CXCL10 (C-X-C motif chemokine ligand 10)

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Gene: CXCL10 (C-X-C motif chemokine ligand 10) Sus scrofa

Analyze

Symbol:

CXCL10

Name:

C-X-C motif chemokine ligand 10

RGD ID:

14269009

Description:

ENCODES a protein that exhibits chemoattractant activity (inferred); CXCR3 chemokine receptor binding (inferred); heparin binding (inferred); INVOLVED IN cellular response to heat (ortholog); chemotaxis (ortholog); G protein-coupled receptor signaling pathway (ortholog); ASSOCIATED WITH Acute Liver Failure (ortholog); Acute-On-Chronic Liver Failure (ortholog); adult respiratory distress syndrome (ortholog); FOUND IN extracellular region (ortholog); INTERACTS WITH deoxynivalenol

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

C-X-C motif chemokine 10; chemokine C-X-C motif ligand 10; chemokine CXC-like protein

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	71,693,339 - 71,695,948 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	71,693,641 - 71,695,948 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	75,829,909 - 75,831,236 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Sscrofa10.2	8	75,881,457 - 75,882,217 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Liver Failure (ISO)

Acute-On-Chronic Liver Failure (ISO)

adult respiratory distress syndrome (ISO)

alopecia areata (ISO)

asthma (ISO)

atopic dermatitis (ISO)

bacterial pneumonia (ISO)

boutonneuse fever (ISO)

Brain Injuries (ISO)

Brain Injuries, Traumatic (ISO)

brain ischemia (ISO)

bronchiolitis obliterans (ISO)

cardiovascular system disease (ISO)

Carrington Syndrome (ISO)

celiac disease (ISO)

cerebrovascular disease (ISO)

Chemical and Drug Induced Liver Injury (ISO)

cholestasis (ISO)

Chronic Hepatitis B (ISO)

Chronic Hepatitis C (ISO)

chronic obstructive pulmonary disease (ISO)

colon carcinoma (ISO)

Colonic Neoplasms (ISO)

common cold (ISO)

coronary restenosis (ISO)

Coronavirus infectious disease (ISO)

COVID-19 (ISO)

cryoglobulinemia (ISO)

Cytomegalovirus Infections (ISO)

Diabetic Nephropathies (ISO)

diabetic retinopathy (ISO)

encephalitis (ISO)

Experimental Autoimmune Myasthenia Gravis (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Liver Cirrhosis (ISO)

extrinsic allergic alveolitis (ISO)

fatty liver disease (ISO)

Foot Ulcer (ISO)

Graft vs Host Disease (ISO)

hepatitis B (ISO)

hepatitis C (ISO)

hepatocellular carcinoma (ISO)

human immunodeficiency virus infectious disease (ISO)

Human Influenza (ISO)

Hypothermia (ISO)

inhalation anthrax (ISO)

interstitial cystitis (ISO)

interstitial lung disease (ISO)

ischemia (ISO)

liver cirrhosis (ISO)

Liver Metastasis (ISO)

Liver Reperfusion Injury (ISO)

middle cerebral artery infarction (ISO)

Middle East respiratory syndrome (ISO)

myasthenia gravis (ISO)

Myocardial Ischemia (ISO)

myocarditis (ISO)

non-alcoholic fatty liver disease (ISO)

non-alcoholic steatohepatitis (ISO)

pleurisy (ISO)

pneumonia (ISO)

primary biliary cholangitis (ISO)

proteinuria (ISO)

pulmonary emphysema (ISO)

pulmonary sarcoidosis (ISO)

pulmonary tuberculosis (ISO)

renovascular hypertension (ISO)

Reperfusion Injury (ISO)

respiratory syncytial virus infectious disease (ISO)

Respiratory Tract Granuloma (ISO)

severe acute respiratory syndrome (ISO)

Spinal Cord Injuries (ISO)

Spontaneous Abortions (ISO)

systemic scleroderma (ISO)

thoracic aortic aneurysm (ISO)

Thyroid Neoplasms (ISO)

Transplant Rejection (ISO)

type 1 diabetes mellitus (ISO)

type 2 diabetes mellitus (ISO)

uveitis (ISO)

Viral Bronchiolitis (ISO)

viral pneumonia (ISO)

visceral leishmaniasis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

deoxynivalenol (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IEA)

antimicrobial humoral immune response mediated by antimicrobial peptide (IBA)

cellular response to heat (ISO)

cellular response to lipopolysaccharide (IBA)

chemokine-mediated signaling pathway (IBA)

chemotaxis (ISO)

defense response to virus (IEA)

endothelial cell activation (IEA)

