CASP9 (caspase 9) - Rat Genome Database

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Gene: CASP9 (caspase 9) Sus scrofa
Analyze
Symbol: CASP9
Name: caspase 9
RGD ID: 13885278
Description: ENCODES a protein that exhibits cysteine-type peptidase activity (ortholog); identical protein binding (ortholog); peptidase activity (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); aging (ortholog); apoptotic process (ortholog); PARTICIPATES IN endometrial cancer pathway; intrinsic apoptotic pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); mitochondrion (ortholog); INTERACTS WITH cadmium atom; cadmium dichloride; cisplatin
Type: protein-coding
RefSeq Status: MODEL
Also known as: caspase 9, apoptosis-related cysteine peptidase; caspase-9
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl674,706,515 - 74,730,092 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1674,707,597 - 74,730,033 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2669,087,179 - 69,111,408 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
bacterial infectious disease  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
Bronchopulmonary Dysplasia  (ISO)
cataract  (ISO)
Cerebral Hemorrhage  (ISO)
colorectal cancer  (ISO)
Diabetes Complications  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Edema  (ISO)
endometritis  (ISO)
Endotoxemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (ISO)
focal segmental glomerulosclerosis  (ISO)
heart disease  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Pancreatitis  (ISO)
Huntington's disease  (ISO)
Hypercholesterolemia  (ISO)
hypertension  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
Mammary Neoplasms, Experimental  (ISO)
middle cerebral artery infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
nervous system disease  (ISO)
NSAID-Enteropathy  (ISO)
osteoarthritis  (ISO)
pancreatic cancer  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
peripheral nervous system disease  (ISO)
post-traumatic stress disorder  (ISO)
pre-malignant neoplasm  (ISO)
Prostatic Neoplasms  (ISO)
Radiation Injuries, Experimental  (ISO)
Reperfusion Injury  (ISO)
retinal detachment  (ISO)
scrapie  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Subarachnoid Hemorrhage  (ISO)
Testis Reperfusion Injury  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
varicocele  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apoptosome  (IEA)
cytoplasm  (IBA,ISO)
cytosol  (ISO)
mitochondrion  (ISO)
nucleus  (IEA,ISO)
protein-containing complex  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:17109142   PMID:17268855   PMID:17976908   PMID:21732350   PMID:22728821  


