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Gene: TFPI2 (tissue factor pathway inhibitor 2) Sus scrofa

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Symbol:

TFPI2

Name:

tissue factor pathway inhibitor 2

RGD ID:

13885844

Description:

ENCODES a protein that exhibits serine-type endopeptidase inhibitor activity (inferred); INVOLVED IN cellular response to fluid shear stress (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Breast Neoplasms (ortholog); Carotid Artery Injuries (ortholog); FOUND IN extracellular region (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	73,673,535 - 73,689,095 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	73,684,236 - 73,694,663 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	80,646,484 - 80,656,913 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

Breast Neoplasms (ISO)

Carotid Artery Injuries (ISO)

Colorectal Neoplasms (ISO)

Experimental Liver Cirrhosis (ISO)

hepatocellular carcinoma (ISO)

melanoma (ISO)

Neoplasm Invasiveness (ISO)

Neoplasm Metastasis (ISO)

osteoarthritis (ISO)

pancreatic cancer (ISO)

pleomorphic xanthoastrocytoma (ISO)

retinal degeneration (ISO)

rheumatoid arthritis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood coagulation (IEA)

cellular response to fluid shear stress (ISO)

Cellular Component

extracellular region (IEA)

Molecular Function

serine-type endopeptidase inhibitor activity (IEA)

References

Additional References at PubMed

PMID:14681463	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

TFPI2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	73,673,535 - 73,689,095 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	73,684,236 - 73,694,663 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	80,646,484 - 80,656,913 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TFPI2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	93,885,396 - 93,890,753 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	93,885,396 - 93,890,753 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	93,514,708 - 93,520,065 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	93,353,678 - 93,358,001 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	93,160,395 - 93,164,716	NCBI
Celera	7	88,214,047 - 88,218,363 (-)	NCBI		Celera
Cytogenetic Map	7	q21.3	NCBI
HuRef	7	88,122,436 - 88,128,017 (-)	NCBI		HuRef
CHM1_1	7	93,444,941 - 93,450,535 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	95,122,034 - 95,127,402 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	92,843,873 - 92,849,467 (-)	NCBI

Tfpi2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	3,962,589 - 3,988,977 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	3,962,595 - 3,988,919 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	3,962,589 - 3,988,978 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	3,962,595 - 3,988,919 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	3,912,595 - 3,918,354 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	3,912,595 - 3,918,356 (-)	NCBI		MGSCv36	mm8
Celera	6	4,109,201 - 4,114,968 (-)	NCBI		Celera
Cytogenetic Map	6	A1	NCBI
cM Map	6	1.81	NCBI

Tfpi2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	32,936,462 - 32,941,385 (-)	NCBI		GRCr8
mRatBN7.2	4	31,981,786 - 31,986,707 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	31,982,178 - 31,986,600 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	36,954,886 - 36,959,308 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	32,881,006 - 32,885,428 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	31,245,301 - 31,249,723 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	28,947,951 - 28,953,261 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	28,947,965 - 28,953,067 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	28,855,875 - 28,860,297 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	28,807,080 - 28,811,502 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	28,825,427 - 28,829,850 (-)	NCBI
Celera	4	27,368,594 - 27,373,001 (-)	NCBI		Celera
Cytogenetic Map	4	q13	NCBI

Tfpi2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955432	10,631,843 - 10,641,538 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955432	10,635,626 - 10,641,345 (-)	NCBI	ChiLan1.0	ChiLan1.0

TFPI2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	111,722,525 - 111,727,596 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	159,986,355 - 159,992,238 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	85,835,141 - 85,839,515 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	99,425,901 - 99,431,099 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	99,426,006 - 99,431,099 (-)	Ensembl	panpan1.1		panPan2

TFPI2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	19,399,259 - 19,403,890 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	19,399,720 - 19,403,708 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	18,958,506 - 18,963,434 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	19,213,421 - 19,218,350 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	19,214,182 - 19,218,634 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	19,365,349 - 19,370,276 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	19,101,187 - 19,106,121 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	19,358,489 - 19,363,420 (-)	NCBI		UU_Cfam_GSD_1.0

