RHOA (ras homolog family member A) - Rat Genome Database
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Gene: RHOA (ras homolog family member A) Sus scrofa
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Symbol: RHOA
Name: ras homolog family member A
RGD ID: 13900973
Description: ENCODES a protein that exhibits GDP binding (ortholog); GTP binding (ortholog); GTPase activity (ortholog); INVOLVED IN embryonic cleavage; establishment or maintenance of actin cytoskeleton polarity; meiotic spindle organization; PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); alopecia (ortholog); Animal Disease Models (ortholog); FOUND IN cell cortex; cleavage furrow; meiotic spindle
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ras homolog gene family, member A; Rho A; transforming protein RhoA
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,918,836 - 32,003,722 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,918,484 - 31,991,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,149,494 - 35,160,516 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Abnormalities, Drug-Induced  (ISO)
alopecia  (ISO)
Animal Disease Models  (ISO)
asthma  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2P  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
Cocaine-Related Disorders  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
Craniofacial Abnormalities  (ISO)
cutaneous T cell lymphoma  (ISO)
ectodermal dysplasia  (ISO)
esophageal carcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Facial Ectodermal Dysplasia  (ISO)
fetal alcohol syndrome  (ISO)
Fibrosis  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
hypertension  (ISO)
Hypopigmentation  (ISO)
Immunoblastic Lymphadenopathy  (ISO)
Left Ventricular Hypertrophy  (ISO)
Leukoencephalopathies  (ISO)
lung adenocarcinoma  (ISO)
Lymphatic Metastasis  (ISO)
membranous glomerulonephritis  (ISO)
multiple sclerosis  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neurocutaneous Syndromes  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (ISO)
Optic Nerve Injuries  (ISO)
ovarian carcinoma  (ISO)
peripheral T-cell lymphoma  (ISO)
proteinuria  (ISO)
pulmonary hypertension  (ISO)
Stomach Neoplasms  (ISO)
T-Cell Lymphoma  (ISO)
tooth disease  (ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO,ISS)
actin cytoskeleton reorganization  (ISO)
actin filament organization  (IBA)
alpha-beta T cell lineage commitment  (ISO,ISS)
androgen receptor signaling pathway  (ISO,ISS)
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  (IEA,ISO)
apical junction assembly  (ISO,ISS)
apolipoprotein A-I-mediated signaling pathway  (ISS)
beta selection  (ISO,ISS)
cell adhesion  (ISO,ISS)
cell differentiation  (ISO,ISS)
cell junction assembly  (ISO)
cell migration  (IBA)
cell morphogenesis  (ISO,ISS)
cell-matrix adhesion  (ISO,ISS)
cellular response to chemokine  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to lipopolysaccharide  (ISO)
cerebral cortex cell migration  (ISO,ISS)
cleavage furrow formation  (ISS)
cortical cytoskeleton organization  (IBA)
cytoplasmic microtubule organization  (ISO)
cytoskeleton organization  (ISO,ISS)
embryonic cleavage  (IMP)
endothelial cell migration  (ISO)
endothelial tube lumen extension  (ISO)
establishment of epithelial cell apical/basal polarity  (ISO)
establishment or maintenance of actin cytoskeleton polarity  (IMP)
establishment or maintenance of cell polarity  (IBA)
forebrain radial glial cell differentiation  (ISO,ISS)
GTP metabolic process  (ISO,ISS)
kidney development  (ISO)
meiotic spindle organization  (IMP)
mitotic cleavage furrow formation  (ISO)
mitotic spindle assembly  (ISS)
negative chemotaxis  (ISS)
negative regulation of cell death  (ISO,ISS)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of cell size  (ISO)
negative regulation of cell-substrate adhesion  (IEA,ISO)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (ISO,ISS)
negative regulation of intracellular steroid hormone receptor signaling pathway  (ISO,ISS)
negative regulation of neuron apoptotic process  (ISO,ISS)
negative regulation of neuron differentiation  (ISO,ISS)
negative regulation of neuron projection development  (ISO)
negative regulation of oxidative phosphorylation  (ISO,ISS)
negative regulation of reactive oxygen species biosynthetic process  (ISO,ISS)
neuron projection morphogenesis  (ISO)
odontogenesis  (IEA,ISO)
ossification involved in bone maturation  (ISO,ISS)
polar body extrusion after meiotic divisions  (IMP)
positive regulation of actin filament polymerization  (ISO,ISS)
positive regulation of alpha-beta T cell differentiation  (ISO,ISS)
positive regulation of cell adhesion  (ISO)
positive regulation of cell growth  (ISO,ISS)
positive regulation of cell migration  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO,ISS)
positive regulation of cytokinesis  (IMP)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of leukocyte adhesion to vascular endothelial cell  (ISO)
positive regulation of lipase activity  (ISS)
positive regulation of neuron apoptotic process  (ISO,ISS)
positive regulation of neuron differentiation  (ISS)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of podosome assembly  (ISO,ISS)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of smooth muscle contraction  (ISO,ISS)
positive regulation of stress fiber assembly  (ISO,ISS)
positive regulation of T cell migration  (ISO)
positive regulation of translation  (ISO)
positive regulation of vascular associated smooth muscle contraction  (IEA,ISO)
positive regulation of vasoconstriction  (ISO)
regulation of actin cytoskeleton organization  (IBA,ISO,ISS)
regulation of actin polymerization or depolymerization  (ISO)
regulation of calcium ion transport  (ISO,ISS)
regulation of cell migration  (ISS)
regulation of cell shape  (IBA)
regulation of dendrite development  (ISO,ISS)
regulation of microtubule cytoskeleton organization  (ISO,ISS)
regulation of modification of postsynaptic actin cytoskeleton  (ISO)
regulation of modification of synaptic structure  (ISO)
regulation of neural precursor cell proliferation  (ISO,ISS)
regulation of neuron projection development  (ISO,ISS)
regulation of osteoblast proliferation  (ISO,ISS)
regulation of systemic arterial blood pressure by endothelin  (IEA,ISO)
regulation of transcription by RNA polymerase II  (ISO,ISS)
response to amino acid  (ISO)
response to drug  (ISO,ISS)
response to ethanol  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to hypoxia  (ISO)
response to mechanical stimulus  (ISO)
Rho protein signal transduction  (IMP,ISO)
Roundabout signaling pathway  (ISO)
skeletal muscle satellite cell migration  (ISS)
skeletal muscle tissue development  (ISO,ISS)
spindle localization  (IMP)
stress fiber assembly  (IBA,ISO,ISS)
stress-activated protein kinase signaling cascade  (ISO,ISS)
substantia nigra development  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
trabecula morphogenesis  (ISO,ISS)
wound healing, spreading of cells  (ISS)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:8886005   PMID:14681463   PMID:15679890   PMID:16428270   PMID:16978608   PMID:17145712   PMID:17407547   PMID:19214992   PMID:19574550   PMID:21926266   PMID:23389627   PMID:25883194  


