PARP1 (poly(ADP-ribose) polymerase 1) - Rat Genome Database
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Gene: PARP1 (poly(ADP-ribose) polymerase 1) Sus scrofa
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Symbol: PARP1
Name: poly(ADP-ribose) polymerase 1
RGD ID: 13868155
Description: ENCODES a protein that exhibits chromatin binding (ortholog); enzyme binding (ortholog); estrogen receptor binding (ortholog); INVOLVED IN base-excision repair (ortholog); behavioral response to cocaine (ortholog); cellular response to amyloid-beta (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute kidney failure (ortholog); Acute Lung Injury (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); protein-containing complex (ortholog); INTERACTS WITH 3-methyladenine; 3-oxalomalic acid; cadmium atom
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1014,203,159 - 14,241,197 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11014,203,157 - 14,241,164 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21016,598,164 - 16,636,214 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adult respiratory distress syndrome  (ISO)
alopecia  (ISO)
Alveolar Bone Loss  (ISO)
Alzheimer's disease  (ISO)
anemia  (ISO)
arthritis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autoimmune disease  (ISO)
bacterial meningitis  (ISO)
borna disease  (ISO)
Brain Injuries  (ISO)
Brain Injuries, Traumatic  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
cardiomyopathy  (ISO)
Carotid Artery Injuries  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
dermatitis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Pancreatitis, Acute  (ISO)
Fibrosis  (ISO)
glomerulonephritis  (ISO)
hepatitis  (ISO)
hepatocellular carcinoma  (ISO)
hereditary renal cell carcinoma  (ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
Inflammation  (ISO)
intellectual disability  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Kyphosis  (ISO)
leiomyoma  (ISO)
liver cirrhosis  (ISO)
Lung Injury  (ISO)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (ISO)
middle cerebral artery infarction  (ISO)
multiple myeloma  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neointima  (ISO)
nephritis  (ISO)
neuronal ceroid lipofuscinosis 1  (ISO)
obesity  (ISO)
pancreatitis  (ISO)
Paralysis  (ISO)
Parkinson's disease  (ISO)
Parkinsonian Disorders  (ISO)
perinatal necrotizing enterocolitis  (ISO)
periodontitis  (ISO)
periventricular leukomalacia  (ISO)
Plaque, Atherosclerotic  (ISO)
pneumonia  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary edema  (ISO)
pulmonary fibrosis  (ISO)
Reperfusion Injury  (ISO)
Spinal Cord Injuries  (ISO)
Spinal Cord Ischemia  (ISO)
Stevens-Johnson syndrome  (ISO)
stomach carcinoma  (ISO)
systemic lupus erythematosus  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
Vitamin A Deficiency  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
ATP generation from poly-ADP-D-ribose  (IEA)
base-excision repair  (ISO)
behavioral response to cocaine  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to DNA damage stimulus  (ISO)
cellular response to insulin stimulus  (IEA)
cellular response to oxidative stress  (IEA)
cellular response to superoxide  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to UV  (IEA)
cellular response to zinc ion  (ISO)
DNA ADP-ribosylation  (IEA)
DNA damage response, detection of DNA damage  (ISO)
DNA metabolic process  (ISO)
double-strand break repair  (IBA)
mitochondrial DNA metabolic process  (ISO)
mitochondrial DNA repair  (IEA)
mitochondrion organization  (ISO)
negative regulation of ATP biosynthetic process  (IEA)
negative regulation of interleukin-17 production  (ISO)
negative regulation of telomere maintenance via telomere lengthening  (ISO)
peptidyl-glutamic acid poly-ADP-ribosylation  (IEA)
peptidyl-serine ADP-ribosylation  (IEA)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of double-strand break repair via homologous recombination  (IEA)
positive regulation of intracellular estrogen receptor signaling pathway  (ISO)
positive regulation of mitochondrial depolarization  (ISO)
positive regulation of myofibroblast differentiation  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of single strand break repair  (IEA)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of transcription regulatory region DNA binding  (ISO)
protein ADP-ribosylation  (ISO)
protein auto-ADP-ribosylation  (IEA)
protein autoprocessing  (ISO)
protein modification process  (ISO)
protein poly-ADP-ribosylation  (IBA)
regulation of catalytic activity  (IEA)
regulation of cellular protein localization  (IEA)
regulation of DNA methylation  (ISO)
regulation of growth rate  (ISO)
regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
regulation of single strand break repair  (ISO)
regulation of SMAD protein complex assembly  (ISO)
response to aldosterone  (ISO)
response to gamma radiation  (ISO)
signal transduction involved in regulation of gene expression  (ISO)
telomere maintenance  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
voluntary musculoskeletal movement  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:23522430   PMID:24062568   PMID:26440043  


Genomics

Comparative Map Data
PARP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1014,203,159 - 14,241,197 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11014,203,157 - 14,241,164 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21016,598,164 - 16,636,214 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PARP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1226,360,691 - 226,408,093 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1226,360,210 - 226,408,154 (-)EnsemblGRCh38hg38GRCh38
