RGN (regucalcin) - Rat Genome Database

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Gene: RGN (regucalcin) Sus scrofa
Analyze
Symbol: RGN
Name: regucalcin
RGD ID: 13853395
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); gluconolactonase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN intracellular calcium ion homeostasis (ortholog); kidney development (ortholog); L-ascorbic acid biosynthetic process (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); INTERACTS WITH deoxynivalenol; zearalenone
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: gluconolactonase; GNL; RC; regucalcin (senescence marker protein-30); senescence marker protein 30; SMP-30
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX41,726,526 - 41,749,381 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X41,725,660 - 41,749,736 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X46,902,494 - 46,926,414 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
intracellular calcium ion homeostasis  (ISO)
kidney development  (ISO)
L-ascorbic acid biosynthetic process  (IBA,IEA,ISS)
liver development  (ISO)
liver regeneration  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of bone development  (ISO)
negative regulation of calcium-dependent ATPase activity  (ISO)
negative regulation of cyclic-nucleotide phosphodiesterase activity  (ISO)
negative regulation of DNA biosynthetic process  (ISO)
negative regulation of DNA catabolic process  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of flagellated sperm motility  (ISO)
negative regulation of GTPase activity  (ISO)
negative regulation of macromolecule biosynthetic process  (ISO)
negative regulation of nitric oxide biosynthetic process  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of RNA biosynthetic process  (ISO)
positive regulation of ATP-dependent activity  (ISO)
positive regulation of ATPase-coupled calcium transmembrane transporter activity  (ISO)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of glucose metabolic process  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of phosphatase activity  (ISO)
positive regulation of proteolysis involved in protein catabolic process  (ISO)
positive regulation of superoxide dismutase activity  (ISO)
positive regulation of triglyceride biosynthetic process  (ISO)
regulation of calcium-mediated signaling  (ISO)
spermatogenesis  (ISO)

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RGN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX41,726,526 - 41,749,381 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X41,725,660 - 41,749,736 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X46,902,494 - 46,926,414 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RGN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,078,443 - 47,093,313 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX47,078,355 - 47,093,314 (+)EnsemblGRCh38hg38GRCh38
GRCh37X46,937,842 - 46,952,712 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X46,822,719 - 46,837,656 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X46,696,510 - 46,708,966NCBI
CeleraX51,129,720 - 51,148,035 (+)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX44,651,176 - 44,667,384 (+)NCBIHuRef
CHM1_1X46,969,564 - 46,984,507 (+)NCBICHM1_1
T2T-CHM13v2.0X46,485,437 - 46,503,065 (+)NCBIT2T-CHM13v2.0
Rgn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,413,980 - 20,428,328 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,416,026 - 20,428,328 (+)EnsemblGRCm39 Ensembl
GRCm38X20,549,766 - 20,562,089 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,549,787 - 20,562,089 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X20,126,944 - 20,139,213 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X19,706,777 - 19,719,046 (+)NCBIMGSCv36mm8
CeleraX18,681,357 - 18,693,626 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.04NCBI
Rgn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X4,172,537 - 4,190,112 (-)NCBIGRCr8
mRatBN7.2X1,619,030 - 1,634,456 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,619,032 - 1,634,450 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,653,062 - 1,668,461 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X5,128,761 - 5,144,164 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X1,444,046 - 1,459,469 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,833,484 - 1,848,904 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,833,492 - 1,848,904 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,626,525 - 2,641,949 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X13,037,171 - 13,052,846NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX2,182,952 - 2,198,371 (-)NCBICelera
Cytogenetic MapXq11NCBI
Rgn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955516955,680 - 978,910 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955516958,416 - 978,829 (-)NCBIChiLan1.0ChiLan1.0
RGN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X48,703,675 - 48,720,753 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X48,707,048 - 48,724,130 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X39,513,135 - 39,530,188 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X47,371,225 - 47,388,881 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX47,371,226 - 47,388,881 (+)Ensemblpanpan1.1panPan2
RGN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X40,697,292 - 40,715,491 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX40,698,768 - 40,715,490 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,074,578 - 15,090,960 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X40,818,343 - 40,849,916 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX40,833,166 - 40,849,918 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X40,806,174 - 40,837,694 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X40,793,810 - 40,825,378 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X40,886,864 - 40,918,439 (+)NCBIUU_Cfam_GSD_1.0
Rgn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,032,122 - 33,050,817 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650212,872,824 - 12,891,506 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650212,872,938 - 12,891,270 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X44,282,825 - 44,299,027 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX44,285,601 - 44,299,258 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660769,539,184 - 9,555,388 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248873,883,213 - 3,899,277 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248873,881,624 - 3,900,144 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RGN
312 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 3 23 3 2 11 9 23 3 6 1

