LGMN (legumain) - Rat Genome Database

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Gene: LGMN (legumain) Pan paniscus
Analyze
Symbol: LGMN
Name: legumain
RGD ID: 11893195
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); endopeptidase activator activity (inferred); INVOLVED IN associative learning (ortholog); dendritic spine organization (ortholog); memory (ortholog); ASSOCIATED WITH achondrogenesis type IA (ortholog); Experimental Liver Cirrhosis (ortholog); High Myopia (ortholog); FOUND IN apical part of cell (ortholog); late endosome (ortholog); lysosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21593,861,233 - 93,907,416 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11493,077,738 - 93,123,921 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01473,337,607 - 73,383,462 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11492,677,608 - 92,723,051 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1492,677,608 - 92,723,051 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LGMNBonoboachondrogenesis type IA  ISOLGMN (Homo sapiens)8554872ClinVar Annotator: match by term: Achondrogenesis and type IAClinVarPMID:28492532
LGMNBonoboHigh Myopia  ISOLGMN (Homo sapiens)8554872ClinVar Annotator: match by term: High myopiaClinVar 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LGMNBonoboExperimental Liver Cirrhosis  ISOLGMN (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:25380136
LGMNBonoboOrthomyxoviridae Infections  ISOLGMN (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:22916010
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LGMNBonobolymphatic system disease  ISOLgmn (Mus musculus)9068941 MouseDO 


Biological Process
1 to 20 of 28 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LGMNBonoboantigen processing and presentation of exogenous peptide antigen via MHC class II involved_inIEAUniProtKB:Q99538 and ensembl:ENSP00000334052150520179 EnsemblGO_REF:0000107
LGMNBonoboassociative learning involved_inISOUniProtKB:P106369068941 PMID:25326800ARUK-UCLPMID:25326800
LGMNBonobocellular response to amyloid-beta involved_inIEAUniProtKB:Q99538 and ensembl:ENSP00000334052150520179 EnsemblGO_REF:0000107
LGMNBonobocellular response to calcium ion involved_inIEAUniProtKB:Q99538 and ensembl:ENSP00000334052150520179 EnsemblGO_REF:0000107
LGMNBonobocellular response to hepatocyte growth factor stimulus involved_inIEAUniProtKB:Q99538 and ensembl:ENSP00000334052150520179 EnsemblGO_REF:0000107
LGMNBonobodendritic spine organization involved_inISOUniProtKB:P106369068941 PMID:25326800ARUK-UCLPMID:25326800
LGMNBonobomemory involved_inISOUniProtKB:P106369068941 PMID:25326800ARUK-UCLPMID:25326800
LGMNBonobonegative regulation of ERBB signaling pathway involved_inISOLgmn (Mus musculus)9068941 PMID:21292981UniProtPMID:21292981
LGMNBonobonegative regulation of gene expression involved_inIEAUniProtKB:Q99538 and ensembl:ENSP00000334052150520179 EnsemblGO_REF:0000107
LGMNBonobonegative regulation of multicellular organism growth acts_upstream_of_or_withinISOMGI:26761259068941 PMID:12775715MGIPMID:12775715
LGMNBonobonegative regulation of neuron apoptotic process acts_upstream_of_or_withinIEAUniProtKB:Q99538 and ensembl:ENSP00000334052150520179 EnsemblGO_REF:0000107
LGMNBonobopositive regulation of cell population proliferation involved_inIEAUniProtKB:Q99538 and ensembl:ENSP00000334052150520179 EnsemblGO_REF:0000107
LGMNBonobopositive regulation of endothelial cell chemotaxis involved_inIEAUniProtKB:Q99538 and ensembl:ENSP00000334052150520179 EnsemblGO_REF:0000107
LGMNBonobopositive regulation of long-term synaptic potentiation involved_inISOUniProtKB:P106369068941 PMID:25326800ARUK-UCLPMID:25326800
LGMNBonobopositive regulation of mitotic cell cycle involved_inIEAUniProtKB:Q99538 and ensembl:ENSP00000334052150520179 EnsemblGO_REF:0000107
LGMNBonobopositive regulation of monocyte chemotaxis involved_inIEAUniProtKB:Q99538 and ensembl:ENSP00000334052150520179 EnsemblGO_REF:0000107
LGMNBonoboprotein maturation involved_inISOLgmn (Mus musculus)9068941 PMID:37347855UniProtPMID:37347855
LGMNBonoboproteolysis involved_inIEAInterPro:IPR001096150520179 InterProGO_REF:0000002
LGMNBonoboproteolysis acts_upstream_of_or_withinISOLgmn (Mus musculus)9068941 PMID:12775715MGIPMID:12775715
LGMNBonoboproteolysis acts_upstream_of_or_withinISOMGI:26761259068941 PMID:18374643MGIPMID:18374643
1 to 20 of 28 rows

