CXCL10 (C-X-C motif chemokine ligand 10) - Rat Genome Database
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Gene: CXCL10 (C-X-C motif chemokine ligand 10) Sus scrofa
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Symbol: CXCL10
Name: C-X-C motif chemokine ligand 10
RGD ID: 14269009
Description: ENCODES a protein that exhibits chemoattractant activity (inferred); CXCR3 chemokine receptor binding (inferred); heparin binding (inferred); INVOLVED IN cellular response to heat (ortholog); chemotaxis (ortholog); G protein-coupled receptor signaling pathway (ortholog); ASSOCIATED WITH Acute Liver Failure (ortholog); Acute-On-Chronic Liver Failure (ortholog); adult respiratory distress syndrome (ortholog); FOUND IN extracellular region (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: C-X-C motif chemokine 10; chemokine C-X-C motif ligand 10; chemokine CXC-like protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl871,693,339 - 71,695,948 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1871,693,641 - 71,695,948 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2875,829,909 - 75,831,236 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2875,881,457 - 75,882,217 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
Acute-On-Chronic Liver Failure  (ISO)
adult respiratory distress syndrome  (ISO)
alopecia areata  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
bacterial pneumonia  (ISO)
boutonneuse fever  (ISO)
Brain Injuries  (ISO)
Brain Injuries, Traumatic  (ISO)
brain ischemia  (ISO)
bronchiolitis obliterans  (ISO)
cardiovascular system disease  (ISO)
Carrington Syndrome  (ISO)
celiac disease  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
common cold  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
COVID-19  (ISO)
cryoglobulinemia  (ISO)
Cytomegalovirus Infections  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
encephalitis  (ISO)
Experimental Autoimmune Myasthenia Gravis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrinsic allergic alveolitis  (ISO)
fatty liver disease  (ISO)
Foot Ulcer  (ISO)
Graft vs Host Disease  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hypothermia  (ISO)
inhalation anthrax  (ISO)
interstitial cystitis  (ISO)
interstitial lung disease  (ISO)
ischemia  (ISO)
liver cirrhosis  (ISO)
Liver Metastasis  (ISO)
Liver Reperfusion Injury  (ISO)
middle cerebral artery infarction  (ISO)
Middle East respiratory syndrome  (ISO)
myasthenia gravis  (ISO)
Myocardial Ischemia  (ISO)
myocarditis  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (ISO)
pleurisy  (ISO)
pneumonia  (ISO)
primary biliary cholangitis  (ISO)
proteinuria  (ISO)
pulmonary emphysema  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
renovascular hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Respiratory Tract Granuloma  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Spontaneous Abortions  (ISO)
systemic scleroderma  (ISO)
thoracic aortic aneurysm  (ISO)
Thyroid Neoplasms  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uveitis  (ISO)
Viral Bronchiolitis  (ISO)
viral pneumonia  (ISO)
visceral leishmaniasis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:17328963   PMID:17676471   PMID:19896155   PMID:24083897   PMID:24889251   PMID:26498738  


Genomics

Comparative Map Data
CXCL10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl871,693,339 - 71,695,948 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1871,693,641 - 71,695,948 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2875,829,909 - 75,831,236 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2875,881,457 - 75,882,217 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CXCL10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl476,021,118 - 76,023,497 (-)EnsemblGRCh38hg38GRCh38
GRCh38476,021,118 - 76,023,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37476,942,269 - 76,944,689 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36477,161,295 - 77,163,674 (-)NCBINCBI36hg18NCBI36
Build 34477,299,451 - 77,301,829NCBI
Celera474,243,028 - 74,245,407 (-)NCBI
Cytogenetic Map4q21.1NCBI
HuRef472,694,720 - 72,697,139 (-)NCBIHuRef
CHM1_1476,918,847 - 76,921,265 (-)NCBICHM1_1
Cxcl10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39592,494,497 - 92,496,748 (-)NCBIGRCm39mm39
GRCm38592,346,638 - 92,348,889 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl592,346,638 - 92,348,889 (-)EnsemblGRCm38mm10GRCm38
MGSCv37592,775,667 - 92,777,880 (-)NCBIGRCm37mm9NCBIm37
MGSCv36593,421,841 - 93,424,054 (-)NCBImm8
Celera590,490,436 - 90,492,644 (-)NCBICelera
Cytogenetic Map5E2NCBI
cM Map546.57NCBI
Cxcl10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01417,210,733 - 17,212,930 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1417,210,733 - 17,212,930 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01417,126,865 - 17,129,062 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41417,265,986 - 17,268,183 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11417,265,985 - 17,268,183 (+)NCBI
Celera1415,099,217 - 15,101,414 (+)NCBICelera
Cytogenetic Map14p22NCBI
RH 3.4 Map14182.09RGD
Cxcl10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955433748,284 - 750,927 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955433748,392 - 750,890 (-)NCBIChiLan1.0ChiLan1.0
CXCL10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1454,020,204 - 54,022,606 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl454,020,204 - 54,022,606 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0448,182,355 - 48,184,733 (+)NCBIMhudiblu_PPA_v0panPan3
CXCL10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl32597,987 - 599,979 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.132598,406 - 599,925 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cxcl10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493667660,869 - 63,028 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CXCL10
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl724,526,680 - 24,529,130 (-)Ensembl
ChlSab1.1724,526,657 - 24,529,193 (-)NCBI
Cxcl10
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475714,989,241 - 14,991,650 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 2 5 1 3
Low 2 2 3 2 22 2 2
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000062500   ⟹   ENSSSCP00000032297
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl871,693,339 - 71,695,948 (-)Ensembl
RefSeq Acc Id: NM_001008691   ⟹   NP_001008691
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1871,693,641 - 71,695,948 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001008691 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAS90942 (Get FASTA)   NCBI Sequence Viewer  
  AAV65839 (Get FASTA)   NCBI Sequence Viewer  
  AAW80469 (Get FASTA)   NCBI Sequence Viewer  
  ABD18444 (Get FASTA)   NCBI Sequence Viewer  
  ABY66144 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001008691   ⟸   NM_001008691
- Peptide Label: precursor
- UniProtKB: Q5S1S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000032297   ⟸   ENSSSCT00000062500
Protein Domains
SCY


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000032474 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070004989 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000032297 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070007763 UniProtKB/TrEMBL
  ENSSSCP00070007777 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000062500 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070009465 UniProtKB/TrEMBL
  ENSSSCT00070009482 UniProtKB/TrEMBL
InterPro Chemokine_CXC UniProtKB/TrEMBL
  Chemokine_CXC_CS UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/TrEMBL
  CXC_Chemokine_domain UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/TrEMBL
KEGG Report ssc:494019 UniProtKB/TrEMBL
NCBI Gene CXCL10 ENTREZGENE
PANTHER PTHR10179 UniProtKB/TrEMBL
Pfam IL8 UniProtKB/TrEMBL
PRINTS SMALLCYTKCXC UniProtKB/TrEMBL
PROSITE SMALL_CYTOKINES_CXC UniProtKB/TrEMBL
SMART SCY UniProtKB/TrEMBL
Superfamily-SCOP SSF54117 UniProtKB/TrEMBL
UniGene Ssc.35257 ENTREZGENE
UniProt A0A4X1SX64_PIG UniProtKB/TrEMBL
  A0A4X1SZ52_PIG UniProtKB/TrEMBL
  Q5S1S3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:87101 ENTREZGENE