G protein-coupled receptor signaling pathway (ISO)

immune response (ISO)

inflammatory response (IBA)

killing of cells of other organism (ISO)

negative regulation of angiogenesis (IEA)

negative regulation of myoblast differentiation (IEA)

negative regulation of myoblast fusion (IEA)

neutrophil chemotaxis (IBA)

positive chemotaxis (IEA)

positive regulation of cell migration (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of leukocyte chemotaxis (ISO)

positive regulation of monocyte chemotaxis (IEA)

positive regulation of release of sequestered calcium ion into cytosol (IEA)

positive regulation of T cell migration (IEA)

regulation of apoptotic process (IEA)

regulation of cell population proliferation (IEA)

regulation of endothelial tube morphogenesis (IEA)

regulation of T cell chemotaxis (IEA)

response to auditory stimulus (ISO)

response to bacterium (ISO)

response to cold (ISO)

response to gamma radiation (ISO)

response to lipopolysaccharide (ISO)

response to virus (ISO)

response to vitamin D (ISO)

T cell chemotaxis (IEA)

Cellular Component

external side of plasma membrane (IEA)

extracellular region (ISO)

extracellular space (IBA)

Molecular Function

chemoattractant activity (IEA)

chemokine activity (IBA)

CXCR chemokine receptor binding (IBA)

CXCR3 chemokine receptor binding (IEA)

heparin binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:17328963	PMID:17676471	PMID:19896155	PMID:24083897	PMID:24889251	PMID:26498738

Genomics

Comparative Map Data

CXCL10
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	71,693,339 - 71,695,948 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	71,693,641 - 71,695,948 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	75,829,909 - 75,831,236 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Sscrofa10.2	8	75,881,457 - 75,882,217 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CXCL10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	4	76,021,118 - 76,023,497 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	4	76,021,118 - 76,023,497 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	4	76,942,269 - 76,944,689 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	77,161,295 - 77,163,674 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	4	77,299,451 - 77,301,829	NCBI
Celera	4	74,243,028 - 74,245,407 (-)	NCBI
Cytogenetic Map	4	q21.1	NCBI
HuRef	4	72,694,720 - 72,697,139 (-)	NCBI		HuRef
CHM1_1	4	76,918,847 - 76,921,265 (-)	NCBI		CHM1_1

Cxcl10
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	92,494,497 - 92,496,748 (-)	NCBI	GRCm39		mm39
GRCm38	5	92,346,638 - 92,348,889 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	92,346,638 - 92,348,889 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	92,775,667 - 92,777,880 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	5	93,421,841 - 93,424,054 (-)	NCBI			mm8
Celera	5	90,490,436 - 90,492,644 (-)	NCBI		Celera
Cytogenetic Map	5	E2	NCBI
cM Map	5	46.57	NCBI

Cxcl10
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	14	17,210,733 - 17,212,930 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	17,210,733 - 17,212,930 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	17,126,865 - 17,129,062 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	17,265,986 - 17,268,183 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	14	17,265,985 - 17,268,183 (+)	NCBI
Celera	14	15,099,217 - 15,101,414 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI
RH 3.4 Map	14	182.09	RGD

Cxcl10
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955433	748,284 - 750,927 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955433	748,392 - 750,890 (-)	NCBI	ChiLan1.0	ChiLan1.0

CXCL10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	4	54,020,204 - 54,022,606 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	54,020,204 - 54,022,606 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	4	48,182,355 - 48,184,733 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

CXCL10
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	32	597,987 - 599,979 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	32	598,406 - 599,925 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Cxcl10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936676	60,869 - 63,028 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CXCL10
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1 Ensembl	7	24,526,680 - 24,529,130 (-)	Ensembl
ChlSab1.1	7	24,526,657 - 24,529,193 (-)	NCBI

Cxcl10
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624757	14,989,241 - 14,991,650 (+)	NCBI

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	hemolymphoid system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system
High
Medium	8	2		5				1	3
Low	2	2	3		2	22	2	2
Below cutoff						1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001008691	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000067	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK231132	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY577902	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY789646	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY894692	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU672252	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU862040	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ372065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU364898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01038825	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSSSCT00000062500 ⟹ ENSSSCP00000032297

RefSeq Status:

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	8	71,693,339 - 71,695,948 (-)	Ensembl

RefSeq Acc Id:

NM_001008691 ⟹ NP_001008691

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	8	71,693,641 - 71,695,948 (-)	NCBI

