LGMN (legumain) - Rat Genome Database

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Gene: LGMN (legumain) Sus scrofa
Analyze
Symbol: LGMN
Name: legumain
RGD ID: 14001031
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activity; INVOLVED IN proteolysis; response to acidic pH; activation of cysteine-type endopeptidase activity (ortholog); ASSOCIATED WITH achondrogenesis type IA (ortholog); Experimental Liver Cirrhosis (ortholog); High Myopia (ortholog); FOUND IN lysosomal lumen (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7114,173,693 - 114,217,102 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17114,176,217 - 114,210,096 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27120,780,926 - 120,811,668 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:23686917   PMID:30032202  


Genomics

Comparative Map Data
LGMN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7114,173,693 - 114,217,102 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17114,176,217 - 114,210,096 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27120,780,926 - 120,811,668 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LGMN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381492,703,809 - 92,748,627 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1492,703,807 - 92,748,679 (-)EnsemblGRCh38hg38GRCh38
GRCh371493,170,154 - 93,214,972 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361492,239,907 - 92,284,765 (-)NCBINCBI36Build 36hg18NCBI36
Build 341492,239,909 - 92,284,765NCBI
Celera1473,224,285 - 73,269,160 (-)NCBICelera
Cytogenetic Map14q32.12NCBI
HuRef1473,353,202 - 73,398,165 (-)NCBIHuRef
CHM1_11493,108,397 - 93,153,238 (-)NCBICHM1_1
T2T-CHM13v2.01486,935,604 - 86,980,392 (-)NCBIT2T-CHM13v2.0
Lgmn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912102,360,341 - 102,405,987 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12102,360,343 - 102,406,072 (-)EnsemblGRCm39 Ensembl
GRCm3812102,394,082 - 102,439,728 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12102,394,084 - 102,439,813 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712103,632,308 - 103,677,907 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612102,795,148 - 102,840,747 (-)NCBIMGSCv36mm8
Celera12103,611,726 - 103,647,892 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1251.45NCBI
Lgmn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86127,308,913 - 127,347,355 (-)NCBIGRCr8
mRatBN7.26121,544,048 - 121,582,495 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6121,544,053 - 121,582,480 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6121,684,520 - 121,722,056 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06121,979,783 - 122,017,312 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06121,315,105 - 121,353,227 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06126,282,246 - 126,308,207 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6126,282,233 - 126,320,726 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06135,492,943 - 135,518,916 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46126,668,905 - 126,694,866 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16126,672,651 - 126,698,616 (-)NCBI
Celera6119,032,612 - 119,058,582 (-)NCBICelera
Cytogenetic Map6q32NCBI
Lgmn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543814,905,856 - 14,939,256 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543814,905,856 - 14,938,722 (-)NCBIChiLan1.0ChiLan1.0
