HGF (hepatocyte growth factor) - Rat Genome Database

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Gene: HGF (hepatocyte growth factor) Sus scrofa
Analyze
Symbol: HGF
Name: hepatocyte growth factor
RGD ID: 14209385
Description: ENCODES a protein that exhibits growth factor activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN animal organ regeneration (ortholog); cell morphogenesis (ortholog); epithelial cell proliferation (ortholog); PARTICIPATES IN E-cadherin signaling pathway; fibroblast growth factor signaling pathway; scatter factor/hepatocyte growth factor signaling pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); acute myeloid leukemia (ortholog); adult-onset Still's disease (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl998,437,087 - 98,513,156 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1998,437,771 - 98,513,573 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29108,765,929 - 108,841,386 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
acute myeloid leukemia  (ISO)
adult-onset Still's disease  (ISO)
angle-closure glaucoma  (ISO)
arteriosclerosis  (ISO)
atrial fibrillation  (ISO)
autosomal recessive nonsyndromic deafness 39  (ISO)
Barrett's esophagus  (ISO)
biliary tract benign neoplasm  (ISO)
bilirubin metabolic disorder  (ISO)
brain infarction  (ISO)
cardiomyopathy  (ISO)
carotid artery disease  (ISO)
central nervous system disease  (ISO)
cholangiocarcinoma  (ISO)
cholesteatoma  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis  (ISO)
Copper-Overload Cirrhosis  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
dermatomyositis  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
epilepsy  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Melanoma  (ISO)
Experimental Neoplasms  (ISO)
Facial Nerve Injuries  (ISO)
Gallbladder Neoplasms  (ISO)
Graft vs Host Disease  (ISO)
Hearing Loss  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
hypertension  (ISO)
interstitial lung disease  (ISO)
inverted papilloma  (ISO)
keratoconus  (ISO)
Lentigo  (ISO)
Limb Ischemia  (ISO)
liver cirrhosis  (ISO)
Liver Injury  (ISO)
Liver Neoplasms  (ISO)
localized scleroderma  (ISO)
malignant astrocytoma  (ISO)
malignant mesothelioma  (ISO)
meningioma  (ISO)
Metabolic Syndrome  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
myopia  (ISO)
myositis  (ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
Nerve Sheath Neoplasms  (ISO)
neuroblastoma  (ISO)
obesity  (ISO)
Optic Nerve Injuries  (ISO)
Pain  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
Parkinson's disease  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
polymyositis  (ISO)
Polyomavirus Infections  (ISO)
pulmonary fibrosis  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
Retinal Neovascularization  (ISO)
retinitis pigmentosa  (ISO)
retinopathy of prematurity  (ISO)
rheumatoid arthritis  (ISO)
Rhinosinusitis  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
Stroke  (ISO)
systemic scleroderma  (ISO)
thrombosis  (ISO)
tongue squamous cell carcinoma  (ISO)
vascular disease  (ISO)
visual epilepsy  (ISO)
vitiligo  (ISO)
Wounds and Injuries  (ISO)
Wounds, Penetrating  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
cell chemotaxis  (IEA)
cell morphogenesis  (IEA,ISO)
cellular response to hepatocyte growth factor stimulus  (IBA)
epithelial cell proliferation  (IEA,ISO)
hepatocyte growth factor receptor signaling pathway  (IBA,ISO)
liver development  (IEA,ISO)
myoblast proliferation  (IEA,ISO)
negative regulation of apoptotic process  (IBA,ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
negative regulation of hydrogen peroxide-mediated programmed cell death  (IEA)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of interleukin-6 production  (IEA,ISO)
negative regulation of peptidyl-serine phosphorylation  (IEA,ISO)
negative regulation of release of cytochrome c from mitochondria  (IEA)
obsolete activation of MAPK activity  (IEA)
positive chemotaxis  (IEA)
positive regulation of angiogenesis  (ISO)
positive regulation of cell migration  (IBA)
positive regulation of DNA biosynthetic process  (IEA)
positive regulation of interleukin-10 production  (IEA,ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of myelination  (ISO)
positive regulation of neuron projection regeneration  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of phosphatidylinositol 3-kinase signaling  (IEA)
positive regulation of protein phosphorylation  (IBA)
proteolysis  (IEA)
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  (IEA,ISO)
regulation of p38MAPK cascade  (IEA,ISO)
regulation of tau-protein kinase activity  (IEA,ISO)
signal transduction  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21723061   PMID:27423905  


Genomics

Comparative Map Data
HGF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl998,437,087 - 98,513,156 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1998,437,771 - 98,513,573 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29108,765,929 - 108,841,386 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HGF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl781,699,010 - 81,770,438 (-)EnsemblGRCh38hg38GRCh38
GRCh38781,699,006 - 81,770,438 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37781,328,326 - 81,399,363 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36781,169,380 - 81,237,388 (-)NCBINCBI36hg18NCBI36
Build 34781,024,867 - 81,044,103NCBI
Celera776,032,788 - 76,100,524 (-)NCBI
Cytogenetic Map7q21.11NCBI
HuRef775,935,402 - 76,003,191 (-)NCBIHuRef
CHM1_1781,258,674 - 81,329,573 (-)NCBICHM1_1
CRA_TCAGchr7v2780,663,506 - 80,731,238 (-)NCBI
Hgf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39516,758,493 - 16,827,448 (+)NCBIGRCm39mm39
GRCm39 Ensembl516,758,493 - 16,825,150 (+)Ensembl
GRCm38516,553,495 - 16,619,439 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl516,553,495 - 16,620,152 (+)EnsemblGRCm38mm10GRCm38
MGSCv37516,059,368 - 16,125,257 (+)NCBIGRCm37mm9NCBIm37
MGSCv36516,065,374 - 16,131,263 (+)NCBImm8
Celera513,552,002 - 13,617,800 (+)NCBICelera
Cytogenetic Map5A3NCBI
cM Map57.07NCBI
Hgf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2418,673,736 - 18,745,582 (-)NCBI
Rnor_6.0 Ensembl415,433,295 - 15,505,362 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0415,435,460 - 15,505,377 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0415,408,857 - 15,478,988 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4414,864,357 - 14,932,513 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1414,864,356 - 14,932,513 (-)NCBI
Celera414,212,976 - 14,281,167 (-)NCBICelera
Cytogenetic Map4q12NCBI
Hgf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554104,114,778 - 4,182,058 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554104,114,280 - 4,181,953 (+)NCBIChiLan1.0ChiLan1.0
HGF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1787,325,741 - 87,396,850 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl787,327,798 - 87,397,811 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0773,667,618 - 73,738,960 (-)NCBIMhudiblu_PPA_v0panPan3
HGF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11821,329,688 - 21,410,257 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1821,332,817 - 21,410,263 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1821,005,145 - 21,082,437 (-)NCBI
ROS_Cfam_1.01821,778,181 - 21,858,827 (-)NCBI
UMICH_Zoey_3.11821,417,964 - 21,495,307 (-)NCBI
UNSW_CanFamBas_1.01820,953,619 - 21,030,809 (-)NCBI
UU_Cfam_GSD_1.01821,607,548 - 21,684,870 (-)NCBI
Hgf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511863,151,279 - 63,227,083 (-)NCBI
SpeTri2.0NW_004936734354,798 - 428,356 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HGF
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12167,118,785 - 67,193,506 (+)NCBI
ChlSab1.1 Ensembl2167,120,722 - 67,193,504 (+)Ensembl
Vero_WHO_p1.0NW_02366604236,762,736 - 36,834,784 (-)NCBI
Hgf
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473930,233,589 - 30,307,508 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2
Low 10 4 3 3 2 16 2 3 3
Below cutoff 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000016778   ⟹   ENSSSCP00000016330
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl998,437,087 - 98,512,980 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000065643   ⟹   ENSSSCP00000058781
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl998,438,224 - 98,513,156 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000076107   ⟹   ENSSSCP00000066628
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl998,438,243 - 98,458,785 (+)Ensembl
RefSeq Acc Id: XM_003130222   ⟹   XP_003130270
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1998,437,777 - 98,513,570 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005667687   ⟹   XP_005667744
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1998,437,771 - 98,513,570 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013979787   ⟹   XP_013835241
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1998,437,775 - 98,513,573 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063485   ⟹   XP_020919144
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1998,438,097 - 98,513,570 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021063486   ⟹   XP_020919145
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1998,438,097 - 98,513,570 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005667744   ⟸   XM_005667687
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013835241   ⟸   XM_013979787
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_003130270   ⟸   XM_003130222
- Peptide Label: isoform X3
- UniProtKB: F1SB93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020919144   ⟸   XM_021063485
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020919145   ⟸   XM_021063486
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSSSCP00000058781   ⟸   ENSSSCT00000065643
RefSeq Acc Id: ENSSSCP00000016330   ⟸   ENSSSCT00000016778
RefSeq Acc Id: ENSSSCP00000066628   ⟸   ENSSSCT00000076107
Protein Domains
Apple   Kringle   Peptidase S1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000015403 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070001541 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000016330 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000058781 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000066628 UniProtKB/TrEMBL
  ENSSSCP00070002442 UniProtKB/TrEMBL
  ENSSSCP00070002453 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000016778 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000065643 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000076107 UniProtKB/TrEMBL
  ENSSSCT00070002966 UniProtKB/TrEMBL
  ENSSSCT00070002978 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  2.40.20.10 UniProtKB/TrEMBL
InterPro Hepatocyte_GF UniProtKB/TrEMBL
  HGF-like UniProtKB/TrEMBL
  Kringle UniProtKB/TrEMBL
  Kringle-like UniProtKB/TrEMBL
  Kringle_CS UniProtKB/TrEMBL
  Kringle_sf UniProtKB/TrEMBL
  Pan_app UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
KEGG Report ssc:100525120 UniProtKB/TrEMBL
NCBI Gene HGF ENTREZGENE
Pfam Kringle UniProtKB/TrEMBL
  PAN_1 UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PIRSF Hepatocyte_GF UniProtKB/TrEMBL
  HGF_MST1 UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE KRINGLE_1 UniProtKB/TrEMBL
  KRINGLE_2 UniProtKB/TrEMBL
  PAN UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
SMART PAN_AP UniProtKB/TrEMBL
  SM00130 UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
  SSF57440 UniProtKB/TrEMBL
UniProt A0A287BRN0_PIG UniProtKB/TrEMBL
  A0A480SZ19_PIG UniProtKB/TrEMBL
  A0A4X1SJC0_PIG UniProtKB/TrEMBL
  A0A5G2QP08_PIG UniProtKB/TrEMBL
  F1SB93 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:88869 ENTREZGENE