Tfpi2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	32,709,624 - 32,714,803 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936803	73,946 - 90,295 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936803	69,296 - 90,270 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TFPI2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	55,134,921 - 55,139,862 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	55,135,198 - 55,140,801 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	49,184,930 - 49,189,763 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tfpi2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624813	571,414 - 577,858 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624813	571,592 - 577,268 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in TFPI2
144 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	hemolymphoid system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
10	4	23	3	2	5	14	12	23	3	6	3

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005667609	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000070	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK234322	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK234618	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK235165	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU656013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01038764	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000016695 ⟹ ENSSSCP00000016249

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	9	73,684,237 - 73,689,038 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000074974 ⟹ ENSSSCP00000066451

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	9	73,673,535 - 73,689,095 (-)	Ensembl

RefSeq Acc Id:

XM_005667609 ⟹ XP_005667666

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	9	73,684,236 - 73,694,663 (-)	NCBI

Sequence:

show sequence

ATGAGCCTGATTTGGGTCCCCACTGTCGTGGAAGAAAAGGATGTGTGCACGGTTCAGCTTTGGT
GGGGAATTCCTCTCCCCCGCACACTTTCCAGCCAGGAGGCTGCAGGGTCAGAGCTCTCTCGCAG
GCATGAATCAGCCTCCCCTCCAGCCTTCGTAAAGGCTTGCTCCGCCCTGTCCGGGGTCAGAGAG
ACGTTCAGACGTCCACCCTACATAAAGCCTCGGCACCCACCGCACAGGAACCAAGACTGCCTCG
AGGTTGGAGGCTGTGCACCCTCGTCCCGCCGGGGCCTTCTGGGGACAACTTGCCCCACCGGCCA
CTTTAAGTCGGACACCATGAACTCTGTTCGCACCCACGGGCTGGTGCTTCTGCCGCTGCTCCTG
GTGGGGACTGCGCTGGGAGATGCTCCTCGGGCGTCGCCAGGAAATTACTCGGAGATCTGCCTCC
TGCCCCCAGACGAGGGGCCCTGCCGTGCCCTGGTCCCCAGTTACTACTACGACAGGTACACGCA
GAGCTGCCGAGAGTTCATGTATGGGGGCTGCGAGGGCAATGCCAACAATTTTGAAACGTGGGAG
GCCTGCGACGAAGCGTGCTGGAGGATAGAGAAAGTTCCCAAAATTTGCCGATTAGAAGTCAGTA
AGAGGCAGTGTGGGGAGCTCAGAGAAGAGTATTTCTTCAATCTAAGTTCCATGACATGTGAAAA
ATTCCTATCTGGCGGGTGTCATGGCAATGCAAATCGGTTTCTGGATGAAGCTACGTGTATGGGC
TTCTGTGCGCCAAAGAAAAGTCCATCATTTTGCTATAGTCCAAAAGATGAGGGACTGTGTTCTG
CTAATGTGACTCGCTATTATTTTAATCCAAGACACAAAGCCTGTGAGACCTTCACCTATACTGG
CTGTGGAGGGAATGACAATAATTTTGTCAGCATGAAGGACTGCAAACGTGCATGTGTAAAAGCC
TTGAAGAAGGAAAAGAAGATGCCAAGACTTCTCCTTGCCAGTAGAAGACTAAAAATTAAGAAGA
AGCAATTTTAACCATTTTTTTTTCTGTATGTCATCTTGTGAATGCCTTTATGGTTATATCTGAA
GGATAATCTGATAACATAAGTAAACAAATCATTAGTGATTTATTCACCAGTTTTTATATGTTAC
ATGTTTTTATTTGTGTATTTTTTATACATAATTAGCTGCTATTCAAACATGAATCTTTTAGCTT
AAATTGACTGTTCAACTCTTTTATGAGGTTAAACTTTTGCTGTGCGTAAGATATAAAAGCAAAT
ATGACTCATCCAGTTATTGGGGTTGCTCCCCCTGACGTCAGAAAGACGACACTAGCTGAAAATT
TTAAGACAGTATAATCATATTTTTTTAACATATTGGATCATAAAAAGGACCAGCAAATATATTT
CATTCTGCCTATAAATGTTAGATTATATTTTAGGCCCAAGGAAACAAACTTGCAGATTTACCAA
CACTTCAAAAAATATTACAAGTGCTATTATGTAGATATTGCTACTTTACTTCCATTTCTGTTGT
GTCATTTAAGAGATAATAAAATAATTGTTTGAATTAAAAAGATAGTAAAGTTATTACAATCAGA
AATATTCTTCTCAGGGGGAAAATTCTCTCTCTCTATCTATCCATCCATCCCCACTCACATGAAA
GTTGTTAAAGTTTTGTACTGTTCAAGGTGTTTATTTATACTATACCAGAGATAATTCATAAACC
TAATAATTTAAATTTTATTAATAAAATATTCCTGATAAATATGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005667666	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000016249.2
	ENSSSCP00000066451.1

