RGD Reference Report - Transgenic expression of osteoactivin in the liver attenuates hepatic fibrosis in rats. - Rat Genome Database

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Transgenic expression of osteoactivin in the liver attenuates hepatic fibrosis in rats.

Authors: Abe, H  Uto, H  Takami, Y  Takahama, Y  Hasuike, S  Kodama, M  Nagata, K  Moriuchi, A  Numata, M  Ido, A  Tsubouchi, H 
Citation: Abe H, etal., Biochem Biophys Res Commun. 2007 May 11;356(3):610-5. Epub 2007 Mar 15.
RGD ID: 11080969
Pubmed: PMID:17382907   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2007.03.035   (Journal Full-text)

The role of osteoactivin (OA) in liver fibrogenesis remains unclear. After feeding wild-type (WT) and OA transgenic (OA-Tg) rats a choline-deficient, L-amino acid-defined (CDAA) diet for 12 weeks, we evaluated liver fibrosis. Hepatic fibrosis and expression of alpha-smooth muscle actin protein in OA-Tg rats were reduced in comparison to WT rats. Our examination of the expression of 31,100 genes by microarray analysis identified 177 and 256 genes that were upregulated and downregulated, respectively, by at least twofold in OA-Tg rat livers in comparison to WT rat livers. Of these genes, we confirmed a significant downregulation in the expression levels of tissue inhibitor of metalloproteinase-1 and -2, type I collagen, and platelet-derived growth factor receptor-alpha and -beta in the livers of OA-Tg rats. These results indicate that transgenic OA expression attenuates the development of hepatic fibrosis in association with the suppression of specific genes involved in its pathogenesis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PDGFRAHumanExperimental Liver Cirrhosis treatmentISOPdgfra (Rattus norvegicus) RGD 
PdgfraRatExperimental Liver Cirrhosis treatmentIDA  RGD 
PdgfraMouseExperimental Liver Cirrhosis treatmentISOPdgfra (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pdgfra  (platelet derived growth factor receptor alpha)

Genes (Mus musculus)
Pdgfra  (platelet derived growth factor receptor, alpha polypeptide)

Genes (Homo sapiens)
PDGFRA  (platelet derived growth factor receptor alpha)


Additional Information