REN (renin) - Rat Genome Database

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Gene: REN (renin) Sus scrofa
Analyze
Symbol: REN
Name: renin
RGD ID: 13854518
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); insulin-like growth factor receptor binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN amyloid-beta metabolic process (ortholog); angiotensin maturation (ortholog); cell maturation (ortholog); PARTICIPATES IN benazepril pharmacodynamics pathway; candesartan pharmacodynamics pathway; captopril pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure (ortholog); Albuminuria (ortholog); anemia (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl964,809,146 - 64,822,658 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1964,809,143 - 64,822,605 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2971,147,542 - 71,151,808 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Albuminuria  (ISO)
anemia  (ISO)
atrial fibrillation  (ISO)
autistic disorder  (ISO)
Autosomal Dominant Tubulointerstitial Kidney Disease 4  (ISO)
Azotemia  (ISO)
Bartter disease  (ISO)
Cardiomegaly  (ISO)
chronic fatigue syndrome  (ISO)
Chronic Intermittent Hypoxia  (ISO)
colitis  (ISO)
congenital adrenal hyperplasia  (ISO)
congestive heart failure  (ISO)
Critical Illness  (ISO)
depressive disorder  (ISO)
Diabetic Nephropathies  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Endotoxemia  (ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial adult myoclonic epilepsy 5  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
hand, foot and mouth disease  (ISO)
Hemorrhage  (ISO)
hepatoblastoma  (ISO)
human cytomegalovirus infection  (ISO)
hypertension  (ISO)
Hypokalemic Periodic Paralysis, Type 1  (ISO)
Hyponatremia  (ISO)
Hypotension  (ISO)
ischemia  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (ISO)
Liddle syndrome  (ISO)
liver cirrhosis  (ISO)
malignant hypertension  (ISO)
myocardial infarction  (ISO)
nephrosis  (ISO)
nephrotic syndrome  (ISO)
obesity  (ISO)
osteoporosis  (ISO)
parathyroid carcinoma  (ISO)
periodontal disease  (ISO)
portal hypertension  (ISO)
Preeclamptic Toxemia  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
primary biliary cholangitis  (ISO)
primary hyperaldosteronism  (ISO)
proteinuria  (ISO)
psoriasis  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
Renal Tubular Dysgenesis  (ISO)
renovascular hypertension  (ISO)
Retina Reperfusion Injury  (ISO)
toxic shock syndrome  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
REN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl964,809,146 - 64,822,658 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1964,809,143 - 64,822,605 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2971,147,542 - 71,151,808 (-)NCBISscrofa10.2Sscrofa10.2susScr3
REN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381204,154,819 - 204,166,337 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1204,154,819 - 204,190,324 (-)EnsemblGRCh38hg38GRCh38
GRCh371204,123,947 - 204,135,465 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361202,390,571 - 202,402,088 (-)NCBINCBI36Build 36hg18NCBI36
Build 341200,855,604 - 200,867,122NCBI
Celera1177,259,194 - 177,270,715 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1175,289,120 - 175,300,481 (-)NCBIHuRef
CHM1_11205,547,624 - 205,559,145 (-)NCBICHM1_1
T2T-CHM13v2.01203,418,967 - 203,430,485 (-)NCBIT2T-CHM13v2.0
Ren1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391133,278,412 - 133,288,058 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1133,278,248 - 133,288,063 (+)EnsemblGRCm39 Ensembl
GRCm381133,350,674 - 133,360,320 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,350,510 - 133,360,325 (+)EnsemblGRCm38mm10GRCm38
MGSCv371135,247,251 - 135,256,894 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361135,178,238 - 135,187,863 (+)NCBIMGSCv36mm8
Celera1135,963,151 - 135,972,794 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map157.91NCBI
Ren
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81347,348,312 - 47,359,539 (+)NCBIGRCr8
mRatBN7.21344,796,260 - 44,807,491 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1344,796,091 - 44,807,489 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1347,406,270 - 47,416,579 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01348,694,375 - 48,704,684 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01345,952,438 - 45,963,417 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01350,502,724 - 50,513,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,502,724 - 50,514,151 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,555,583 - 55,566,812 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41346,262,936 - 46,275,213 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11346,277,000 - 46,288,249 (+)NCBI
Celera1345,129,122 - 45,139,889 (+)NCBICelera
RH 3.4 Map13170.9RGD
Cytogenetic Map13q13NCBI
Ren
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540640,016,630 - 40,026,286 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540640,016,624 - 40,026,286 (-)NCBIChiLan1.0ChiLan1.0
REN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2145,210,086 - 45,221,659 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1145,175,312 - 45,186,915 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01179,757,653 - 179,769,530 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11184,045,917 - 184,057,431 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1184,046,117 - 184,057,393 (-)Ensemblpanpan1.1panPan2
REN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.138744,540 - 766,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl38744,614 - 755,012 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha38840,126 - 850,501 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.038740,693 - 762,325 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl38740,767 - 751,204 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.138736,523 - 746,891 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0381,127,902 - 1,138,260 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0381,328,102 - 1,338,487 (-)NCBIUU_Cfam_GSD_1.0
Ren
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934471,363,409 - 71,373,041 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936567598,048 - 607,497 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936567598,044 - 607,628 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
REN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12525,159,816 - 25,193,620 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2525,183,037 - 25,193,420 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605525,943,204 - 25,954,169 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ren
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248076,817,195 - 6,827,462 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248076,817,472 - 6,827,374 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in REN
497 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system nervous system renal system
High
Medium
Low 1
Below cutoff 3 4 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000043605   ⟹   ENSSSCP00000045910
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl964,809,146 - 64,822,636 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000053358   ⟹   ENSSSCP00000049573
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl964,809,146 - 64,822,658 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000090617   ⟹   ENSSSCP00000059766
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl964,809,146 - 64,818,619 (-)Ensembl
RefSeq Acc Id: XM_021063211   ⟹   XP_020918870
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1964,809,143 - 64,822,605 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021063212   ⟹   XP_020918871
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1964,809,338 - 64,822,604 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020918870   ⟸   XM_021063211
- Peptide Label: isoform X1
- UniProtKB: A0A4X1V377 (UniProtKB/TrEMBL),   A0A287B096 (UniProtKB/TrEMBL),   A0A287APG1 (UniProtKB/TrEMBL),   A0A8D1TQZ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020918871   ⟸   XM_021063212
- Peptide Label: isoform X2
- UniProtKB: A0A4X1UXZ7 (UniProtKB/TrEMBL),   A0A8D1TQZ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000059766   ⟸   ENSSSCT00000090617
RefSeq Acc Id: ENSSSCP00000045910   ⟸   ENSSSCT00000043605
RefSeq Acc Id: ENSSSCP00000049573   ⟸   ENSSSCT00000053358
Protein Domains
Peptidase A1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000031235 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015070734 UniProtKB/TrEMBL
  ENSSSCG00025011703 UniProtKB/TrEMBL
  ENSSSCG00030045653 UniProtKB/TrEMBL
  ENSSSCG00035002308 UniProtKB/TrEMBL
  ENSSSCG00040027985 UniProtKB/TrEMBL
  ENSSSCG00045035041 UniProtKB/TrEMBL
  ENSSSCG00050076114 UniProtKB/TrEMBL
  ENSSSCG00055024705 UniProtKB/TrEMBL
  ENSSSCG00060056245 UniProtKB/TrEMBL
  ENSSSCG00065061210 UniProtKB/TrEMBL
  ENSSSCG00070021064 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000053358 ENTREZGENE
  ENSSSCT00000053358.3 UniProtKB/TrEMBL
  ENSSSCT00000090617.1 UniProtKB/TrEMBL
  ENSSSCT00015094811.1 UniProtKB/TrEMBL
  ENSSSCT00015095009.1 UniProtKB/TrEMBL
  ENSSSCT00015095138.1 UniProtKB/TrEMBL
  ENSSSCT00015095224.1 UniProtKB/TrEMBL
  ENSSSCT00025015430.1 UniProtKB/TrEMBL
  ENSSSCT00025015478.1 UniProtKB/TrEMBL
  ENSSSCT00025015532.1 UniProtKB/TrEMBL
  ENSSSCT00030063714.1 UniProtKB/TrEMBL
  ENSSSCT00030063755.1 UniProtKB/TrEMBL
  ENSSSCT00030063788.1 UniProtKB/TrEMBL
  ENSSSCT00035002892.1 UniProtKB/TrEMBL
  ENSSSCT00035002896.1 UniProtKB/TrEMBL
  ENSSSCT00035002898.1 UniProtKB/TrEMBL
  ENSSSCT00040037518.1 UniProtKB/TrEMBL
  ENSSSCT00040037594.1 UniProtKB/TrEMBL
  ENSSSCT00040037662.1 UniProtKB/TrEMBL
  ENSSSCT00045060251.1 UniProtKB/TrEMBL
  ENSSSCT00045060339.1 UniProtKB/TrEMBL
  ENSSSCT00045060427.1 UniProtKB/TrEMBL
  ENSSSCT00050104477.1 UniProtKB/TrEMBL
  ENSSSCT00050104478.1 UniProtKB/TrEMBL
  ENSSSCT00055048736.1 UniProtKB/TrEMBL
  ENSSSCT00055048824.1 UniProtKB/TrEMBL
  ENSSSCT00055048899.1 UniProtKB/TrEMBL
  ENSSSCT00060076631.1 UniProtKB/TrEMBL
  ENSSSCT00060076643.1 UniProtKB/TrEMBL
  ENSSSCT00065083873.1 UniProtKB/TrEMBL
  ENSSSCT00065083879.1 UniProtKB/TrEMBL
  ENSSSCT00070041852.1 UniProtKB/TrEMBL
  ENSSSCT00070041856.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.70.10 UniProtKB/TrEMBL
InterPro Aspartic_peptidase_A1 UniProtKB/TrEMBL
  Aspartic_peptidase_AS UniProtKB/TrEMBL
  Aspartic_peptidase_N UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/TrEMBL
  Peptidase_aspartic_dom_sf UniProtKB/TrEMBL
  Renin-like_dom UniProtKB/TrEMBL
NCBI Gene REN ENTREZGENE
PANTHER PTHR47966 UniProtKB/TrEMBL
  RENIN UniProtKB/TrEMBL
Pfam A1_Propeptide UniProtKB/TrEMBL
  Asp UniProtKB/TrEMBL
PRINTS PEPSIN UniProtKB/TrEMBL
PROSITE ASP_PROTEASE UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
Superfamily-SCOP SSF50630 UniProtKB/TrEMBL
UniProt A0A287APG1 ENTREZGENE, UniProtKB/TrEMBL
  A0A287B096 ENTREZGENE
  A0A4X1UXZ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1V377 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QN71_PIG UniProtKB/TrEMBL
  A0A8D0PTL6_PIG UniProtKB/TrEMBL
  A0A8D1TQZ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1W3W8_PIG UniProtKB/TrEMBL
UniProt Secondary A0A287B096 UniProtKB/TrEMBL
VGNC ID VGNC:92211 ENTREZGENE