Sequence


Ensembl Acc Id: ENSSSCT00000023142   ⟹   ENSSSCP00000023581
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX41,727,453 - 41,749,726 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000034632   ⟹   ENSSSCP00000028730
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX41,726,526 - 41,749,381 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000079146   ⟹   ENSSSCP00000065614
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX41,726,526 - 41,749,381 (+)Ensembl
RefSeq Acc Id: NM_001077220   ⟹   NP_001070688
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X41,728,898 - 41,749,246 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005673573   ⟹   XP_005673630
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X41,727,915 - 41,749,736 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005673574   ⟹   XP_005673631
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X41,727,955 - 41,749,736 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005673575   ⟹   XP_005673632
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X41,725,736 - 41,749,736 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005673576   ⟹   XP_005673633
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X41,725,660 - 41,749,736 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005673633   ⟸   XM_005673576
- Peptide Label: isoform X1
- UniProtKB: A0A8D1TTT2 (UniProtKB/TrEMBL),   A0A8D2A1A7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005673632   ⟸   XM_005673575
- Peptide Label: isoform X1
- UniProtKB: A0A8D1TTT2 (UniProtKB/TrEMBL),   A0A8D2A1A7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005673630   ⟸   XM_005673573
- Peptide Label: isoform X1
- UniProtKB: A0A8D1TTT2 (UniProtKB/TrEMBL),   A0A8D2A1A7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005673631   ⟸   XM_005673574
- Peptide Label: isoform X1
- UniProtKB: A0A8D1TTT2 (UniProtKB/TrEMBL),   A0A8D2A1A7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001070688   ⟸   NM_001077220
- UniProtKB: Q06AA3 (UniProtKB/Swiss-Prot),   A0A8D1TTT2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000028730   ⟸   ENSSSCT00000034632
Ensembl Acc Id: ENSSSCP00000065614   ⟸   ENSSSCT00000079146
Ensembl Acc Id: ENSSSCP00000023581   ⟸   ENSSSCT00000023142
Protein Domains
SMP-30/Gluconolactonase/LRE-like region


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000022390 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015017682 UniProtKB/TrEMBL
  ENSSSCG00025058051 UniProtKB/TrEMBL
  ENSSSCG00030052783 UniProtKB/TrEMBL
  ENSSSCG00035078196 UniProtKB/TrEMBL
  ENSSSCG00040049175 UniProtKB/TrEMBL
  ENSSSCG00045021230 UniProtKB/TrEMBL
  ENSSSCG00050076197 UniProtKB/TrEMBL
  ENSSSCG00055002480 UniProtKB/TrEMBL
  ENSSSCG00060078981 UniProtKB/TrEMBL
  ENSSSCG00065072239 UniProtKB/TrEMBL
  ENSSSCG00070024778 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000034632 ENTREZGENE
  ENSSSCT00000034632.4 UniProtKB/TrEMBL
  ENSSSCT00000079146.2 UniProtKB/TrEMBL
  ENSSSCT00015023380.1 UniProtKB/TrEMBL
  ENSSSCT00015023569.1 UniProtKB/TrEMBL
  ENSSSCT00015023644.1 UniProtKB/TrEMBL
  ENSSSCT00025079474.1 UniProtKB/TrEMBL
  ENSSSCT00025079617.1 UniProtKB/TrEMBL
  ENSSSCT00030073637.1 UniProtKB/TrEMBL
  ENSSSCT00030073650.1 UniProtKB/TrEMBL
  ENSSSCT00035106701.1 UniProtKB/TrEMBL
  ENSSSCT00035106714.1 UniProtKB/TrEMBL
  ENSSSCT00040066564.1 UniProtKB/TrEMBL
  ENSSSCT00040066656.1 UniProtKB/TrEMBL
  ENSSSCT00045036282.1 UniProtKB/TrEMBL
  ENSSSCT00045036346.1 UniProtKB/TrEMBL
  ENSSSCT00050104628.1 UniProtKB/TrEMBL
  ENSSSCT00050104630.1 UniProtKB/TrEMBL
  ENSSSCT00055004743.1 UniProtKB/TrEMBL
  ENSSSCT00055004773.1 UniProtKB/TrEMBL
  ENSSSCT00060109308.1 UniProtKB/TrEMBL
  ENSSSCT00060109309.1 UniProtKB/TrEMBL
  ENSSSCT00065099271.1 UniProtKB/TrEMBL
  ENSSSCT00065099278.1 UniProtKB/TrEMBL
  ENSSSCT00070049489.1 UniProtKB/TrEMBL
  ENSSSCT00070049490.1 UniProtKB/TrEMBL
  ENSSSCT00070049492.1 UniProtKB/TrEMBL
  ENSSSCT00070049495.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Regucalcin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SGL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMP-30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:768107 UniProtKB/Swiss-Prot
NCBI Gene RGN ENTREZGENE
PANTHER REGUCALCIN UniProtKB/Swiss-Prot
  REGUCALCIN UniProtKB/Swiss-Prot
  REGUCALCIN UniProtKB/TrEMBL
  REGUCALCIN UniProtKB/TrEMBL
Pfam SGL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS REGUCALCIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMP30FAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Calcium-dependent phosphotriesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5G2R4X2_PIG UniProtKB/TrEMBL
  A0A8D0LYT6_PIG UniProtKB/TrEMBL
  A0A8D1TTT2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D2A1A7 ENTREZGENE, UniProtKB/TrEMBL
  F1RWY0_PIG UniProtKB/TrEMBL
  Q06AA3 ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID VGNC:92256 ENTREZGENE