Cellular Component
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LGMNBonoboapical part of cell located_inISOLgmn (Mus musculus)9068941 PMID:12775715MGIPMID:12775715
LGMNBonobocytoplasm located_inIEAUniProtKB:Q99538 and ensembl:ENSP00000334052150520179 EnsemblGO_REF:0000107
LGMNBonoboextracellular region located_inIEAUniProtKB:Q99538 and ensembl:ENSP00000334052150520179 EnsemblGO_REF:0000107
LGMNBonobolate endosome located_inISOLgmn (Mus musculus)9068941 PMID:12775715MGIPMID:12775715
LGMNBonobolysosomal lumen is_active_inIEAUniProtKB:Q99538 and ensembl:ENSP00000334052150520179 EnsemblGO_REF:0000107
LGMNBonobolysosome located_inISOLgmn (Mus musculus)9068941 PMID:9742219UniProtPMID:9742219
LGMNBonobolysosome located_inISOLgmn (Rattus norvegicus)9068941PMID:9742219UniProtPMID:9742219 and REF_RGD_ID:704328
LGMNBonoboperinuclear region of cytoplasm located_inIEAUniProtKB:Q99538 and ensembl:ENSP00000334052150520179 EnsemblGO_REF:0000107
LGMNBonobovacuole located_inIEAGO:0006624150520179 GOCGO_REF:0000108
1 to 9 of 9 rows

Molecular Function
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LGMNBonobocysteine-type endopeptidase activity enablesIEAPANTHER:PTN000243193 and PANTHER:PTN004332289150520179 TreeGrafterGO_REF:0000118
LGMNBonobocysteine-type endopeptidase activity enablesIEAUniProtKB:Q99538 and ensembl:ENSP00000334052150520179 EnsemblGO_REF:0000107
LGMNBonobocysteine-type endopeptidase activity enablesIEAEC:3.4.22.34150520179 UniProtGO_REF:0000003
LGMNBonobocysteine-type endopeptidase activity enablesIEAInterPro:IPR043577150520179 InterProGO_REF:0000002
LGMNBonobocysteine-type peptidase activity enablesIEAUniProtKB-KW:KW-0788150520179 UniProtGO_REF:0000043
LGMNBonoboendopeptidase activator activity enablesIEAUniProtKB:Q99538 and ensembl:ENSP00000334052150520179 EnsemblGO_REF:0000107
LGMNBonoboendopeptidase activity enablesIEAARBA:ARBA00028131150520179 UniProtGO_REF:0000117
LGMNBonobohydrolase activity enablesIEAUniProtKB-KW:KW-0378150520179 UniProtGO_REF:0000043
LGMNBonobopeptidase activity enablesIEAUniProtKB-KW:KW-0645150520179 UniProtGO_REF:0000043
LGMNBonobopeptidase activity enablesIEAInterPro:IPR001096150520179 InterProGO_REF:0000002
LGMNBonobopeptidase activity enablesIEAUniProtKB:Q99538 and ensembl:ENSP00000334052150520179 EnsemblGO_REF:0000107
LGMNBonoboprotein binding enablesISOUniProtKB:P01034-PRO_0000006639 and UniProtKB:Q15828-PRO_00000066489068941 PMID:25630877IntActPMID:25630877
1 to 12 of 12 rows

