GSN (gelsolin) - Rat Genome Database

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Gene: GSN (gelsolin) Sus scrofa
Analyze
Symbol: GSN
Name: gelsolin
RGD ID: 14194412
Description: ENCODES a protein that exhibits actin binding (ortholog); myosin II binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament capping (ortholog); actin filament reorganization (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; N-cadherin signaling pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); amyloidosis (ortholog); Brain Injuries (ortholog); FOUND IN actin cap (ortholog); actin cytoskeleton (ortholog); cortical actin cytoskeleton (ortholog)
Type: ncrna
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1261,295,713 - 261,385,287 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11261,295,711 - 261,372,848 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21293,381,825 - 293,388,559 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
actin filament capping  (ISO)
actin filament depolymerization  (IEA)
actin filament polymerization  (IEA)
actin filament reorganization  (ISO)
actin filament severing  (IEA,ISO)
actin nucleation  (IEA)
actin polymerization or depolymerization  (ISO)
aging  (ISO)
amyloid fibril formation  (ISO)
apoptotic process  (ISO)
barbed-end actin filament capping  (IEA)
cardiac muscle cell contraction  (IEA)
cell projection organization  (IEA)
cellular response to cadmium ion  (ISO)
cellular response to interferon-gamma  (IEA,ISO)
cilium assembly  (ISO)
extracellular matrix disassembly  (ISO)
hepatocyte apoptotic process  (ISO)
negative regulation of viral entry into host cell  (ISO)
oligodendrocyte development  (ISO)
phagocytosis, engulfment  (IEA)
phosphatidylinositol-mediated signaling  (ISO)
positive regulation of actin nucleation  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of keratinocyte apoptotic process  (ISO)
positive regulation of protein processing in phagocytic vesicle  (IEA)
protein destabilization  (ISO)
regulation of cell adhesion  (ISO)
regulation of establishment of T cell polarity  (ISO)
regulation of plasma membrane raft polarization  (ISO)
regulation of podosome assembly  (ISO)
regulation of receptor clustering  (ISO)
relaxation of cardiac muscle  (IEA)
renal protein absorption  (ISO)
response to ethanol  (ISO)
response to folic acid  (ISO)
response to muscle stretch  (IEA)
sequestering of actin monomers  (ISO)
striated muscle atrophy  (ISO)
tissue regeneration  (ISO)
vesicle-mediated transport  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:2850369   PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
GSN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1261,295,713 - 261,385,287 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11261,295,711 - 261,372,848 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21293,381,825 - 293,388,559 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GSN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9121,207,794 - 121,332,843 (+)EnsemblGRCh38hg38GRCh38
GRCh389121,201,483 - 121,332,844 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379123,963,761 - 124,095,120 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369123,070,201 - 123,134,941 (+)NCBINCBI36hg18NCBI36
Build 349121,109,960 - 121,174,674NCBI
Celera994,678,898 - 94,743,628 (+)NCBI
Cytogenetic Map9q33.2NCBI
HuRef993,648,171 - 93,712,883 (+)NCBIHuRef
CHM1_19124,177,269 - 124,242,004 (+)NCBICHM1_1
Gsn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39235,146,371 - 35,197,914 (+)NCBIGRCm39mm39
GRCm39 Ensembl235,146,392 - 35,197,904 (+)Ensembl
GRCm38235,256,359 - 35,307,902 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl235,256,380 - 35,307,892 (+)EnsemblGRCm38mm10GRCm38
MGSCv37235,137,960 - 35,163,412 (+)NCBIGRCm37mm9NCBIm37
MGSCv36235,104,449 - 35,129,901 (+)NCBImm8
Celera234,977,113 - 35,002,613 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map223.5NCBI
Gsn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2318,585,166 - 18,638,404 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl318,585,172 - 18,638,402 (+)Ensembl
Rnor_6.0314,456,106 - 14,508,922 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl314,467,330 - 14,508,911 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0319,773,655 - 19,826,463 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4314,360,245 - 14,386,313 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1314,256,616 - 14,282,685 (+)NCBI
Celera313,325,045 - 13,351,501 (+)NCBICelera
Cytogenetic Map3p11NCBI
Gsn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554196,682,058 - 6,733,361 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554196,682,202 - 6,733,361 (-)NCBIChiLan1.0ChiLan1.0
GSN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19120,741,148 - 120,805,831 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9120,741,148 - 120,805,831 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0992,413,819 - 92,460,483 (+)NCBIMhudiblu_PPA_v0panPan3
GSN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11174,248,227 - 74,268,129 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1174,233,457 - 74,268,129 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1172,637,556 - 72,678,974 (+)NCBI
ROS_Cfam_1.01175,364,194 - 75,405,704 (+)NCBI
UMICH_Zoey_3.11173,871,291 - 73,912,586 (+)NCBI
