REN (renin) - Rat Genome Database

Name: REN
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Advanced Search (OLGA)

Gene: REN (renin) Sus scrofa

Analyze

Symbol:

REN

Name:

renin

RGD ID:

13854518

Description:

ENCODES a protein that exhibits endopeptidase activity (ortholog); insulin-like growth factor receptor binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN amyloid-beta metabolic process (ortholog); angiotensin maturation (ortholog); cell maturation (ortholog); PARTICIPATES IN benazepril pharmacodynamics pathway; candesartan pharmacodynamics pathway; captopril pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure (ortholog); Albuminuria (ortholog); anemia (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	REN (renin)	HGNC	Ensembl, NCBI, OrthoDB
Mus musculus (house mouse):	Ren1 (renin 1 structural)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Ren (renin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ren (renin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	REN (renin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	REN (renin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ren (renin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	REN (renin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ren (renin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	64,809,146 - 64,822,658 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	64,809,143 - 64,822,605 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	71,147,542 - 71,151,808 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (ISO)

Albuminuria (ISO)

anemia (ISO)

atrial fibrillation (ISO)

autistic disorder (ISO)

Autosomal Dominant Tubulointerstitial Kidney Disease 4 (ISO)

Azotemia (ISO)

Bartter disease (ISO)

Cardiomegaly (ISO)

chronic fatigue syndrome (ISO)

Chronic Intermittent Hypoxia (ISO)

colitis (ISO)

congenital adrenal hyperplasia (ISO)

congestive heart failure (ISO)

Critical Illness (ISO)

depressive disorder (ISO)

Diabetic Nephropathies (ISO)

Endotoxemia (ISO)

essential hypertension (ISO)

Experimental Diabetes Mellitus (ISO)

familial adult myoclonic epilepsy 5 (ISO)

Fetal Growth Retardation (ISO)

Fibrosis (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

hand, foot and mouth disease (ISO)

Hemorrhage (ISO)

hepatoblastoma (ISO)

human cytomegalovirus infection (ISO)

hypertension (ISO)

Hypokalemic Periodic Paralysis, Type 1 (ISO)

Hyponatremia (ISO)

Hypotension (ISO)

ischemia (ISO)

kidney disease (ISO)

kidney failure (ISO)

Left Ventricular Hypertrophy (ISO)

Liddle syndrome (ISO)

liver cirrhosis (ISO)

malignant hypertension (ISO)

metabolic dysfunction and alcohol associated liver disease (ISO)

myocardial infarction (ISO)

nephrosis (ISO)

nephrotic syndrome (ISO)

obesity (ISO)

osteoporosis (ISO)

parathyroid carcinoma (ISO)

periodontal disease (ISO)

portal hypertension (ISO)

Preeclamptic Toxemia (ISO)

Prenatal Exposure Delayed Effects (ISO)

primary biliary cholangitis (ISO)

primary hyperaldosteronism (ISO)

proteinuria (ISO)

psoriasis (ISO)

Puromycin Aminonucleoside Nephrosis (ISO)

Renal Tubular Dysgenesis (ISO)

renovascular hypertension (ISO)

Retina Reperfusion Injury (ISO)

Tonne-Kalscheuer syndrome (ISO)

toxic shock syndrome (ISO)

withdrawal disorder (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amyloid-beta metabolic process (ISO)

angiotensin maturation (IBA,IEA,ISO)

cell maturation (IEA,ISO)

cellular response to xenobiotic stimulus (ISO)

drinking behavior (IEA,ISO)

establishment of blood-nerve barrier (ISO)

hormone-mediated signaling pathway (IEA,ISO)

juxtaglomerular apparatus development (ISO)

kidney development (IEA)

male gonad development (IEA)

mesonephros development (IEA)

proteolysis (IEA)

regulation of blood pressure (IEA,ISO)

regulation of blood volume by renin-angiotensin (IEA,ISO)

regulation of MAPK cascade (IEA)

renin-angiotensin regulation of aldosterone production (IEA,ISO)

response to cAMP (ISO)

response to cGMP (ISO)

response to immobilization stress (ISO)

response to lipopolysaccharide (ISO)

response to xenobiotic stimulus (ISO)

