PARP1 (poly(ADP-ribose) polymerase 1)

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Gene: PARP1 (poly(ADP-ribose) polymerase 1) Sus scrofa

Analyze

Symbol:

PARP1

Name:

poly(ADP-ribose) polymerase 1

RGD ID:

13868155

Description:

ENCODES a protein that exhibits chromatin binding (ortholog); enzyme binding (ortholog); estrogen receptor binding (ortholog); INVOLVED IN base-excision repair (ortholog); behavioral response to cocaine (ortholog); cellular response to amyloid-beta (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute kidney failure (ortholog); Acute Lung Injury (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); protein-containing complex (ortholog); INTERACTS WITH 3-methyladenine; 3-oxalomalic acid; cadmium atom

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase 1

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	14,203,159 - 14,241,197 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	14,203,157 - 14,241,164 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	16,598,164 - 16,636,214 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

abdominal aortic aneurysm (ISO)

acute kidney failure (ISO)

Acute Lung Injury (ISO)

adult respiratory distress syndrome (ISO)

alopecia (ISO)

Alveolar Bone Loss (ISO)

Alzheimer's disease (ISO)

anemia (ISO)

arthritis (ISO)

asthma (ISO)

atherosclerosis (ISO)

autoimmune disease (ISO)

bacterial meningitis (ISO)

borna disease (ISO)

Brain Injuries (ISO)

Brain Injuries, Traumatic (ISO)

brain ischemia (ISO)

Breast Neoplasms (ISO)

cardiomyopathy (ISO)

Carotid Artery Injuries (ISO)

Colorectal Neoplasms (ISO)

congestive heart failure (ISO)

dermatitis (ISO)

Diabetic Nephropathies (ISO)

diabetic neuropathy (ISO)

Experimental Arthritis (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Pancreatitis, Acute (ISO)

Fibrosis (ISO)

glomerulonephritis (ISO)

hepatitis (ISO)

hepatocellular carcinoma (ISO)

hereditary renal cell carcinoma (ISO)

Huntington's disease (ISO)

hyperglycemia (ISO)

idiopathic pulmonary fibrosis (ISO)

Inflammation (ISO)

intellectual disability (ISO)

kidney disease (ISO)

kidney failure (ISO)

Kyphosis (ISO)

leiomyoma (ISO)

liver cirrhosis (ISO)

Lung Injury (ISO)

Mammary Neoplasms, Experimental (ISO)

melanoma (ISO)

middle cerebral artery infarction (ISO)

multiple myeloma (ISO)

myocardial infarction (ISO)

Myocardial Reperfusion Injury (ISO)

Neointima (ISO)

nephritis (ISO)

neuronal ceroid lipofuscinosis 1 (ISO)

obesity (ISO)

pancreatitis (ISO)

Paralysis (ISO)

Parkinson's disease (ISO)

Parkinsonian Disorders (ISO)

perinatal necrotizing enterocolitis (ISO)

periodontitis (ISO)

periventricular leukomalacia (ISO)

Plaque, Atherosclerotic (ISO)

pneumonia (ISO)

Prostatic Neoplasms (ISO)

pulmonary edema (ISO)

pulmonary fibrosis (ISO)

Reperfusion Injury (ISO)

Spinal Cord Injuries (ISO)

Spinal Cord Ischemia (ISO)

Stevens-Johnson syndrome (ISO)

stomach carcinoma (ISO)

systemic lupus erythematosus (ISO)

toxic shock syndrome (ISO)

transient cerebral ischemia (ISO)

type 2 diabetes mellitus (ISO)

ureteral obstruction (ISO)

Vitamin A Deficiency (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

3-methyladenine (EXP)

3-oxalomalic acid (EXP)

cadmium atom (EXP)

cadmium dichloride (EXP)

chloroquine (EXP)

cisplatin (EXP)

ochratoxin A (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (IEA)