Sequence:

show sequence

ACGCGGGGGAGACACTCTTCAACTGCTCATTCTGAGCCTACTGCAGAAGAATCTTCAGCTGCAG
CACCATGAACCAAAGTGCTGTTCTTATTTTCTGCCTTATTCTTCTGACTCTGAGTGGAACTCAA
GGAATACCTCTCTCCAGAACTGTTCGCTGTACCTGCATCAAGATCAGTGACAGACCTGTTAATC
CGAGGTCCTTAGAAAAACTTGAAATGATTCCTGCAAGTCAATCTTGCCCACATGTTGAGATCAT
TGCCACAATGAAAAAGAATGGGGAGAAAAGATGTCTGAATCCAGAGTCTAAGACCATCAAGAAT
TTACTGAAAGCAATTAGCAAAGAAAGGTCTAAAAGATCTCCTCGAACACAGAGAGAAGCATAAT
CACGGCACTACTGATAAGGATGGGCCGGAGAGAATCTACCTCTGCCATCATCTCTCTACATACA
CCATACATCAAGCCCTAACTGTCCATGGATTGCAGTCACCAAGTTAGCTGCTCCCACACTTGCA
GGGCAGCAGATGGTTCATCATCCCGAGCTGTTGAGCAGTAACTCTGCCCAGGCACTATACTATA
AGCTACACTGAGGTGCTACATTCTTAGTGAATGTGCCAAGTCCTGGCCCTGCTACTGACACTTT
CCTCACCTTTCCTATCGTCTGGTTATTAAGGGATCATTCCACTTTGGGACTTAATCGAAGTTCT
TAGAATCTCAAATAACCAAGAGGTATTTAAAACAATAATAAAACCTGCTTTTTAAAGAAAGATC
TTTACTCCGTGGGCTTCTACTGCTTTCCTTCCAAGGGGCCCATATTCTCTTGGTGATTACATAC
ATAATTCTAAATACACAGGAGAAGCTAGAAATCCCTGAAAATGTATATGAAAATAGTATTATTT
AGTGAAAGACTATATAAAGTAGGATTCTTAGATGTATATGTTTCTTATAGTTTTCAGTGTTTAT
GGAATACCTTGTAAAAGTATGTACTACAATGAGATAAATTTTTAAATGTGGATACATGTTCTGC
ATGTTATGTAAGACAAATACGCTGAGTGGGTGCTCTTCAAAATAAAACTAATGTTCTCTCCTAG
AAACATTAAGAAAGACTAACTGTTCAGACAAAAAAGGTAATAAAGTTACTATAAGCCAAAAAAA
AAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001008691	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAS90942	(Get FASTA)	NCBI Sequence Viewer
	AAV65839	(Get FASTA)	NCBI Sequence Viewer
	AAW80469	(Get FASTA)	NCBI Sequence Viewer
	ABD18444	(Get FASTA)	NCBI Sequence Viewer
	ABY66144	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001008691 ⟸ NM_001008691
- Peptide Label:	precursor
- UniProtKB:	Q5S1S3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MNQSAVLIFCLILLTLSGTQGIPLSRTVRCTCIKISDRPVNPRSLEKLEMIPASQSCPHVEIIA TMKKNGEKRCLNPESKTIKNLLKAISKERSKRSPRTQREA hide sequence

RefSeq Acc Id:

ENSSSCP00000032297 ⟸ ENSSSCT00000062500

Protein Domains

SCY

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000032474	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00070004989	UniProtKB/TrEMBL
Ensembl Protein	ENSSSCP00000032297	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCP00070007763	UniProtKB/TrEMBL
	ENSSSCP00070007777	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000062500	ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCT00070009465	UniProtKB/TrEMBL
	ENSSSCT00070009482	UniProtKB/TrEMBL
InterPro	Chemokine_CXC	UniProtKB/TrEMBL
	Chemokine_CXC_CS	UniProtKB/TrEMBL
	Chemokine_IL8-like_dom	UniProtKB/TrEMBL
	CXC_Chemokine_domain	UniProtKB/TrEMBL
	Interleukin_8-like_sf	UniProtKB/TrEMBL
KEGG Report	ssc:494019	UniProtKB/TrEMBL
NCBI Gene	CXCL10	ENTREZGENE
PANTHER	PTHR10179	UniProtKB/TrEMBL
Pfam	IL8	UniProtKB/TrEMBL
PRINTS	SMALLCYTKCXC	UniProtKB/TrEMBL
PROSITE	SMALL_CYTOKINES_CXC	UniProtKB/TrEMBL
SMART	SCY	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54117	UniProtKB/TrEMBL
UniGene	Ssc.35257	ENTREZGENE
UniProt	A0A4X1SX64_PIG	UniProtKB/TrEMBL
	A0A4X1SZ52_PIG	UniProtKB/TrEMBL
	Q5S1S3	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:87101	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD