia  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
malignant mesothelioma  (ISO)
megacolon  (ISO)
membranoproliferative glomerulonephritis  (ISO)
myocardial infarction  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
nephrotic syndrome  (ISO)
Neurodevelopmental Disorders  (ISO)
osteoarthritis  (ISO)
pulmonary fibrosis  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
renovascular hypertension  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (ISO)
spondyloepimetaphyseal dysplasia, Strudwick type  (ISO)
spondylometaphyseal dysplasia  (ISO)
spondylometaphyseal dysplasia corner fracture type  (ISO)
Spontaneous Abortions  (ISO)
Staphylococcal Pneumonia  (ISO)
Sturge-Weber syndrome  (ISO)
submandibular gland disease  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
VACTERL association  (ISO)
X-linked Alport syndrome  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (IEA)
biological process involved in interaction with symbiont  (IEA)
calcium-independent cell-matrix adhesion  (IEA,ISO)
cell adhesion  (IEA,ISO)
cell-matrix adhesion  (IBA,IEA,ISO)
cell-substrate junction assembly  (IBA,IEA,ISO)
cellular response to amyloid-beta  (ISO)
cellular response to angiotensin  (ISO)
cellular response to BMP stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mercury ion  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to prostaglandin E stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
endodermal cell differentiation  (IEA)
extracellular matrix organization  (ISO)
glial cell migration  (ISO)
heart development  (IBA,IEA)
integrin activation  (IEA)
integrin-mediated signaling pathway  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of collagen biosynthetic process  (ISO)
negative regulation of monocyte activation  (IEA)
negative regulation of transforming growth factor beta production  (IEA)
nervous system development  (IBA,IEA)
neural crest cell migration involved in autonomic nervous system development  (IEA)
positive regulation of axon extension  (IEA,ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (IEA)
positive regulation of chemotaxis  (ISO)
positive regulation of fibroblast proliferation  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of substrate-dependent cell migration, cell attachment to substrate  (IEA)
regulation of cell shape  (IEA)
regulation of ERK1 and ERK2 cascade  (IEA)
regulation of protein phosphorylation  (IEA)
response to activity  (ISO)
response to glucocorticoid  (ISO)
response to iron ion  (ISO)
response to ischemia  (ISO)
response to ozone  (ISO)
response to xenobiotic stimulus  (ISO)
substrate adhesion-dependent cell spreading  (IEA)
wound healing  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:15123658   PMID:22301074   PMID:23139787   PMID:24738072   PMID:29254288   PMID:30032202   PMID:32165261  


