PARP1 (poly(ADP-ribose) polymerase 1)

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Gene: PARP1 (poly(ADP-ribose) polymerase 1) Sus scrofa

Analyze

Symbol:

PARP1

Name:

poly(ADP-ribose) polymerase 1

RGD ID:

13868155

Description:

ENCODES a protein that exhibits chromatin binding (ortholog); histone deacetylase binding (ortholog); NAD binding (ortholog); INVOLVED IN base-excision repair (ortholog); behavioral response to cocaine (ortholog); carbohydrate biosynthetic process (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Experimental Pancreatitis (ortholog); acute kidney failure (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 3-methyladenine; 3-oxalomalic acid; cadmium atom

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

poly [ADP-ribose] polymerase 1

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	14,203,160 - 14,241,196 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	14,203,157 - 14,241,164 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	16,598,164 - 16,636,214 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

abdominal aortic aneurysm (ISO)

Acute Experimental Pancreatitis (ISO)

acute kidney failure (ISO)

Acute Lung Injury (ISO)

adult respiratory distress syndrome (ISO)

alopecia (ISO)

Alveolar Bone Loss (ISO)

Alzheimer's disease (ISO)

anemia (ISO)

arthritis (ISO)

asthma (ISO)

atherosclerosis (ISO)

autoimmune disease (ISO)

bacterial meningitis (ISO)

borna disease (ISO)

Brain Injuries (ISO)

brain ischemia (ISO)

Breast Neoplasms (ISO)

cardiomyopathy (ISO)

Carotid Artery Injuries (ISO)

Colorectal Neoplasms (ISO)

congestive heart failure (ISO)

dermatitis (ISO)

Diabetic Nephropathies (ISO)

diabetic neuropathy (ISO)

Experimental Arthritis (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Mammary Neoplasms (ISO)

Fibrosis (ISO)

gastrointestinal stromal tumor (ISO)

glomerulonephritis (ISO)

hepatitis (ISO)

hepatocellular carcinoma (ISO)

hereditary renal cell carcinoma (ISO)

Huntington's disease (ISO)

hyperglycemia (ISO)

idiopathic pulmonary fibrosis (ISO)

Inflammation (ISO)

intellectual disability (ISO)

kidney disease (ISO)

kidney failure (ISO)

Kyphosis (ISO)

leiomyoma (ISO)

liver cirrhosis (ISO)

Lung Injury (ISO)

malignant mesothelioma (ISO)

melanoma (ISO)

middle cerebral artery infarction (ISO)

multiple myeloma (ISO)

myocardial infarction (ISO)

Myocardial Reperfusion Injury (ISO)

Neointima (ISO)

Neoplastic Cell Transformation (ISO)

nephritis (ISO)

neuronal ceroid lipofuscinosis 1 (ISO)

obesity (ISO)

pancreatitis (ISO)

Paralysis (ISO)

parathyroid carcinoma (ISO)

Parkinson's disease (ISO)

Parkinsonism (ISO)

perinatal necrotizing enterocolitis (ISO)

periodontitis (ISO)

periventricular leukomalacia (ISO)

Plaque, Atherosclerotic (ISO)

pneumonia (ISO)

Prostatic Neoplasms (ISO)

pulmonary edema (ISO)

pulmonary fibrosis (ISO)

Reperfusion Injury (ISO)

Spinal Cord Injuries (ISO)

Spinal Cord Ischemia (ISO)

Stevens-Johnson syndrome (ISO)

stomach cancer (ISO)

stomach carcinoma (ISO)

systemic lupus erythematosus (ISO)

toxic shock syndrome (ISO)

transient cerebral ischemia (ISO)

Traumatic Brain Injuries (ISO)

type 2 diabetes mellitus (ISO)

ureteral obstruction (ISO)

Vitamin A Deficiency (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

3-methyladenine (EXP)

3-oxalomalic acid (EXP)

cadmium atom (EXP)

cadmium dichloride (EXP)

chloroquine (EXP)

cisplatin (EXP)

ochratoxin A (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (IEA)

ATP generation from poly-ADP-D-ribose (IEA)

base-excision repair (ISO)

behavioral response to cocaine (ISO)

carbohydrate biosynthetic process (ISO)

cellular response to amyloid-beta (ISO)

cellular response to DNA damage stimulus (IEA,ISO)

cellular response to insulin stimulus (IEA)

cellular response to nerve growth factor stimulus (ISO)

cellular response to oxidative stress (IEA,ISO)

cellular response to superoxide (ISO)

cellular response to transforming growth factor beta stimulus (ISO)

cellular response to UV (IEA)

cellular response to zinc ion (ISO)

decidualization (ISO)

DNA ADP-ribosylation (IEA)

DNA metabolic process (ISO)

DNA repair (ISO)

double-strand break repair (IBA,IEA,ISO)

mitochondrial DNA metabolic process (IEA,ISO)

mitochondrial DNA repair (IEA,ISO)

mitochondrion organization (IEA,ISO)

negative regulation of adipose tissue development (ISO)

negative regulation of ATP biosynthetic process (IEA)

negative regulation of DNA-templated transcription (ISO)

negative regulation of innate immune response (IEA)

negative regulation of interleukin-17 production (ISO)

negative regulation of telomere maintenance via telomere lengthening (ISO)

negative regulation of transcription by RNA polymerase II (IEA)

obsolete peptidyl-glutamic acid poly-ADP-ribosylation (IEA)

obsolete peptidyl-serine ADP-ribosylation (IEA)

obsolete protein ADP-ribosylation (ISO)

positive regulation of cardiac muscle hypertrophy (ISO)

positive regulation of double-strand break repair via homologous recombination (IEA)

positive regulation of intracellular estrogen receptor signaling pathway (ISO)

positive regulation of mitochondrial depolarization (ISO)

positive regulation of myofibroblast differentiation (ISO)

positive regulation of necroptotic process (ISO)

positive regulation of neuron death (ISO)

positive regulation of protein localization to nucleus (ISO)

positive regulation of single strand break repair (IEA)

positive regulation of SMAD protein signal transduction (ISO)

positive regulation of transcription by RNA polymerase II (IEA)

positive regulation of transcription regulatory region DNA binding (ISO)

protein auto-ADP-ribosylation (IEA)

protein autoprocessing (ISO)

protein modification process (IEA,ISO)

protein poly-ADP-ribosylation (IBA,IEA,ISO)

regulation of catalytic activity (IEA)

regulation of circadian sleep/wake cycle, non-REM sleep (ISO)

regulation of DNA metabolic process (IEA)

regulation of DNA methylation (ISO)

regulation of growth rate (ISO)

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway (ISO)

regulation of protein localization (IEA,ISO)

regulation of single strand break repair (ISO)

regulation of SMAD protein complex assembly (ISO)

replication fork reversal (IEA)

response to aldosterone (ISO)

response to gamma radiation (ISO)

signal transduction involved in regulation of gene expression (ISO)

telomere maintenance (ISO)

transforming growth factor beta receptor signaling pathway (ISO)

voluntary musculoskeletal movement (ISO)

Cellular Component

chromatin (IEA,ISO)

chromosome (IEA)

cytoplasm (ISO)

cytosol (IEA,ISO)

mitochondrion (IEA)

nuclear body (IEA)

nuclear envelope (IEA)

nuclear replication fork (IEA,ISO)

nucleolus (IBA,IEA)

nucleoplasm (IEA)

nucleus (IEA,ISO)

protein-containing complex (IEA)

protein-DNA complex (IEA)

site of DNA damage (IEA,ISO)

site of double-strand break (IEA,ISO)

transcription regulator complex (IEA)

Molecular Function

chromatin binding (ISO)

damaged DNA binding (IEA)

DNA binding (IEA)

enzyme binding (IEA)

glycosyltransferase activity (IEA)

histone deacetylase binding (ISO)

identical protein binding (IEA)

metal ion binding (IEA)

NAD binding (IEA,ISO)

NAD DNA ADP-ribosyltransferase activity (IEA)

NAD+ ADP-ribosyltransferase activity (IBA,IEA,ISO)

NAD+- protein-aspartate ADP-ribosyltransferase activity (IEA)

NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity (ISO)

NAD+-protein ADP-ribosyltransferase activity (IBA,IEA)

NAD+-protein-glutamate ADP-ribosyltransferase activity (IEA)

NAD+-protein-histidine ADP-ribosyltransferase activity (IEA)

NAD+-protein-serine ADP-ribosyltransferase activity (IEA)

NAD+-protein-tyrosine ADP-ribosyltransferase activity (IEA)

nuclear estrogen receptor binding (ISO)

nucleosome binding (IEA)

nucleotidyltransferase activity (IEA)

protein binding (ISO)

protein homodimerization activity (IEA)

protein kinase binding (IEA)

protein N-terminus binding (IEA)

protein serine/threonine kinase inhibitor activity (ISO)

R-SMAD binding (ISO)

RNA polymerase II-specific DNA-binding transcription factor binding (IEA)

SMAD binding (ISO)

transferase activity (IEA)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

ADP-ribosylation pathway, mono and poly-ribosylation (ISO)

References

Additional References at PubMed

PMID:14681463	PMID:17145712	PMID:23522430	PMID:24062568	PMID:26440043

Genomics

Comparative Map Data

PARP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	14,203,160 - 14,241,196 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	14,203,157 - 14,241,164 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	16,598,164 - 16,636,214 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PARP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	226,360,691 - 226,408,093 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	1	226,360,210 - 226,408,154 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	226,548,392 - 226,595,794 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	224,615,015 - 224,662,424 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	222,855,240 - 222,902,526	NCBI
Celera	1	199,739,310 - 199,786,722 (-)	NCBI		Celera
Cytogenetic Map	1	q42.12	NCBI
HuRef	1	197,065,678 - 197,113,094 (-)	NCBI		HuRef
CHM1_1	1	227,821,256 - 227,868,667 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	225,548,804 - 225,596,198 (-)	NCBI		T2T-CHM13v2.0

Parp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	180,396,456 - 180,428,564 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	180,396,489 - 180,428,819 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	180,568,891 - 180,600,999 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	180,568,924 - 180,601,254 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	182,499,106 - 182,531,385 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	182,405,650 - 182,437,929 (+)	NCBI		MGSCv36	mm8
Celera	1	187,634,811 - 187,667,071 (+)	NCBI		Celera
Cytogenetic Map	1	H4	NCBI
cM Map	1	84.44	NCBI

Parp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	92,307,593 - 92,339,406 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	92,307,586 - 92,339,404 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	94,812,753 - 94,844,565 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	13	96,212,939 - 96,244,750 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	13	93,387,644 - 93,419,455 (+)	NCBI	Rnor_WKY
Rnor_6.0	13	98,857,255 - 98,889,444 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	98,857,177 - 98,889,716 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	103,859,760 - 103,891,949 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	96,309,670 - 96,341,486 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	96,498,605 - 96,530,421 (+)	NCBI
Celera	13	91,853,812 - 91,885,580 (+)	NCBI		Celera
Cytogenetic Map	13	q26	NCBI

Parp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955489	520,875 - 557,615 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955489	520,875 - 557,609 (-)	NCBI	ChiLan1.0	ChiLan1.0

PARP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	206,812,981 - 206,860,356 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	206,812,981 - 206,860,356 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	201,820,355 - 201,867,673 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

PARP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	38,503,072 - 38,542,556 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	38,503,067 - 38,542,127 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	37,984,470 - 38,024,231 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	38,336,543 - 38,376,496 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	38,336,478 - 38,376,795 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	38,175,521 - 38,215,272 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	38,182,459 - 38,222,219 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	38,453,305 - 38,493,301 (+)	NCBI		UU_Cfam_GSD_1.0

Parp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	51,599,711 - 51,644,827 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936526	3,102,468 - 3,147,601 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PARP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	3,350,798 - 3,405,040 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666055	3,353,198 - 3,400,806 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Parp1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624807	446,647 - 479,069 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624807	446,662 - 478,571 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium	5	3	3	5	2	23	1	3	3
Low	5	1					1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003357641	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000071	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK351117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FP312825	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FP340210	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBZA01000466	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01119537	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSSSCT00000028077 ⟹ ENSSSCP00000022104

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	10	14,203,160 - 14,241,196 (-)	Ensembl

RefSeq Acc Id:

ENSSSCT00000075629 ⟹ ENSSSCP00000070720

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	10	14,235,769 - 14,241,197 (-)	Ensembl

RefSeq Acc Id:

XM_003357641 ⟹ XP_003357689

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	10	14,203,157 - 14,241,164 (-)	NCBI

Sequence:

show sequence

TCAGCAATCTATCGGGAGCGGCGGGTGGTCGGCGCGGCGTGCTTGGCGGCAGCGGCGGCGGCTC
TGGGCACTGGGGGCCCTGCTGGGAGGAGACAGGCAAGCAAGGCGGCGGCGGCGGCGGCGGCGGT
TGCGGTTGCGTGTCTGCAGGTCGCAGCGTCAGGCTTCGGGAGCTGCATCGGCACAGGGAGGAGG
ATGGCGGAGTCATCGGACAAGCTCTATCGGGTCGAGTATGCTAAGAGTGGGCGCGCCTCCTGCA
AGAAATGCAGCGAGAGCATCCCCAAGGACTCGCTCCGGATGGCCATCATGGTGCAGTCGCCCAT
GTTCGATGGGAAAGTCCCGCACTGGTACCACTTCTCCTGCTTCTGGAAGGTCGGCCACGCCATC
CGGCACCCTGACATCGAGGTGGACGGGTTCTCCGAGCTCCGGTGGGACGACCAGCAGAAAGTCA
AGAAGACGGCGGAGGCTGGAGGAGTGACAGGCAAAGGCCAAGATGGGGTTGGCAGCAAGGCGGA
GAAGACGCTGGGTGACTTCGCGGCCGAGTATGCCAAGTCCAACAGAAGCACGTGCAAGGGCTGC
ATGGAGAAGATCGAGAAGGGCCACGTGCGCCTGTCCAAGAAGATGCTGGACCCCGAGAAGCCCC
AGCTGGGCATGATCGACCGCTGGTACCACCCAAACTGCTTTGTTCAGAACCGGGAGGAGCTGGG
CTTCCGGCCCGAGTACAGCGCCAGCCAGCTTAAGGGCTTCAGCCTGCTCACCGCAGAGGACAAA
GAAGCGCTGAAGAAGCAGCTCCCGGGCATCAAGAGTGAAGGAAAGAGAAAAGGTGACGAGGTAG
ATGGAGTGGATGGAGTGGCCAAGAAGAAATCTAAAAAAGAAAAGGACAAGGAGAGTAAGCTCGA
AAAGGCCCTCAAGGCCCAGAACGACCTGATCTGGAATATCAAGGACGAGCTAAAGAAAGTGTGT
TCAACCAATGACCTGAAAGAGCTGCTCATCTTCAACAAGCAGCAAGTGCCCTCCGGGGAGTCGG
CGATCTTGGACCGAGTGGCCGACGGCATGGTGTTCGGCGCCCTTCTTCCCTGTGAGGAATGCTC
AGGCCAGCTGGTCTTCAAGAGCGATGCCTACTACTGTACTGGGGACGTCACTGCCTGGACCAAG
TGCATGGTCAAGACACAGACGCCTAACCGGAAGGAGTGGGTGACCCCAAAGGAATTCCGAGAAA
TCACTTACCTCAAGAAATTGAAGATCAAAAAACAGGACCGTATATTCCCCCCCGAGGCCAGCAC
CCCTGTGGCCACAGCACCCCCACCCCCCGCAGCCTCTGCACCCACCGCCGTGAACTCCTCGGCC
CCACCAGACAAGCCGTTATCCAACATGAAGATCCTGACTCTTGGGAAACTCTCCCGGAACAAGG
ATGAAGTGAAGGCCGCGATCGAGAAACTCGGGGGGAAGTTGACAGGGACGGCCAGCAAGGCCTC
CCTGTGCGTCAGCACCAAGAAGGAGGTGGACAAGATGAGTAAGAAGATGGAGGAAGTGAAAGAA
GCGAATGTCCGAGTGGTGTCCGAGGATTTCCTCCAGGACGTCTCGGCCTCGACCAAGAGCCTTC
AGGAGCTGCTCTGCACCCACATCCTGTCCCCCTGGGGGGCCGAAATGAAGGCTGAGGTGAAGGC
CGAACCTGTGGAAGCCGTGGCCCCCAGAGGGAAGTCAGGGGGTGCACTCCCCAAGAAGAGCAAG
GGCCCCATCAGGGAGGAAGGTGCCAACAAATCTGAAAAAAGAATGAAATTAACTCTTAAAGGAG
GAGCAGCCGTGGACCCCGATTCTGGTCTGGAACACTCGGCCCATGTCCTGGAGAAAGGCGGGAA
GGTCTTCAGTGCCACACTCGGCCTGGTGGATATTGTCAAGGGAACCAACTCCTATTACAAGCTG
CAGCTCCTGGAGGATGACAAGGAGAGCAGGTACTGGATATTCAGGTCCTGGGGCCGTGTGGGCA
CCGTAATTGGTAGTAACAAACTGGAGCAGATGCCATCCAAGGAGGATGCCATTGATCATNTTAT
GAAATTATATGAAGAGAAAACTGGGAATGCCTGGCACTCCAAAAACTTCACAAAGTATCCCAAG
AAGTTCTACCCTCTGGAGATTGACTATGGCCAGGATGAAGAGGCAGTGAAGAAGCTGACAGTAA
ACCCTGGCACCAAATCCAAGCTCCCCAAATCGGTGCAGGAACTCATCAAGATGATCTTTGATGT
GGAAAGTATGAAGAAAGCCATGGTGGAGTACGAGATTGACCTTCAGAAGATGCCGTTGGGGAAG
CTGAGCAAAAGGCAGATCCAGGCCGCGTACGCCATCCTCAGTGAGGTCCAGCAGGCCGTGTCCC
AGGGCAGCAGCGACTCCCAGATCCTGGATCTCTCAAATCGATTCTACACCTTGATCCCCCATGA
CTTTGGGATGAAGAAGCCTCCACTGCTGAACAATGCGGACAGCGTGCAGGCCAAGGTGGAAATG
CTAGACAACCTATTGGACATCGAGGTGGCCTACAGTCTGCTCAGGGGTGGTTCTGATGACAGCA
GCAAGGACCCCATTGATGTCAACTATGAGAAGCTCAAAACTGATATTAAGGTGGTGGACAGGGA
TTCTGAAGAAGCCGAGACCATCAGGAAGTACGTTAAGAACACTCACGCAACCACACACAATGCA
TATGACTTGGAAGTTATCGATATCTTTAAGATCGAGCGTGAAGGGGAGAGTCAGCGTTACAAGC
CATTTAAACAGCTGCATAACCGGAGGTTGCTGTGGCACGGGTCCAGGACCACCAACTTCGCCGG
GATCTTGTCCCAGGGTCTCCGGATAGCCCCACCTGAAGCACCTGTGACGGGCTACATGTTTGGG
AAGGGGATCTATTTCGCCGACATGGTCTCCAAGAGTGCCAACTACTGCCACACGTCCCAGGGAG
ACCCCATAGGCTTGATCCTGTTGGGAGAAGTTGCCCTTGGAAACATGTATGAGCTGAAGCACGC
TTCGCACATCAGCAAGTTACCCAAGGGCAAGCACAGTGTCAAAGGCTTAGGCAAAACGACCCCT
GACCCCGCAGCCAGTATTACTATGGATGGTGTGGAGGTTCCTCTTGGGACCGGGATCCCATCTG
GTGTGAACGATACCTGTCTGCTGTATAACGAGTACATTGTCTACGATATCGCTCAGGTCAATCT
CAAGTATCTACTGAAGCTGAAATTCAACTTTAAGACGTCCCTGTGGTGAGCTGTGAACCGCAGC
CCCAGGATCGTGGGGTGTCACCCCACGTGCTGTGCACCAACCAACCAGGCAGAAACCTCGGCCA
AGTTGCCGAGGGATGGTACCTTCACTGAATCTCCTTAGAAAGGATTTATATGAACACTTGGTCA
CATGTTAGTGATTTTCCCAACTTCTCCAATCCGTTGTTTGTGTTGGTCGGGGTGGGGGGCGGTC
GTTTGGGGCTTCTTTCCTGCCAGCCATAACCCTGGTAGGTACAACTGACAATAGGGGAAACGTT
GGGAGGGTTTTGTTTTTGTTTTTGTTTTTGTTTTGCGTCTAGACTAGTCCAGCGAAAGAACCTT
GCAAGCCACCTTATAACGTCTGCCTTACTGGTTTCCCCAGGGAAGGAAAAAAATAATCTTCCAC
CCTTATTTCTAAGTGTTCATCTTTAGTTTTGGAAAAACGTTAAGCATTTATTTTAAGGTCAAAA
TAAAAACTAATTTCATACTATTTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003357689	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	JAG69302	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_003357689 ⟸ XM_003357641

