TFPI (tissue factor pathway inhibitor) - Rat Genome Database

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Gene: TFPI (tissue factor pathway inhibitor) Sus scrofa
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Symbol: TFPI
Name: tissue factor pathway inhibitor
RGD ID: 14246903
Description: INVOLVED IN cellular response to interleukin-1 (ortholog); cellular response to lipopolysaccharide (ortholog); response to estradiol (ortholog); PARTICIPATES IN coagulation cascade pathway; syndecan signaling pathway; ASSOCIATED WITH Airway Obstruction (ortholog); atrial fibrillation (ortholog); B-lymphoblastic leukemia/lymphoma (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH resveratrol
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1592,345,075 - 92,409,905 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11592,345,083 - 92,409,962 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215102,535,224 - 102,694,356 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
resveratrol  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:18611227  


Genomics

Comparative Map Data
TFPI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1592,345,075 - 92,409,905 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11592,345,083 - 92,409,962 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215102,535,224 - 102,694,356 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TFPI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2187,464,230 - 187,565,760 (-)EnsemblGRCh38hg38GRCh38
GRCh382187,464,230 - 187,554,501 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372188,328,957 - 188,419,162 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362188,037,202 - 188,127,464 (-)NCBINCBI36hg18NCBI36
Build 342188,156,790 - 188,244,556NCBI
Celera2181,925,068 - 182,015,356 (-)NCBI
Cytogenetic Map2q32.1NCBI
HuRef2180,188,532 - 180,278,959 (-)NCBIHuRef
CHM1_12188,334,627 - 188,424,881 (-)NCBICHM1_1
Tfpi
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39284,263,199 - 84,307,119 (-)NCBIGRCm39mm39
GRCm39 Ensembl284,263,199 - 84,307,119 (-)Ensembl
GRCm38284,432,855 - 84,476,775 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl284,432,855 - 84,476,775 (-)EnsemblGRCm38mm10GRCm38
MGSCv37284,273,017 - 84,316,932 (-)NCBIGRCm37mm9NCBIm37
MGSCv36284,233,699 - 84,275,013 (-)NCBImm8
Celera286,041,007 - 86,084,914 (-)NCBICelera
Cytogenetic Map2DNCBI
Tfpi
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2369,533,156 - 69,582,547 (-)NCBI
Rnor_6.0 Ensembl371,852,744 - 71,893,618 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0371,852,738 - 71,902,127 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0378,373,808 - 78,423,115 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4367,654,389 - 67,697,178 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1367,550,760 - 67,593,550 (-)NCBI
Celera368,890,124 - 68,933,788 (-)NCBICelera
Cytogenetic Map3q24NCBI
Tfpi
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540310,924,893 - 11,004,284 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540310,925,155 - 11,004,229 (+)NCBIChiLan1.0ChiLan1.0
TFPI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B192,541,881 - 192,631,867 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B192,541,881 - 192,581,384 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B74,744,154 - 74,834,338 (-)NCBIMhudiblu_PPA_v0panPan3
TFPI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13629,457,131 - 29,546,455 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3629,459,371 - 29,511,310 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3629,358,584 - 29,410,512 (-)NCBI
ROS_Cfam_1.03629,680,362 - 29,769,683 (-)NCBI
UMICH_Zoey_3.13629,744,554 - 29,796,457 (-)NCBI
UNSW_CanFamBas_1.03629,679,616 - 29,731,462 (-)NCBI
UU_Cfam_GSD_1.03629,848,287 - 29,900,234 (-)NCBI
Tfpi
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303146,663,997 - 146,734,969 (-)NCBI
SpeTri2.0NW_00493650610,103,120 - 10,172,800 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TFPI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11073,004,762 - 73,105,772 (-)NCBI
ChlSab1.1 Ensembl1073,002,522 - 73,105,858 (-)Ensembl
Vero_WHO_p1.0NW_023666040126,397,666 - 126,498,612 (+)NCBI
Tfpi
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248992,401,861 - 2,473,762 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system reproductive system respiratory system
High
Medium
Low 7 2 3 2 2 5 2
Below cutoff 3 2 2 10 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000040738   ⟹   ENSSSCP00000048443
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1592,345,075 - 92,409,905 (-)Ensembl
RefSeq Acc Id: NM_001135258   ⟹   NP_001128730
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11592,347,443 - 92,384,259 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005672009   ⟹   XP_005672066
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11592,345,083 - 92,409,959 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013984326   ⟹   XP_013839780
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11592,345,083 - 92,409,961 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013984328   ⟹   XP_013839782
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11592,345,083 - 92,409,961 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013984329   ⟹   XP_013839783
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11592,345,083 - 92,409,962 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021074527   ⟹   XP_020930186
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11592,355,288 - 92,409,960 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_013839783   ⟸   XM_013984329
- Peptide Label: isoform X1
- UniProtKB: B5ST96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013839780   ⟸   XM_013984326
- Peptide Label: isoform X1
- UniProtKB: B5ST96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013839782   ⟸   XM_013984328
- Peptide Label: isoform X1
- UniProtKB: B5ST96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005672066   ⟸   XM_005672009
- Peptide Label: isoform X1
- UniProtKB: B5ST96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001128730   ⟸   NM_001135258
- Peptide Label: precursor
- UniProtKB: B5ST96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020930186   ⟸   XM_021074527
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSSSCP00000048443   ⟸   ENSSSCT00000040738
Protein Domains
BPTI/Kunitz inhibitor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000016032 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070011732 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000048443 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070018926 UniProtKB/TrEMBL
  ENSSSCP00070018933 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000040738 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070022885 UniProtKB/TrEMBL
  ENSSSCT00070022892 UniProtKB/TrEMBL
Gene3D-CATH 4.10.410.10 UniProtKB/TrEMBL
InterPro Kunitz_BPTI UniProtKB/TrEMBL
  Kunitz_BPTI_sf UniProtKB/TrEMBL
  Prtase_inh_Kunz-CS UniProtKB/TrEMBL
  TFPI-like UniProtKB/TrEMBL
KEGG Report ssc:100155068 UniProtKB/TrEMBL
NCBI Gene TFPI ENTREZGENE
Pfam Kunitz_BPTI UniProtKB/TrEMBL
PIRSF TFPI UniProtKB/TrEMBL
PRINTS BASICPTASE UniProtKB/TrEMBL
PROSITE BPTI_KUNITZ_1 UniProtKB/TrEMBL
  BPTI_KUNITZ_2 UniProtKB/TrEMBL
SMART SM00131 UniProtKB/TrEMBL
Superfamily-SCOP SSF57362 UniProtKB/TrEMBL
UniProt A0A4X1TUD5_PIG UniProtKB/TrEMBL
  B5ST96 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1RYJ0 UniProtKB/TrEMBL
VGNC ID VGNC:98366 ENTREZGENE