Genomics

Comparative Map Data
RHOA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,918,836 - 32,003,722 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,918,484 - 31,991,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,149,494 - 35,160,516 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RHOA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl349,359,139 - 49,412,998 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl349,359,145 - 49,412,998 (-)EnsemblGRCh38hg38GRCh38
GRCh38349,359,145 - 49,411,976 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37349,396,578 - 49,449,409 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,371,582 - 49,424,530 (-)NCBINCBI36hg18NCBI36
Build 34349,371,584 - 49,424,530NCBI
Celera349,361,450 - 49,414,313 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef349,456,057 - 49,509,248 (-)NCBIHuRef
CHM1_1349,349,379 - 49,402,297 (-)NCBICHM1_1
Rhoa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,183,359 - 108,215,142 (+)NCBIGRCm39mm39
GRCm39 Ensembl9108,183,328 - 108,215,133 (+)Ensembl
GRCm389108,306,160 - 108,337,943 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,306,129 - 108,337,934 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,208,536 - 108,240,270 (+)NCBIGRCm37mm9NCBIm37
MGSCv369108,164,298 - 108,196,026 (+)NCBImm8
Celera9107,915,249 - 107,947,041 (+)NCBICelera
Cytogenetic Map9F2NCBI
Rhoa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28108,991,926 - 109,025,746 (+)NCBI
Rnor_6.0 Ensembl8117,106,576 - 117,116,167 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08117,082,440 - 117,116,244 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08116,431,244 - 116,464,932 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,319,010 - 108,327,586 (+)NCBICelera
Cytogenetic Map8q32NCBI
Rhoa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,300,462 - 1,347,451 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,300,821 - 1,347,453 (-)NCBIChiLan1.0ChiLan1.0
RHOA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1350,362,698 - 50,584,600 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0349,282,009 - 49,339,887 (-)NCBIMhudiblu_PPA_v0panPan3
RHOA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2039,824,575 - 39,887,215 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12039,824,552 - 39,888,089 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Rhoa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365291,000,050 - 1,045,655 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHOA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,757,381 - 10,809,257 (-)NCBI
ChlSab1.1 Ensembl2210,757,337 - 10,772,704 (-)Ensembl
Rhoa
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247303,316,122 - 3,361,820 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001244437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021068521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021068522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK231928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK392765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK393825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK395083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK398342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK400537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY609757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D89492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB807234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EH007776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV970410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EW113459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FP326740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01043466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000062870   ⟹   ENSSSCP00000045785
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1331,918,836 - 32,003,722 (-)Ensembl
RefSeq Acc Id: NM_001244437   ⟹   NP_001231366
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11331,918,484 - 31,991,207 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021068521   ⟹   XP_020924180
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11331,918,484 - 31,991,201 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021068522   ⟹   XP_020924181
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11331,918,484 - 31,932,094 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001231366 (Get FASTA)   NCBI Sequence Viewer  
  XP_020924180 (Get FASTA)   NCBI Sequence Viewer  
  XP_020924181 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA13966 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001231366   ⟸   NM_001244437
- UniProtKB: I3LVS7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020924180   ⟸   XM_021068521
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020924181   ⟸   XM_021068522
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000045785   ⟸   ENSSSCT00000062870


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000022080 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070003849 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000045785 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070005908 UniProtKB/TrEMBL
  ENSSSCP00070005914 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000062870 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070007219 UniProtKB/TrEMBL
  ENSSSCT00070007227 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/TrEMBL
KEGG Report ssc:396849 UniProtKB/TrEMBL
NCBI Gene RHOA ENTREZGENE
Pfam Ras UniProtKB/TrEMBL
PROSITE RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
TIGRFAMs small_GTP UniProtKB/TrEMBL
UniProt A0A4X1ST20_PIG UniProtKB/TrEMBL
  I3LVS7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:92284 ENTREZGENE