LGMN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21593,861,233 - 93,907,416 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11493,077,738 - 93,123,921 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01473,337,607 - 73,383,462 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11492,677,608 - 92,723,051 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1492,677,608 - 92,723,051 (-)Ensemblpanpan1.1panPan2
LGMN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.181,810,263 - 1,843,116 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl81,728,273 - 1,843,050 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha81,834,051 - 1,866,767 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.081,864,425 - 1,878,822 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl81,782,672 - 1,889,344 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.181,802,050 - 1,834,797 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.081,752,395 - 1,785,146 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.081,879,451 - 1,912,213 (-)NCBIUU_Cfam_GSD_1.0
Lgmn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864012,674,224 - 12,694,251 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936733772,708 - 792,995 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936733772,764 - 792,792 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGMN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12470,456,463 - 70,500,345 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2470,456,095 - 70,486,087 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605357,705,088 - 57,748,692 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lgmn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247349,204,790 - 9,240,309 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247349,207,496 - 9,240,026 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LGMN
1927 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000002722   ⟹   ENSSSCP00000002653
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl7114,173,693 - 114,210,017 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000002723   ⟹   ENSSSCP00000002654
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl7114,173,693 - 114,190,045 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000030342   ⟹   ENSSSCP00000024644
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl7114,176,249 - 114,210,039 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000046926   ⟹   ENSSSCP00000048178
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl7114,176,222 - 114,217,102 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000059637   ⟹   ENSSSCP00000054335
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl7114,173,693 - 114,210,017 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000101588   ⟹   ENSSSCP00000080109
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl7114,173,693 - 114,210,017 (-)Ensembl
RefSeq Acc Id: XM_001927082   ⟹   XP_001927117
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.17114,176,217 - 114,210,061 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005656451   ⟹   XP_005656508
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.17114,176,217 - 114,210,096 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_001927117 (Get FASTA)   NCBI Sequence Viewer  