Genomics

Comparative Map Data
FN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15117,658,099 - 117,731,014 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115117,658,158 - 117,737,145 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215130,357,895 - 130,430,785 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382215,360,865 - 215,436,068 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2215,360,440 - 215,436,073 (-)EnsemblGRCh38hg38GRCh38
GRCh372216,225,588 - 216,300,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362215,933,422 - 216,009,036 (-)NCBINCBI36Build 36hg18NCBI36
Build 342216,050,686 - 216,126,297NCBI
Celera2209,994,808 - 210,070,377 (-)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2208,082,209 - 208,158,070 (-)NCBIHuRef
CHM1_12216,231,077 - 216,306,650 (-)NCBICHM1_1
T2T-CHM13v2.02215,845,895 - 215,921,094 (-)NCBIT2T-CHM13v2.0
Fn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39171,624,632 - 71,692,439 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl171,624,679 - 71,692,359 (-)EnsemblGRCm39 Ensembl
GRCm38171,585,473 - 71,653,280 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl171,585,520 - 71,653,200 (-)EnsemblGRCm38mm10GRCm38
MGSCv37171,632,097 - 71,699,745 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36171,518,731 - 71,586,379 (-)NCBIMGSCv36mm8
Celera172,141,007 - 72,208,976 (-)NCBICelera
Cytogenetic Map1C3NCBI
cM Map136.05NCBI
Fn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8980,645,507 - 80,714,200 (-)NCBIGRCr8
mRatBN7.2973,196,044 - 73,264,695 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl973,196,044 - 73,264,678 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx981,661,421 - 81,730,088 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0986,790,269 - 86,858,938 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0985,180,537 - 85,249,204 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0978,900,111 - 78,969,018 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl978,900,103 - 78,969,078 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0978,674,437 - 78,743,423 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4970,702,181 - 70,771,155 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1970,849,162 - 70,918,137 (-)NCBI
Celera970,607,233 - 70,675,716 (-)NCBICelera
RH 3.4 Map9673.9RGD
Cytogenetic Map9q33NCBI
Fn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955457629,518 - 696,975 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955457629,599 - 694,948 (+)NCBIChiLan1.0ChiLan1.0
FN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213117,990,599 - 118,066,026 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B118,005,563 - 118,080,823 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B102,623,568 - 102,698,747 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B221,208,431 - 221,284,003 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B221,208,431 - 221,284,003 (-)Ensemblpanpan1.1panPan2
FN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13722,456,854 - 22,522,410 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3722,420,428 - 22,523,123 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3723,283,410 - 23,349,813 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03722,479,930 - 22,546,207 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3722,479,939 - 22,546,755 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13722,368,332 - 22,434,691 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03722,319,732 - 22,386,105 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03722,336,313 - 22,402,763 (-)NCBIUU_Cfam_GSD_1.0
Fn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303170,852,488 - 170,917,088 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365861,708,684 - 1,773,383 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365861,708,803 - 1,773,372 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110101,177,867 - 101,254,613 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10101,176,789 - 101,254,633 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604098,128,602 - 98,204,117 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624765707,755 - 775,056 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624765707,872 - 775,056 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FN1
2866 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 1 5 2 3 2 3 3
Low 2 20
Below cutoff

Sequence


RefSeq Acc Id: ENSSSCT00000017610   ⟹   ENSSSCP00000017132
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15117,658,156 - 117,730,867 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000048029   ⟹   ENSSSCP00000036609
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15117,658,099 - 117,731,014 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000089736   ⟹   ENSSSCP00000060763
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl15117,658,156 - 117,731,014 (-)Ensembl
RefSeq Acc Id: XM_003133642   ⟹   XP_003133690
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.115117,658,158 - 117,737,145 (-)NCBI
Sequence:
RefSeq Acc Id: XP_003133690   ⟸   XM_003133642
- UniProtKB: A0A8D1VDG8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000060763   ⟸   ENSSSCT00000089736
RefSeq Acc Id: ENSSSCP00000017132   ⟸   ENSSSCT00000017610
RefSeq Acc Id: ENSSSCP00000036609   ⟸   ENSSSCT00000048029