Genomics

Comparative Map Data
CASP9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl674,706,515 - 74,730,092 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1674,707,597 - 74,730,033 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2669,087,179 - 69,111,408 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CASP9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl115,490,832 - 15,526,534 (-)EnsemblGRCh38hg38GRCh38
GRCh38115,491,401 - 15,524,912 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37115,817,896 - 15,851,285 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36115,691,378 - 15,723,377 (-)NCBINCBI36hg18NCBI36
Build 34115,564,102 - 15,596,096NCBI
Celera114,301,661 - 14,333,662 (-)NCBI
Cytogenetic Map1p36.21NCBI
HuRef114,337,387 - 14,370,798 (-)NCBIHuRef
CHM1_1115,616,531 - 15,649,948 (-)NCBICHM1_1
Casp9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,520,923 - 141,543,289 (+)NCBIGRCm39mm39
GRCm39 Ensembl4141,520,923 - 141,543,287 (+)Ensembl
GRCm384141,793,612 - 141,815,978 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,793,612 - 141,815,976 (+)EnsemblGRCm38mm10GRCm38
MGSCv374141,349,527 - 141,371,890 (+)NCBIGRCm37mm9NCBIm37
MGSCv364141,065,688 - 141,088,051 (+)NCBImm8
Celera4143,618,711 - 143,640,921 (+)NCBICelera
Cytogenetic Map4D3NCBI
Casp9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25154,108,872 - 154,126,628 (+)NCBI
Rnor_6.0 Ensembl5160,355,833 - 160,373,778 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05160,356,211 - 160,373,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05164,067,734 - 164,085,297 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,704,234 - 160,721,796 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15160,714,421 - 160,731,984 (+)NCBI
Celera5152,461,154 - 152,478,717 (+)NCBICelera
Cytogenetic Map5q36NCBI
Casp9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555272,613,683 - 2,629,738 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555272,613,691 - 2,630,217 (+)NCBIChiLan1.0ChiLan1.0
CASP9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1115,624,666 - 15,656,266 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl115,624,666 - 15,656,266 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0114,630,659 - 14,662,865 (-)NCBIMhudiblu_PPA_v0panPan3
CASP9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1282,033,759 - 82,076,710 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl282,031,563 - 82,090,484 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha278,571,149 - 78,590,692 (+)NCBI
ROS_Cfam_1.0282,683,018 - 82,723,170 (+)NCBI
UMICH_Zoey_3.1279,435,738 - 79,455,337 (+)NCBI
UNSW_CanFamBas_1.0280,453,740 - 80,473,245 (+)NCBI
UU_Cfam_GSD_1.0281,519,391 - 81,539,023 (+)NCBI
Casp9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505837,353,117 - 37,371,367 (-)NCBI
SpeTri2.0NW_0049364743,178,097 - 3,196,130 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP9
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120116,772,819 - 116,798,402 (+)NCBI
ChlSab1.1 Ensembl20116,772,155 - 116,798,930 (+)Ensembl
Casp9
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247641,769,270 - 1,789,399 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 4 3 5 2 23 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000003846   ⟹   ENSSSCP00000003758
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl674,706,515 - 74,730,092 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000025859   ⟹   ENSSSCP00000020615
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl674,707,056 - 74,729,981 (-)Ensembl
RefSeq Acc Id: XM_003127618   ⟹   XP_003127666
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1674,707,597 - 74,730,032 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013998997   ⟹   XP_013854451
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1674,707,597 - 74,730,033 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003127666 (Get FASTA)   NCBI Sequence Viewer  
  XP_013854451 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013854451   ⟸   XM_013998997
- Peptide Label: isoform X2
- UniProtKB: I3L9A3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003127666   ⟸   XM_003127618
- Peptide Label: isoform X1
- UniProtKB: F1SUV9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000020615   ⟸   ENSSSCT00000025859
RefSeq Acc Id: ENSSSCP00000003758   ⟸   ENSSSCT00000003846
Protein Domains
CARD   CASPASE_P10   CASPASE_P20


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003460 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070029388 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000003758 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000020615 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070050244 UniProtKB/TrEMBL
  ENSSSCP00070050246 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003846 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000025859 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070059033 UniProtKB/TrEMBL
  ENSSSCT00070059035 UniProtKB/TrEMBL
InterPro CARD UniProtKB/TrEMBL
  CARD_CASP9 UniProtKB/TrEMBL
  Caspase-9 UniProtKB/TrEMBL
  Caspase-like_dom_sf UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/TrEMBL
  Caspase_his_AS UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  Pept_C14 UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/TrEMBL
  Pept_C14_p20 UniProtKB/TrEMBL
  Pept_C14A UniProtKB/TrEMBL
KEGG Report ssc:100518913 UniProtKB/TrEMBL
NCBI Gene CASP9 ENTREZGENE
PANTHER PTHR10454 UniProtKB/TrEMBL
  PTHR10454:SF157 UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
PRINTS IL1BCENZYME UniProtKB/TrEMBL
PROSITE CARD UniProtKB/TrEMBL
  CASPASE_CYS UniProtKB/TrEMBL
  CASPASE_HIS UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/TrEMBL
  CASPASE_P20 UniProtKB/TrEMBL
SMART CARD UniProtKB/TrEMBL
  CASc UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF52129 UniProtKB/TrEMBL
UniProt A0A4X1W1Y9_PIG UniProtKB/TrEMBL
  A0A4X1W839_PIG UniProtKB/TrEMBL
  F1SUV9 ENTREZGENE, UniProtKB/TrEMBL
  I3L9A3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:96938 ENTREZGENE