- Sequence:

show sequence

MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHAI
RHPDIEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGVGSKAEKTLGDFAAEYAKSNRSTCKGC
MEKIEKGHVRLSKKMLDPEKPQLGMIDRWYHPNCFVQNREELGFRPEYSASQLKGFSLLTAEDK
EALKKQLPGIKSEGKRKGDEVDGVDGVAKKKSKKEKDKESKLEKALKAQNDLIWNIKDELKKVC
STNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTK
CMVKTQTPNRKEWVTPKEFREITYLKKLKIKKQDRIFPPEASTPVATAPPPPAASAPTAVNSSA
PPDKPLSNMKILTLGKLSRNKDEVKAAIEKLGGKLTGTASKASLCVSTKKEVDKMSKKMEEVKE
ANVRVVSEDFLQDVSASTKSLQELLCTHILSPWGAEMKAEVKAEPVEAVAPRGKSGGALPKKSK
GPIREEGANKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKL
QLLEDDKESRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIDHXMKLYEEKTGNAWHSKNFTKYPK
KFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKSVQELIKMIFDVESMKKAMVEYEIDLQKMPLGK
LSKRQIQAAYAILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEM
LDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAETIRKYVKNTHATTHNA
YDLEVIDIFKIEREGESQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFG
KGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTP
DPAASITMDGVEVPLGTGIPSGVNDTCLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW

hide sequence

RefSeq Acc Id:

ENSSSCP00000070720 ⟸ ENSSSCT00000075629

RefSeq Acc Id:

ENSSSCP00000022104 ⟸ ENSSSCT00000028077

Protein Domains

BRCT PARP alpha-helical PARP catalytic PARP-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000023660	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00015016825	UniProtKB/TrEMBL
	ENSSSCG00025031659	UniProtKB/TrEMBL
	ENSSSCG00030070443	UniProtKB/TrEMBL
	ENSSSCG00035025274	UniProtKB/TrEMBL
	ENSSSCG00040026695	UniProtKB/TrEMBL
	ENSSSCG00045026626	UniProtKB/TrEMBL
	ENSSSCG00050051006	UniProtKB/TrEMBL
	ENSSSCG00055011938	UniProtKB/TrEMBL
	ENSSSCG00060077342	UniProtKB/TrEMBL
	ENSSSCG00065000778	UniProtKB/TrEMBL
	ENSSSCG00070008636	UniProtKB/TrEMBL
Ensembl Protein	ENSSSCP00000022104	ENTREZGENE
	ENSSSCP00000022104.3	UniProtKB/TrEMBL
	ENSSSCP00000070720.1	UniProtKB/TrEMBL
	ENSSSCP00015008692.1	UniProtKB/TrEMBL
	ENSSSCP00015008703.1	UniProtKB/TrEMBL
	ENSSSCP00025018322.1	UniProtKB/TrEMBL
	ENSSSCP00025018353.1	UniProtKB/TrEMBL
	ENSSSCP00025018408.1	UniProtKB/TrEMBL
	ENSSSCP00030045373.1	UniProtKB/TrEMBL
	ENSSSCP00030045390.1	UniProtKB/TrEMBL
	ENSSSCP00030045429.1	UniProtKB/TrEMBL
	ENSSSCP00030045438.1	UniProtKB/TrEMBL
	ENSSSCP00035013112.1	UniProtKB/TrEMBL
	ENSSSCP00035013117.1	UniProtKB/TrEMBL
	ENSSSCP00035013119.1	UniProtKB/TrEMBL
	ENSSSCP00035013122.1	UniProtKB/TrEMBL
	ENSSSCP00040014815.1	UniProtKB/TrEMBL
	ENSSSCP00040014840.1	UniProtKB/TrEMBL
	ENSSSCP00040014870.1	UniProtKB/TrEMBL
	ENSSSCP00040014891.1	UniProtKB/TrEMBL
	ENSSSCP00045031464.1	UniProtKB/TrEMBL
	ENSSSCP00045031625.1	UniProtKB/TrEMBL
	ENSSSCP00045031775.1	UniProtKB/TrEMBL
	ENSSSCP00045031814.1	UniProtKB/TrEMBL
	ENSSSCP00050029840.1	UniProtKB/TrEMBL
	ENSSSCP00050029846.1	UniProtKB/TrEMBL
	ENSSSCP00050029847.1	UniProtKB/TrEMBL
	ENSSSCP00050029848.1	UniProtKB/TrEMBL
	ENSSSCP00055018492.1	UniProtKB/TrEMBL
	ENSSSCP00055018546.1	UniProtKB/TrEMBL
	ENSSSCP00055018598.1	UniProtKB/TrEMBL
	ENSSSCP00055018629.1	UniProtKB/TrEMBL
	ENSSSCP00060046982.1	UniProtKB/TrEMBL
	ENSSSCP00060046988.1	UniProtKB/TrEMBL
	ENSSSCP00060046999.1	UniProtKB/TrEMBL
	ENSSSCP00060047010.1	UniProtKB/TrEMBL
	ENSSSCP00065000247.1	UniProtKB/TrEMBL
	ENSSSCP00065000251.1	UniProtKB/TrEMBL
	ENSSSCP00065000253.1	UniProtKB/TrEMBL
	ENSSSCP00065000254.1	UniProtKB/TrEMBL
	ENSSSCP00070013920.1	UniProtKB/TrEMBL
	ENSSSCP00070013930.1	UniProtKB/TrEMBL
	ENSSSCP00070013946.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000028077	ENTREZGENE
	ENSSSCT00000028077.3	UniProtKB/TrEMBL
	ENSSSCT00000075629.1	UniProtKB/TrEMBL
	ENSSSCT00015022264.1	UniProtKB/TrEMBL
	ENSSSCT00015022298.1	UniProtKB/TrEMBL
	ENSSSCT00025043057.1	UniProtKB/TrEMBL
	ENSSSCT00025043139.1	UniProtKB/TrEMBL
	ENSSSCT00025043292.1	UniProtKB/TrEMBL
	ENSSSCT00030098569.1	UniProtKB/TrEMBL
	ENSSSCT00030098609.1	UniProtKB/TrEMBL
	ENSSSCT00030098690.1	UniProtKB/TrEMBL
	ENSSSCT00030098718.1	UniProtKB/TrEMBL