  XP_005656508 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000002653.4
  ENSSSCP00000002654.4
  ENSSSCP00000024644
  ENSSSCP00000024644.3
  ENSSSCP00000048178
  ENSSSCP00000048178.1
  ENSSSCP00000054335.1
  ENSSSCP00000080109.1
  ENSSSCP00005037417.1
  ENSSSCP00005037470.1
  ENSSSCP00005037489.1
  ENSSSCP00005037506.1
  ENSSSCP00005037524.1
  ENSSSCP00005037548.1
  ENSSSCP00015012867.1
  ENSSSCP00015012902.1
  ENSSSCP00015013058.1
  ENSSSCP00015013089.1
  ENSSSCP00025011090.1
  ENSSSCP00025011099.1
  ENSSSCP00025011115.1
  ENSSSCP00025011145.1
  ENSSSCP00025011167.1
  ENSSSCP00030047782.1
  ENSSSCP00030047790.1
  ENSSSCP00030047795.1
  ENSSSCP00030047805.1
  ENSSSCP00035019495.1
  ENSSSCP00035019497.1
  ENSSSCP00035019499.1
  ENSSSCP00035019503.1
  ENSSSCP00035019507.1
  ENSSSCP00040024034.1
  ENSSSCP00040024193.1
  ENSSSCP00040024341.1
  ENSSSCP00040024408.1
  ENSSSCP00045044137.1
  ENSSSCP00045044184.1
  ENSSSCP00045044267.1
  ENSSSCP00045044322.1
  ENSSSCP00045044367.1
  ENSSSCP00050028644.1
  ENSSSCP00050028654.1
  ENSSSCP00055004565.1
  ENSSSCP00055004585.1
  ENSSSCP00055004619.1
  ENSSSCP00055004636.1
  ENSSSCP00055004653.1
  ENSSSCP00060028184.1
  ENSSSCP00060028186.1
  ENSSSCP00060028192.1
  ENSSSCP00060028198.1
  ENSSSCP00060028199.1
  ENSSSCP00065043029.1
  ENSSSCP00065043032.1
  ENSSSCP00065043036.1
  ENSSSCP00065043083.1
  ENSSSCP00065043112.1
  ENSSSCP00065043117.1
  ENSSSCP00070003346.1
  ENSSSCP00070003357.1
  ENSSSCP00070003369.1
  ENSSSCP00070003392.1
  ENSSSCP00070003401.1
GenBank Protein JAG69414 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005656508   ⟸   XM_005656451
- UniProtKB: A0A287AW67 (UniProtKB/TrEMBL),   A0A4X1SMU4 (UniProtKB/TrEMBL),   A0A0B8RSP0 (UniProtKB/TrEMBL),   A0A8D1MVI1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_001927117   ⟸   XM_001927082
- UniProtKB: A0A287AW67 (UniProtKB/TrEMBL),   A0A4X1SMU4 (UniProtKB/TrEMBL),   A0A0B8RSP0 (UniProtKB/TrEMBL),   A0A8D1MVI1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000024644   ⟸   ENSSSCT00000030342
Ensembl Acc Id: ENSSSCP00000002653   ⟸   ENSSSCT00000002722
Ensembl Acc Id: ENSSSCP00000002654   ⟸   ENSSSCT00000002723
Ensembl Acc Id: ENSSSCP00000054335   ⟸   ENSSSCT00000059637
Ensembl Acc Id: ENSSSCP00000048178   ⟸   ENSSSCT00000046926
Ensembl Acc Id: ENSSSCP00000080109   ⟸   ENSSSCT00000101588
Protein Domains
Legumain prodomain


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000002452 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005037022 UniProtKB/TrEMBL
  ENSSSCG00015024441 UniProtKB/TrEMBL
  ENSSSCG00025019279 UniProtKB/TrEMBL
  ENSSSCG00030073810 UniProtKB/TrEMBL
  ENSSSCG00035036772 UniProtKB/TrEMBL
  ENSSSCG00040041649 UniProtKB/TrEMBL
  ENSSSCG00045035808 UniProtKB/TrEMBL
  ENSSSCG00050048998 UniProtKB/TrEMBL
  ENSSSCG00055003001 UniProtKB/TrEMBL
  ENSSSCG00060048459 UniProtKB/TrEMBL
  ENSSSCG00065071438 UniProtKB/TrEMBL
  ENSSSCG00070002144 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000002722.4 UniProtKB/TrEMBL
  ENSSSCT00000002723.4 UniProtKB/TrEMBL
  ENSSSCT00000030342 ENTREZGENE
  ENSSSCT00000030342.4 UniProtKB/TrEMBL
  ENSSSCT00000046926 ENTREZGENE
  ENSSSCT00000046926.3 UniProtKB/TrEMBL
  ENSSSCT00000059637.2 UniProtKB/TrEMBL
  ENSSSCT00000101588.1 UniProtKB/TrEMBL
  ENSSSCT00005060582.1 UniProtKB/TrEMBL
  ENSSSCT00005060665.1 UniProtKB/TrEMBL
  ENSSSCT00005060698.1 UniProtKB/TrEMBL