Cellular Component

apical part of cell (IEA)

extracellular region (IEA,ISO)

extracellular space (IBA,IEA,ISO)

Molecular Function

aspartic-type endopeptidase activity (IBA,IEA)

endopeptidase activity (IEA,ISO)

insulin-like growth factor receptor binding (ISO)

peptidase activity (IEA)

protein binding (ISO)

signaling receptor binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

benazepril pharmacodynamics pathway (ISO)

candesartan pharmacodynamics pathway (ISO)

captopril pharmacodynamics pathway (ISO)

cilazapril pharmacodynamics pathway (ISO)

enalapril pharmacodynamics pathway (ISO)

eprosartan pharmacodynamics pathway (ISO)

forasartsn pharmacodynamics pathway (ISO)

fosinopril pharmacodynamics pathway (ISO)

irbesartan pharmacodynamics pathway (ISO)

lisinopril pharmacodynamics pathway (ISO)

losartan pharmacodynamics pathway (ISO)

moexipril pharmacodynamics pathway (ISO)

olmesartan pharmacodynamics pathway (ISO)

perindopril pharmacodynamics pathway (ISO)

quinapril pharmacodynamics pathway (ISO)

ramipril pharmacodynamics pathway (ISO)

renin-angiotensin cascade pathway (ISO)

spirapril pharmacodynamics pathway (ISO)

telmisartan pharmacodynamics pathway (ISO)

trandolapril pharmacodynamics pathway (ISO)

valsartan pharmacodynamics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

REN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	64,809,146 - 64,822,658 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	64,809,143 - 64,822,605 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	71,147,542 - 71,151,808 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

REN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	204,154,819 - 204,166,337 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	204,154,819 - 204,190,324 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	204,123,947 - 204,135,465 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	202,390,571 - 202,402,088 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	200,855,604 - 200,867,122	NCBI
Celera	1	177,259,194 - 177,270,715 (-)	NCBI		Celera
Cytogenetic Map	1	q32.1	NCBI
HuRef	1	175,289,120 - 175,300,481 (-)	NCBI		HuRef
CHM1_1	1	205,547,624 - 205,559,145 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	203,418,967 - 203,430,485 (-)	NCBI		T2T-CHM13v2.0

Ren1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	133,278,412 - 133,288,058 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	133,278,248 - 133,288,063 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	133,350,674 - 133,360,320 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	133,350,510 - 133,360,325 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	135,247,251 - 135,256,894 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	135,178,238 - 135,187,863 (+)	NCBI		MGSCv36	mm8
Celera	1	135,963,151 - 135,972,794 (+)	NCBI		Celera
Cytogenetic Map	1	E4	NCBI
cM Map	1	57.91	NCBI

Ren
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	47,348,312 - 47,359,539 (+)	NCBI		GRCr8
mRatBN7.2	13	44,796,260 - 44,807,491 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	44,796,091 - 44,807,489 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	47,406,270 - 47,416,579 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	48,694,375 - 48,704,684 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	45,952,438 - 45,963,417 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	50,502,724 - 50,513,953 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	50,502,724 - 50,514,151 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	55,555,583 - 55,566,812 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	46,262,936 - 46,275,213 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	46,277,000 - 46,288,249 (+)	NCBI
Celera	13	45,129,122 - 45,139,889 (+)	NCBI		Celera
RH 3.4 Map	13	170.9	RGD
Cytogenetic Map	13	q13	NCBI

Ren
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	40,016,630 - 40,026,286 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	40,016,624 - 40,026,286 (-)	NCBI	ChiLan1.0	ChiLan1.0

REN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	45,210,086 - 45,221,659 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	45,175,312 - 45,186,915 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	179,757,653 - 179,769,530 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	184,045,917 - 184,057,431 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	184,046,117 - 184,057,393 (-)	Ensembl	panpan1.1		panPan2

REN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	744,540 - 766,998 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	744,614 - 755,012 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	840,126 - 850,501 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	740,693 - 762,325 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	740,767 - 751,204 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	736,523 - 746,891 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	1,127,902 - 1,138,260 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	1,328,102 - 1,338,487 (-)	NCBI		UU_Cfam_GSD_1.0

Ren
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	71,363,409 - 71,373,041 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936567	598,048 - 607,497 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936567	598,044 - 607,628 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

REN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	25,159,816 - 25,193,620 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	25,183,037 - 25,193,420 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	25,943,204 - 25,954,169 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ren
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624807	6,817,195 - 6,827,462 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624807	6,817,472 - 6,827,374 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in REN
487 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	mesenchyme	nervous system	renal system	reproductive system
4	3	2	4	2	3

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021063211	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021063212	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000070	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK398198	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU571280	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000043605 ⟹ ENSSSCP00000045910

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	9	64,809,146 - 64,822,636 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000053358 ⟹ ENSSSCP00000049573

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	9	64,809,146 - 64,822,658 (-)	Ensembl

Ensembl Acc Id:

ENSSSCT00000090617 ⟹ ENSSSCP00000059766

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	9	64,809,146 - 64,818,619 (-)	Ensembl

RefSeq Acc Id:

XM_021063211 ⟹ XP_020918870

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	9	64,809,143 - 64,822,605 (-)	NCBI

Sequence:

show sequence

AAGGGATCTTCATCGGATCCCAGGAAGGGCTGGGGACCCAGGTGGAGCATGGACCGGTGGAGCA
GCATGCCGTGCTGGGGACTCCTGCTGGTGCTTTGGGGCTCCTGCACCTTCGGTCTCCCTGCAGA
CACTGGCGCCTTCAGTCGGATCTTCCTCAAGAAAATGCCCTCAGTCCGGGAAAGCCTGAAGGAG
CGAGGCGTGGACATGGCCAGGCTGGGTGCTGAGTGGAGCCAGTTCAGCAAGAGACTCTCCTTTG
GCAACAGAACCAGCCCCGTGGTCCTCACCAACTACCTGGATACCCAGTACTATGGCGAGATCGG
CATTGGCACCCCGCCACAGACCTTCAAAGTCATCTTCGACACAGGCTCGGCCAACCTCTGGGTG
CCCTCCACCAAATGCAGCCCTCTCTACACGGCCTGTGAGATTCACAGCCTCTACGACTCCTCGG
AATCCTCCAGCTATGTGGAAAACGGGACGGAATTCACCATCCACTATGGGTCCGGGAAGGTCAA
AGGCTTCCTGAGCCAGGACCTAGTGACTGTGGGCGGATTCACAGTCACACAGACGTTTGGAGAG
GTCACAGAGCTGCCCCTGATCCCCTTCATGCTGGCCAAGTTCGATGGTGTTCTGGGCATGGGCT
TCCCTGCACAGGCCGTCGGCGGGGTCACCCCCGTCTTTGACCACATCCTTTCCCAGAAGGTGCT
GAAGGAGGACGTTTTCTCCGTCTACTACAGCAGAAATTCCAAGAATTCCCAGTTGCTGGGGGGA
GAGATTGTGCTGGGCGGCAGTGACCCCCAGTATTACCAGGACAGTTTCCACTACGTGAGCATCA
GCAAGACTGGCTCCTGGCAGATCAAAATGAAAGGGGTGTCTGTGAGGTCGGCCACCTTGCTCTG
TGAGGAGGGCTGCATGGTGGTAGTGGATACCGGGGCATCCTACATCTCAGGTCCCACTAGCTCC
CTGAGGCTGCTCATGGAGACCCTGGGGGCCAAGGAGCTGAGCACAGATGAATATGTTGTGAACT
GTAACCAAGTGCCCACACTCCCCGACATCTCCTTCCATCTCGGAGGCAGAGCCTACACGCTCAC
CAGTGCGGACTACGTCTTACAGGACCCCTACAATAACGATGATCTGTGCACACTGGCCCTCCAC
GGTCTGGACGTTCCACCGCCCACTGGACCCGTCTGGGTCCTTGGTGCCAGCTTCATCCGAAAGT
TCTACACGGAGTTTGATCGACGTAACAATCGCATTGGCTTTGCCCTGGCCCGCTGAGGCCCACT
GCTGCCTTGCAGGCCCTGCGCTCGGCCCTAGCCCAGAGCTACATCACTCTCTGTGACCCATCCC
CACCCTGCCTATGCTTGTGTCCTTACTCAGGGGCACAGGGCTTGGAGCACCTCCTGGATGTGTG
TCCTGCCCCCAGCATCGGCTCTTCCTGCTTTGAGGACAAATAAAAACTTCATGTTCACA

hide sequence

RefSeq Acc Id:

XM_021063212 ⟹ XP_020918871

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	9	64,809,338 - 64,822,604 (-)	NCBI

Sequence:

show sequence

AGGGATCTTCATCGGATCCCAGGAAGGGCTGGGGACCCAGGTGGAGCATGGACCGGTGGAGCAG
CATGCCGTGCTGGGGACTCCTGCTGGTGCTTTGGGGCTCCTGCACCTTCGGTCTCCCTGCAGAC
ACTGGCGCCTTCAGTCGGATCTTCCTCAAGAAAATGCCCTCAGTCCGGGAAAGCCTGAAGGAGC
GAGGCGTGGACATGGCCAGGCTGGGTGCTGAGTGGAGCCAGTTCAGCAAGAGACTCTCCTTTGG
CAACAGAACCAGCCCCGTGGTCCTCACCAACTACCTGGATACCCAGTACTATGGCGAGATCGGC
ATTGGCACCCCGCCACAGACCTTCAAAGTCATCTTCGACACAGGCTCGGCCAACCTCTGGGTGC
CCTCCACCAAATGCAGCCCTCTCTACACGGCCTGTGAGATTCACAGCCTCTACGACTCCTCGGA
ATCCTCCAGCTATGTGGAAAACGGGACGGAATTCACCATCCACTATGGGTCCGGGAAGGTCAAA
GGCTTCCTGAGCCAGGACCTAGTGACTGTGGGCGGATTCACAGTCACACAGACGTTTGGAGAGG
TCACAGAGCTGCCCCTGATCCCCTTCATGCTGGCCAAGTTCGATGGTGTTCTGGGCATGGGCTT
CCCTGCACAGGCCGTCGGCGGGGTCACCCCCGTCTTTGACCACATCCTTTCCCAGAAGGTGCTG
AAGGAGGACGTTTTCTCCGTCTACTACAGCAGGAATTCCCAGTTGCTGGGGGGAGAGATTGTGC
TGGGCGGCAGTGACCCCCAGTATTACCAGGACAGTTTCCACTACGTGAGCATCAGCAAGACTGG
CTCCTGGCAGATCAAAATGAAAGGGGTGTCTGTGAGGTCGGCCACCTTGCTCTGTGAGGAGGGC
TGCATGGTGGTAGTGGATACCGGGGCATCCTACATCTCAGGTCCCACTAGCTCCCTGAGGCTGC
TCATGGAGACCCTGGGGGCCAAGGAGCTGAGCACAGATGAATATGTTGTGAACTGTAACCAAGT
GCCCACACTCCCCGACATCTCCTTCCATCTCGGAGGCAGAGCCTACACGCTCACCAGTGCGGAC
TACGTCTTACAGGACCCCTACAATAACGATGATCTGTGCACACTGGCCCTCCACGGTCTGGACG
TTCCACCGCCCACTGGACCCGTCTGGGTCCTTGGTGCCAGCTTCATCCGAAAGTTCTACACGGA
GTTTGATCGACGTAACAATCGCATTGGCTTTGCCCTGGCCCGCTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_020918870	(Get FASTA)	NCBI Sequence Viewer
	XP_020918871	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000049573
	ENSSSCP00000049573.2
	ENSSSCP00000059766.1
	ENSSSCP00015038889.1
	ENSSSCP00015038994.1
	ENSSSCP00015039050.1
	ENSSSCP00015039095.1
	ENSSSCP00025006080.1
	ENSSSCP00025006112.1
	ENSSSCP00025006139.1
	ENSSSCP00030029166.1
	ENSSSCP00030029187.1
	ENSSSCP00030029206.1
	ENSSSCP00035000983.1
	ENSSSCP00035000985.1
	ENSSSCP00035000986.1
	ENSSSCP00040015625.1
	ENSSSCP00040015658.1
	ENSSSCP00040015687.1
	ENSSSCP00045042313.1
	ENSSSCP00045042380.1
	ENSSSCP00045042435.1
	ENSSSCP00050045814.1
	ENSSSCP00050045815.1
	ENSSSCP00055038898.1
	ENSSSCP00055038971.1
	ENSSSCP00055039038.1
	ENSSSCP00060033114.1
	ENSSSCP00060033121.1
	ENSSSCP00065036559.1
	ENSSSCP00065036562.1
	ENSSSCP00070035148.1
	ENSSSCP00070035152.1

RefSeq Acc Id:	XP_020918870 ⟸ XM_021063211
- Peptide Label:	isoform X1
- UniProtKB:	A0A4X1V377 (UniProtKB/TrEMBL), A0A287B096 (UniProtKB/TrEMBL), A0A287APG1 (UniProtKB/TrEMBL), A0A8D1TQZ6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDRWSSMPCWGLLLVLWGSCTFGLPADTGAFSRIFLKKMPSVRESLKERGVDMARLGAEWSQFS KRLSFGNRTSPVVLTNYLDTQYYGEIGIGTPPQTFKVIFDTGSANLWVPSTKCSPLYTACEIHS LYDSSESSSYVENGTEFTIHYGSGKVKGFLSQDLVTVGGFTVTQTFGEVTELPLIPFMLAKFDG VLGMGFPAQAVGGVTPVFDHILSQKVLKEDVFSVYYSRNSKNSQLLGGEIVLGGSDPQYYQDSF HYVSISKTGSWQIKMKGVSVRSATLLCEEGCMVVVDTGASYISGPTSSLRLLMETLGAKELSTD EYVVNCNQVPTLPDISFHLGGRAYTLTSADYVLQDPYNNDDLCTLALHGLDVPPPTGPVWVLGA SFIRKFYTEFDRRNNRIGFALAR hide sequence

RefSeq Acc Id:	XP_020918871 ⟸ XM_021063212
- Peptide Label:	isoform X2
- UniProtKB:	A0A4X1UXZ7 (UniProtKB/TrEMBL), A0A8D1TQZ6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDRWSSMPCWGLLLVLWGSCTFGLPADTGAFSRIFLKKMPSVRESLKERGVDMARLGAEWSQFS KRLSFGNRTSPVVLTNYLDTQYYGEIGIGTPPQTFKVIFDTGSANLWVPSTKCSPLYTACEIHS LYDSSESSSYVENGTEFTIHYGSGKVKGFLSQDLVTVGGFTVTQTFGEVTELPLIPFMLAKFDG VLGMGFPAQAVGGVTPVFDHILSQKVLKEDVFSVYYSRNSQLLGGEIVLGGSDPQYYQDSFHYV SISKTGSWQIKMKGVSVRSATLLCEEGCMVVVDTGASYISGPTSSLRLLMETLGAKELSTDEYV VNCNQVPTLPDISFHLGGRAYTLTSADYVLQDPYNNDDLCTLALHGLDVPPPTGPVWVLGASFI RKFYTEFDRRNNRIGFALAR hide sequence

Ensembl Acc Id:

ENSSSCP00000059766 ⟸ ENSSSCT00000090617

Ensembl Acc Id:

ENSSSCP00000045910 ⟸ ENSSSCT00000043605

Ensembl Acc Id:

ENSSSCP00000049573 ⟸ ENSSSCT00000053358

Protein Domains

Peptidase A1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000031235	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00015070734	UniProtKB/TrEMBL
	ENSSSCG00025011703	UniProtKB/TrEMBL
	ENSSSCG00030045653	UniProtKB/TrEMBL
	ENSSSCG00035002308	UniProtKB/TrEMBL
	ENSSSCG00040027985	UniProtKB/TrEMBL
	ENSSSCG00045035041	UniProtKB/TrEMBL
	ENSSSCG00050076114	UniProtKB/TrEMBL
	ENSSSCG00055024705	UniProtKB/TrEMBL
	ENSSSCG00060056245	UniProtKB/TrEMBL
	ENSSSCG00065061210	UniProtKB/TrEMBL
	ENSSSCG00070021064	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000053358	ENTREZGENE
	ENSSSCT00000053358.3	UniProtKB/TrEMBL
	ENSSSCT00000090617.1	UniProtKB/TrEMBL
	ENSSSCT00015094811.1	UniProtKB/TrEMBL
	ENSSSCT00015095009.1	UniProtKB/TrEMBL
	ENSSSCT00015095138.1	UniProtKB/TrEMBL
	ENSSSCT00015095224.1	UniProtKB/TrEMBL
	ENSSSCT00025015430.1	UniProtKB/TrEMBL
	ENSSSCT00025015478.1	UniProtKB/TrEMBL
	ENSSSCT00025015532.1	UniProtKB/TrEMBL
	ENSSSCT00030063714.1	UniProtKB/TrEMBL
	ENSSSCT00030063755.1	UniProtKB/TrEMBL
	ENSSSCT00030063788.1	UniProtKB/TrEMBL
	ENSSSCT00035002892.1	UniProtKB/TrEMBL
	ENSSSCT00035002896.1	UniProtKB/TrEMBL
	ENSSSCT00035002898.1	UniProtKB/TrEMBL
	ENSSSCT00040037518.1	UniProtKB/TrEMBL
	ENSSSCT00040037594.1	UniProtKB/TrEMBL
	ENSSSCT00040037662.1	UniProtKB/TrEMBL
	ENSSSCT00045060251.1	UniProtKB/TrEMBL
	ENSSSCT00045060339.1	UniProtKB/TrEMBL
	ENSSSCT00045060427.1	UniProtKB/TrEMBL
	ENSSSCT00050104477.1	UniProtKB/TrEMBL
	ENSSSCT00050104478.1	UniProtKB/TrEMBL
	ENSSSCT00055048736.1	UniProtKB/TrEMBL
	ENSSSCT00055048824.1	UniProtKB/TrEMBL
	ENSSSCT00055048899.1	UniProtKB/TrEMBL
	ENSSSCT00060076631.1	UniProtKB/TrEMBL
	ENSSSCT00060076643.1	UniProtKB/TrEMBL
	ENSSSCT00065083873.1	UniProtKB/TrEMBL
	ENSSSCT00065083879.1	UniProtKB/TrEMBL
	ENSSSCT00070041852.1	UniProtKB/TrEMBL
	ENSSSCT00070041856.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.70.10	UniProtKB/TrEMBL
InterPro	Aspartic_peptidase_A1	UniProtKB/TrEMBL
	Aspartic_peptidase_AS	UniProtKB/TrEMBL
	Aspartic_peptidase_N	UniProtKB/TrEMBL
	PEPTIDASE_A1	UniProtKB/TrEMBL
	Peptidase_aspartic_dom_sf	UniProtKB/TrEMBL
	Renin-like_dom	UniProtKB/TrEMBL
NCBI Gene	REN	ENTREZGENE
PANTHER	PTHR47966	UniProtKB/TrEMBL
	RENIN	UniProtKB/TrEMBL
Pfam	A1_Propeptide	UniProtKB/TrEMBL
	Asp	UniProtKB/TrEMBL
PRINTS	PEPSIN	UniProtKB/TrEMBL
PROSITE	ASP_PROTEASE	UniProtKB/TrEMBL
	PEPTIDASE_A1	UniProtKB/TrEMBL
	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50630	UniProtKB/TrEMBL
UniProt	A0A287APG1	ENTREZGENE, UniProtKB/TrEMBL
	A0A287B096	ENTREZGENE
	A0A4X1UXZ7	ENTREZGENE, UniProtKB/TrEMBL
	A0A4X1V377	ENTREZGENE, UniProtKB/TrEMBL
	A0A5G2QN71_PIG	UniProtKB/TrEMBL
	A0A8D0PTL6_PIG	UniProtKB/TrEMBL
	A0A8D1TQZ6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8D1W3W8_PIG	UniProtKB/TrEMBL
UniProt Secondary	A0A287B096	UniProtKB/TrEMBL
VGNC ID	VGNC:92211	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

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Imported Annotations - SMPDB