RGD Reference Report - Comparison of active renin concentration and plasma renin activity as a prognostic predictor in patients with heart failure. - Rat Genome Database

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Comparison of active renin concentration and plasma renin activity as a prognostic predictor in patients with heart failure.

Authors: Tsutamoto, Takayoshi  Sakai, Hiroshi  Tanaka, Toshinari  Fujii, Masanori  Yamamoto, Takashi  Wada, Atsuyuki  Ohnishi, Masato  Horie, Minoru 
Citation: Tsutamoto T, etal., Circ J. 2007 Jun;71(6):915-21. doi: 10.1253/circj.71.915.
RGD ID: 126908011
Pubmed: PMID:17526990   (View Abstract at PubMed)
DOI: DOI:10.1253/circj.71.915   (Journal Full-text)


BACKGROUND: Plasma renin activity (PRA) may be limited to angiotensinogen levels, which decrease in patients with heart failure (HF) because of liver congestion.
METHODS AND RESULTS: To evaluate whether the plasma active renin concentration (ARC) is a more useful prognostic predictor than PRA, the plasma levels of ARC, PRA, angiotensin II, aldosterone, brain natriuretic peptide (BNP), norepinephrine, and hemodynamic parameters were measured in 214 consecutive HF patients who were already taking angiotensin-converting enzyme inhibitors (ACEI) or angiotensin-receptor blockers (ARB). Median follow-up period was 1,197 days. Of the clinical variables, including pulmonary capillary wedge pressure, right atrial pressure, left ventricular ejection fraction, and neurohumoral factors, only high plasma levels of log ARC (p<0.0001) and log BNP (p=0.0009), but not log PRA, were significant independent prognostic predictors. Log ARC/PRA ratio was significantly higher in nonsurvivors than in survivors. Log ARC/PRA significantly correlated with pulmonary capillary wedge pressure (r=0.305, p<0.0001), right atrial pressure (r=0.222, p=0.0011), and log BNP (r=0.242, p=0.0004).
CONCLUSIONS: Plasma ARC is superior to PRA and a high plasma ARC is an independent prognostic predictor in HF patients who are already receiving ACEI or ARB.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
RENHumancongestive heart failure exacerbatesIEP protein:increased activity:blood plasma (human)RGD 
RenRatcongestive heart failure exacerbatesISOREN (Homo sapiens)protein:increased activity:blood plasma (human)RGD 
Ren1Mousecongestive heart failure exacerbatesISOREN (Homo sapiens)protein:increased activity:blood plasma (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ren  (renin)

Genes (Mus musculus)
Ren1  (renin 1 structural)

Genes (Homo sapiens)
REN  (renin)


Additional Information