RGD Reference Report - Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats.

Authors: St. Lezin, EM  Pravenec, M  Wong, AL  Liu, W  Wang, N  Lu, S  Jacob, HJ  Roman, RJ  Stec, DE  Wang, JM  Reid, IA  Kurtz, TW 
Citation: St. Lezin EM, etal., J Clin Invest 1996 Jan 15;97(2):522-7
RGD ID: 61046
Pubmed: PMID:8567976   (View Abstract at PubMed)
PMCID: PMC507046   (View Article at PubMed Central)
DOI: DOI:10.1172/JCI118444   (Journal Full-text)

To investigate whether a BP-regulatory locus exists in the vicinity of the renin locus on rat chromosome 13, we transferred this chromosome segment from the Dahl salt-sensitive (S) rat onto the genetic background of the Dahl salt-resistant (R) rat. In congenic Dahl R rats carrying the S renin gene and fed an 8% salt diet, systolic BP was significantly lower than in progenitor Dahl R rats: 127 +/- 1 mmHg versus 138 +/- 4 mmHg, respectively (P < 0.05). Moreover, the decreased BP in the congenic Dahl R strain was associated with decreased kidney renin mRNA and decreased plasma renin concentration. These findings demonstrate that the Dahl S strain carries alleles in or near the renin locus that confer lower plasma renin concentration and lower BP than the corresponding alleles in the Dahl R strain, at least when studied on the genetic background of the Dahl R rat and in the environment of a high salt diet. The occurrence of coincident reductions in kidney renin mRNA, plasma renin concentration, and BP after interstrain transfer of naturally occurring renin gene variants strongly suggests that genetically determined variation in renin gene expression can affect BP.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Hypotension  IAGP 61046 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
regulation of blood pressure  IMP 61046 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
decreased systemic arterial systolic blood pressure  IAGP 61046 RGD 
decreased systemic arterial systolic blood pressure sexual_dimorphismIAGP 61046males compared to SR/Jr malesRGD 
increased systemic arterial blood pressure  IAGP 61046 RGD 

Related Phenotype Data for this Reference

Phenominer Options:  View all phenotype data for this reference  |  Download all phenotype data for this reference

Select a value below to view phenotype data for a specific strain, measurment, or condition.

Objects Annotated

Genes (Rattus norvegicus)
Ren  (renin)

QTLs
Bp24  (Blood pressure QTL 24)

Strains
SHR.BN-(D13Arb5-Ren1)/Ipcv  (NA)
SR/Jr  (Salt Resistant)
SS/Jr  (Salt Sensitive)

Objects referenced in this article
Marker D13Mit1 D13Mit1 Rattus norvegicus
QTL Bp11 Blood pressure QTL 11 Rattus norvegicus
QTL Bp25 Blood pressure QTL 25 Rattus norvegicus
QTL Bp31 Blood pressure QTL 31 Rattus norvegicus
QTL Bp5 Blood pressure QTL 5 Rattus norvegicus
Strain SS.SR-(D13Mit9-D13Mit1)/Jr null Rattus norvegicus

Additional Information