  ENSSSCT00005060731.1 UniProtKB/TrEMBL
  ENSSSCT00005060754.1 UniProtKB/TrEMBL
  ENSSSCT00005060785.1 UniProtKB/TrEMBL
  ENSSSCT00015032403.1 UniProtKB/TrEMBL
  ENSSSCT00015032494.1 UniProtKB/TrEMBL
  ENSSSCT00015032882.1 UniProtKB/TrEMBL
  ENSSSCT00015032954.1 UniProtKB/TrEMBL
  ENSSSCT00025026243.1 UniProtKB/TrEMBL
  ENSSSCT00025026260.1 UniProtKB/TrEMBL
  ENSSSCT00025026286.1 UniProtKB/TrEMBL
  ENSSSCT00025026336.1 UniProtKB/TrEMBL
  ENSSSCT00025026382.1 UniProtKB/TrEMBL
  ENSSSCT00030103458.1 UniProtKB/TrEMBL
  ENSSSCT00030103468.1 UniProtKB/TrEMBL
  ENSSSCT00030103475.1 UniProtKB/TrEMBL
  ENSSSCT00030103485.1 UniProtKB/TrEMBL
  ENSSSCT00035048757.1 UniProtKB/TrEMBL
  ENSSSCT00035048760.1 UniProtKB/TrEMBL
  ENSSSCT00035048764.1 UniProtKB/TrEMBL
  ENSSSCT00035048776.1 UniProtKB/TrEMBL
  ENSSSCT00035048783.1 UniProtKB/TrEMBL
  ENSSSCT00040057711.1 UniProtKB/TrEMBL
  ENSSSCT00040058053.1 UniProtKB/TrEMBL
  ENSSSCT00040058339.1 UniProtKB/TrEMBL
  ENSSSCT00040058442.1 UniProtKB/TrEMBL
  ENSSSCT00045062637.1 UniProtKB/TrEMBL
  ENSSSCT00045062707.1 UniProtKB/TrEMBL
  ENSSSCT00045062821.1 UniProtKB/TrEMBL
  ENSSSCT00045062893.1 UniProtKB/TrEMBL
  ENSSSCT00045062955.1 UniProtKB/TrEMBL
  ENSSSCT00050066696.1 UniProtKB/TrEMBL
  ENSSSCT00050066721.1 UniProtKB/TrEMBL
  ENSSSCT00055005849.1 UniProtKB/TrEMBL
  ENSSSCT00055005870.1 UniProtKB/TrEMBL
  ENSSSCT00055005912.1 UniProtKB/TrEMBL
  ENSSSCT00055005932.1 UniProtKB/TrEMBL
  ENSSSCT00055005952.1 UniProtKB/TrEMBL
  ENSSSCT00060065840.1 UniProtKB/TrEMBL
  ENSSSCT00060065844.1 UniProtKB/TrEMBL
  ENSSSCT00060065859.1 UniProtKB/TrEMBL
  ENSSSCT00060065870.1 UniProtKB/TrEMBL
  ENSSSCT00060065875.1 UniProtKB/TrEMBL
  ENSSSCT00065098144.1 UniProtKB/TrEMBL
  ENSSSCT00065098147.1 UniProtKB/TrEMBL
  ENSSSCT00065098154.1 UniProtKB/TrEMBL
  ENSSSCT00065098242.1 UniProtKB/TrEMBL
  ENSSSCT00065098300.1 UniProtKB/TrEMBL
  ENSSSCT00065098316.1 UniProtKB/TrEMBL
  ENSSSCT00070004043.1 UniProtKB/TrEMBL
  ENSSSCT00070004055.1 UniProtKB/TrEMBL
  ENSSSCT00070004073.1 UniProtKB/TrEMBL
  ENSSSCT00070004107.1 UniProtKB/TrEMBL
  ENSSSCT00070004125.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.132.130 UniProtKB/TrEMBL
  3.40.50.1460 UniProtKB/TrEMBL
InterPro IPR043577 UniProtKB/TrEMBL
  Legum_prodom UniProtKB/TrEMBL
  Legumain_prodom_sf UniProtKB/TrEMBL
  Peptidase_C13 UniProtKB/TrEMBL
KEGG Report ssc:100154477 UniProtKB/TrEMBL
NCBI Gene LGMN ENTREZGENE
PANTHER LEGUMAIN UniProtKB/TrEMBL
  PTHR12000 UniProtKB/TrEMBL
Pfam Legum_prodom UniProtKB/TrEMBL
  Peptidase_C13 UniProtKB/TrEMBL
PIRSF Legumain UniProtKB/TrEMBL
  PIRSF500139 UniProtKB/TrEMBL
PRINTS HEMOGLOBNASE UniProtKB/TrEMBL
UniProt A0A0B8RSP0 ENTREZGENE
  A0A287AW67 ENTREZGENE, UniProtKB/TrEMBL
  A0A287BCT6_PIG UniProtKB/TrEMBL
  A0A4X1SLM7_PIG UniProtKB/TrEMBL
  A0A4X1SLU8_PIG UniProtKB/TrEMBL
  A0A4X1SMU4 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1SMW5_PIG UniProtKB/TrEMBL
  A0A8D0K6G4_PIG UniProtKB/TrEMBL
  A0A8D0KEQ1_PIG UniProtKB/TrEMBL
  A0A8D0KFT9_PIG UniProtKB/TrEMBL
  A0A8D0KFV7_PIG UniProtKB/TrEMBL
  A0A8D0LVZ4_PIG UniProtKB/TrEMBL
  A0A8D1CTC2_PIG UniProtKB/TrEMBL
  A0A8D1EMM4_PIG UniProtKB/TrEMBL
  A0A8D1MVI1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FL93_PIG UniProtKB/TrEMBL
  F1SD69_PIG UniProtKB/TrEMBL
  F1SD70_PIG UniProtKB/TrEMBL
  I3LKM9_PIG UniProtKB/TrEMBL
VGNC ID VGNC:89702 ENTREZGENE