	ENSSSCT00035033261.1	UniProtKB/TrEMBL
	ENSSSCT00035033267.1	UniProtKB/TrEMBL
	ENSSSCT00035033270.1	UniProtKB/TrEMBL
	ENSSSCT00035033274.1	UniProtKB/TrEMBL
	ENSSSCT00040035744.1	UniProtKB/TrEMBL
	ENSSSCT00040035810.1	UniProtKB/TrEMBL
	ENSSSCT00040035901.1	UniProtKB/TrEMBL
	ENSSSCT00040035937.1	UniProtKB/TrEMBL
	ENSSSCT00045045353.1	UniProtKB/TrEMBL
	ENSSSCT00045045577.1	UniProtKB/TrEMBL
	ENSSSCT00045045783.1	UniProtKB/TrEMBL
	ENSSSCT00045045836.1	UniProtKB/TrEMBL
	ENSSSCT00050069444.1	UniProtKB/TrEMBL
	ENSSSCT00050069452.1	UniProtKB/TrEMBL
	ENSSSCT00050069456.1	UniProtKB/TrEMBL
	ENSSSCT00050069457.1	UniProtKB/TrEMBL
	ENSSSCT00055023394.1	UniProtKB/TrEMBL
	ENSSSCT00055023460.1	UniProtKB/TrEMBL
	ENSSSCT00055023515.1	UniProtKB/TrEMBL
	ENSSSCT00055023552.1	UniProtKB/TrEMBL
	ENSSSCT00060106430.1	UniProtKB/TrEMBL
	ENSSSCT00060106436.1	UniProtKB/TrEMBL
	ENSSSCT00060106448.1	UniProtKB/TrEMBL
	ENSSSCT00060106462.1	UniProtKB/TrEMBL
	ENSSSCT00065000930.1	UniProtKB/TrEMBL
	ENSSSCT00065000937.1	UniProtKB/TrEMBL
	ENSSSCT00065000942.1	UniProtKB/TrEMBL
	ENSSSCT00065000947.1	UniProtKB/TrEMBL
	ENSSSCT00070016790.1	UniProtKB/TrEMBL
	ENSSSCT00070016800.1	UniProtKB/TrEMBL
	ENSSSCT00070016817.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.142.10	UniProtKB/TrEMBL
	2.20.25.630	UniProtKB/TrEMBL
	3.30.1740.10	UniProtKB/TrEMBL
	3.40.50.10190	UniProtKB/TrEMBL
InterPro	BRCT_dom	UniProtKB/TrEMBL
	BRCT_dom_sf	UniProtKB/TrEMBL
	PADR1	UniProtKB/TrEMBL
	PADR1_dom_sf	UniProtKB/TrEMBL
	PARP	UniProtKB/TrEMBL
	Poly(ADP-ribose)pol_cat_dom	UniProtKB/TrEMBL
	Poly(ADP-ribose)pol_reg_dom	UniProtKB/TrEMBL
	Poly(ADP-ribose)pol_reg_dom_sf	UniProtKB/TrEMBL
	WGR_dom_sf	UniProtKB/TrEMBL
	WGR_domain	UniProtKB/TrEMBL
	Znf_PARP	UniProtKB/TrEMBL
	Znf_PARP_sf	UniProtKB/TrEMBL
NCBI Gene	PARP1	ENTREZGENE
Pfam	BRCT	UniProtKB/TrEMBL
	PADR1	UniProtKB/TrEMBL
	PARP	UniProtKB/TrEMBL
	PARP_reg	UniProtKB/TrEMBL
	WGR	UniProtKB/TrEMBL
	zf-PARP	UniProtKB/TrEMBL
PIRSF	NAD_ADPRT	UniProtKB/TrEMBL
PROSITE	BRCT	UniProtKB/TrEMBL
	PARP_ALPHA_HD	UniProtKB/TrEMBL
	PARP_CATALYTIC	UniProtKB/TrEMBL
	PARP_ZN_FINGER_1	UniProtKB/TrEMBL
	PARP_ZN_FINGER_2	UniProtKB/TrEMBL
SMART	BRCT	UniProtKB/TrEMBL
	PADR1	UniProtKB/TrEMBL
	WGR	UniProtKB/TrEMBL
	zf-PARP	UniProtKB/TrEMBL
Superfamily-SCOP	SSF142921	UniProtKB/TrEMBL
	SSF47587	UniProtKB/TrEMBL
	SSF52113	UniProtKB/TrEMBL
UniProt	A0A4X1TFK2_PIG	UniProtKB/TrEMBL
	A0A4X1TFL4_PIG	UniProtKB/TrEMBL
	A0A4X1TFR8_PIG	UniProtKB/TrEMBL
	A0A5G2R0N8_PIG	UniProtKB/TrEMBL
	A0A8D0RK66_PIG	UniProtKB/TrEMBL
	A0A8D0Y3B1_PIG	UniProtKB/TrEMBL
	A0A8D0Z8X7_PIG	UniProtKB/TrEMBL
	A0A8D1DZT3_PIG	UniProtKB/TrEMBL
	A0A8D1X5N3_PIG	UniProtKB/TrEMBL
	I3LDH3_PIG	UniProtKB/TrEMBL
VGNC ID	VGNC:96677	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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