SERPINC1 (serpin family C member 1) - Rat Genome Database

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Gene: SERPINC1 (serpin family C member 1) Sus scrofa
Analyze
Symbol: SERPINC1
Name: serpin family C member 1
RGD ID: 14220753
Description: ENCODES a protein that exhibits heparin binding (ortholog); serine-type endopeptidase inhibitor activity (ortholog); INVOLVED IN acute inflammatory response to antigenic stimulus (ortholog); lactation (ortholog); response to nutrient (ortholog); PARTICIPATES IN coagulation cascade pathway; enoxaparin pharmacodynamics pathway; fondaparinux pharmacodynamics pathway; ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); Acute Coronary Syndrome (ortholog); acute kidney failure (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: antithrombin III; antithrombin-III; AT3; serpin peptidase inhibitor, clade C (antithrombin), member 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9116,181,980 - 116,193,201 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19116,181,988 - 116,193,100 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29127,817,120 - 127,828,237 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,IEA,ISO)

Molecular Function

References
Additional References at PubMed
PMID:14681463  


Genomics

Comparative Map Data
SERPINC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9116,181,980 - 116,193,201 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19116,181,988 - 116,193,100 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29127,817,120 - 127,828,237 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SERPINC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1173,903,800 - 173,917,327 (-)EnsemblGRCh38hg38GRCh38
GRCh381173,903,800 - 173,917,327 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371173,872,938 - 173,886,465 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361172,139,565 - 172,153,096 (-)NCBINCBI36hg18NCBI36
Build 341170,604,599 - 170,618,130NCBI
Celera1146,982,409 - 146,995,977 (-)NCBI
Cytogenetic Map1q25.1NCBI
HuRef1145,098,064 - 145,111,634 (-)NCBIHuRef
CHM1_11175,295,382 - 175,308,956 (-)NCBICHM1_1
Serpinc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,806,153 - 160,830,113 (+)NCBIGRCm39mm39
GRCm39 Ensembl1160,806,155 - 160,833,433 (+)Ensembl
GRCm381160,978,583 - 161,002,543 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,978,585 - 161,005,863 (+)EnsemblGRCm38mm10GRCm38
MGSCv371162,908,737 - 162,933,146 (+)NCBIGRCm37mm9NCBIm37
MGSCv361162,824,166 - 162,839,687 (+)NCBImm8
Celera1163,418,142 - 163,442,757 (+)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.75NCBI
Serpinc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21373,257,208 - 73,271,476 (+)NCBI
Rnor_6.0 Ensembl1378,805,347 - 78,833,192 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01378,806,107 - 78,820,375 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01383,700,761 - 83,715,029 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41376,548,456 - 76,562,724 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11376,562,643 - 76,576,911 (+)NCBI
Celera1373,045,672 - 73,059,940 (+)NCBICelera
Cytogenetic Map13q22NCBI
Serpinc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540614,024,313 - 14,035,948 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540614,024,183 - 14,036,206 (-)NCBIChiLan1.0ChiLan1.0
SERPINC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11153,126,031 - 153,139,369 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1153,126,031 - 153,139,369 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01149,421,737 - 149,435,301 (-)NCBIMhudiblu_PPA_v0panPan3
SERPINC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1725,322,668 - 25,333,022 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl725,316,129 - 25,332,987 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha724,855,807 - 24,866,147 (+)NCBI
ROS_Cfam_1.0725,073,311 - 25,083,857 (+)NCBI
UMICH_Zoey_3.1724,993,149 - 25,003,688 (+)NCBI
UNSW_CanFamBas_1.0725,074,836 - 25,085,380 (+)NCBI
UU_Cfam_GSD_1.0725,220,039 - 25,230,581 (+)NCBI
Serpinc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934496,134,261 - 96,146,884 (+)NCBI
SpeTri2.0NW_00493648113,981,014 - 13,993,750 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12555,271,823 - 55,289,855 (+)NCBI
Vero_WHO_p1.0NW_02366605556,831,874 - 56,851,329 (+)NCBI
Serpinc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247717,955,778 - 7,966,637 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 6 1 3 4 12 1 1 1
Below cutoff 4 3 1 2 10 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000016877   ⟹   ENSSSCP00000016426
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl9116,181,980 - 116,193,174 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000074457   ⟹   ENSSSCP00000067774
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl9116,181,990 - 116,193,201 (-)Ensembl
RefSeq Acc Id: NM_001129958   ⟹   NP_001123430
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.19116,181,988 - 116,193,100 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001123430 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG01450 (Get FASTA)   NCBI Sequence Viewer  
  ABF82362 (Get FASTA)   NCBI Sequence Viewer  
  ABM30151 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001123430   ⟸   NM_001129958
- Peptide Label: precursor
- UniProtKB: Q19AZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000067774   ⟸   ENSSSCT00000074457
RefSeq Acc Id: ENSSSCP00000016426   ⟸   ENSSSCT00000016877
Protein Domains
SERPIN


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000015493 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000016426 UniProtKB/TrEMBL
  ENSSSCP00000067774 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000016877 UniProtKB/TrEMBL
  ENSSSCT00000074457 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Antithrombin_domain UniProtKB/TrEMBL
  AT-III UniProtKB/TrEMBL
  Serpin_CS UniProtKB/TrEMBL
  Serpin_dom UniProtKB/TrEMBL
  Serpin_fam UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report ssc:100125972 UniProtKB/TrEMBL
NCBI Gene SERPINC1 ENTREZGENE
PANTHER PTHR11461 UniProtKB/TrEMBL
  PTHR11461:SF53 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PROSITE SERPIN UniProtKB/TrEMBL
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/TrEMBL
UniProt A0A5G2QUE0_PIG UniProtKB/TrEMBL
  F2Z5E2_PIG UniProtKB/TrEMBL
  Q19AZ5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:92740 ENTREZGENE