GRCh381226,360,691 - 226,408,093 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371226,548,392 - 226,595,801 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361224,615,015 - 224,662,424 (-)NCBINCBI36hg18NCBI36
Build 341222,855,240 - 222,902,526NCBI
Celera1199,739,310 - 199,786,722 (-)NCBI
Cytogenetic Map1q42.12NCBI
HuRef1197,065,678 - 197,113,094 (-)NCBIHuRef
CHM1_11227,821,256 - 227,868,667 (-)NCBICHM1_1
Parp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,396,456 - 180,428,564 (+)NCBIGRCm39mm39
GRCm381180,568,891 - 180,600,999 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,568,924 - 180,601,254 (+)EnsemblGRCm38mm10GRCm38
MGSCv371182,499,106 - 182,531,385 (+)NCBIGRCm37mm9NCBIm37
MGSCv361182,405,650 - 182,437,929 (+)NCBImm8
Celera1187,634,811 - 187,667,071 (+)NCBICelera
Cytogenetic Map1H4NCBI
cM Map184.44NCBI
Parp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01398,857,255 - 98,889,444 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1398,857,177 - 98,889,716 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013103,859,760 - 103,891,949 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,309,670 - 96,341,486 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11396,498,605 - 96,530,421 (+)NCBI
Celera1391,853,812 - 91,885,580 (+)NCBICelera
Cytogenetic Map13q26NCBI
Parp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955489520,875 - 557,615 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955489520,875 - 557,609 (-)NCBIChiLan1.0ChiLan1.0
PARP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11206,812,981 - 206,860,356 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1206,812,981 - 206,860,356 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01201,820,355 - 201,867,673 (-)NCBIMhudiblu_PPA_v0panPan3
PARP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl738,503,067 - 38,542,127 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1738,503,072 - 38,542,556 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Parp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365263,102,468 - 3,147,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PARP1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1253,350,798 - 3,405,040 (+)NCBI
Parp1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624807446,662 - 478,571 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 5 3 3 5 2 23 1 3 3
Low 5 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000028077   ⟹   ENSSSCP00000022104
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1014,203,159 - 14,241,197 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000075629   ⟹   ENSSSCP00000070720
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1014,235,769 - 14,241,197 (-)Ensembl
RefSeq Acc Id: XM_003357641   ⟹   XP_003357689
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11014,203,157 - 14,241,164 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003357689 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein JAG69302 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003357689   ⟸   XM_003357641
- Sequence:
RefSeq Acc Id: ENSSSCP00000070720   ⟸   ENSSSCT00000075629
RefSeq Acc Id: ENSSSCP00000022104   ⟸   ENSSSCT00000028077
Protein Domains
BRCT   PARP alpha-helical   PARP catalytic   PARP-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000023660 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070008636 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000022104 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000070720 UniProtKB/TrEMBL
  ENSSSCP00070013920 UniProtKB/TrEMBL
  ENSSSCP00070013930 UniProtKB/TrEMBL
  ENSSSCP00070013946 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000028077 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000075629 UniProtKB/TrEMBL
  ENSSSCT00070016790 UniProtKB/TrEMBL
  ENSSSCT00070016800 UniProtKB/TrEMBL
  ENSSSCT00070016817 UniProtKB/TrEMBL
Gene3D-CATH 1.20.142.10 UniProtKB/TrEMBL
  2.20.140.10 UniProtKB/TrEMBL
  2.20.25.630 UniProtKB/TrEMBL
  3.30.1740.10 UniProtKB/TrEMBL
  3.40.50.10190 UniProtKB/TrEMBL
InterPro BRCT_dom UniProtKB/TrEMBL
  BRCT_dom_sf UniProtKB/TrEMBL
  PADR1 UniProtKB/TrEMBL
  PADR1_dom_sf UniProtKB/TrEMBL
  PARP UniProtKB/TrEMBL
  Poly(ADP-ribose)pol_cat_dom UniProtKB/TrEMBL
  Poly(ADP-ribose)pol_reg_dom UniProtKB/TrEMBL
  Poly(ADP-ribose)pol_reg_dom_sf UniProtKB/TrEMBL
  WGR_dom_sf UniProtKB/TrEMBL
  WGR_domain UniProtKB/TrEMBL
  Znf_PARP UniProtKB/TrEMBL
  Znf_PARP_sf UniProtKB/TrEMBL
NCBI Gene PARP1 ENTREZGENE
Pfam BRCT UniProtKB/TrEMBL
  PADR1 UniProtKB/TrEMBL
  PARP UniProtKB/TrEMBL
  PARP_reg UniProtKB/TrEMBL
  WGR UniProtKB/TrEMBL
  zf-PARP UniProtKB/TrEMBL
PIRSF NAD_ADPRT UniProtKB/TrEMBL
PROSITE BRCT UniProtKB/TrEMBL
  PARP_ALPHA_HD UniProtKB/TrEMBL
  PARP_CATALYTIC UniProtKB/TrEMBL
  PARP_ZN_FINGER_1 UniProtKB/TrEMBL
  PARP_ZN_FINGER_2 UniProtKB/TrEMBL
SMART BRCT UniProtKB/TrEMBL
  PADR1 UniProtKB/TrEMBL
  WGR UniProtKB/TrEMBL
  zf-PARP UniProtKB/TrEMBL
Superfamily-SCOP SSF142921 UniProtKB/TrEMBL
  SSF47587 UniProtKB/TrEMBL
  SSF52113 UniProtKB/TrEMBL
UniProt A0A4X1TFK2_PIG UniProtKB/TrEMBL
  A0A4X1TFL4_PIG UniProtKB/TrEMBL
  A0A4X1TFR8_PIG UniProtKB/TrEMBL
  A0A5G2R0N8_PIG UniProtKB/TrEMBL
  I3LDH3_PIG UniProtKB/TrEMBL
VGNC ID VGNC:96677 ENTREZGENE