RGD Reference Report - Circulating MicroRNA-145 is Associated with Acute Myocardial Infarction and Heart Failure. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Circulating MicroRNA-145 is Associated with Acute Myocardial Infarction and Heart Failure.

Authors: Zhang, Ming  Cheng, Yun-Jiu  Sara, Jaskanwal Ds  Liu, Li-Juan  Liu, Li-Ping  Zhao, Xin  Gao, Hai 
Citation: Zhang M, etal., Chin Med J (Engl). 2017 5th Jan 2017;130(1):51-56. doi: 10.4103/0366-6999.196573.
RGD ID: 155260283
Pubmed: PMID:28051023   (View Abstract at PubMed)
PMCID: PMC5221112   (View Article at PubMed Central)
DOI: DOI:10.4103/0366-6999.196573   (Journal Full-text)


BACKGROUND: Recent studies show that microRNA-145 (miRNA-145) might be an attractive tumor biomarker of considerable prognostic value, but little is known about their relationship with acute myocardial infarction (AMI). This study investigated the correlation between the level of miR-145 and AMI.
METHODS: One-hundred patients were divided into three groups: no coronary artery disease (CAD) group, non-ST segment elevation myocardial infarction group, and ST segment elevation myocardial infarction group. The plasma levels of miR-145 were quantified using real-time quantitative polymerase chain reaction. Logarithmic transformation of miRNA-145 levels (Ln_miRNA-145) was used for statistical analysis due to the skewed data distribution.
RESULTS: Plasma levels of miR-145 were significantly lower in patients with AMI compared to patients in the non-CAD group (-6.38 ± 0.11 vs. -4.47 ± 0.17, P< 0.0001). Compared to those without heart failure, the levels of miR-145 were significantly lower in patients with heart failure (-6.91 ± 0.20 vs. -5.35 ± 0.13, P< 0.0001). We also found that the lower plasma levels of miRNA-145 significantly correlated with increased serum levels of B-type natriuretic peptide (Spearman ρ= -0.60, P< 0.0001), troponin T (Spearman ρ= -0.62, P< 0.0001), and decreased ejection fraction (Spearman ρ= 0.65, P< 0.0001). In a multivariable linear regression analysis, AMI and heart failure were independently associated with lower Ln_miRNA-145 (estimate -0.99, standard error [SE] 0.28; P= 0.001 and estimate -0.62, SE 0.21; P= 0.004).
CONCLUSIONS: Our results suggest that decreased plasma levels of miR-145 are associated with AMI. Circulating miR-145 may be useful in prognosticating cardiac function and the risk of developing heart failure.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
congestive heart failure disease_progressionISOMir145 (Rattus norvegicus)155260283; 155260283associated with acute myocardial infarction and miRNA:decreased expression:blood plasma (rat)RGD 
congestive heart failure disease_progressionIEP 155260283associated with acute myocardial infarction and miRNA:decreased expression:blood plasma (rat)RGD 
diabetes mellitus  ISOMir145 (Rattus norvegicus)155260283; 155260283miRNA:decreased expression:blood plasma (rat)RGD 
diabetes mellitus  IEP 155260283miRNA:decreased expression:blood plasma (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mir145  (microRNA 145)

Genes (Mus musculus)
Mir145a  (microRNA 145a)

Genes (Homo sapiens)
MIR145  (microRNA 145)


Additional Information