PMID:22301074   PMID:30032202  



LGMN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21593,861,233 - 93,907,416 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11493,077,738 - 93,123,921 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01473,337,607 - 73,383,462 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11492,677,608 - 92,723,051 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1492,677,608 - 92,723,051 (-)Ensemblpanpan1.1panPan2
LGMN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381492,703,809 - 92,748,627 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1492,703,807 - 92,748,679 (-)EnsemblGRCh38hg38GRCh38
GRCh371493,170,154 - 93,214,972 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361492,239,907 - 92,284,765 (-)NCBINCBI36Build 36hg18NCBI36
Build 341492,239,909 - 92,284,765NCBI
Celera1473,224,285 - 73,269,160 (-)NCBICelera
Cytogenetic Map14q32.12NCBI
HuRef1473,353,202 - 73,398,165 (-)NCBIHuRef
CHM1_11493,108,397 - 93,153,238 (-)NCBICHM1_1
T2T-CHM13v2.01486,935,604 - 86,980,392 (-)NCBIT2T-CHM13v2.0
Lgmn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912102,360,341 - 102,405,987 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12102,360,343 - 102,406,072 (-)EnsemblGRCm39 Ensembl
GRCm3812102,394,082 - 102,439,728 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12102,394,084 - 102,439,813 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712103,632,308 - 103,677,907 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612102,795,148 - 102,840,747 (-)NCBIMGSCv36mm8
Celera12103,611,726 - 103,647,892 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1251.45NCBI
Lgmn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86127,308,913 - 127,347,355 (-)NCBIGRCr8
mRatBN7.26121,544,048 - 121,582,495 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6121,544,053 - 121,582,480 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6121,684,520 - 121,722,056 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06121,979,783 - 122,017,312 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06121,315,105 - 121,353,227 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06126,282,246 - 126,308,207 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6126,282,233 - 126,320,726 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06135,492,943 - 135,518,916 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46126,668,905 - 126,694,866 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16126,672,651 - 126,698,616 (-)NCBI
Celera6119,032,612 - 119,058,582 (-)NCBICelera
Cytogenetic Map6q32NCBI
Lgmn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543814,905,856 - 14,939,256 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543814,905,856 - 14,938,722 (-)NCBIChiLan1.0ChiLan1.0
LGMN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.181,810,263 - 1,843,116 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl81,728,273 - 1,843,050 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha81,834,051 - 1,866,767 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.081,864,425 - 1,878,822 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl81,782,672 - 1,889,344 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.181,802,050 - 1,834,797 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.081,752,395 - 1,785,146 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.081,879,451 - 1,912,213 (-)NCBIUU_Cfam_GSD_1.0
Lgmn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864012,674,224 - 12,694,251 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936733772,708 - 792,995 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936733772,764 - 792,792 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGMN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7114,173,693 - 114,217,102 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17114,176,217 - 114,210,096 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27120,780,926 - 120,811,668 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LGMN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12470,456,463 - 70,500,345 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2470,456,095 - 70,486,087 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605357,705,088 - 57,748,692 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lgmn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247349,204,790 - 9,240,309 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247349,207,496 - 9,240,026 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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RefSeq Transcripts XM_003832785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008958213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000054510   ⟹   ENSPPAP00000031644
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1492,677,608 - 92,723,051 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000054516   ⟹   ENSPPAP00000031651
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1492,678,067 - 92,707,255 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000054521   ⟹   ENSPPAP00000031656
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1492,678,123 - 92,707,255 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000054527   ⟹   ENSPPAP00000031662
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1492,688,179 - 92,707,255 (-)Ensembl
RefSeq Acc Id: XM_003832785   ⟹   XP_003832833
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21593,861,233 - 93,907,416 (-)NCBI
NHGRI_mPanPan11493,077,738 - 93,123,921 (-)NCBI
Mhudiblu_PPA_v01473,337,607 - 73,383,446 (-)NCBI
PanPan1.11492,677,608 - 92,723,051 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008958213   ⟹   XP_008956461
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21593,861,233 - 93,907,116 (-)NCBI
NHGRI_mPanPan11493,077,738 - 93,123,621 (-)NCBI
Mhudiblu_PPA_v01473,337,607 - 73,383,462 (-)NCBI
PanPan1.11492,677,608 - 92,723,019 (-)NCBI
Sequence:
Protein RefSeqs XP_003832833 (Get FASTA)   NCBI Sequence Viewer  
  XP_008956461 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000031644.1
  ENSPPAP00000031651.1
  ENSPPAP00000031656.1
  ENSPPAP00000031662.1
RefSeq Acc Id: XP_008956461   ⟸   XM_008958213
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_003832833   ⟸   XM_003832785
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BQF5 (UniProtKB/TrEMBL),   A0A2R9BPS2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000031644   ⟸   ENSPPAT00000054510
Ensembl Acc Id: ENSPPAP00000031651   ⟸   ENSPPAT00000054516
Ensembl Acc Id: ENSPPAP00000031656   ⟸   ENSPPAT00000054521
Legumain prodomain



1 to 24 of 24 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSPPAG00000038740 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000054510.1 UniProtKB/TrEMBL
  ENSPPAT00000054516.1 UniProtKB/TrEMBL
  ENSPPAT00000054521.1 UniProtKB/TrEMBL
  ENSPPAT00000054527.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.132.130 UniProtKB/TrEMBL
  3.40.50.1460 UniProtKB/TrEMBL
InterPro IPR043577 UniProtKB/TrEMBL
  Legum_prodom UniProtKB/TrEMBL
  Legumain_prodom_sf UniProtKB/TrEMBL
  Peptidase_C13 UniProtKB/TrEMBL
KEGG Report pps:100979480 UniProtKB/TrEMBL
NCBI Gene LGMN ENTREZGENE
PANTHER LEGUMAIN UniProtKB/TrEMBL
  PTHR12000 UniProtKB/TrEMBL
Pfam Legum_prodom UniProtKB/TrEMBL
  Peptidase_C13 UniProtKB/TrEMBL
PIRSF Legumain UniProtKB/TrEMBL
  PIRSF500139 UniProtKB/TrEMBL
PRINTS HEMOGLOBNASE UniProtKB/TrEMBL
UniProt A0A2R9BPR8_PANPA UniProtKB/TrEMBL
  A0A2R9BPS2 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BQF5 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BYR8_PANPA UniProtKB/TrEMBL
1 to 24 of 24 rows