ATP generation from poly-ADP-D-ribose (IEA)

base-excision repair (ISO)

behavioral response to cocaine (ISO)

cellular response to amyloid-beta (ISO)

cellular response to DNA damage stimulus (ISO)

cellular response to insulin stimulus (IEA)

cellular response to oxidative stress (IEA)

cellular response to superoxide (ISO)

cellular response to transforming growth factor beta stimulus (ISO)

cellular response to UV (IEA)

cellular response to zinc ion (ISO)

DNA ADP-ribosylation (IEA)

DNA damage response, detection of DNA damage (ISO)

DNA metabolic process (ISO)

double-strand break repair (IBA)

mitochondrial DNA metabolic process (ISO)

mitochondrial DNA repair (IEA)

mitochondrion organization (ISO)

negative regulation of ATP biosynthetic process (IEA)

negative regulation of interleukin-17 production (ISO)

negative regulation of telomere maintenance via telomere lengthening (ISO)

peptidyl-glutamic acid poly-ADP-ribosylation (IEA)

peptidyl-serine ADP-ribosylation (IEA)

positive regulation of cardiac muscle hypertrophy (ISO)

positive regulation of double-strand break repair via homologous recombination (IEA)

positive regulation of intracellular estrogen receptor signaling pathway (ISO)

positive regulation of mitochondrial depolarization (ISO)

positive regulation of myofibroblast differentiation (ISO)

positive regulation of neuron death (ISO)

positive regulation of protein localization to nucleus (ISO)

positive regulation of single strand break repair (IEA)

positive regulation of SMAD protein signal transduction (ISO)

positive regulation of transcription by RNA polymerase II (IEA)

positive regulation of transcription regulatory region DNA binding (ISO)

protein ADP-ribosylation (ISO)

protein auto-ADP-ribosylation (IEA)

protein autoprocessing (ISO)

protein modification process (ISO)

protein poly-ADP-ribosylation (IBA)

regulation of catalytic activity (IEA)

regulation of cellular protein localization (IEA)

regulation of DNA methylation (ISO)

regulation of growth rate (ISO)

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway (ISO)

regulation of single strand break repair (ISO)

regulation of SMAD protein complex assembly (ISO)

response to aldosterone (ISO)

response to gamma radiation (ISO)

signal transduction involved in regulation of gene expression (ISO)

telomere maintenance (ISO)

transforming growth factor beta receptor signaling pathway (ISO)

voluntary musculoskeletal movement (ISO)

Cellular Component

cytoplasm (ISO)

mitochondrion (IEA)

nuclear body (IEA)

nuclear envelope (IEA)

nucleolus (IBA)

nucleoplasm (ISO)

nucleus (IEA)

protein-containing complex (ISO)

protein-DNA complex (IEA)

site of DNA damage (ISO)

site of double-strand break (IEA)

transcription regulator complex (IEA)

Molecular Function

chromatin binding (ISO)

DNA binding (IEA)

enzyme binding (ISO)

estrogen receptor binding (ISO)

histone deacetylase binding (ISO)

identical protein binding (IEA)

NAD binding (IEA)

NAD DNA ADP-ribosyltransferase activity (IEA)

NAD+ ADP-ribosyltransferase activity (IBA)

protein ADP-ribosylase activity (IBA)

protein binding (ISO)

protein kinase binding (IEA)

protein N-terminus binding (IEA)

R-SMAD binding (ISO)

SMAD binding (ISO)

transcription factor binding (IEA)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

ADP-ribosylation pathway, mono and poly-ribosylation (ISO)

References

Additional References at PubMed

PMID:14681463	PMID:17145712	PMID:23522430	PMID:24062568	PMID:26440043

Genomics

Comparative Map Data

PARP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	14,203,159 - 14,241,197 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	14,203,157 - 14,241,164 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	16,598,164 - 16,636,214 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PARP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	1	226,360,691 - 226,408,093 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p13 Ensembl	1	226,360,210 - 226,408,154 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	1	226,360,691 - 226,408,093 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	1	226,548,392 - 226,595,801 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	224,615,015 - 224,662,424 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	1	222,855,240 - 222,902,526	NCBI
Celera	1	199,739,310 - 199,786,722 (-)	NCBI
Cytogenetic Map	1	q42.12	NCBI
HuRef	1	197,065,678 - 197,113,094 (-)	NCBI		HuRef
CHM1_1	1	227,821,256 - 227,868,667 (-)	NCBI		CHM1_1