UNSW_CanFamBas_1.01173,902,056 - 73,943,469 (+)NCBI
UU_Cfam_GSD_1.01174,663,262 - 74,683,140 (+)NCBI
Gsn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947189,981,162 - 190,034,252 (+)NCBI
SpeTri2.0NW_0049364879,749,755 - 9,802,787 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11218,253,079 - 18,317,285 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1218,253,324 - 18,285,938 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603524,700,374 - 24,764,693 (+)NCBIVero_WHO_p1.0
Gsn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476013,943,680 - 14,004,660 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 9 4 3 5 2 8 3 3
Low 1 15 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XR_002337462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002337463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002337467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002337468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002337469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002337470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002337471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002337472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002337473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK232529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK233441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK240319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK345873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK347224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK351603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK393612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK393823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU467561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF070196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01070986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M36927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000039685   ⟹   ENSSSCP00000034477
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1261,321,769 - 261,372,848 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000054653   ⟹   ENSSSCP00000033104
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1261,295,713 - 261,372,845 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000059979   ⟹   ENSSSCP00000039436
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1261,344,927 - 261,385,287 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000061208   ⟹   ENSSSCP00000056479
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1261,330,973 - 261,372,848 (+)Ensembl
RefSeq Acc Id: XR_002337462
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11261,344,872 - 261,372,848 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002337463
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11261,328,339 - 261,372,848 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002337467
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11261,315,005 - 261,372,848 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002337468
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11261,315,015 - 261,372,848 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002337469
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11261,314,712 - 261,372,848 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002337470
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11261,295,711 - 261,372,848 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002337471
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11261,316,608 - 261,372,848 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002337472
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11261,340,126 - 261,372,848 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002337473
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11261,314,986 - 261,372,848 (+)NCBI
Sequence:
Protein Sequences
GenBank Protein AAA31042 (Get FASTA)   NCBI Sequence Viewer  
  CAA32077 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: ENSSSCP00000033104   ⟸   ENSSSCT00000054653
RefSeq Acc Id: ENSSSCP00000034477   ⟸   ENSSSCT00000039685
RefSeq Acc Id: ENSSSCP00000056479   ⟸   ENSSSCT00000061208
RefSeq Acc Id: ENSSSCP00000039436   ⟸   ENSSSCT00000059979
Protein Domains
Gelsolin-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000037508 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000033104 UniProtKB/TrEMBL
  ENSSSCP00000034477 UniProtKB/TrEMBL
  ENSSSCP00000039436 UniProtKB/TrEMBL
  ENSSSCP00000056479 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000039685 UniProtKB/TrEMBL
  ENSSSCT00000054653 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000059979 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000061208 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.40.20.10 UniProtKB/TrEMBL
InterPro ADF-H/Gelsolin-like_dom_sf UniProtKB/TrEMBL
  Gelsolin UniProtKB/TrEMBL
  Gelsolin-like_dom UniProtKB/TrEMBL
  Villin/Gelsolin UniProtKB/TrEMBL
NCBI Gene GSN ENTREZGENE
PANTHER PTHR11977 UniProtKB/TrEMBL
  PTHR11977:SF27 UniProtKB/TrEMBL
Pfam Gelsolin UniProtKB/TrEMBL
PRINTS GELSOLIN UniProtKB/TrEMBL
SMART GEL UniProtKB/TrEMBL
UniProt A0A286ZIC1_PIG UniProtKB/TrEMBL
  A0A286ZSM7_PIG UniProtKB/TrEMBL
  A0A287A6P1_PIG UniProtKB/TrEMBL
  A0A287BJC6_PIG UniProtKB/TrEMBL