MIR145 (microRNA mir-145) - Rat Genome Database

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Gene: MIR145 (microRNA mir-145) Sus scrofa
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Symbol: MIR145 (Ensembl: ssc-mir-145)
Name: microRNA mir-145 (Ensembl:ssc-mir-145)
RGD ID: 13936694
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA 145; ssc-mir-145
RGD Orthologs
Human
Mouse
Rat
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2150,580,126 - 150,580,211 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12150,580,126 - 150,580,211 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22157,346,127 - 157,346,212 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aorta smooth muscle tissue morphogenesis  (ISO)
cardiac vascular smooth muscle cell differentiation  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to estrogen stimulus  (ISO)
cellular response to ethanol  (ISO)
cellular response to hydroperoxide  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
ectodermal cell differentiation  (ISO)
hematopoietic stem cell proliferation  (ISO)
long-term synaptic potentiation  (ISO)
mesodermal cell differentiation  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (IEA)
negative regulation of angiogenesis  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cellular response to transforming growth factor beta stimulus  (ISO)
negative regulation of cholesterol efflux  (ISO)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of extracellular matrix assembly  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-16 production  (ISO)
negative regulation of SMAD protein signal transduction  (ISO)
negative regulation of somatic stem cell division  (ISO)
negative regulation of somatic stem cell population maintenance  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
positive regulation of cellular response to hypoxia  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of macrophage activation  (ISO)
positive regulation of macrophage differentiation  (ISO)
positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching  (ISO)
response to alkaloid  (ISO)
response to ischemia  (ISO)
retina layer formation  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:15885146   PMID:16381832   PMID:18548309   PMID:19917043   PMID:20180025   PMID:21312241   PMID:23197937   PMID:24499489  


Genomics

Comparative Map Data
MIR145
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2150,580,126 - 150,580,211 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12150,580,126 - 150,580,211 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22157,346,127 - 157,346,212 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MIR145
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385149,430,646 - 149,430,733 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5149,430,646 - 149,430,733 (+)EnsemblGRCh38hg38GRCh38
GRCh375148,810,209 - 148,810,296 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365148,790,401 - 148,790,488 (+)NCBINCBI36Build 36hg18NCBI36
Celera5144,892,189 - 144,892,276 (+)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5143,956,545 - 143,956,632 (+)NCBIHuRef
CHM1_15148,242,644 - 148,242,731 (+)NCBICHM1_1
T2T-CHM13v2.05149,965,492 - 149,965,579 (+)NCBIT2T-CHM13v2.0
Mir145a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391861,780,896 - 61,780,965 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1861,780,896 - 61,780,965 (-)EnsemblGRCm39 Ensembl
GRCm381861,647,825 - 61,647,894 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1861,647,825 - 61,647,894 (-)EnsemblGRCm38mm10GRCm38
MGSCv371861,807,479 - 61,807,548 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1862,930,620 - 62,930,689 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.64NCBI
Mir145
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81857,369,983 - 57,370,070 (-)NCBIGRCr8
mRatBN7.21855,099,640 - 55,099,727 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1855,099,640 - 55,099,727 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1857,193,356 - 57,193,443 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,907,967 - 57,908,054 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,723,506 - 55,723,593 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,969,907 - 56,969,994 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,969,907 - 56,969,994 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01856,198,820 - 56,198,907 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1853,250,138 - 53,250,225 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
MIR145
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1459,533,128 - 59,533,210 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl459,533,128 - 59,533,210 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha459,298,427 - 59,298,509 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0460,015,687 - 60,015,769 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl460,015,687 - 60,015,769 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1459,802,584 - 59,802,666 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0459,917,043 - 59,917,125 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0460,447,590 - 60,447,672 (-)NCBIUU_Cfam_GSD_1.0

Variants

.
Variants in MIR145
1 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 3 5 1 4 13 11 5 2 4 1

Sequence


Ensembl Acc Id: ENSSSCT00000020108
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl2150,580,126 - 150,580,211 (+)Ensembl
RefSeq Acc Id: NR_038484
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.12150,580,126 - 150,580,211 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000018513 Ensembl, ENTREZGENE
Ensembl Transcript ENSSSCT00000020108 ENTREZGENE
miRBase MI0002417 ENTREZGENE
NCBI Gene MIR145 ENTREZGENE
RNAcentral URS000052F380 RNACentral
  URS000053F5B2 RNACentral
  URS000075AED0 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 MIR145  microRNA mir-145    microRNA 145  Symbol and/or name change 5135510 APPROVED