RefSeq Acc Id:

XP_005667666 ⟸ XM_005667609

- Sequence:

show sequence

MSLIWVPTVVEEKDVCTVQLWWGIPLPRTLSSQEAAGSELSRRHESASPPAFVKACSALSGVRE
TFRRPPYIKPRHPPHRNQDCLEVGGCAPSSRRGLLGTTCPTGHFKSDTMNSVRTHGLVLLPLLL
VGTALGDAPRASPGNYSEICLLPPDEGPCRALVPSYYYDRYTQSCREFMYGGCEGNANNFETWE
ACDEACWRIEKVPKICRLEVSKRQCGELREEYFFNLSSMTCEKFLSGGCHGNANRFLDEATCMG
FCAPKKSPSFCYSPKDEGLCSANVTRYYFNPRHKACETFTYTGCGGNDNNFVSMKDCKRACVKA
LKKEKKMPRLLLASRRLKIKKKQF

hide sequence

Ensembl Acc Id:

ENSSSCP00000016249 ⟸ ENSSSCT00000016695

Ensembl Acc Id:

ENSSSCP00000066451 ⟸ ENSSSCT00000074974

Protein Domains

BPTI/Kunitz inhibitor

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000015322	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000016695.5	UniProtKB/TrEMBL
	ENSSSCT00000074974.1	UniProtKB/TrEMBL
Gene3D-CATH	4.10.410.10	UniProtKB/TrEMBL
InterPro	Kunitz-type_SerProtInhib	UniProtKB/TrEMBL
	Kunitz_BPTI	UniProtKB/TrEMBL
	Kunitz_BPTI_sf	UniProtKB/TrEMBL
	Prtase_inh_Kunz-CS	UniProtKB/TrEMBL
	TFPI-like	UniProtKB/TrEMBL
NCBI Gene	TFPI2	ENTREZGENE
PANTHER	KUNITZ-TYPE PROTEASE INHIBITOR-RELATED	UniProtKB/TrEMBL
	TISSUE FACTOR PATHWAY INHIBITOR 2	UniProtKB/TrEMBL
Pfam	Kunitz_BPTI	UniProtKB/TrEMBL
PIRSF	TFPI	UniProtKB/TrEMBL
PRINTS	BASICPTASE	UniProtKB/TrEMBL
PROSITE	BPTI_KUNITZ_1	UniProtKB/TrEMBL
	BPTI_KUNITZ_2	UniProtKB/TrEMBL
SMART	SM00131	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57362	UniProtKB/TrEMBL
UniProt	A0A4X1U3A3_PIG	UniProtKB/TrEMBL
	A0A5G2R773_PIG	UniProtKB/TrEMBL
UniProt Secondary	F1SFC1	UniProtKB/TrEMBL
VGNC ID	VGNC:93922	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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