Parp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	180,396,456 - 180,428,564 (+)	NCBI	GRCm39		mm39
GRCm38	1	180,568,891 - 180,600,999 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	180,568,924 - 180,601,254 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	182,499,106 - 182,531,385 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	1	182,405,650 - 182,437,929 (+)	NCBI			mm8
Celera	1	187,634,811 - 187,667,071 (+)	NCBI		Celera
Cytogenetic Map	1	H4	NCBI
cM Map	1	84.44	NCBI

Parp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	13	98,857,255 - 98,889,444 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	98,857,177 - 98,889,716 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	103,859,760 - 103,891,949 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	96,309,670 - 96,341,486 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	13	96,498,605 - 96,530,421 (+)	NCBI
Celera	13	91,853,812 - 91,885,580 (+)	NCBI		Celera
Cytogenetic Map	13	q26	NCBI

Parp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955489	520,875 - 557,615 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955489	520,875 - 557,609 (-)	NCBI	ChiLan1.0	ChiLan1.0

PARP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	206,812,981 - 206,860,356 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	206,812,981 - 206,860,356 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	201,820,355 - 201,867,673 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

PARP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	7	38,503,067 - 38,542,127 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	7	38,503,072 - 38,542,556 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Parp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936526	3,102,468 - 3,147,601 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PARP1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	3,350,798 - 3,405,040 (+)	NCBI

Parp1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624807	446,662 - 478,571 (-)	NCBI

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium	5	3	3	5	2	23	1	3	3
Low	5	1					1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003357641	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000071	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK351117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FP312825	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FP340210	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBZA01000466	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01119537	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSSSCT00000028077 ⟹ ENSSSCP00000022104

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	10	14,203,159 - 14,241,197 (-)	Ensembl

RefSeq Acc Id:

ENSSSCT00000075629 ⟹ ENSSSCP00000070720

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	10	14,235,769 - 14,241,197 (-)	Ensembl

RefSeq Acc Id:

XM_003357641 ⟹ XP_003357689

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	10	14,203,157 - 14,241,164 (-)	NCBI

Sequence:

show sequence

TCAGCAATCTATCGGGAGCGGCGGGTGGTCGGCGCGGCGTGCTTGGCGGCAGCGGCGGCGGCTC
TGGGCACTGGGGGCCCTGCTGGGAGGAGACAGGCAAGCAAGGCGGCGGCGGCGGCGGCGGCGGT
TGCGGTTGCGTGTCTGCAGGTCGCAGCGTCAGGCTTCGGGAGCTGCATCGGCACAGGGAGGAGG
ATGGCGGAGTCATCGGACAAGCTCTATCGGGTCGAGTATGCTAAGAGTGGGCGCGCCTCCTGCA
AGAAATGCAGCGAGAGCATCCCCAAGGACTCGCTCCGGATGGCCATCATGGTGCAGTCGCCCAT
GTTCGATGGGAAAGTCCCGCACTGGTACCACTTCTCCTGCTTCTGGAAGGTCGGCCACGCCATC
CGGCACCCTGACATCGAGGTGGACGGGTTCTCCGAGCTCCGGTGGGACGACCAGCAGAAAGTCA
AGAAGACGGCGGAGGCTGGAGGAGTGACAGGCAAAGGCCAAGATGGGGTTGGCAGCAAGGCGGA
GAAGACGCTGGGTGACTTCGCGGCCGAGTATGCCAAGTCCAACAGAAGCACGTGCAAGGGCTGC
ATGGAGAAGATCGAGAAGGGCCACGTGCGCCTGTCCAAGAAGATGCTGGACCCCGAGAAGCCCC
AGCTGGGCATGATCGACCGCTGGTACCACCCAAACTGCTTTGTTCAGAACCGGGAGGAGCTGGG
CTTCCGGCCCGAGTACAGCGCCAGCCAGCTTAAGGGCTTCAGCCTGCTCACCGCAGAGGACAAA
GAAGCGCTGAAGAAGCAGCTCCCGGGCATCAAGAGTGAAGGAAAGAGAAAAGGTGACGAGGTAG
ATGGAGTGGATGGAGTGGCCAAGAAGAAATCTAAAAAAGAAAAGGACAAGGAGAGTAAGCTCGA
AAAGGCCCTCAAGGCCCAGAACGACCTGATCTGGAATATCAAGGACGAGCTAAAGAAAGTGTGT
TCAACCAATGACCTGAAAGAGCTGCTCATCTTCAACAAGCAGCAAGTGCCCTCCGGGGAGTCGG
CGATCTTGGACCGAGTGGCCGACGGCATGGTGTTCGGCGCCCTTCTTCCCTGTGAGGAATGCTC
AGGCCAGCTGGTCTTCAAGAGCGATGCCTACTACTGTACTGGGGACGTCACTGCCTGGACCAAG
TGCATGGTCAAGACACAGACGCCTAACCGGAAGGAGTGGGTGACCCCAAAGGAATTCCGAGAAA
TCACTTACCTCAAGAAATTGAAGATCAAAAAACAGGACCGTATATTCCCCCCCGAGGCCAGCAC
CCCTGTGGCCACAGCACCCCCACCCCCCGCAGCCTCTGCACCCACCGCCGTGAACTCCTCGGCC
CCACCAGACAAGCCGTTATCCAACATGAAGATCCTGACTCTTGGGAAACTCTCCCGGAACAAGG
ATGAAGTGAAGGCCGCGATCGAGAAACTCGGGGGGAAGTTGACAGGGACGGCCAGCAAGGCCTC
CCTGTGCGTCAGCACCAAGAAGGAGGTGGACAAGATGAGTAAGAAGATGGAGGAAGTGAAAGAA
GCGAATGTCCGAGTGGTGTCCGAGGATTTCCTCCAGGACGTCTCGGCCTCGACCAAGAGCCTTC
AGGAGCTGCTCTGCACCCACATCCTGTCCCCCTGGGGGGCCGAAATGAAGGCTGAGGTGAAGGC
CGAACCTGTGGAAGCCGTGGCCCCCAGAGGGAAGTCAGGGGGTGCACTCCCCAAGAAGAGCAAG
GGCCCCATCAGGGAGGAAGGTGCCAACAAATCTGAAAAAAGAATGAAATTAACTCTTAAAGGAG
GAGCAGCCGTGGACCCCGATTCTGGTCTGGAACACTCGGCCCATGTCCTGGAGAAAGGCGGGAA
GGTCTTCAGTGCCACACTCGGCCTGGTGGATATTGTCAAGGGAACCAACTCCTATTACAAGCTG
CAGCTCCTGGAGGATGACAAGGAGAGCAGGTACTGGATATTCAGGTCCTGGGGCCGTGTGGGCA
CCGTAATTGGTAGTAACAAACTGGAGCAGATGCCATCCAAGGAGGATGCCATTGATCATNTTAT
GAAATTATATGAAGAGAAAACTGGGAATGCCTGGCACTCCAAAAACTTCACAAAGTATCCCAAG
AAGTTCTACCCTCTGGAGATTGACTATGGCCAGGATGAAGAGGCAGTGAAGAAGCTGACAGTAA
ACCCTGGCACCAAATCCAAGCTCCCCAAATCGGTGCAGGAACTCATCAAGATGATCTTTGATGT
GGAAAGTATGAAGAAAGCCATGGTGGAGTACGAGATTGACCTTCAGAAGATGCCGTTGGGGAAG
CTGAGCAAAAGGCAGATCCAGGCCGCGTACGCCATCCTCAGTGAGGTCCAGCAGGCCGTGTCCC
AGGGCAGCAGCGACTCCCAGATCCTGGATCTCTCAAATCGATTCTACACCTTGATCCCCCATGA
CTTTGGGATGAAGAAGCCTCCACTGCTGAACAATGCGGACAGCGTGCAGGCCAAGGTGGAAATG
CTAGACAACCTATTGGACATCGAGGTGGCCTACAGTCTGCTCAGGGGTGGTTCTGATGACAGCA
GCAAGGACCCCATTGATGTCAACTATGAGAAGCTCAAAACTGATATTAAGGTGGTGGACAGGGA
TTCTGAAGAAGCCGAGACCATCAGGAAGTACGTTAAGAACACTCACGCAACCACACACAATGCA
TATGACTTGGAAGTTATCGATATCTTTAAGATCGAGCGTGAAGGGGAGAGTCAGCGTTACAAGC
CATTTAAACAGCTGCATAACCGGAGGTTGCTGTGGCACGGGTCCAGGACCACCAACTTCGCCGG
GATCTTGTCCCAGGGTCTCCGGATAGCCCCACCTGAAGCACCTGTGACGGGCTACATGTTTGGG
AAGGGGATCTATTTCGCCGACATGGTCTCCAAGAGTGCCAACTACTGCCACACGTCCCAGGGAG
ACCCCATAGGCTTGATCCTGTTGGGAGAAGTTGCCCTTGGAAACATGTATGAGCTGAAGCACGC
TTCGCACATCAGCAAGTTACCCAAGGGCAAGCACAGTGTCAAAGGCTTAGGCAAAACGACCCCT
GACCCCGCAGCCAGTATTACTATGGATGGTGTGGAGGTTCCTCTTGGGACCGGGATCCCATCTG
GTGTGAACGATACCTGTCTGCTGTATAACGAGTACATTGTCTACGATATCGCTCAGGTCAATCT
CAAGTATCTACTGAAGCTGAAATTCAACTTTAAGACGTCCCTGTGGTGAGCTGTGAACCGCAGC
CCCAGGATCGTGGGGTGTCACCCCACGTGCTGTGCACCAACCAACCAGGCAGAAACCTCGGCCA
AGTTGCCGAGGGATGGTACCTTCACTGAATCTCCTTAGAAAGGATTTATATGAACACTTGGTCA
CATGTTAGTGATTTTCCCAACTTCTCCAATCCGTTGTTTGTGTTGGTCGGGGTGGGGGGCGGTC
GTTTGGGGCTTCTTTCCTGCCAGCCATAACCCTGGTAGGTACAACTGACAATAGGGGAAACGTT
GGGAGGGTTTTGTTTTTGTTTTTGTTTTTGTTTTGCGTCTAGACTAGTCCAGCGAAAGAACCTT
GCAAGCCACCTTATAACGTCTGCCTTACTGGTTTCCCCAGGGAAGGAAAAAAATAATCTTCCAC
CCTTATTTCTAAGTGTTCATCTTTAGTTTTGGAAAAACGTTAAGCATTTATTTTAAGGTCAAAA
TAAAAACTAATTTCATACTATTTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003357689	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	JAG69302	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_003357689 ⟸ XM_003357641