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000016174 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015050921 UniProtKB/TrEMBL
  ENSSSCG00025023944 UniProtKB/TrEMBL
  ENSSSCG00030024219 UniProtKB/TrEMBL
  ENSSSCG00035009420 UniProtKB/TrEMBL
  ENSSSCG00040044302 UniProtKB/TrEMBL
  ENSSSCG00045008562 UniProtKB/TrEMBL
  ENSSSCG00055018067 UniProtKB/TrEMBL
  ENSSSCG00060039465 UniProtKB/TrEMBL
  ENSSSCG00065043402 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000017610.5 UniProtKB/TrEMBL
  ENSSSCT00000048029.2 UniProtKB/TrEMBL
  ENSSSCT00000089736 ENTREZGENE
  ENSSSCT00000089736.2 UniProtKB/TrEMBL
  ENSSSCT00015067915.1 UniProtKB/TrEMBL
  ENSSSCT00015068665.1 UniProtKB/TrEMBL
  ENSSSCT00015070281.1 UniProtKB/TrEMBL
  ENSSSCT00015070850.1 UniProtKB/TrEMBL
  ENSSSCT00015071573.1 UniProtKB/TrEMBL
  ENSSSCT00025032583.1 UniProtKB/TrEMBL
  ENSSSCT00025032824.1 UniProtKB/TrEMBL
  ENSSSCT00025033289.1 UniProtKB/TrEMBL
  ENSSSCT00025033771.1 UniProtKB/TrEMBL
  ENSSSCT00030033720.1 UniProtKB/TrEMBL
  ENSSSCT00030033734.1 UniProtKB/TrEMBL
  ENSSSCT00030033776.1 UniProtKB/TrEMBL
  ENSSSCT00030033792.1 UniProtKB/TrEMBL
  ENSSSCT00035011812.1 UniProtKB/TrEMBL
  ENSSSCT00035011825.1 UniProtKB/TrEMBL
  ENSSSCT00035011852.1 UniProtKB/TrEMBL
  ENSSSCT00035011866.1 UniProtKB/TrEMBL
  ENSSSCT00040060088.1 UniProtKB/TrEMBL
  ENSSSCT00040060658.1 UniProtKB/TrEMBL
  ENSSSCT00040061466.1 UniProtKB/TrEMBL
  ENSSSCT00040061717.1 UniProtKB/TrEMBL
  ENSSSCT00040062067.1 UniProtKB/TrEMBL
  ENSSSCT00045014451.1 UniProtKB/TrEMBL
  ENSSSCT00045014645.1 UniProtKB/TrEMBL
  ENSSSCT00045014958.1 UniProtKB/TrEMBL
  ENSSSCT00045015180.1 UniProtKB/TrEMBL
  ENSSSCT00055052061.1 UniProtKB/TrEMBL
  ENSSSCT00055052426.1 UniProtKB/TrEMBL
  ENSSSCT00055052723.1 UniProtKB/TrEMBL
  ENSSSCT00055053067.1 UniProtKB/TrEMBL
  ENSSSCT00060053399.1 UniProtKB/TrEMBL
  ENSSSCT00060053408.1 UniProtKB/TrEMBL
  ENSSSCT00060053429.1 UniProtKB/TrEMBL
  ENSSSCT00060053440.1 UniProtKB/TrEMBL
  ENSSSCT00065059400.1 UniProtKB/TrEMBL
  ENSSSCT00065059445.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.10.10 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/TrEMBL
InterPro Fibronectin_type1 UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  FN_type2_dom UniProtKB/TrEMBL
  FN_type2_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Kringle-like UniProtKB/TrEMBL
KEGG Report ssc:397620 UniProtKB/TrEMBL
NCBI Gene FN1 ENTREZGENE
PANTHER FIBRONECTIN UniProtKB/TrEMBL
  SUBSTRATE-ADHESION MOLECULE UniProtKB/TrEMBL
  TENASCIN UniProtKB/TrEMBL
Pfam fn1 UniProtKB/TrEMBL
  fn2 UniProtKB/TrEMBL
  fn3 UniProtKB/TrEMBL
PRINTS FNTYPEII UniProtKB/TrEMBL
PROSITE FN1_1 UniProtKB/TrEMBL
  FN1_2 UniProtKB/TrEMBL
  FN2_1 UniProtKB/TrEMBL
  FN2_2 UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
SMART FN1 UniProtKB/TrEMBL
  FN2 UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
Superfamily-SCOP FnI-like domain UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
  SSF57440 UniProtKB/TrEMBL
UniProt A0A286ZY95_PIG UniProtKB/TrEMBL
  A0A5G2QFE3_PIG UniProtKB/TrEMBL
  A0A8D0P6F5_PIG UniProtKB/TrEMBL
  A0A8D0RAL1_PIG UniProtKB/TrEMBL
  A0A8D0W2M6_PIG UniProtKB/TrEMBL
  A0A8D0W356_PIG UniProtKB/TrEMBL
  A0A8D0W5Z3_PIG UniProtKB/TrEMBL
  A0A8D0YKI6_PIG UniProtKB/TrEMBL
  A0A8D1C3D1_PIG UniProtKB/TrEMBL
  A0A8D1ET23_PIG UniProtKB/TrEMBL
  A0A8D1S2V5_PIG UniProtKB/TrEMBL
  A0A8D1VDG8 ENTREZGENE, UniProtKB/TrEMBL
  F1SS24_PIG UniProtKB/TrEMBL
VGNC ID VGNC:96305 ENTREZGENE