- Sequence:

show sequence

MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHAI
RHPDIEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGVGSKAEKTLGDFAAEYAKSNRSTCKGC
MEKIEKGHVRLSKKMLDPEKPQLGMIDRWYHPNCFVQNREELGFRPEYSASQLKGFSLLTAEDK
EALKKQLPGIKSEGKRKGDEVDGVDGVAKKKSKKEKDKESKLEKALKAQNDLIWNIKDELKKVC
STNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTK
CMVKTQTPNRKEWVTPKEFREITYLKKLKIKKQDRIFPPEASTPVATAPPPPAASAPTAVNSSA
PPDKPLSNMKILTLGKLSRNKDEVKAAIEKLGGKLTGTASKASLCVSTKKEVDKMSKKMEEVKE
ANVRVVSEDFLQDVSASTKSLQELLCTHILSPWGAEMKAEVKAEPVEAVAPRGKSGGALPKKSK
GPIREEGANKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKL
QLLEDDKESRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIDHXMKLYEEKTGNAWHSKNFTKYPK
KFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKSVQELIKMIFDVESMKKAMVEYEIDLQKMPLGK
LSKRQIQAAYAILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEM
LDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAETIRKYVKNTHATTHNA
YDLEVIDIFKIEREGESQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFG
KGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTP
DPAASITMDGVEVPLGTGIPSGVNDTCLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW

hide sequence

RefSeq Acc Id:

ENSSSCP00000070720 ⟸ ENSSSCT00000075629

RefSeq Acc Id:

ENSSSCP00000022104 ⟸ ENSSSCT00000028077

Protein Domains

BRCT PARP alpha-helical PARP catalytic PARP-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000023660	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00070008636	UniProtKB/TrEMBL
Ensembl Protein	ENSSSCP00000022104	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCP00000070720	UniProtKB/TrEMBL
	ENSSSCP00070013920	UniProtKB/TrEMBL
	ENSSSCP00070013930	UniProtKB/TrEMBL
	ENSSSCP00070013946	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000028077	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCT00000075629	UniProtKB/TrEMBL
	ENSSSCT00070016790	UniProtKB/TrEMBL
	ENSSSCT00070016800	UniProtKB/TrEMBL
	ENSSSCT00070016817	UniProtKB/TrEMBL
Gene3D-CATH	1.20.142.10	UniProtKB/TrEMBL
	2.20.140.10	UniProtKB/TrEMBL
	2.20.25.630	UniProtKB/TrEMBL
	3.30.1740.10	UniProtKB/TrEMBL
	3.40.50.10190	UniProtKB/TrEMBL
InterPro	BRCT_dom	UniProtKB/TrEMBL
	BRCT_dom_sf	UniProtKB/TrEMBL
	PADR1	UniProtKB/TrEMBL
	PADR1_dom_sf	UniProtKB/TrEMBL
	PARP	UniProtKB/TrEMBL
	Poly(ADP-ribose)pol_cat_dom	UniProtKB/TrEMBL
	Poly(ADP-ribose)pol_reg_dom	UniProtKB/TrEMBL
	Poly(ADP-ribose)pol_reg_dom_sf	UniProtKB/TrEMBL
	WGR_dom_sf	UniProtKB/TrEMBL
	WGR_domain	UniProtKB/TrEMBL
	Znf_PARP	UniProtKB/TrEMBL
	Znf_PARP_sf	UniProtKB/TrEMBL
NCBI Gene	PARP1	ENTREZGENE
Pfam	BRCT	UniProtKB/TrEMBL
	PADR1	UniProtKB/TrEMBL
	PARP	UniProtKB/TrEMBL
	PARP_reg	UniProtKB/TrEMBL
	WGR	UniProtKB/TrEMBL
	zf-PARP	UniProtKB/TrEMBL
PIRSF	NAD_ADPRT	UniProtKB/TrEMBL
PROSITE	BRCT	UniProtKB/TrEMBL
	PARP_ALPHA_HD	UniProtKB/TrEMBL
	PARP_CATALYTIC	UniProtKB/TrEMBL
	PARP_ZN_FINGER_1	UniProtKB/TrEMBL
	PARP_ZN_FINGER_2	UniProtKB/TrEMBL
SMART	BRCT	UniProtKB/TrEMBL
	PADR1	UniProtKB/TrEMBL
	WGR	UniProtKB/TrEMBL
	zf-PARP	UniProtKB/TrEMBL
Superfamily-SCOP	SSF142921	UniProtKB/TrEMBL
	SSF47587	UniProtKB/TrEMBL
	SSF52113	UniProtKB/TrEMBL
UniProt	A0A4X1TFK2_PIG	UniProtKB/TrEMBL
	A0A4X1TFL4_PIG	UniProtKB/TrEMBL
	A0A4X1TFR8_PIG	UniProtKB/TrEMBL
	A0A5G2R0N8_PIG	UniProtKB/TrEMBL
	I3LDH3_PIG	UniProtKB/TrEMBL
VGNC ID	VGNC:96677	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations